CoReCG

Search results:

General Information

Gene_Symbol	Gene_ID	Gene_Name	Chromosome	Alias
MSH6	2956	MutS homolog 6 (E. coli)	2	GTBP; HSAP; HNPCC5

Evidence
Gene
mRNA
CDS
Protein
PTM
Enzyme
PPi
Pathway
Structural
Domain
Ontology
SNP
Drug
External Links

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
21836479	2011	Cell line : - Source : - Sample Type : - No. of Sample : - Stage : -	-	Down-regulation	-	Mismatch repair defects were identified in 92% of MSH6 tumors, with high concordance between microsatellite instability and loss of immunohistochemical MSH6 expression.
22283331	2012	Cell line : - Source : - Sample Type : - No. of Sample : - Stage : -	real time PCR-HRM analysis.	Mutation	-	-
22495361	2012	Cell line : - Source : - Sample Type : - No. of Sample : - Stage : -	Immunohistochemistry	Mutation	-	In 56 (7%) of 815 families, at least 1 MSH6 mutation, 23 definitively pathogenic mutations and 38 missense mutations or unclassified variants, and several polymorphisms in the MSH6 gene were detected.
22918162	2012	Cell line : - Source : - Sample Type : CRC tumor and Normal tissue No. of Sample : 420 Stage : -	Immunohistochemistry	Mutation	-	Significant reduction of MSH6 staining is more likely to occur in colorectal carcinoma, and suggest that somatic mutations of the coding region microsatellites of the MSH6 gene is an underlying mechanism for this staining phenomenon in MLH1/PMS2-deficient carcinomas.
22933731	2012	Cell line : - Source : Colon Cancer Family Registry. Sample Type : - No. of Sample : - Stage : -	-	Mutation	-	Obtained data from the Colon Cancer Family Registry for 764 carriers of an MMR gene mutation (316 MLH1, 357 MSH2, 49 MSH6, and 42 PMS2), who had a previous diagnosis of colorectal cancer.
22997602	2012	Cell line : - Source : - Sample Type : - No. of Sample : - Stage : -	-	Mutation	-	Mutationm due to inactivation of DNA mismatch repair syste,results MSI.

Gene Details

Chromosome: 2; NC_000002.11 (48010221..48034092)
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Gene Type	protein coding
Gene Family	-
Description	This gene encodes a protein similar to the MutS protein. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides, prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein of this gene combines with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene have been identified in individuals with hereditary nonpolyposis colon cancer (HNPCC) and endometrial cancer. [provided by RefSeq, Jul 2008]
Chromosome	2
Location	2p16
Start	47783082
End	47806953
Strand	+
Gene Sequence	>gi\|568815596:47783082-47806953 Homo sapiens chromosome 2, GRCh38.p2 Primary Assembly GGCGAGGCGCCTGTTGATTGGCCACTGGGGCCCGGGTTCCTCCGGCGGAGCGCGCCTCCCCCCAGATTTC CCGCCAGCAGGAGCCGCGCGGTAGATGCGGTGCTTTTAGGAGCTCCGTCCGACAGAACGGTTGGGCCTTG CCGGCTGTCGGTATGTCGCGACAGAGCACCCTGTACAGCTTCTTCCCCAAGTCTCCGGCGCTGAGTGATG CCAACAAGGCCTCGGCCAGGGCCTCACGCGAAGGCGGCCGTGCCGCCGCTGCCCCCGGGGCCTCTCCTTC CCCAGGCGGGGATGCGGCCTGGAGCGAGGCTGGGCCTGGGCCCAGGCCCTTGGCGCGCTCCGCGTCACCG CCCAAGGCGAAGAACCTCAACGGAGGGCTGCGGAGATCGGTAGCGCCTGCTGCCCCCACCAGGTAGCGGG GTGGGGGTGGGGTCGAAGGCGGGGGCATAGCGGCGGGGCGCTTGGAACCCGGCGAGGGGAGGCTCGCACA GGGGGTTGGGGGGGTGCACGGCCTGGCCCTGGGCTCGGAGGAGGCGGGGCCGCAGAGTTGGCTTGAATGA GTGCAGGGGTCGAGTCTGGAGCATTTGGGGGTGTAGCTTGTAAACAGGGTCGGAGGAGAGAGGCTGTGCA GGAAGAGGGCTGCAGGGGAGACGCGGAGAGTTCGGGCCTTTTGGAGGGAGGAGACGCGTCCCGCCAGGTG GGGGTGCTGGGCTAAGGAAGGGGCGACGCGCGCAGCTCCGGGTGGGGAGGGGGCCTGGGAGGTGGGAGCA CTGGGGGTGGGGCGAGAAGGGGAAGGCGCCCGGCCCACTTGGTGGGCGGGGCGGGGGGCGGGGTGGCGGG AAGGAGGAATGCCTGCGGGAGGCCGAACGGGGAGAGTCCGGTGGTGTGGGGTGCGAAAGGAGGTTCCTCG GCCGGCGCGGAGATAGTGAGTTGGGGCTCCAGTAGTCGATCGAGGTAGACACTTAGAGGTAGTTAAGAGC CGCGGTCGCCGAGACGCCTTGGGGACGGTGGGCCTTCGGCCTAGGTGAGGGGCCGCCGAGGGGGTGGGCC ACGAGCTGCGAGCGCGGGGGGGTGTGTCACCATGGGGACCGCGGGGCCTAATTGGGCGGGGCGGGGCCGT GGGGAGCCGAAGTGCTGGGATCCGGCTGGGTCCTTCGGTAGGTAGGCTGCACGTGCACCGAGACGAAGAT AGAATATTTTGACGTATGTGGAAATTCGTGTCGAGTGGAAAATATTTTATTTTATGAAATAGTGTAATTT TTATGGGGCACCACTGGGCTTTTAGAGGCCTTAATCGGGCGCTGGACAAAGATGTGTGGACGTGAGTGAC TCCGGGGAAGCCTGTCGGGAGTTGTCCTCACTTTATGGGCAGTTAAGTGCTTTTTTTTTTTTTTCCTTTT TGAGAGAGAGTTTCGCTCAAGTCCAGGCTGGAGTGCAATGGCGCGATCTCAGCTCACCGCAATCTCCGCG TCCCGGCTTCAAGCGATTCCCCAGCTTCAGCCTCCCGAGTAGTCGGGATTACAGGAATGCGCCCCCACAC CCCGCCAATTTTGTATTTTTAGTAGAGACGGGGTTTCTCCATGTTGGTCAGGCTAGTCTCGGAATTCCCG ACCTCAGGTGATCCACCCGCCTCGGCCTCAAAGTGCTGGGATTACAGGCGCTAGCCACCGCGCCCGGTCT GTTTAGGGCTTTTTATCCGGGCAGCTGGCGACATTTTGAAAAGCTTGCTTTTGCTGTTTGCCAGATACAT ATATATGTATTTTGAGACAGAGTCTTGCTCTTTTGTCCAGGCTAGAGTGCAGTGGCGCGTTCTTGGCTCA CCACAACCTCTGTCTCTGGATCAAGAGATTATCCTGCCTCAGCCTCCCAAGTAGCTGGGACTACAGGTGC GCCCCACCACGCCTGGCTAATTTTTGTATTTTTAGTAGAGACGGGTTTCACTATGTTGGCCAGGCTGGTA TCGAACTCCTGACCTCTTGATCGGCCCGCATTGGCCTACCAAAGTGCTGGGATTACAGGCATGAACCACC GAGCCCGGCCGTTTGTCAGATACTAAACACAAAGTTTAATGGTCGCTATTTGAACAAACGAAGAAATAAA GGCTCAGAAAAAATAACTCATTCAAGATAAGAGCCAGTTCGTGTTTTTTGTTTGGTTTTGTTTTGAAATG GAGTCTCGCTCTGTCGCCCAGGCTGGAGTGCTGTGGCGCTTTCTCGGCTCACTGCAACCTCTGCCCGCCG GGTTCAAGTGATTCTCCTGCCTCAGCTTCCCGAGTAGCTGGGATTACGGGTGTGCCCACCGCGGTCCGGC TGATTTTTCACCATGGAGTTTCACCATGTTGGCCAGGCTGGTCTTGAAACTGCTGACCTCAAGTGGTCCA CCCACTTCAGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCGTGCCCGGCCGCTAGTTAGTGGTT TTGAGTAATGGATTTCAAATCCATTTAAATCCAGTTTAAAGTGTCCTAAAGGAATTCTGAGATTTTTCTA AGTGTAATTATAGTGTTACCCTTGTTTAAGCGACCCTTTCCCGCAGTTTAAATATATATAGTTGTGCATT AGTAGAATATGCTTGTGGGGAACAGAGCCAGCATCCGCAATAACAAACTCCTGGTTAGAAAAGCATGACG TATTGTTTACTTGAGCATGAATTGATTGTTGAATCCAAACCAAACGGGTGTATTTATTGTAAGGATGTAC TTTACATTCATATTGAATAGCGTATGTTATTTGTTTCTTGAGGTTGAGTTTAAGAGACTTGTAAAAATAA AACGTATACATTTCACCTCCCGTTATGGAGAGGATTCCAGGGTATTCAAGAAAGATGGGCATTTGATACT AGGTTTCTAAAGAAACTGCAGTGTCTAGATCACTCTGCCGAGCACAGCATTAGGCATTATGGATCCTGGA TACAACCATGAACAGGACAAAGCAAAGAGGCAATTGTAGACTCCAAGTGGAAAGGGGACGGAGAGGATGC GGGTCAGGCTAGGCTCTCAGCTCTGTAAACCGAAACCAGAAGGACAAATAAGCTTAGACAGATTATAGTG AGAGTGGGAAGCTGGTTCAGGAAGAGGAAGGTCTGCAAATTGTGGGTAGGATGAAAGGAGGAGGAGGGAG CATTGGAGAAGTTAAGCAGAGATCCAATCATGAACAGTCTGATGAGCTACAGAGACATTCGGACTTACTC CATGAATCATTTAAGCCTTAAAACATGTTGAGCGTATTTTTTTTTTTTTTGAGACGGAATTTCACTCTTG TTGCCCAAGCTGGAGTGCAGTGGTGTGGTCTCAGCTCACTGCAACCTCCGCCTCCTGGGTTCCAGCGATT CTCCTGCCTCATCCTCTCAAGTACCTGGTATTACAGGTGCCTGCCACCACGCCCAGCTAATTTTTGTGTT TATAGTAGAGACGGGTTTCACCATGTTGGTCAGGCCAGTCGTGAACTCCTGACCTCAGGTGATCCACCCA CCTCAGCCTCCCAAAGTGTTGGGATTACAGGCGTGAACCACCGCACCTGGCCGTGAGCCACCGTGTCTGT CCGAGCATCTTTTAATGTTTGTCATTTAGATTTCTTCTTGTGCTGAAGTGTTTGTCTTTTGCTGTTTCTT TTTTTTTTCCTAGTTCTTTGTCATTTGTGTGTGATATAAATGTCTTCTTTCACAATGAGTTCTTTCATTT AGTTTATGGCTTTGTTGTTGTTGTTGAATAATAGAGGTCTCACTTTGTTGCCCAGGCTGGTGTTGAACTC TTGCTCTCAAGCGATCCTCCCACTTCAGCCTCCCAACCTGTTGGGATTACAAGTGTGAGCCACCACACCC AGCCTTATGGCATCTTTCGATGAACAAATTATTGATTATAATGTGGAATTTGTCCTTTTATTTTCTCTGT GGTTAGTGTTTCTATAGGTTTTATTTAAGAAATCCACAGGGAGGCTGGGTGCAGTGGCTCATGCCTGTAA ACCCAACACTTTGGGAGGCCAAGGCAGGCCAACATGGCTAGACCCTGTCTCTCCAAAAAATAAGAAAATT AGCCAGGCATGGTGGCGTGTGCCTGTAGTCCCAGCTTCTTGGGAGACTGAGATGGGAGGATCGCTTGAGT CCAGGAGGTTGAGGCTGCAGTAAGCCAAGAGATCATGCCATGCACTCCAGCCTGGGTGGCAGAGTCAGAC CCTGTCTGCCAAAAAATAAAATAAAAGTTGGTGAAAATGTTGATTATATATTTTAGGAACAACTAGTAAT TGACATCAAAATTATGGGCTAAAGAGAAAGCAAAAATAATGTGATTTTAAACCAGAATTCAAAAGATCTG TTTAGCGTATGTTTAGACAAAGCCATTACTTATTATATCAAAGTTTTAACATTTATTTTGTGAGCTGTCA GCTTTTCCTCTTAACATTTTTCCCCACCGTCTTAAAAAACCCCAAGAATACCGGACATTTAAGACTCACT TAAAGCTTTAAAAGCACTTGCAAAATCCTAAAATCATAATTTAAGGTGTTTTTGGAGGGCAGGAGCAATG GTGGCAGGCAGTGTTTTGCTTTGTTGCCCAGGCTGAAGTACAGTGGCAGATCTCGGTTCACTGCACCCTC GACCTATTCGGCTCAAGTGATCCTCCCACCTCAGCTTTCTGAGTAGCTGGGACCCCAAGTGCACACCACC CCATGCCTGGCTAATTTTTAAATTTTTTTGTAGAAACAAGGTCTCACTGTGTAGCCCAGATGGTCTCGAA TTCCTGGGCTCTTAAGAGATCCTCCCAAAGTGCTGGGATCATAGGTGTGAGCCACCACACCTGGCCTATT TTGGCATTCTTGAAAACCGCAGGATTACCACGGATAAAATTTTAAAATTACCTTTAAAGAATTCAGGTTT ACACACAAAAAAAATTTGGTTTGTTAGCAGTGAGTGAAGAAAAATTTTGAGAAATGTTTAAAATTTTTAG TTTTGTTACACAATACATTTTACTACCTGTTTAATTATCTTTTTTGACTCAGAAACCAGTTTCCTGGGTC CAGGATGTTTAGTGGTACTCTTTTTCTTCAAGCTTTTTAGCATTGGAGGAACTGCATATTAGTAAAATTT TTAGTCTTAGCATTTTATAGCTTACTGCTATTTCTTTTCTTTCATTCTTTCTTTCTTTTTTTTTTTTTTT TTTTTTTTTTTGAGATGGAGTCTCGCCCTGTCACCCAGGCTGGAGTGCAGTGGCACGATCTCGGCTTACT GCAACCTCTGCCTTCCAGGTTCAAATGATTCTCCTGCTTCAGCCTCCCGAGTAGCTGGGATTACAGATGC CCGCCACCATGCCCAGCTAATTTTTATTTTTTTAGTAGAGATGGGGTTTCACCATGTTGGCCAGGCCAGT CTCGAACTCCTGACCTCGTGATCAACCCGCCTTGGCCTTTCAAAGTGCTGGGATTACAGGCGTGAGCCAC CGTGCCCAGCCTTTTTCTTTTTCTTTTTCTTTTTTTTTTTTTTTTTGAGACGGAGTCTTGCTCTGTTACC CAGGCTGGAGTGTAGTGGCATGATCTGGGCTCACTGCAACCTCCACCTCCCGGGTTCAAGGGAGTCTCCT GCTTCAGCCTCCCGAGTAGCTGGGATTACAGGCGCCTGCCACCATGCCCAGCTAATTTTTGTATTTTTTT AGTAGAGATGGGGTTTCGCCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCTGCCTGCC TCGTCCTCCCAAAATGCTGGGATTATAGGAGTGAGCCACTGCGCCCGGCCCAGCATACTGCTATTTCTTT CTTTCTTTCTTCTTCCTTTTTTTTTTTTTTGTTTTTTTTTTTTTTTTTTTTTTTTTGTGAGACGGAGTCT GTCGTCCAGGCTGGAATGCAGTGGCGTTTTCTTGGCTCACTGCAACCTCTGCTGCCCGGGTTCAAGTGAT TCTCCTGCTTCAGGCTCCCAAGTAGCTGGGATTATAGGCCTCTGCCACTGCACTTGGCTAATTTTTGTAT TTTTGGTAGAGACGGGGTTTCACCATCTTGGCCAGGCTGGTCTTGAACTCCTGACCTCGTGATCCACCTG CCTTGGCCTCCCAAAGTGCTGGGATTACAGACCTGAGCCACCGCACCCGGCCCATACTGCTATTTCTTAA CAGCAGAGAAATTATGTGTCAGATTCTGTAAGTGTAATGGTATATAAAGGATAAAATGATGTTGAAAAAC AAAATTTTTTGTTTAAATGCTTATGTTTCTAATATTTTATTTCAGAAAGGAATTTATTTCAAAACTGATA ATGGTTGGATCCAGCTTTTCACACAAACTTTTTTTTCCTAGTGAGGATGCACATTTATCCTGTAAACAAA TGGAAGACATTATTTTTTTAATTGCTTGCTTAGAAATGAAATAATTCTTTTCTAATGATCTTTTAAAGCA TGAGACCTCATACATCATTTAAAACAATTTATACTGTATTTTACACATGACAAAGTTCTAAGGTAACAGC CCTTTTCTAAGACTAAAGTTACAGTCCTCCCTTTGTATCTGAGGGGGATTGGTTGCAGGACCCCCCTGTG AATACCCAAATCCTTGGATGTCCAAGTCCCTTATGAGATGTAGTATTTGCATATAACCTATACACATCTT CCCCTGTACTTTATCTCTAGATTACGTACAATACCTAATAGAATGTAAATGCTTTGAAATTAGTTGTTCA GCTGTATTTTAAATTTTGTATTTTTTTTCCTTTTTTTTTGAGACAGAGTCTTGCTCTGTTGCCCAGGCTG GAGTACAGTACAGTGATCACAGCTCACTGCACCTTTAACCTCCCAGGCTCAAGCTGTCCTGCCTCGGCCT CCCCAAGTGTTGGGATTACAGGTGTGAGCCATCATACCTGGTCACTGTTTTTTATTGGTTTTAAATTTTT GATTTAAAATTTTTAATCTAGGTTGGTTGAATCTGGACTGGAACCCAAGGATATGTTTGTTGAGCATACT GTATTTACTTTGGAATACAACTAGAATGCTTAACTTGTATGTTAAAAATACTTTATTTGGCCAGGCGCGG TGGCTCACGCCTGTAATCCCAGCACTTTGAGAGGCCAAGGCGGGTGAATCATTTGAGGTCAGGAGTTTAA GACGAGCCTGGCCAACATGGCAAAACCCTGACTCTACAAAAAAAAGGTAAAAATAAGCCAGGTGTGATGG CGTGTGCCTGTAGTCTTGGCTATTCAGGAGGCTGAGACACAAGAATCGCTTGAACCGGGGAGGCACGTTA CGCCCTCAGTTGTTGACTTGAGTTTTTCCGTAGTTTGTAGGGGGAGGGTAATAGAGTATTAGGTAGCTTT TGGAATACATAGGAGTGTAACTGGAAAAAGATTCCAAGCAAGTCTAATGAATTAGATAATTTACCTAATT AGTAAATTATGTAATCAGTATGCTTTATAATAATATTGTGAGTTAGATCCTGTTTCTGATATGTACATAC CATATTGTATAGGTGCTACTAATTTGGAGAGCATATACAGTGAGTCCATGCCTTTTTCCTGCCATCAGCA TTATACCAAAATTCTGCCATGGTTTTTAAACTTTGATTCTGAGAAAGTTTCTCACCCTAATAACATAACT ATATTTGTGTTTGTCTTCATAGTTAAATATGCATTATGATATCAGCTTGCATACATTTTTTAAATGACTT GAATATCTGACTTTAAAAATTATTCTAGAATTTCTGTGCTTCAATATTAATGCCAGAAGACTTGGAATTG TTTATTTGTAGGTAACTGCCTTTAAGGAAACTTGACCAAATATTAACTAAGTTATGTATTTCCTTTTGGC AACAGTTGTGACTTCTCACCAGGAGATTTGGTTTGGGCCAAGATGGAGGGTTACCCCTGGTGGCCTTGTC TGGTTTACAACCACCCCTTTGATGGAACATTCATCCGCGAGAAAGGGAAATCAGTCCGTGTTCATGTACA GTTTTTTGATGACAGCCCAACAAGGGGCTGGGTTAGCAAAAGGCTTTTAAAGCCATATACAGGTAAGAGT CACTACTGCCATGTGTGTGTGTTTGTGTGTGTGTGTGTGTGTGTGAGAGAAACAGACAGACAGGCAGACT TTTTTCTATATGATGAAATTAAGTGTATTTTACCCCAGTAAATTGCAAGGGGTGGCAGTTGTGAAAGCTT CTGGCATGGGAAAGGGATGTAACATGGTCTTTAGCTGGTTTGTTTTGTGGAATGGAATTTTTATTTCTGT CCTTTGAGTGACTTACAGCAATATTATACCCTTAATAAGGGTAAACTAAACTGTCCCCCCATCTTGAAGG GTCCAAGAGAAAGTTAATGTCATCAGGATACATAGCCTATAGATAGCGACATTCTCTAGGGAAAGATGGA GATGCGCACTACCTGGCCTTCAAACTACTCACTAATGAACACATCTGAGTTGAGTTTCACACCAAACTCC TGGAACCATAACTTTCTTTTCCCAGATCTAGTCTTGTTTATCACAGACATCAACAGCCTGGCATGTTTAG CCTCACTTGGGCTAGGTGCACCCCATCGTCTCTTGTACAAGTTCTCTTTCTTTCTTTTTTTTTTTTTTTT TTCTGGAGACAGAGTCTCACTCTGTTGCCTAGGCTGGAGTGCAGTGGCGCAATCTCGGCCCACTGCAACC TCCGTCTCCTGGGTTCAAGAGTTTCCTACCTCAGCCTCCCGAGTAGCTTGGGATTATAGGCACACGCCAC GTTGCCTGGCTATATATATATATTTTTTTTTTGAGACGGAGTTTTGCTCTTTTGGCCCAGGCTGGAGTGC AATGGCGCAATCTCAGCTCACTGCAACCGCCACCTCCCGGGTTCAGGTGATTCTCCTTCCTCAGCCTCTA AAGTAGCTGGGATTACAGGTGCACACCACCAAGCCCAGCTAATTTTTTATTTCTAGTAGAGATGGGGTTT CACCATGTTGGCCAAGCTGGTCTTGAACTGCTGACCTCCAGTAATCCACCCACCTCCCCCTACCAAAGTG CTGGGATTATAGGCGTGAGCCACTGTGCCCAGCCGCCCAGCTAATTTTTGTATTTTTAGTAGAGACGGGG TTTCACCATGTTGGCCAGGCTGGTCTCCAACTTCTGACCTCAGGTGATCTGCCCATTTCGGCCTCCCAAG AGTCTCCAGTCTAGTACGTTGTCGTACTCGGTGTTGTAAAATCCAAACAAGGGTCAGTTTCCCAGGTAAC TGGGAAATTCCCAGAATCACACTCTTTCGTCATAGTGCTCATCCTACAAAAAAGGATTGGGGGCATTTTG TCTAAAATTAAATGTAAATGGTGATCTGACATACAGGTGGAAAGAGAATTGGGAAGTTTTGTTCTCTCTT CTACCAACTTGCCACATAATCTTGGCCAAGCAAAGTAACTTGTTTTTTCTTTTAATCTTTTTAAAAGAAA TAGAGACACAGTTTTGCCATGTTGCCCAAGCTGGTCTCAAACTCCTGCCTGAGCTCAAGCAGTCTGCCCA CTTCGGCCTCCCAAAGTGCTGAGACTACAGGCATAAGCCACCATGCCCCTGGGCTCGGCCAACTTTTTCG TTTTCTTTTCAAGAGATGGGGGTCTCACTCTGTCACCCAGCCTGGAGTATAGTGTTGGGATCATAGCTCA CTGGAGCCTTGAACTCCTGGGCTCAAGTGATTCCCCCCTGTTTTAGCCTCCTCAGTAACCGGGACTAGAG GTGTCTGCCACCACACCTGGCTAATTTTTATATAGTTTTTTTTTTTTTTTTTTTTTTTTAAAGAGATGAC GGTCTTGCTATGTTGCCCCCAGGGTGGTCTTGAATTCTTGGCCTCCAGTGATCCTTCTGCATCAGGCTCC CAAGTAGTTGGGTGATCTGGCTAAAGTAACTTATTTTCTGATACTGTTTACTTATATTTAGAATGAATCT CATTGGGGTTGCACTGGGGCCGGGCATGGTGGCTCACACCTGTAATCCCAGCGCTTTGGAAGGCCAAGGC AGGTGGATCACCTGAGGTCAGGAGTTCCAGACTAGCCTGGCAAACATGGTGAAATCCCGTCTCTACTAAA AATACAAAAATTAGCTGGGCATGGTGGCACATGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAAGAG AATCGCTTGAATCTAGGAGGCGGAGGTTGCAGTGAGTCAAGATCATGCCACCGCACTCCAACCTGGGTGA CAGAGCGAGACTGTCTCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAGGCTGGGCACGGTGGCTCGCGCCT GTAATCCCAACACTTTGGGAGGCCCAGGCGGGTGGATCACGAGGTCAGGCGTTCGAGACCAGCCTGACCA AGATGGTGAAACACTGTCTCTACTAAAAATACAAAAATAAGCTGAAATCCCAGCTACTCGTGAAGCTGAG GCAGAGAATTGCTTAAACCTGGTAGGCGGAGGTTGCAGTGAGCCGAGATCGCGCCACTGCACTCCAGCCT GGGGAACGGAGTGAGACTTCATCTCAAAAATAAATAAATAAATAAATAAATAAAATAAAATAATAAATAA AGTAAAAAGATCTCTCATTGAACCAGATGATATATGAAGTCTCTTTTAGGACCAATTTCGAGATTTAAAA AATTTGGCAGAATTACTTTTTTTTTTTGCAGCGGAGTCCAGCTTTATCACCCAGGCTGGAGTGGAATGGC ACAATCTCAGCTCACTGCAACCTCTGCCTCCTGGGTTCAAGCGATTCTCCTGCCTCTGCCTCCCAAGTAG CTGTGATTATAGGCGCCCACCACCAGGCCCAGCTGATTTTTGTATTTTTCAGTAGAGTTGAGGTTTCACC ACGTTGTCCAGGCTGGTCTCAAACTCCTGACCTTAAGTGATCCGTCCACCTTGGCCTCCCAAAGTGCTGG GATTAGGTGTGAGCCACTGGGCTGGCCCAGAATGATTTTTAAAAAGAGATCAGTAAGGCCAGGCAGTGGT GGCTCACGCCTGTAATCCCAGCACTTTGGGAGACTAAGGTAGGTGGATCACCTGAGGTCAGGAGTTGCAG ACAAGCCTGGCCAACATGGTGAAACCCTGTCTCTACTAAAAATACAAAAATTAGCCAGGCATGGTGACAC ATGCCTGTAATCTCAGCTACTCAGGAGGGTGAGGCAGAATTGCTTGAACCCGGGAGTCAGTTTCTTTTTT CTTTTTTTGAGATGGAGACCCACTTTGTCACCCAGGCTGGAGTGCAATGGTGCAGTCTTGGCTCACTGCA ATCTCTGTCTCCGGGGTTCAAGTGATCCTCCTGCCTCAGTCTCCTTAGTAGCTGAGACTACAGGTGTGCA CCACCACACCTGGCTAATTTTTGTATTTTTAGGAGAGATGGATGTCACCATGTTGGCCAGGCTGATCTTT AAACTCGTGACCTGAAGTGATCCACCCGCCTTGGCCTCCCAAAATGCTGGGATTACAGGTGTGAGCCACC ACGCCCAGCCCTAAAGTTGTATTTTGATGGAACGAACTGTTTTGAGAAATAAATTTTAACGCGTTGAGTC TGAACTGGGCTGCCCTTTCAAAATGTGAAGGCCCCTTAAAGTAGCACATTGGTTGGTTATTCTTTTATTT ATTTAGATATATCTGATCTAGTTGTCTTTGGGACAAACTCATATTTAATATCATAGCTGCATGTAACTGA CAGTGTAGTCTTTGTCTTCCTGAAGTGTTTGTTTGTTTTTTGAGATGGAGTCTTGCTCTGTCGCCCAGGC TGAAGTGCAGTGGTGCGATCTTGGCTCACTGCAACCTCTGCCTCCCGGGTTCAAGTGATTCTCCTTCCTC AGCCTCCCGAGTAGCTAGGACTACAGGCATGTGCCACCACACCCAGCTAATTTTTGTATTTTTAGTAGAG ATGGGGTTTCACCATATTGGTCAGGTTGGTCTTGAACTCCTGACCTCGTGATCTGCCTGCTTCTGCCTCC CAGAGTGCTGGGATTACAGGTGCGAGCCATTGTGCCCAGCTAGTAAGTTTTTAAGAAAGATTCTCAAACC TCTTTTAAATCGTCTGCCTCACTTGAAGAGGTATGCCCTACCTGTTTAGGGCTGTAGACCCAGGTCATTA GAAGACAGACTAAGTAGTCCTGGGTGAACCCATAGGGCACCTTCAAGGAGGTAAAATTGGTGATTTTAGT TTCACCAGTAGTTTTTCCCTGAATATTTATTCCTTTTGTGCTTTATTGATCTATCTATATCAATAAAAAG TAATGGGGCATAACAAATTATACTTGTCATTCTTGTTCATTAGGGCAAATGTTGTAGGTTGAGTCAAGTG TCCAGCCAACAAGTTATTTTATGTGTGTGTGTGTGTGTGTGTGTGTGTATACATATATACATTTTTTTTT TTTTTTTTCATCGAGACAGGGTCTTGCACTGTCGCCCAGGCTGGAGTGAAGTGGTGCAATCTCGGCTCAC TGCAACCTCTGCCTCCCAGGTTTAAGTGATCTTCCCACCTCAGCCTCCCAAGTAGCTGGGACTACAGGCG CACACCACCACCCTTGGCTAATTTTTGTATTTTTTTTTTGGTAGAGATGGGGTTTCACCACATTGCCCAG GCTGGTCTTGAATTCCTGACCTCAAGTAGTCCGCCCACCTAAGCCTCCCAAAATGCTGGGATTACAGGCG TGAGCCACCACACCTGGCATATATATATTTTAAGATAGAGATGGGGTTTGCTATGTTGCCCAGGCTGGTC TTGAACTGCTGGGATTACAGGCGTGAGCCTCTGCACCCGGCCCTTATTGTTTATAAATACATTTCTTTCT AGGTTCAAAATCAAAGGAAGCCCAGAAGGGAGGTCATTTTTACAGTGCAAAGCCTGAAATACTGAGAGCA ATGCAACGTGCAGATGAAGCCTTAAATAAAGACAAGATTAAGAGGCTTGAATTGGCAGTTTGTGATGAGC CCTCAGAGCCAGAAGAGGAAGAAGAGATGGAGGTGGGACACGGCAAGCATTCAGTTGTTATTTATGTTAG GGTGATGGGGGAAGAAAGGGGGAGGGTGTATTAACAAGATACCTTGTTTTATATATGTGTGTGTATATGT ATTATTTTATTATACATACATGCATACTTCTGTAGTTCCCTGGACTGTAGGATAAGTTAGGTTACTTAGA ATCTCAACAGCTAGCATCGTTTTTACTTAGGTTTTCAAGCCTACTGGCAGGGTAAGCAAGAGGTAGTACC ATTTTGGTAAGAAGTAGAGAGCTAGGGACAGTAAAGATGGAGTAATATATATATGAGGGTATAGTCAGGC CCTAGAAATTAATTATCCAGTTTTATGCTTTTTATAAAAAAACTGAGATGGGGTCTTGCTATGTTGCCCA GGCTGGTCTCAAACTCCTGAGTTCAAGGGATCTGCCCACCTGGGCCTCCCAAAGTGTTGGGATTACAGGC ATGAGCCACAGCACCCAGCCCCAGCTTTATGCTTTTAATTCTAAAACTTTTTTTGTTGTATTTTGCATTC ATAAGAATAGATGTTAAATAAACCTTGAAATACAACCTTGGCTCAAACGTTAATGGTCATGGATAAAGTG AATTAAAACTTGTTAGGGGCCAGGTGTGGTGGTTAATGCCTATAATCCCAGCACTTTAGGAAGCTGAGGC AGTTGGATGTCCTGAGGACAGGAGTTCAAGACCAGCCTGGCCAACACAGTGAAACCCTGTTTCTATAAAA AATACAAAAATTAGCTGGGCGTGGTGGCACACACCTGTAGTCCCAACCACTTGGGAGGCTGAGGCATGAG AATTGCTTGAACTTGGGAGGCAGAGGGACTTGGGAGGCAGAGGGTGTAGTGAGCCAAGATCGCACCACTG CATTCCAGCCAGGGTGACAGAGCAAGAAGACTGTCAACAACAACAAAAAATGTTATAGAAGTGAAAAAAA TTGATTAATTTAGAACAAGCTTGTCCAGTCTGTGGCCCAGGATGGCGTTTAAATCAGCCCAACACAAATT TGTAAACTTTCTTAAAACATTTTGTGATTTGTTGTTGTTGTTTAGCTCATCAGCTATCATTAGCATTAGT GTATTTTATGTGTGGCCTAAGACAATTCTTCCAGTGTGGCCCAGGGAAGCTGAAAGATCATTATCCTCTG ATCTATCATATTAATGAGCTGCATCCTAAAAGACATTCATCTATAACTAAGCTCAGTTTCATGTTTTGTT CCTTTTTCAATAGATAAGATAGGGAATGAGCAAGTTAATAAAGTGGGTATTTTAATTTTAAGGTTGAAAC TAAGGATCATAACATTATCAGAGGTCTAGAACTGGATGGCAGCTACAGAGATCATTTAGCCTAATACTGG TTTAACAAATAATCCGGGAGATCCGTGATATGTGAATGTGCTAGGCCTGAGATGAGACAGCCAATTGTGG AAGAGCAAACACTAGAACCAGTATAAGTTGCTTACTGCTTTCTTATGCTATTAATGAGCATATCGCCTCC TGATATTTATGATATATGGTCATGCCAACAGCTTTGTCATAAATAGAACTCCCATGGCAGCAATCACTTA ATCTTGTAGTTAGAGGTGGGGTCTCACCATGTTGCCGAGCTGGCCTTGAACTTCTGGGCTCAGCGATTTT CTCCACAGGCACCTGCTACTGTGCTCGGTGCAGCACTTTGTGTTTTTGAACATAACCTCAAGATGTTATT GTCTTCATAGTAAAACAAAAGATGAGGCTTAGAACTGGATCACTTTGCCTGTCTCTTCTTACCTCCTCCC AGTTCAAAATGCTTGCATCTCTTAATAGCTAGCATTCCCTTGGATTTTGCACATGAGCTCAAACTCAAGC CTCAGCACAATCTTTTTTATAGTTTTAGTCTTTTAGCCAGAGTCGACTTACCCCCCATACCCACTCTGCT TCCTTCATAATGCTGCTTTCCCTGGGCAGAGAATCCTTGCCCTTCTTGTATTATGTCACTTTGTGGGGTT GGTGTCTGCTACACTTACAGCAAGTCCAGAGATTTTTTTTCCACCACGTTTGCAGGAGAACTATTGGCAT GGAAAATGACAATTGTTTTAATGTCAAGTGAAACTGAAGTTGATGTTCATTGAGAGGTTTCTAATTTCTA GAGGTGGGTTCTTTTTTTGGCATATGAAGTTGCAGCATATTAAGAGAATTTACAGTAGTACAGATGGGGT TATCCCATCCACAACTTATGATGGGGTTACATAAACTAAAAACGTGTTTAATACACCTACCCCACCGAAT ATTGTAGCTTGGGCGTAGCCTAACCTATCTCAGACGTGCTCAGAACACTTAAATGTTAGCCTAAAGTTGG GCAAGATCATCTAACACAAAGCCTATTTTATAATAAGGAATTGCCTATCTCATGTAATTCATCGAATACT GTACTAAAAATGAAAAACAGTGGCTGCACGGGTACCATTATAAAGTCAAAAAATCATAAGTTGAACTGTC TTACATTATGGTTTTCCAAATTTTGATTTGTTTTTAAATACTCTTTCCTTGCCTGGCAGGTAGGCACAAC TTACGTAACAGATAAGAGTGAAGAAGATAATGAAATTGAGAGTGAAGAGGAAGTACAGCCTAAGACACAA GGATCTAGGCGAAGTAGCCGCCAAATAAAAAAACGAAGGGTCATATCAGATTCTGAGAGTGACATTGGTG GCTCTGATGTGGAATTTAAGCCAGACACTAAGGAGGAAGGAAGCAGTGATGAAATAAGCAGTGGAGTGGG GGATAGTGAGAGTGAAGGCCTGAACAGCCCTGTCAAAGTTGCTCGAAAGCGGAAGAGAATGGTGACTGGA AATGGCTCTCTTAAAAGGAAAAGCTCTAGGAAGGAAACGCCCTCAGCCACCAAACAAGCAACTAGCATTT CATCAGAAACCAAGAATACTTTGAGAGCTTTCTCTGCCCCTCAAAATTCTGAATCCCAAGCCCACGTTAG TGGAGGTGGTGATGACAGTAGTCGCCCTACTGTTTGGTATCATGAAACTTTAGAATGGCTTAAGGAGGAA AAGAGAAGAGATGAGCACAGGAGGAGGCCTGATCACCCCGATTTTGATGCATCTACACTCTATGTGCCTG AGGATTTCCTCAATTCTTGTACTCCTGGGATGAGGAAGTGGTGGCAGATTAAGTCTCAGAACTTTGATCT TGTCATCTGTTACAAGGTGGGGAAATTTTATGAGCTGTACCACATGGATGCTCTTATTGGAGTCAGTGAA CTGGGGCTGGTATTCATGAAAGGCAACTGGGCCCATTCTGGCTTTCCTGAAATTGCATTTGGCCGTTATT CAGATTCCCTGGTGCAGAAGGGCTATAAAGTAGCACGAGTGGAACAGACTGAGACTCCAGAAATGATGGA GGCACGATGTAGAAAGATGGCACATATATCCAAGTATGATAGAGTGGTGAGGAGGGAGATCTGTAGGATC ATTACCAAGGGTACACAGACTTACAGTGTGCTGGAAGGTGATCCCTCTGAGAACTACAGTAAGTATCTTC TTAGCCTCAAAGAAAAAGAGGAAGATTCTTCTGGCCATACTCGTGCATATGGTGTGTGCTTTGTTGATAC TTCACTGGGAAAGTTTTTCATAGGTCAGTTTTCAGATGATCGCCATTGTTCGAGATTTAGGACTCTAGTG GCACACTATCCCCCAGTACAAGTTTTATTTGAAAAAGGAAATCTCTCAAAGGAAACTAAAACAATTCTAA AGAGTTCATTGTCCTGTTCTCTTCAGGAAGGTCTGATACCCGGCTCCCAGTTTTGGGATGCATCCAAAAC TTTGAGAACTCTCCTTGAGGAAGAATATTTTAGGGAAAAGCTAAGTGATGGCATTGGGGTGATGTTACCC CAGGTGCTTAAAGGTATGACTTCAGAGTCTGATTCCATTGGGTTGACACCAGGAGAGAAAAGTGAATTGG CCCTCTCTGCTCTAGGTGGTTGTGTCTTCTACCTCAAAAAATGCCTTATTGATCAGGAGCTTTTATCAAT GGCTAATTTTGAAGAATATATTCCCTTGGATTCTGACACAGTCAGCACTACAAGATCTGGTGCTATCTTC ACCAAAGCCTATCAACGAATGGTGCTAGATGCAGTGACATTAAACAACTTGGAGATTTTTCTGAATGGAA CAAATGGTTCTACTGAAGGAACCCTACTAGAGAGGGTTGATACTTGCCATACTCCTTTTGGTAAGCGGCT CCTAAAGCAATGGCTTTGTGCCCCACTCTGTAACCATTATGCTATTAATGATCGTCTAGATGCCATAGAA GACCTCATGGTTGTGCCTGACAAAATCTCCGAAGTTGTAGAGCTTCTAAAGAAGCTTCCAGATCTTGAGA GGCTACTCAGTAAAATTCATAATGTTGGGTCTCCCCTGAAGAGTCAGAACCACCCAGACAGCAGGGCTAT AATGTATGAAGAAACTACATACAGCAAGAAGAAGATTATTGATTTTCTTTCTGCTCTGGAAGGATTCAAA GTAATGTGTAAAATTATAGGGATCATGGAAGAAGTTGCTGATGGTTTTAAGTCTAAAATCCTTAAGCAGG TCATCTCTCTGCAGACAAAAAATCCTGAAGGTCGTTTTCCTGATTTGACTGTAGAATTGAACCGATGGGA TACAGCCTTTGACCATGAAAAGGCTCGAAAGACTGGACTTATTACTCCCAAAGCAGGCTTTGACTCTGAT TATGACCAAGCTCTTGCTGACATAAGAGAAAATGAACAGAGCCTCCTGGAATACCTAGAGAAACAGCGCA ACAGAATTGGCTGTAGGACCATAGTCTATTGGGGGATTGGTAGGAACCGTTACCAGCTGGAAATTCCTGA GAATTTCACCACTCGCAATTTGCCAGAAGAATACGAGTTGAAATCTACCAAGAAGGGCTGTAAACGATAC TGGACCAAAACTATTGAAAAGAAGTTGGCTAATCTCATAAATGCTGAAGAACGGAGGGATGTATCATTGA AGGACTGCATGCGGCGACTGTTCTATAACTTTGATAAAAATTACAAGGACTGGCAGTCTGCTGTAGAGTG TATCGCAGTGTTGGGTAAGACTTTGAACAAGCTTGTTCTCAGGCTTTGATAAGTAGTGCTGTTTGCCAGC TGTATATTATCCCTAAAAATAAGTAATAAGGTATATATGGTACATATTTTGACATGCATATACATATTTG CATCCTGACTAGGCTGCCCACAGCAATTTAAGTTACTTGAAACTCGCTTTTATCTTAGTAGCCCTTTGGC CTTTCTTCAGTTTTTTTTTTTTTTTTTTTTTTTTTGAGACATGGTCTTGCTCTGTTGCCCAGGCTAGAAT ATGGTGACACAACCATGGCTACTGCAGCCTCGACCTCCCAGGCTTAAGTGATCTTTCCACCTCAGCCTCC CAAGTAGCTGAGATTACAGATATGCACCACCATGCATGGCTAATATTTAAATGTTTGTAGAGAGATGGGG TCTCACTGTGTTGCCAGGACTGGTCTTGAACTCCTGGGCTCAAGTGATCCTCCTGCCTCGGCTTCCCAAA GTGCTGAGGTTACAGGCATGACCCATTGCGCCTGGCCCTTTCTTCAGTCTTTAATAATCGAACAAAAGGT TTTTGTTTTTAGACAGTGTCTTGCTCTGTTACCCAGGACAGACCTCTCGTGTCAGCCTCTTAGGTAGCTA GGATTTACAGGTAAGCACCGGCGTGCCCTGCTTTATTTTTTTGGTGGGGGAAGGGGGAAGGGAGTTGAAG CTTCCCTATGTTGCCCAGGCTGGTCTTGAACTCCTGGCCTCAAGTGATCCTCCAGTCTCCCAAAAGTGCT GGGATTACAGGCATGAGCCACCGCTCCCGGCCCAAAAGATTTTTAAATGTGTTATACTTCATGAGACAGG CTTTATTTTAGATCGAATTTTATTTATCAATAAAAAGTTGAGCTTTTTATTATTTGGTGAATACTGTTTC AAGGTGCTTTGTTACACTATCTGTTGATCCAACATTTAAAAATTGTTTTATTACAACCTTTGCATTTCAG TGAATCCATCTGCATACAATTTTAAAAGAATCATTCCTTTTTTCTGTAGCCAAATTGTCAAAGATTCTTT CCTACAATTGATTTTTCAAAGCCCTGAGTTAGGAATTTACAATTTGGCAACCATCTCAACTTCATAAGCA ATTTTGTTCTTTAAATGTCACGGCCAACATTACCTGGAACCATTGCTGTTTTATAGTTTAGGTTTATGTT GTATATTTTTTTTAATTTTTTAGAGACGGGGTCTTGCTGTTTTCAGACTGGAGTACAATGGGATGACTAG CTCACTGCAGCCTCAAACTGCTGGGTTCAAGTGATTCTCCTTCCTCAGCCTCCTGAGTAGCTGGGACTAC AGGTGGTCACCATCACACCTGGCTAATTTTTGTATTTTTGGTAGAGACAGGGTTTTTCCCGTGTTGGCCA GGCTGTTCTTGAATTCCTGACCTCAAAGCGATCTGCCCGCCTTGATCTCCGAAAGAGCTGGGATTACACG CATGAGCCACTGCGCCCAGCCCTGTTTTTTTTTTTTTTTTTTTTTTAAATAATGGTAGTTTACTTGAATT TGTAACACAGTAACACAAAACTATTTTGATCTGAACGCAAGTATCTAATGGAACAGAATAATATACTTCC TTTTAGTGTGCTGCATTTGGTTACTGGGTAATTTAAAATTCTTCCTCAGCACAGGTGTTCAAAAACCAGT CTTCAGAGATTGTTTTCATATCAGTGTGCCAACTTTGGCACATTCTGCTAAGTAAGAGGCTTAAGTGTAG CATGTTTCTGCTGTTTTGTGTTTGTTTTGTTTTGTTTTTTGAGACAGAGTCTCTCTGTCGCCCAGGCTGG AGTGCATTGGTGCGATCTTGGCTCATTGCAACCTCTGCCTCCCAGGTTCAAGTGATTCTCCTGCCTCAGC CTCCTGCGTAGCTGGGATTACAGGCATATGCCACGTGTATTAGGCACTGCTAATTTCTGTATTTTTAGTA GAGACGAGGTTTCACCATGTTGGTCAGGCTGGTCCTGAACTGCTGACCTCGTGAACTCTGCCCGCCTAGG CCTCCTGAAGTGCTGGGATTACAGGCGTGAGCCACCGTGCCTGGCCTCTGCTCTATCTTTTAGCTTTCCC TTGGCACTTCTATGGTCCAGATGTTAGAGGGTAAGTATTTTGATGGGGGAGATCGTTGGACTGTAATTGA AAGTTATGTCTTATAATGAAATGTGTTATATAAAGAAGACCTATAAAACACTTAGGCTGATAAAACCCCC AAACGATGAAGCCTCACTTTTACCCTCTCTTTTAACAGATGTTTTACTGTGCCTGGCTAACTATAGTCGA GGGGGTGATGGTCCTATGTGTCGCCCAGTAATTCTGTTGCCGGAAGATACCCCCCCCTTCTTAGAGCTTA AAGGATCACGCCATCCTTGCATTACGAAGACTTTTTTTGGAGATGATTTTATTCCTAATGACATTCTAAT AGGCTGTGAGGAAGAGGAGCAGGAAAATGGCAAAGCCTATTGTGTGCTTGTTACTGGACCAAATATGGGG GGCAAGTCTACGCTTATGAGACAGGTAACTGATTCTTAAAGTTTTGTTATCAGAAAGTCATTTGTGACAT TAGGAATAACATACTTAGGTGATCATTTTCCAAACACAGTTACATAAAAGTCAGCCAGTGACTTAATAGG AAGCAAAGGGAAATTACTCCCTGTGTTATAAAATTGAGAATTATATTTAGCTGAAACATCGATGCTTAAT GTTAAGGGGAATATATGTTAAAAAGGGGAAGGAGGTCAGTCATTCAGGTCATGAGGCCCTTTGACTTGAA TTCATTTCCTCAGAAGGTAGGTATATTCATAGTGAACAAAAATACAAAGGCTGTATGAAAAGATGAAAAT GTTACAGGTTTATCCTTAAATTAGACTCATTTGCAGAAATGCAAATGAGGTAAGAAAGCAAATATAGTTC ATGACCTCTAGCAACTGTTGAAAACTGCTCTTTAGGGATGACATGCTGGCCCTTTTTTTTTTGTTGTTGC CAAGGCTGAAGTGCAGTGGCACCATCACAGCTCACTGCAGCCTCGAACTCCCAGGTTCAACCCTTCCTCC TGCCTCAGCCTCCCCAGTAGCTGGGACTACAGATGTACACCATCATGCCTAGCTCATTTTTAAAAAAATT TTTTATGGCATTGTATTTATCTTCTCTTTATAACCAGGGGTTGACCAGCCACAGAACTTGTAAAGTTTTT TATATTTTTAAAAGGTTGTAAGAAATAGTAGTAGTTGGCTGGTCCCCGCTGCTCTCCTGCATTATAGTAT ACTTCTGTTCACCTAGTTTGCTAGAGAGAGGCAGTATAGTGTGTATAGTGATTTCCAAACTTTTTCTTTA AATCAGAATCACCTGAAAGAATGTGACAACGTGTAAAAAAAAAAAAAAAGGTGCAGAGATTCCATCCTGA CATGGATTCACTTGATTGGAATTGATTCTAGGCATCTCAGTAGTTTTAAAGAGCTCCTAGGTGATTCTAT TCTGGCCAGCGTTGAGAATCACTAGGGTAGTGGGTTGGTAAGCAGGCTCTGATGTTTTAAAGGCCAGGTG AGGCCCTATGCCTCTTGTCTCTCTTAGCCTCAACTTTCTCCATGTTAGCAAATGGATTTCAGAACAGAAC CAACGTACATGTGATTGTGAAAGTTGTTTTAGAGTGCCTAGCTCTTACGTAAGGGTTCATAAGAAAGACA AAAGTTTATGAAACTGTTACTACCAGTCATAAAAGACCTTTTCCTCCCTCATTCACAGGCTGGCTTATTA GCTGTAATGGCCCAGATGGGTTGTTACGTCCCTGCTGAAGTGTGCAGGCTCACACCAATTGATAGAGTGT TTACTAGACTTGGTGCCTCAGACAGAATAATGTCAGGTGAGTTTTTTGTTTCCCACTTAAGTTCTCATTC AGTCATTTAGATGTGATAAAAGATATTTGCTTCTTGTATATGAGCCTTTTAAATCTAATATTTGATTTTT CTGGTGTTACTTTAAAAACATCACTTTTTAAGAACTGCATAGTCTCTCTCTCTTTTTTTTTTTTTTGAGA TGGAGTTTCCCTCTTGTTGCCCAAGCTGGAGTGCAATGGCACGATCTTGGCTCACTGCAACCTCTGCTTC CAGGTTCAAGTGATTCTCCTGCCTCAGCCTCTCGAGTAGCTGGGATTACAGGCGCATGCCATCACGCCCA GCTAATTTTTTGTATTTTTAGTAGAAGCGGGGTTTCACCATGTTAGGCTGGTCTCTTAACTCCTGACCTC AGGTGATCTGCTTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGTGCCCGGCCAATA ATTGCATAGTCTCTTAATGAGATTTAATCTTTTATACCAATATGTGTAGCTCATGATAGCTATATAACCT AGAAGATGAATTTATGTAATATGATTTGCAAAATGAGTATTCATTTGTGATTTTTTTTTTTTTAAGGTGA AAGTACATTTTTTGTTGAATTAAGTGAAACTGCCAGCATACTCATGCATGCAACAGCACATTCTCTGGTG CTTGTGGATGAATTAGGTAAGACATTAAACTTCTCATTTGAAGACTATCTATCTTAAAAACATTTGTACA AATAACTATTTTTATAGAAGATTATCTGAAGTACATTTAAACAATATGAATGTTTTTAGAGCACGCACTC ACCATTGTGGCACAGACCGATAGTTGGAGATAAAAGGTGATATTGTGAAAGGTTTTTGATTACCCATTAA TTATTAGGCCTTACACTGTTTAGTTGTAATAAAACATTTGTTATACTACGGGGATGAGAACACTAATAGG AGGACTCAGGAAGTTTATGACCTTGAGCGATACTGTATTTTCTTTAAAAGAAACCTCACTCCCCATGGGC TGCTAAGCAGACTCGTGTAGCTAAACAAGGCCTATTTATAGAATGCTTTTAGACGTGGATGTACTAACCG ATGTTGCTTTTCTGTCCTAGCATTTTTGTTTTAATTCCTTTTTTGTTTTAATTCCTTTGAGTTACTTCCT TATGCATATTTTACTTTAACAGGAAGAGGTACTGCAACATTTGATGGGACGGCAATAGCAAATGCAGTTG TTAAAGAACTTGCTGAGACTATAAAATGTCGTACATTATTTTCAACTCACTACCATTCATTAGTAGAAGA TTATTCTCAAAATGTTGCTGTGCGCCTAGGACATATGGTATGTGCAAATTGTTTTTTTCCACAAATTCGG TTTTTTGAGAGGGCACTTCTCTTGCTAGCACATGTATCGCTAATATTTTTCTTTCTTAAGGCATGCATGG TAGAAAATGAATGTGAAGACCCCAGCCAGGAGACTATTACGTTCCTCTATAAATTCATTAAGGGAGCTTG TCCTAAAAGCTATGGCTTTAATGCAGCAAGGCTTGCTAATCTCCCAGAGGAAGTTATTCAAAAGGGACAT AGAAAAGCAAGAGAATTTGAGAAGATGAATCAGTCACTACGATTATTTCGGTAACTAACTAACTATAATG GAATTATAACTAACTGACCTTAAGTTTCAAAGAAACAGTAAAAGGGGAAGGGATGATGCACTATGAAAAA ACAAAAAAACTTTTTTTTTTTTTTTTTTAATTTTAAGGGAAGTTTGCCTGGCTAGTGAAAGGTCAACTGT AGATGCTGAAGCTGTCCATAAATTGCTGACTTTGATTAAGGAATTATAGACTGACTACATTGGAAGCTTT GAGTTGACTTCTGACAAAGGTGGTAAATTCAGACAACATTATGATCTAATAAACTTTATTTTTTAAAAAT GA Download Select all
Length	23872
OMIM ID	600678
HGNC ID	HGNC:7329
Unigene ID	Hs.445052
Ensembl ID	ENSG00000116062
PharmGKB ID	PA184

mRNA Information

mRNA ID	NM_000179.2
Exon	join(1..412,7846..8042,12813..12982,15530..18074, 20339..20604,21829..21946,22537..22626,23123..23277, 23371..23570,23698..23872)
mRNA Sequence	>2956 GGCGAGGCGCCTGTTGATTGGCCACTGGGGCCCGGGTTCCTCCGGCGGAGCGCGCCTCCCCCCA GATTTCCCGCCAGCAGGAGCCGCGCGGTAGATGCGGTGCTTTTAGGAGCTCCGTCCGACAGAAC GGTTGGGCCTTGCCGGCTGTCGGTATGTCGCGACAGAGCACCCTGTACAGCTTCTTCCCCAAGT CTCCGGCGCTGAGTGATGCCAACAAGGCCTCGGCCAGGGCCTCACGCGAAGGCGGCCGTGCCGC CGCTGCCCCCGGGGCCTCTCCTTCCCCAGGCGGGGATGCGGCCTGGAGCGAGGCTGGGCCTGGG CCCAGGCCCTTGGCGCGCTCCGCGTCACCGCCCAAGGCGAAGAACCTCAACGGAGGGCTGCGGA GATCGGTAGCGCCTGCTGCCCCCACCAGTTGTGACTTCTCACCAGGAGATTTGGTTTGGGCCAA GATGGAGGGTTACCCCTGGTGGCCTTGTCTGGTTTACAACCACCCCTTTGATGGAACATTCATC CGCGAGAAAGGGAAATCAGTCCGTGTTCATGTACAGTTTTTTGATGACAGCCCAACAAGGGGCT GGGTTAGCAAAAGGCTTTTAAAGCCATATACAGGTTCAAAATCAAAGGAAGCCCAGAAGGGAGG TCATTTTTACAGTGCAAAGCCTGAAATACTGAGAGCAATGCAACGTGCAGATGAAGCCTTAAAT AAAGACAAGATTAAGAGGCTTGAATTGGCAGTTTGTGATGAGCCCTCAGAGCCAGAAGAGGAAG AAGAGATGGAGGTAGGCACAACTTACGTAACAGATAAGAGTGAAGAAGATAATGAAATTGAGAG TGAAGAGGAAGTACAGCCTAAGACACAAGGATCTAGGCGAAGTAGCCGCCAAATAAAAAAACGA AGGGTCATATCAGATTCTGAGAGTGACATTGGTGGCTCTGATGTGGAATTTAAGCCAGACACTA AGGAGGAAGGAAGCAGTGATGAAATAAGCAGTGGAGTGGGGGATAGTGAGAGTGAAGGCCTGAA CAGCCCTGTCAAAGTTGCTCGAAAGCGGAAGAGAATGGTGACTGGAAATGGCTCTCTTAAAAGG AAAAGCTCTAGGAAGGAAACGCCCTCAGCCACCAAACAAGCAACTAGCATTTCATCAGAAACCA AGAATACTTTGAGAGCTTTCTCTGCCCCTCAAAATTCTGAATCCCAAGCCCACGTTAGTGGAGG TGGTGATGACAGTAGTCGCCCTACTGTTTGGTATCATGAAACTTTAGAATGGCTTAAGGAGGAA AAGAGAAGAGATGAGCACAGGAGGAGGCCTGATCACCCCGATTTTGATGCATCTACACTCTATG TGCCTGAGGATTTCCTCAATTCTTGTACTCCTGGGATGAGGAAGTGGTGGCAGATTAAGTCTCA GAACTTTGATCTTGTCATCTGTTACAAGGTGGGGAAATTTTATGAGCTGTACCACATGGATGCT CTTATTGGAGTCAGTGAACTGGGGCTGGTATTCATGAAAGGCAACTGGGCCCATTCTGGCTTTC CTGAAATTGCATTTGGCCGTTATTCAGATTCCCTGGTGCAGAAGGGCTATAAAGTAGCACGAGT GGAACAGACTGAGACTCCAGAAATGATGGAGGCACGATGTAGAAAGATGGCACATATATCCAAG TATGATAGAGTGGTGAGGAGGGAGATCTGTAGGATCATTACCAAGGGTACACAGACTTACAGTG TGCTGGAAGGTGATCCCTCTGAGAACTACAGTAAGTATCTTCTTAGCCTCAAAGAAAAAGAGGA AGATTCTTCTGGCCATACTCGTGCATATGGTGTGTGCTTTGTTGATACTTCACTGGGAAAGTTT TTCATAGGTCAGTTTTCAGATGATCGCCATTGTTCGAGATTTAGGACTCTAGTGGCACACTATC CCCCAGTACAAGTTTTATTTGAAAAAGGAAATCTCTCAAAGGAAACTAAAACAATTCTAAAGAG TTCATTGTCCTGTTCTCTTCAGGAAGGTCTGATACCCGGCTCCCAGTTTTGGGATGCATCCAAA ACTTTGAGAACTCTCCTTGAGGAAGAATATTTTAGGGAAAAGCTAAGTGATGGCATTGGGGTGA TGTTACCCCAGGTGCTTAAAGGTATGACTTCAGAGTCTGATTCCATTGGGTTGACACCAGGAGA GAAAAGTGAATTGGCCCTCTCTGCTCTAGGTGGTTGTGTCTTCTACCTCAAAAAATGCCTTATT GATCAGGAGCTTTTATCAATGGCTAATTTTGAAGAATATATTCCCTTGGATTCTGACACAGTCA GCACTACAAGATCTGGTGCTATCTTCACCAAAGCCTATCAACGAATGGTGCTAGATGCAGTGAC ATTAAACAACTTGGAGATTTTTCTGAATGGAACAAATGGTTCTACTGAAGGAACCCTACTAGAG AGGGTTGATACTTGCCATACTCCTTTTGGTAAGCGGCTCCTAAAGCAATGGCTTTGTGCCCCAC TCTGTAACCATTATGCTATTAATGATCGTCTAGATGCCATAGAAGACCTCATGGTTGTGCCTGA CAAAATCTCCGAAGTTGTAGAGCTTCTAAAGAAGCTTCCAGATCTTGAGAGGCTACTCAGTAAA ATTCATAATGTTGGGTCTCCCCTGAAGAGTCAGAACCACCCAGACAGCAGGGCTATAATGTATG AAGAAACTACATACAGCAAGAAGAAGATTATTGATTTTCTTTCTGCTCTGGAAGGATTCAAAGT AATGTGTAAAATTATAGGGATCATGGAAGAAGTTGCTGATGGTTTTAAGTCTAAAATCCTTAAG CAGGTCATCTCTCTGCAGACAAAAAATCCTGAAGGTCGTTTTCCTGATTTGACTGTAGAATTGA ACCGATGGGATACAGCCTTTGACCATGAAAAGGCTCGAAAGACTGGACTTATTACTCCCAAAGC AGGCTTTGACTCTGATTATGACCAAGCTCTTGCTGACATAAGAGAAAATGAACAGAGCCTCCTG GAATACCTAGAGAAACAGCGCAACAGAATTGGCTGTAGGACCATAGTCTATTGGGGGATTGGTA GGAACCGTTACCAGCTGGAAATTCCTGAGAATTTCACCACTCGCAATTTGCCAGAAGAATACGA GTTGAAATCTACCAAGAAGGGCTGTAAACGATACTGGACCAAAACTATTGAAAAGAAGTTGGCT AATCTCATAAATGCTGAAGAACGGAGGGATGTATCATTGAAGGACTGCATGCGGCGACTGTTCT ATAACTTTGATAAAAATTACAAGGACTGGCAGTCTGCTGTAGAGTGTATCGCAGTGTTGGATGT TTTACTGTGCCTGGCTAACTATAGTCGAGGGGGTGATGGTCCTATGTGTCGCCCAGTAATTCTG TTGCCGGAAGATACCCCCCCCTTCTTAGAGCTTAAAGGATCACGCCATCCTTGCATTACGAAGA CTTTTTTTGGAGATGATTTTATTCCTAATGACATTCTAATAGGCTGTGAGGAAGAGGAGCAGGA AAATGGCAAAGCCTATTGTGTGCTTGTTACTGGACCAAATATGGGGGGCAAGTCTACGCTTATG AGACAGGCTGGCTTATTAGCTGTAATGGCCCAGATGGGTTGTTACGTCCCTGCTGAAGTGTGCA GGCTCACACCAATTGATAGAGTGTTTACTAGACTTGGTGCCTCAGACAGAATAATGTCAGGTGA AAGTACATTTTTTGTTGAATTAAGTGAAACTGCCAGCATACTCATGCATGCAACAGCACATTCT CTGGTGCTTGTGGATGAATTAGGAAGAGGTACTGCAACATTTGATGGGACGGCAATAGCAAATG CAGTTGTTAAAGAACTTGCTGAGACTATAAAATGTCGTACATTATTTTCAACTCACTACCATTC ATTAGTAGAAGATTATTCTCAAAATGTTGCTGTGCGCCTAGGACATATGGCATGCATGGTAGAA AATGAATGTGAAGACCCCAGCCAGGAGACTATTACGTTCCTCTATAAATTCATTAAGGGAGCTT GTCCTAAAAGCTATGGCTTTAATGCAGCAAGGCTTGCTAATCTCCCAGAGGAAGTTATTCAAAA GGGACATAGAAAAGCAAGAGAATTTGAGAAGATGAATCAGTCACTACGATTATTTCGGGAAGTT TGCCTGGCTAGTGAAAGGTCAACTGTAGATGCTGAAGCTGTCCATAAATTGCTGACTTTGATTA AGGAATTATAGACTGACTACATTGGAAGCTTTGAGTTGACTTCTGACAAAGGTGGTAAATTCAG ACAACATTATGATCTAATAAACTTTATTTTTTAAAAATGAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAA Download Select all
Length	4435

CDS Information

Location	join(153..412,7846..8042,12813..12982,15530..18074, 20339..20604,21829..21946,22537..22626,23123..23277, 23371..23570,23698..23779)
CDS Sequence	>gi\|157426894:153-4235 Homo sapiens mutS homolog 6 (E. coli) (MSH6), mRNA ATGTCGCGACAGAGCACCCTGTACAGCTTCTTCCCCAAGTCTCCGGCGCTGAGTGATGCCAACAAGGCCT CGGCCAGGGCCTCACGCGAAGGCGGCCGTGCCGCCGCTGCCCCCGGGGCCTCTCCTTCCCCAGGCGGGGA TGCGGCCTGGAGCGAGGCTGGGCCTGGGCCCAGGCCCTTGGCGCGCTCCGCGTCACCGCCCAAGGCGAAG AACCTCAACGGAGGGCTGCGGAGATCGGTAGCGCCTGCTGCCCCCACCAGTTGTGACTTCTCACCAGGAG ATTTGGTTTGGGCCAAGATGGAGGGTTACCCCTGGTGGCCTTGTCTGGTTTACAACCACCCCTTTGATGG AACATTCATCCGCGAGAAAGGGAAATCAGTCCGTGTTCATGTACAGTTTTTTGATGACAGCCCAACAAGG GGCTGGGTTAGCAAAAGGCTTTTAAAGCCATATACAGGTTCAAAATCAAAGGAAGCCCAGAAGGGAGGTC ATTTTTACAGTGCAAAGCCTGAAATACTGAGAGCAATGCAACGTGCAGATGAAGCCTTAAATAAAGACAA GATTAAGAGGCTTGAATTGGCAGTTTGTGATGAGCCCTCAGAGCCAGAAGAGGAAGAAGAGATGGAGGTA GGCACAACTTACGTAACAGATAAGAGTGAAGAAGATAATGAAATTGAGAGTGAAGAGGAAGTACAGCCTA AGACACAAGGATCTAGGCGAAGTAGCCGCCAAATAAAAAAACGAAGGGTCATATCAGATTCTGAGAGTGA CATTGGTGGCTCTGATGTGGAATTTAAGCCAGACACTAAGGAGGAAGGAAGCAGTGATGAAATAAGCAGT GGAGTGGGGGATAGTGAGAGTGAAGGCCTGAACAGCCCTGTCAAAGTTGCTCGAAAGCGGAAGAGAATGG TGACTGGAAATGGCTCTCTTAAAAGGAAAAGCTCTAGGAAGGAAACGCCCTCAGCCACCAAACAAGCAAC TAGCATTTCATCAGAAACCAAGAATACTTTGAGAGCTTTCTCTGCCCCTCAAAATTCTGAATCCCAAGCC CACGTTAGTGGAGGTGGTGATGACAGTAGTCGCCCTACTGTTTGGTATCATGAAACTTTAGAATGGCTTA AGGAGGAAAAGAGAAGAGATGAGCACAGGAGGAGGCCTGATCACCCCGATTTTGATGCATCTACACTCTA TGTGCCTGAGGATTTCCTCAATTCTTGTACTCCTGGGATGAGGAAGTGGTGGCAGATTAAGTCTCAGAAC TTTGATCTTGTCATCTGTTACAAGGTGGGGAAATTTTATGAGCTGTACCACATGGATGCTCTTATTGGAG TCAGTGAACTGGGGCTGGTATTCATGAAAGGCAACTGGGCCCATTCTGGCTTTCCTGAAATTGCATTTGG CCGTTATTCAGATTCCCTGGTGCAGAAGGGCTATAAAGTAGCACGAGTGGAACAGACTGAGACTCCAGAA ATGATGGAGGCACGATGTAGAAAGATGGCACATATATCCAAGTATGATAGAGTGGTGAGGAGGGAGATCT GTAGGATCATTACCAAGGGTACACAGACTTACAGTGTGCTGGAAGGTGATCCCTCTGAGAACTACAGTAA GTATCTTCTTAGCCTCAAAGAAAAAGAGGAAGATTCTTCTGGCCATACTCGTGCATATGGTGTGTGCTTT GTTGATACTTCACTGGGAAAGTTTTTCATAGGTCAGTTTTCAGATGATCGCCATTGTTCGAGATTTAGGA CTCTAGTGGCACACTATCCCCCAGTACAAGTTTTATTTGAAAAAGGAAATCTCTCAAAGGAAACTAAAAC AATTCTAAAGAGTTCATTGTCCTGTTCTCTTCAGGAAGGTCTGATACCCGGCTCCCAGTTTTGGGATGCA TCCAAAACTTTGAGAACTCTCCTTGAGGAAGAATATTTTAGGGAAAAGCTAAGTGATGGCATTGGGGTGA TGTTACCCCAGGTGCTTAAAGGTATGACTTCAGAGTCTGATTCCATTGGGTTGACACCAGGAGAGAAAAG TGAATTGGCCCTCTCTGCTCTAGGTGGTTGTGTCTTCTACCTCAAAAAATGCCTTATTGATCAGGAGCTT TTATCAATGGCTAATTTTGAAGAATATATTCCCTTGGATTCTGACACAGTCAGCACTACAAGATCTGGTG CTATCTTCACCAAAGCCTATCAACGAATGGTGCTAGATGCAGTGACATTAAACAACTTGGAGATTTTTCT GAATGGAACAAATGGTTCTACTGAAGGAACCCTACTAGAGAGGGTTGATACTTGCCATACTCCTTTTGGT AAGCGGCTCCTAAAGCAATGGCTTTGTGCCCCACTCTGTAACCATTATGCTATTAATGATCGTCTAGATG CCATAGAAGACCTCATGGTTGTGCCTGACAAAATCTCCGAAGTTGTAGAGCTTCTAAAGAAGCTTCCAGA TCTTGAGAGGCTACTCAGTAAAATTCATAATGTTGGGTCTCCCCTGAAGAGTCAGAACCACCCAGACAGC AGGGCTATAATGTATGAAGAAACTACATACAGCAAGAAGAAGATTATTGATTTTCTTTCTGCTCTGGAAG GATTCAAAGTAATGTGTAAAATTATAGGGATCATGGAAGAAGTTGCTGATGGTTTTAAGTCTAAAATCCT TAAGCAGGTCATCTCTCTGCAGACAAAAAATCCTGAAGGTCGTTTTCCTGATTTGACTGTAGAATTGAAC CGATGGGATACAGCCTTTGACCATGAAAAGGCTCGAAAGACTGGACTTATTACTCCCAAAGCAGGCTTTG ACTCTGATTATGACCAAGCTCTTGCTGACATAAGAGAAAATGAACAGAGCCTCCTGGAATACCTAGAGAA ACAGCGCAACAGAATTGGCTGTAGGACCATAGTCTATTGGGGGATTGGTAGGAACCGTTACCAGCTGGAA ATTCCTGAGAATTTCACCACTCGCAATTTGCCAGAAGAATACGAGTTGAAATCTACCAAGAAGGGCTGTA AACGATACTGGACCAAAACTATTGAAAAGAAGTTGGCTAATCTCATAAATGCTGAAGAACGGAGGGATGT ATCATTGAAGGACTGCATGCGGCGACTGTTCTATAACTTTGATAAAAATTACAAGGACTGGCAGTCTGCT GTAGAGTGTATCGCAGTGTTGGATGTTTTACTGTGCCTGGCTAACTATAGTCGAGGGGGTGATGGTCCTA TGTGTCGCCCAGTAATTCTGTTGCCGGAAGATACCCCCCCCTTCTTAGAGCTTAAAGGATCACGCCATCC TTGCATTACGAAGACTTTTTTTGGAGATGATTTTATTCCTAATGACATTCTAATAGGCTGTGAGGAAGAG GAGCAGGAAAATGGCAAAGCCTATTGTGTGCTTGTTACTGGACCAAATATGGGGGGCAAGTCTACGCTTA TGAGACAGGCTGGCTTATTAGCTGTAATGGCCCAGATGGGTTGTTACGTCCCTGCTGAAGTGTGCAGGCT CACACCAATTGATAGAGTGTTTACTAGACTTGGTGCCTCAGACAGAATAATGTCAGGTGAAAGTACATTT TTTGTTGAATTAAGTGAAACTGCCAGCATACTCATGCATGCAACAGCACATTCTCTGGTGCTTGTGGATG AATTAGGAAGAGGTACTGCAACATTTGATGGGACGGCAATAGCAAATGCAGTTGTTAAAGAACTTGCTGA GACTATAAAATGTCGTACATTATTTTCAACTCACTACCATTCATTAGTAGAAGATTATTCTCAAAATGTT GCTGTGCGCCTAGGACATATGGCATGCATGGTAGAAAATGAATGTGAAGACCCCAGCCAGGAGACTATTA CGTTCCTCTATAAATTCATTAAGGGAGCTTGTCCTAAAAGCTATGGCTTTAATGCAGCAAGGCTTGCTAA TCTCCCAGAGGAAGTTATTCAAAAGGGACATAGAAAAGCAAGAGAATTTGAGAAGATGAATCAGTCACTA CGATTATTTCGGGAAGTTTGCCTGGCTAGTGAAAGGTCAACTGTAGATGCTGAAGCTGTCCATAAATTGC TGACTTTGATTAAGGAATTATAG Download Select all
CCDS ID	CCDS1836.1

Protein Information

Protein ID	NP_000170.1
Protein Name	MutS homolog 6 (E. coli)
Molecular Wt. (Da)	152655
Protein Sequence	>2956 MSRQSTLYSFFPKSPALSDANKASARASREGGRAAAAPGASPSPGGDAAWSEAGPGPRPLARSA SPPKAKNLNGGLRRSVAPAAPTSCDFSPGDLVWAKMEGYPWWPCLVYNHPFDGTFIREKGKSVR VHVQFFDDSPTRGWVSKRLLKPYTGSKSKEAQKGGHFYSAKPEILRAMQRADEALNKDKIKRLE LAVCDEPSEPEEEEEMEVGTTYVTDKSEEDNEIESEEEVQPKTQGSRRSSRQIKKRRVISDSES DIGGSDVEFKPDTKEEGSSDEISSGVGDSESEGLNSPVKVARKRKRMVTGNGSLKRKSSRKETP SATKQATSISSETKNTLRAFSAPQNSESQAHVSGGGDDSSRPTVWYHETLEWLKEEKRRDEHRR RPDHPDFDASTLYVPEDFLNSCTPGMRKWWQIKSQNFDLVICYKVGKFYELYHMDALIGVSELG LVFMKGNWAHSGFPEIAFGRYSDSLVQKGYKVARVEQTETPEMMEARCRKMAHISKYDRVVRRE ICRIITKGTQTYSVLEGDPSENYSKYLLSLKEKEEDSSGHTRAYGVCFVDTSLGKFFIGQFSDD RHCSRFRTLVAHYPPVQVLFEKGNLSKETKTILKSSLSCSLQEGLIPGSQFWDASKTLRTLLEE EYFREKLSDGIGVMLPQVLKGMTSESDSIGLTPGEKSELALSALGGCVFYLKKCLIDQELLSMA NFEEYIPLDSDTVSTTRSGAIFTKAYQRMVLDAVTLNNLEIFLNGTNGSTEGTLLERVDTCHTP FGKRLLKQWLCAPLCNHYAINDRLDAIEDLMVVPDKISEVVELLKKLPDLERLLSKIHNVGSPL KSQNHPDSRAIMYEETTYSKKKIIDFLSALEGFKVMCKIIGIMEEVADGFKSKILKQVISLQTK NPEGRFPDLTVELNRWDTAFDHEKARKTGLITPKAGFDSDYDQALADIRENEQSLLEYLEKQRN RIGCRTIVYWGIGRNRYQLEIPENFTTRNLPEEYELKSTKKGCKRYWTKTIEKKLANLINAEER RDVSLKDCMRRLFYNFDKNYKDWQSAVECIAVLDVLLCLANYSRGGDGPMCRPVILLPEDTPPF LELKGSRHPCITKTFFGDDFIPNDILIGCEEEEQENGKAYCVLVTGPNMGGKSTLMRQAGLLAV MAQMGCYVPAEVCRLTPIDRVFTRLGASDRIMSGESTFFVELSETASILMHATAHSLVLVDELG RGTATFDGTAIANAVVKELAETIKCRTLFSTHYHSLVEDYSQNVAVRLGHMACMVENECEDPSQ ETITFLYKFIKGACPKSYGFNAARLANLPEEVIQKGHRKAREFEKMNQSLRLFREVCLASERST VDAEAVHKLLTLIKEL Download Select all
Length	1360
Uniprot ID	P35613
Ensembl Protein ID	ENSP00000333769

Post-translational Modification Information (Source : HPRD)

Residue	Type	site
S	Phosphorylation	227
S	Phosphorylation	252
S	Phosphorylation	254
S	Phosphorylation	256
S	Phosphorylation	261
S	Phosphorylation	830
S	Phosphorylation	137
S	Phosphorylation	137;-
S	Phosphorylation	348;-
T	Phosphorylation	924;-
S	Phosphorylation	219;-
T	Phosphorylation	139;-
S	Phosphorylation	144;-
S	Phosphorylation	14
S	Phosphorylation	79
S	Phosphorylation	91
S	Phosphorylation	200
T	Phosphorylation	213
Y	Phosphorylation	214
T	Phosphorylation	305
S	Phosphorylation	309
T	Phosphorylation	86
K	Acetylation	504
K	Acetylation	70
S	Phosphorylation	274
S	Phosphorylation	275
S	Phosphorylation	279
S	Phosphorylation	280
S	Phosphorylation	285
S	Phosphorylation	292
T	Phosphorylation	269
S	Phosphorylation	935
S	Phosphorylation	43
T	Phosphorylation	488
T	Phosphorylation	895
S	Phosphorylation	87
S	Phosphorylation	666
S	Phosphorylation	668

Enzyme Information

No matching records could be found.

PPi Information

(Click to view network : Source STRING) View

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
4436	MSH2	389	NP_000242.1	in vitro;in vivo;yeast 2-hybrid	97 746 768 942 985
4595	MUTYH	5380	NP_001121897.1	in vitro;in vivo	11801590
5111	PCNA	1456	NP_002583.1	in vitro;in vivo	110 058 031 217 192 000 000 000

Pathway Information

Pathway Name	Pathway ID
Colorectal cancer	hsa05210
Mismatch repair	hsa03430
Pathways in cancer	hsa05200

Structure Information

No matching records could be found.

Domain Information

ID	Location	Description
cd05837	88-195	MSH6_like
cl02554	88-195	PWWP superfamily
cd03286	1091-1313	ABC_MSH6_euk
cl21455	1091-1313	P-loop_NTPase superfamily
pfam00488	1074-1325	MutS_V
smart00534	1129-1320	MUTSac
cd03284	1090-1315	ABC_MutS1
cd03243	1090-1308	ABC_MutS_homologs
cd03285	1091-1324	ABC_MSH2_euk
cd03287	1089-1315	ABC_MSH3_euk
pfam05192	737-1064	MutS_III
cl17822	737-1064	MutS_III superfamily
cd03281	1090-1308	ABC_MSH5_euk
cd03282	1093-1308	ABC_MSH4_euk
pfam01624	407-525	MutS_I
cl03286	407-525	MutS_I superfamily
cd03280	1090-1304	ABC_MutS2
cd05162	90-181	PWWP
cd03283	1090-1299	ABC_MutS-like
cd03227	1090-1273	ABC_Class2
pfam00855	90-182	PWWP
smart00293	90-152	PWWP
pfam05190	932-1024	MutS_IV
pfam05188	538-693	MutS_II
cl04975	538-693	MutS_II superfamily
cd00267	1104-1262	ABC_ATPase
cd05836	90-168	N_Pac_NP60
cd05839	92-184	BR140_related
cd05835	90-183	Dnmt3b_related
cd05834	89-159	HDGF_related
cd05840	90-155	SPBC215_ISWI_like
cd06080	90-151	MUM1_like
cd05841	92-152	BS69_related
cd05838	93-162	WHSC1_related
COG0249	407-1336	MutS
PRK05399	407-1360	PRK05399
TIGR01070	407-1325	mutS1
smart00533	755-1099	MUTSd
TIGR01069	1011-1330	mutS2
COG1193	778-1330	MutS2
PRK00409	1042-1328	PRK00409
pfam04502	248-359	DUF572

Ontology Information

HPRD ID	176
Molecular Class	DNA repair protein
Molecular Function	Receptor activity (GO:0004872)
Biological Process	Cell communication (GO:0007154); Signal transduction (GO:0007165)

SNP Information

View SNP Geneview Report

Drug Information

No matching records could be found.

External Links

ArrayExpress GO
ICGC GO
Cancer3D GO
COSMIC GO
NCG GO
TSGene GO
Tumor Gene Family of Databases GO
CCDB GO
G2SBC GO
Osteosarcoma Database GO
RCDB GO

ArrayExpress	GO
ICGC	GO
Cancer3D	GO
COSMIC	GO
NCG	GO
TSGene	GO
Tumor Gene Family of Databases	GO
CCDB	GO
G2SBC	GO
Osteosarcoma Database	GO
RCDB	GO