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General Information
- Evidence
- Gene
- mRNA
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- Protein
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- Enzyme
- PPi
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- Domain
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25413075 | 2014 | Cell line : SW480 Source : - Sample Type : - No. of Sample : - Stage : - | RT-PCR, MTT assay,MACS | Up-regulation | - | The expression of MsrA was significantly higher in cancer stem cells than in the cancer cells and normal mucosa cells. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a ubiquitous and highly conserved protein that carries out the enzymatic reduction of methionine sulfoxide to methionine. Human and animal studies have shown the highest levels of expression in kidney and nervous tissue. The protein functions in the repair of oxidatively damaged proteins to restore biological activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014] | Chromosome | 8 |
| Location | 8p23.1 |
| Start | 9911830 |
| End | 10286401 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 374572 |
| OMIM ID | 601250 |
| HGNC ID | HGNC:7377 |
| Unigene ID | Hs.490981 |
| Ensembl ID | ENSG00000175806 |
| PharmGKB ID | PA31182 |
mRNA Information
| mRNA ID | XM_011543822.1 |
|---|---|
| Exon | join(1..435,153610..153678,190881..191000,247311..247415, 265660..265766,356916..359452) | mRNA Sequence | Download Select all |
| Length | 3373 |
Protein Information
| Protein ID | XP_011542124.1 |
|---|---|
| Protein Name | methionine sulfoxide reductase A |
| Molecular Wt. (Da) | 5939 |
| Protein Sequence | Download Select all |
| Length | 201 |
| Uniprot ID | O75962 |
| Ensembl Protein ID | ENSP00000339291 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| PRK00058 | 30-232 | PRK00058 |
| cl00366 | 30-232 | PMSR superfamily |
| COG0225 | 60-235 | MsrA |
| TIGR00401 | 66-216 | msrA |
| pfam01625 | 68-216 | PMSR |
| PRK14054 | 63-220 | PRK14054 |
| PRK13014 | 58-217 | PRK13014 |
| PRK05528 | 70-220 | PRK05528 |
| PRK05550 | 63-220 | PRK05550 |
| PRK14018 | 73-220 | PRK14018 |
Ontology Information
| HPRD ID | 1850 |
|---|---|
| Molecular Class | Enzyme: Reductase |
| Molecular Function | GTPase activator activity (GO:0005096) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| Q9UJ68 | DB00134 | L-Methionine | SmallMoleculeDrug |