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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 17513868 | 2007 | Cell line : SW480 CCL-228, HT-29,HTB 38, HCT 116, CCL 247 Source : ATCC Sample Type : - No. of Sample : - Stage : - | Immunohistolochemistry,real time RT-PCR,Immunoblotting | Up-regulation | - | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily, attached to the plasma membrane via a glycosylphosphatidyl inositol anchor. In response to bacterial infection or inflammation, the encoded protein is thought to inactivate alpha-1 proteinase inhibitor, a major tissue protectant against proteolytic enzymes released by activated neutrophils, facilitating the transendothelial migration of neutrophils to inflammatory sites. The encoded protein may also play a role in tumor invasion and metastasis through activation of MMP2. The gene has previously been referred to as MMP20 but has been renamed MMP25. [provided by RefSeq, Jul 2008] | Chromosome | 16 |
| Location | 16p13.3 |
| Start | 3096682 |
| End | 3110727 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 14046 |
| OMIM ID | 608482 |
| HGNC ID | HGNC:14246 |
| Unigene ID | Hs.654979 |
| Ensembl ID | - |
| PharmGKB ID | PA30882 |
Protein Information
| Protein ID | NP_071913.1 |
|---|---|
| Protein Name | matrix metallopeptidase 25 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 562 |
| Uniprot ID | Q96J02 |
| Ensembl Protein ID | ENSP00000262650 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1191 | CLU | 1706 | NP_001822.2 | in vitro;in vivo | 12860995 |
| 4313 | MMP2 | 386 | NP_004521.1 | in vitro | 866 333 214 583 471 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd04278 | 115-280 | ZnMc_MMP |
| cl00064 | 115-280 | ZnMc superfamily |
| cd00094 | 314-508 | HX |
| cl02471 | 314-508 | HX superfamily |
| cd04279 | 117-280 | ZnMc_MMP_like_1 |
| cd00203 | 129-279 | ZnMc |
| cd04277 | 108-280 | ZnMc_serralysin_like |
| cd04268 | 117-279 | ZnMc_MMP_like |
| pfam01471 | 25-85 | PG_binding_1 |
| cl18368 | 25-85 | PG_binding_1 superfamily |
| smart00120 | 416-462 | HX |
| pfam00045 | 416-462 | Hemopexin |
| cd04327 | 148-243 | ZnMc_MMP_like_3 |
| smart00120 | 321-364 | HX |
| pfam00045 | 321-364 | Hemopexin |
| cd11375 | 230-253 | Peptidase_M54 |
| pfam00045 | 465-486 | Hemopexin |
| pfam00413 | 115-280 | Peptidase_M10 |
| smart00235 | 115-281 | ZnMc |
Ontology Information
| HPRD ID | 17964 |
|---|---|
| Molecular Class | Metallo protease |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Cell growth and/or maintenance (GO:0008151) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| Q9NPA2 | DB00786 | Marimastat | SmallMoleculeDrug |