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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
MYB 4602 v-myb avian myeloblastosis viral oncogene homolog  6c-myb 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
11290547   2001Cell line : -

Source : Regina Elena Cancer Institute

Sample Type : CRC tumor and normal tissue

No. of Sample : 91 CRC (70 colon and 21 rectum cancers)

Stage : Duke Stage A-D

Flow Cytometry,Immunohistochemistry,Western Blotting, Northern BlottingUp-regulation-Association between c-Myb and Bcl-x expression and suggest that expression of both molecules might be a useful prognostic marker in CRC.

20096072   2010Cell line : -

Source : -

Sample Type : Sporadic (A/J mice) and colitis-associated (ICR mice) models

No. of Sample : -

Stage : -

real time RT-PCRUp-regulation--

20237898   2010Cell line : COLO 205

Source : -

Sample Type : -

No. of Sample : -

Stage : -

SDS-PAGE, Western blotting and immunoblotting, real time RT-PCR,DNA fragmentation gel electrophoresisUp-regulation--


Gene Details



NC_000006.11 (135502453..135540311)

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Gene Type protein coding
Gene Family -
Description This gene encodes a protein with three HTH DNA-binding domains that functions as a transcription regulator. This protein plays an essential role in the regulation of hematopoiesis. This gene may be aberrently expressed or rearranged or undergo translocation in leukemias and lymphomas, and is considered to be an oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]  
Chromosome 6
Location 6q22-q23
Start 135502453  
End 135540311  
Strand +  
Gene Sequence

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Length 37859  
OMIM ID 189990   
HGNC ID HGNC:7545   
Unigene ID Hs.606320   
Ensembl ID ENSG00000118513   
PharmGKB ID PA31345   

mRNA Information


mRNA ID NM_001130173.1
Exon join(335..556,4923..5040,6854..6925,8811..8903,9147..9367, 11344..11578,12858..12938,13376..13480,14768..15022, 15981..16343,17928..18070,19105..19219,19310..19435, 20659..20769,22237..22344,36884..38193)  
mRNA Sequence

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Length 3681  



CDS Information


   
Location200..2485
CDS Sequence

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CCDS ID CCDS47481.1



Protein Information


      
Protein IDNP_001123645.1
Protein Namev-myb avian myeloblastosis viral oncogene homolog
Molecular Wt. (Da)78633
Protein Sequence

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Length 761  
Uniprot IDP10599
Ensembl Protein ID ENSP00000363639  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation532
KAcetylation471
KAcetylation480
KAcetylation485
SPhosphorylation11
SPhosphorylation12

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                                     
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
1051CEBPB1801NP_005185.2in vitro11792321   
4094MAF1518NP_005351.2in vitro;yeast 2-hybrid9566892   
4691NCL1245NP_005372.2in vitro;in vivo10660576   
5079PAX51334NP_057953.1in vivo11781241   
5371PML23NP_150241.2in vitro;in vivo15194430   
6502SKP23256NP_005974.2in vivo18765672   
8945BTRC4596NP_378663.1in vivo18765672   
9125RQCD18828NP_005435.1in vitro;in vivo;yeast 2-hybrid15209511   
26190FBXW29950NP_036296.2in vivo18765672   
54461FBXW510955NP_061871.1in vivo18765672   
55294FBXW75888NP_361014.1in vivo18765672   


Pathway Information


            
Pathway Name Pathway ID
HTLV-I infection hsa05166
PI3K-Akt signaling pathway hsa04151


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd0016794-138  SANT
cl2149894-138  SANT superfamily
cd0016742-86  SANT
cl2149842-86  SANT superfamily
cd00167146-186  SANT
cl21498146-186  SANT superfamily
pfam09316402-567  Cmyb_C
cl07814402-567  Cmyb_C superfamily
pfam07988266-313  LMSTEN
cl06845266-313  LMSTEN superfamily
pfam0024992-138  Myb_DNA-binding
pfam1392143-103  Myb_DNA-bind_6
pfam0024940-86  Myb_DNA-binding
pfam1392195-155  Myb_DNA-bind_6
pfam00249144-189  Myb_DNA-binding
pfam13921147-201  Myb_DNA-bind_6
cd1166094-136  SANT_TRF
cd1165988-134  SANT_CDC5_II
cd1165938-87  SANT_CDC5_II
cd1166042-82  SANT_TRF
cd11659140-179  SANT_CDC5_II
cd0183928-74  SGNH_arylesterase_like
cl0105328-74  SGNH_hydrolase superfamily
pfam1383740-82  Myb_DNA-bind_4
smart0071792-140  SANT
smart0071740-88  SANT
smart00717144-191  SANT
COG514789-202  REB1
PLN0321292-241  PLN03212
PLN0309189-246  PLN03091
COG514735-184  REB1
COG514740-177  REB1


Ontology Information


   
HPRD ID1774
Molecular ClassTranscription factor
Molecular FunctionLigase activity (GO:0016874)
Biological ProcessMetabolism (GO:0008152); Energy pathways (GO:0006091)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO