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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22628407 | 2012 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : - Stage : TNM Stage I-IV | Mouse Tiling Array Studies, MicroRNA Isolation and real time RT-PCR | Down-regulation | - | Metastasis suppressor 1 (MTSS1) is a direct miR-23a target and microRNA (miRNA) 23a and -27a (miR). miR-23a and -27a levels are upregulated in mouse intestinal adenocarcinomas, primary tumors from patients with stage I/II colorectal cancers, as well as in human colorectal cancer cell lines and cancer stem cells. MTSS1 is downregulated in Adenocarcinoma stage I and II but upregulated in Stage III and IV. |
| 22684455 | 2012 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | - | Down-regulation | - | miR-23a promotes the transition from indolent to invasive colorectal cancer through inhibition of the MTSS1 tumor suppressor. miR-23a accelerates colorectal cancer progression. |
| 23017832 | 2012 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | RT-PCR, Western blotting , Luciferase report assay, MTT | Down-regulation | - | miR-135a inhibits the expression of MTSS1 in colorctal cancer and miR-135a promotes the growth and invasion of CRC cells, at least partially, through targeting MTSS1. MTSS1 was identified as a candidate target gene of miR-135a by luciferase report assay. SW480 and SW620 CRC cell lines were used. |
| 21562916 | 2011 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 135 Stage : - | Immunohistochemistry, Mann-Whitney U test, Western blotting, Spearman rank correlation analysis | Up-regulation | - | MTSS1 may be a good biomarker to be applied in the clinical setting to predict the prognosis of CRC patients with completely resected. MTSS1 expression rates were significantly higher in CRC tissues (99 out of 135, 73.30%) than that in normal colorectal tissues. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | - | Chromosome | 8 |
| Location | 8p22 |
| Start | 124550770 |
| End | 124728507 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 177738 |
| OMIM ID | 608486 |
| HGNC ID | HGNC:20443 |
| Unigene ID | Hs.336994 |
| Ensembl ID | ENSG00000170873 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_014751.5 |
|---|---|
| Exon | join(1..624,24317..24378,28909..28982,137273..137357, 138797..138888,143347..143421,159972..160129, 161330..161437,162749..162846,165516..165726, 170633..170827,172103..172276,172604..172766, 174816..177738) | mRNA Sequence | Download Select all |
| Length | 5054 |
CDS Information
| Location | join(553..624,24317..24378,28909..28982,137273..137357, 138797..138888,143347..143421,159972..160129, 161330..161437,162749..162846,165516..165726, 170633..170827,172103..172276,172604..172766, 174816..175516) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS6353.1 |
Protein Information
| Protein ID | NP_001269900.1 |
|---|---|
| Protein Name | Metastasis suppressor 1 |
| Molecular Wt. (Da) | 82549 |
| Protein Sequence | Download Select all |
| Length | 759 |
| Uniprot ID | Q15375 |
| Ensembl Protein ID | ENSP00000358303 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| T | Phosphorylation | 258 |
| S | Phosphorylation | 261 |
| S | Phosphorylation | 644 |
| S | Phosphorylation | 649 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 3064 | HTT | 883 | NP_002102.4 | yeast 2-hybrid | 15383276 |
| 5789 | PTPRD | 3358 | NP_002830.1 | in vitro;yeast 2-hybrid | 12570871 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd07643 | 7-237 | I-BAR_IMD_MIM |
| cl12013 | 7-237 | BAR superfamily |
| pfam08397 | 16-236 | IMD |
| cd07605 | 10-230 | I-BAR_IMD |
| cd07307 | 19-216 | BAR |
| cd07646 | 15-196 | I-BAR_IMD_IRSp53 |
| cd07645 | 28-196 | I-BAR_IMD_BAIAP2L1 |
| pfam02205 | 724-750 | WH2 |
| cl08342 | 724-750 | WH2 superfamily |
| smart00935 | 108-193 | OmpH |
| cl21485 | 108-193 | OmpH superfamily |
| smart00935 | 110-208 | OmpH |
| PHA03247 | 326-725 | PHA03247 |
| PHA03247 | 564-754 | PHA03247 |
| PHA03247 | 579-717 | PHA03247 |
| PTZ00441 | 605-751 | PTZ00441 |
| COG1196 | 72-229 | Smc |
| PRK14950 | 564-661 | PRK14950 |
| PHA03264 | 624-713 | PHA03264 |
| PHA03307 | 564-737 | PHA03307 |
| PHA03307 | 563-739 | PHA03307 |
| pfam09606 | 597-721 | Med15 |
| pfam04652 | 616-727 | DUF605 |
Ontology Information
| HPRD ID | 2481 |
|---|---|
| Molecular Class | Cytoskeletal associated protein |
| Molecular Function | Transmembrane receptor protein tyrosine kinase activity (GO:0004714) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.