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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| MTAP | 4507 | methylthioadenosine phosphorylase | 9 | MSAP, c86fus |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 19622299 | 2009 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 50 Stage : - | real-time PCR, immunohistochemistry,methylation-specified PCR | Up-regulation | - | Expression of MTAP is significantly higher in human colorectal cancer than in normal colorectal tissues. Demethylation of MTAP promoter may play an important role in up-regulating MTAP expression. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes an enzyme that plays a major role in polyamine metabolism and is important for the salvage of both adenine and methionine. The encoded enzyme is deficient in many cancers because this gene and the tumor suppressor p16 gene are co-deleted. Multiple alternatively spliced transcript variants have been described for this gene, but their full-length natures remain unknown. [provided by RefSeq, Jul 2008] | Chromosome | 9 |
| Location | 9p21 |
| Start | 21802635 |
| End | 21941040 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 138406 |
| OMIM ID | 156540 |
| HGNC ID | HGNC:7413 |
| Unigene ID | Hs.193268 |
| Ensembl ID | ENSG00000099810 |
| PharmGKB ID | PA31220 |
mRNA Information
| mRNA ID | NM_002451.3 |
|---|---|
| Exon | join(1..146,12798..12884,14079..14137,15400..15567, 35273..35375,51996..52235,56668..56790,59341..63336) | mRNA Sequence | Download Select all |
| Length | 4937 |
Protein Information
| Protein ID | NP_002442.2 |
|---|---|
| Protein Name | methylthioadenosine phosphorylase |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 283 |
| Uniprot ID | Q92574 |
| Ensembl Protein ID | ENSP00000298552 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 183 |
| T | Phosphorylation | 188 |
| T | Phosphorylation | 7 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Cysteine and methionine metabolism | hsa00270 |
| Metabolic pathways | hsa01100 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| PRK08564 | 10-273 | PRK08564 |
| cl00303 | 10-273 | PNP_UDP_1 superfamily |
| TIGR01694 | 11-257 | MTAP |
| PRK08931 | 7-260 | PRK08931 |
| PRK08666 | 10-258 | PRK08666 |
| PRK07432 | 8-258 | PRK07432 |
| PRK07823 | 12-258 | PRK07823 |
| PRK09136 | 12-251 | PRK09136 |
| pfam01048 | 11-255 | PNP_UDP_1 |
| PRK08202 | 5-258 | PRK08202 |
| TIGR01697 | 11-255 | PNPH-PUNA-XAPA |
| TIGR01700 | 11-253 | PNPH |
| TIGR01698 | 80-221 | PUNP |
| TIGR01699 | 11-236 | XAPA |
| COG0005 | 6-258 | XapA |
Ontology Information
| HPRD ID | 1583 |
|---|---|
| Molecular Class | Enzyme: Phosphorylase |
| Molecular Function | Sulfotransferase activity (GO:0008146) |
| Biological Process | Metabolism (GO:0008152); Energy pathways (GO:0006091) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| Q13126 | DB00173 | Adenine | SmallMoleculeDrug |