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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
MUC5B 727897 mucin 5B, oligomeric mucus/gel-forming  11MG1 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
21215095   2010Cell line : -

Source : -

Sample Type : CRC tumor and normal tissue

No. of Sample : 97

Stage : TNM Stage I-IV

Chip technology and immunohistochemistryUnknown-The expression of PLAC1/CP1 genes correlates with various clinical and pathologic parameters.


Gene Details



NC_000011.9 (1244295..1283406)

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Gene Type protein coding
Gene Family Mucins
Description This gene encodes a member of the mucin family of proteins, which are highly glycosylated macromolecular components of mucus secretions. This family member is the major gel-forming mucin in mucus. It is a major contributor to the lubricating and viscoelastic properties of whole saliva, normal lung mucus and cervical mucus. This gene has been found to be up-regulated in some human diseases, including sinus mucosa of chronic rhinosinusitis (CRS), CRS with nasal polyposis, chronic obstructive pulmonary disease (COPD) and H. pylori-associated gastric disease, and it may be involved in the pathogenesis of these diseases. [provided by RefSeq, Jul 2010]  
Chromosome 11
Location 11p15.5
Start 1244295  
End 1283406  
Strand +  
Gene Sequence

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Length 39112  
OMIM ID 600770   
HGNC ID HGNC:7516   
Unigene ID Hs.523395   
Ensembl ID -   
PharmGKB ID PA31321   

mRNA Information


mRNA ID ?NM_002458.2
Exon  
mRNA Sequence

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Length  



CDS Information


   
Location
CDS Sequence

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CCDS ID CCDS44515.2



Protein Information


      
Protein IDNP_002449.2
Protein Namemucin 5B, oligomeric mucus/gel-forming
Molecular Wt. (Da)0
Protein Sequence

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Length 5762  
Uniprot IDQ96JG8
Ensembl Protein ID ENSP00000335385  



Post-translational Modification Information (Source : HPRD)


No matching records could be found.

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

No matching records from HPRD source could be found.

Pathway Information


      
Pathway Name Pathway ID
Salivary secretion hsa04970


Structure Information


No matching records could be found.

Domain Information




ID Location Description
smart00216884-1041  VWD
cl02516884-1041  VWD superfamily
smart002165064-5237  VWD
cl025165064-5237  VWD superfamily
pfam00094895-1041  VWD
smart0021670-223  VWD
cl0251670-223  VWD superfamily
pfam000945075-5238  VWD
pfam0009477-223  VWD
smart00216414-578  VWD
cl02516414-578  VWD superfamily
pfam133301789-1878  Mucin2_WxxW
cl162391789-1878  Mucin2_WxxW superfamily
pfam133301340-1426  Mucin2_WxxW
cl162391340-1426  Mucin2_WxxW superfamily
pfam00094425-579  VWD
pfam133301508-1597  Mucin2_WxxW
cl162391508-1597  Mucin2_WxxW superfamily
pfam133304134-4222  Mucin2_WxxW
cl162394134-4222  Mucin2_WxxW superfamily
smart00832615-685  C8
cl07383615-685  C8 superfamily
pfam133303577-3665  Mucin2_WxxW
cl162393577-3665  Mucin2_WxxW superfamily
pfam133302320-2408  Mucin2_WxxW
cl162392320-2408  Mucin2_WxxW superfamily
pfam133302877-2965  Mucin2_WxxW
cl162392877-2965  Mucin2_WxxW superfamily
pfam08742615-685  C8
pfam087421078-1152  C8
cl073831078-1152  C8 superfamily
smart008321078-1152  C8
smart000415660-5742  CT
cl215455660-5742  GHB_like superfamily
pfam08742259-326  C8
cl07383259-326  C8 superfamily
pfam087425290-5351  C8
cl073835290-5351  C8 superfamily
pfam01826329-385  TIL
cl20226329-385  TIL superfamily
smart008325291-5351  C8
smart00832271-326  C8
pfam01826794-855  TIL
cl20226794-855  TIL superfamily
smart002145523-5586  VWC
cl177355523-5586  VWC superfamily
pfam000075676-5739  Cys_knot
smart00215387-432  VWC_out
cl17735387-432  VWC superfamily
pfam01826695-752  TIL
cl20226695-752  TIL superfamily
pfam000935523-5586  VWC
pfam051093295-3570  Herpes_BLLF1
PHA032553434-3564  PHA03255
pfam051093173-3562  Herpes_BLLF1
PRK130423470-3565  PRK13042
PHA032473295-3564  PHA03247
pfam051093160-3518  Herpes_BLLF1
PRK127993449-3566  motB
COG38893444-3569  COG3889
PRK119073438-3552  PRK11907
PRK119073473-3574  PRK11907
PHA032472594-2864  PHA03247
pfam051092010-2313  Herpes_BLLF1
pfam051091954-2312  Herpes_BLLF1
pfam154023457-3562  Spc7_N
PRK124953485-3565  PRK12495


Ontology Information


   
HPRD ID19369
Molecular ClassAdhesion molecule
Molecular Function-
Biological ProcessCell growth and/or maintenance (GO:0008151)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO