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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
MPO 4353 myeloperoxidase  17- 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
23734221   2013Cell line : -

Source : -

Sample Type : CRC tumor and normal tissue

No. of Sample : A TMA including healthy mucosa and clinically annotated CRC specimens (n?=?1491) was .

Stage : -

 Flow cytometry , splitting randomized data in training and validation subsets, multivariate analysisUp-regulation-High density MPO+ cell infiltration is a novel independent favorable prognostic factor in CRC.


Gene Details



NC_000017.10 (56347217..56358296, complement)

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Gene Type protein coding
Gene Family -
Description Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of neutrophils. [provided by RefSeq, Nov 2014]  
Chromosome 17
Location 17q21.3-q2
Start 56347217  
End 56358296  
Strand -  
Gene Sequence

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Length 11080  
OMIM ID 606989   
HGNC ID HGNC:7218   
Unigene ID Hs.458272   
Ensembl ID -   
PharmGKB ID PA243   

mRNA Information


mRNA ID XM_011524821.1
Exon join(1..85,3245..3389,3585..3709,3855..3948,4300..4475, 4668..4791,4888..5017,5100..5306,6169..6487,8612..8772, 10645..10900,11396..11566,12422..12659,13451..14459)  
mRNA Sequence

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Length 3240  



CDS Information


   
Location16..2439
CDS Sequence

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CCDS ID CCDS11604.1



Protein Information


      
Protein IDXP_011523123.1
Protein Namemyeloperoxidase
Molecular Wt. (Da)19765
Protein Sequence

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Length 807  
Uniprot IDQ13077
Ensembl Protein ID ENSP00000362994  



Post-translational Modification Information (Source : HPRD)


Residue Type site
NGlycosylation355
NGlycosylation391
MProteolytic Cleavage409
NGlycosylation323;-
NGlycosylation729

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

               
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
1356CP317NP_000087.1in vitro9097926   


Pathway Information


            
Pathway Name Pathway ID
Phagosome hsa04145
Transcriptional misregulation in cancer hsa05202


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd09824316-728  myeloperoxidase_like
cl14561316-728  An_peroxidase_like superfamily
cd09825189-743  thyroid_peroxidase
cd09826297-732  peroxidasin_like
cd09823327-706  peroxinectin_like
cd05396329-706  An_peroxidase_like
cd09822227-719  peroxinectin_like_bacterial
cd09820181-724  dual_peroxidase_like
cd09821251-724  An_peroxidase_bacterial_2
cd09816312-666  prostaglandin_endoperoxide_synthase
cd09818330-655  PIOX_like
cd09819400-531  An_peroxidase_bacterial_1
PLN02283312-467  PLN02283
cd09817586-678  linoleate_diol_synthase_like
pfam03098173-715  An_peroxidase


Ontology Information


   
HPRD ID5091
Molecular ClassEnzyme: Oxidoreductase
Molecular FunctionTranscription factor activity (GO:0003700)
Biological ProcessRegulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)  



SNP Information


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Drug Information


Uniprot ID DrugBank ID Name Type
P05164DB00006BivalirudinSmallMoleculeDrug
P05164DB00062Human Serum AlbuminBiotechDrug
P05164DB00104OctreotideSmallMoleculeDrug
P05164DB00208TiclopidineSmallMoleculeDrug
P05164DB00233Aminosalicylic AcidSmallMoleculeDrug
P05164DB00250DapsoneSmallMoleculeDrug
P05164DB00461NabumetoneSmallMoleculeDrug
P05164DB00500TolmetinSmallMoleculeDrug
P05164DB00515CisplatinSmallMoleculeDrug
P05164DB00526OxaliplatinSmallMoleculeDrug
P05164DB00550PropylthiouracilSmallMoleculeDrug
P05164DB00833CefaclorSmallMoleculeDrug
P05164DB00847CysteamineSmallMoleculeDrug
P05164DB00958CarboplatinSmallMoleculeDrug
P05164DB01065MelatoninSmallMoleculeDrug
P05164DB01225EnoxaparinSmallMoleculeDrug
P05164DB02300CalcipotriolSmallMoleculeDrug
P05164DB06774CapsaicinSmallMoleculeDrug
P05164DB06823TioproninSmallMoleculeDrug
P05164DB00244MesalazineSmallMoleculeDrug
P05164DB00535CefdinirSmallMoleculeDrug
P05164DB00583L-CarnitineSmallMoleculeDrug
P05164DB01065MelatoninSmallMoleculeDrug

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO