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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
MPP3 4356 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)  17 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
23011156   2012Cell line : -

Source : -

Sample Type : CRC tumor and normal tissue

No. of Sample : 23

Stage : TNM Stage I-IV

-Hypermethylation-Epigenetic inactivation of MPP3 frequently occurred during the development of colorectal cancer and might also be a potential biomarker for molecular classification of colorectal cancer patients


Gene Details



Chromosome 17 - NC_000017.11 (43800799..43833179, complement)

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Gene Type protein coding
Gene Family
Description This gene product is a member of a family of membrane-associated proteins termed MAGUKs (membrane-associated guanylate kinase homologs). MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intracellular junctions. This protein contains a conserved sequence, called the SH3 (src homology 3) motif, found in several other proteins that associate with the cytoskeleton and are suspected to play important roles in signal transduction. Alternatively spliced transcript variants have been identified. One transcript variant is experimentally supported, but it doesn't encode a protein.  
Chromosome 17
Location 17q12-q21
Start 43800799  
End 43833179  
Strand -  
Gene Sequence

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Length 32381  
OMIM ID 601114   
HGNC ID HGNC:7221   
Unigene ID Hs.396566   
Ensembl ID ENSG00000161647   
PharmGKB ID -   

mRNA Information


mRNA ID NM_001932.4
Exon join(1..79,361..419,1237..1298,1503..1621,1859..1936, 3073..3153,3389..3526,5348..5429,7339..7424,9175..9249, 12122..12318,15070..15134,16483..16503,17101..17142, 18819..18983,19089..19169,21975..22068,22265..22373, 24102..24224,31303..32381)  
mRNA Sequence

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Length 2851  



CDS Information


   
Locationjoin(1199..1298,1503..1621,1859..1936,3073..3153, 3389..3526,5348..5429,7339..7424,9175..9249,12122..12318, 15070..15134,16483..16503,17101..17142,18819..18983, 19089..19169,21975..22068,22265..22373,24102..24224, 31303..31479)
CDS Sequence

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CCDS ID -



Protein Information


      
Protein IDNP_001923.2
Protein Namemembrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
Molecular Wt. (Da)66021
Protein Sequence

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Length 585  
Uniprot IDP09429
Ensembl Protein ID ENSP00000343040  



Post-translational Modification Information (Source : HPRD)


No matching records could be found.

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                                                    
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
6187RPS24690NP_002943.2yeast 2-hybrid16169070   
6326SCN2A3133NP_066287.2yeast 2-hybrid16169070   
9001HAP12972NP_003940.3yeast 2-hybrid16169070   
10769PLK26118NP_006613.2yeast 2-hybrid16169070   
11031RAB315751NP_006859.2yeast 2-hybrid16169070   
23450SF3B312027NP_036558.3yeast 2-hybrid16169070   
55709KBTBD413757NP_060565.4yeast 2-hybrid16169070   
84273C4orf1412823NP_115689.1yeast 2-hybrid16169070   
90933TRIM4115558NP_291027.3yeast 2-hybrid16169070   
284208B3GNTL118527NP_001009905.1yeast 2-hybrid16169070   
339230CCDC13711313AAH09369.1yeast 2-hybrid16169070   
378464MORN217587NP_919246.1yeast 2-hybrid16169070   


Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd12039230-291  SH3_MPP3
cl17036230-291  SH3 superfamily
cd00071387-505  GMPK
cl17190387-505  NK superfamily
cd00992135-215  PDZ_signaling
cl00117135-215  PDZ superfamily
smart00072395-571  GuKc
cd11862230-289  SH3_MPP
cd12033230-289  SH3_MPP7
TIGR03263386-566  guanyl_kin
COG0194384-570  Gmk
cd12035230-288  SH3_MPP1-like
cd12036231-289  SH3_MPP5
cd12034230-290  SH3_MPP4
PRK00300408-566  gmk
cd12080230-288  SH3_MPP1
cd12081230-288  SH3_CASK
cd12037230-289  SH3_MPP2
cd12038230-289  SH3_MPP6
smart00228135-216  PDZ
PRK14738383-506  gmk
smart0056971-121  L27
cl0267271-121  L27 superfamily
cd00136146-215  PDZ
pfam00595138-215  PDZ
pfam0282868-117  L27
PRK14737385-509  gmk
cd11861230-289  SH3_DLG-like
smart00569Dec-64  L27
cl02672Dec-64  L27 superfamily
pfam02828Oct-60  L27
cd12032225-295  SH3_DLG2
cd00988147-225  PDZ_CTP_protease
cd12031229-289  SH3_DLG1
smart00326227-288  SH3
cd12029229-289  SH3_DLG3
pfam07653230-289  SH3_2
cd12030230-289  SH3_DLG4
cd11949230-288  SH3_GRB2_C
cd00989160-222  PDZ_metalloprotease
cd00174230-288  SH3
cd11840232-288  SH3_Intersectin_5
cd11951230-287  SH3_GRAP_C
cd11758232-287  SH3_CRK_N
cd00987141-215  PDZ_serine_protease
cd11772230-288  SH3_OSTF1
pfam00018232-288  SH3_1
cd11996249-288  SH3_Intersectin2_5
cd11995252-288  SH3_Intersectin1_5
cd00990151-229  PDZ_glycyl_aminopeptidase
cd11845232-288  SH3_Src_like
pfam14604233-288  SH3_9
pfam13180147-214  PDZ_2
cd11767231-288  SH3_Nck_3
pfam14685147-191  Tricorn_PDZ
cd11773232-288  SH3_Sla1p_1
cd12013231-293  SH3_RIM-BP_3
cd11851231-288  SH3_RIM-BP
pfam00625384-572  Guanylate_kin
PLN02772364-569  PLN02772
COG0793147-223  CtpA


Ontology Information


   
HPRD ID2829
Molecular ClassUnclassified
Molecular FunctionDNA binding (GO:0003677)
Biological ProcessRegulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO