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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
MYBL2 4605 v-myb avian myeloblastosis viral oncogene homolog-like 2  20BMYB, B-MYB 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
26101717   2015Cell line : SW480

Source : -

Sample Type : CRC tumor and normal tissue

No. of Sample : CRC tissues 97 and adjacent noncancerous tissues 104

Stage : -

 Immunohistochemistry,RT-PCR,Western blottingUp-regulation-MYBL2 is overexpressed in CRC and may therefore play an important role in tumourigenesis.


Gene Details



NC_000020.10 (42295659..42345136)

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Gene Type protein coding
Gene Family -
Description The protein encoded by this gene, a member of the MYB family of transcription factor genes, is a nuclear protein involved in cell cycle progression. The encoded protein is phosphorylated by cyclin A/cyclin-dependent kinase 2 during the S-phase of the cell cycle and possesses both activator and repressor activities. It has been shown to activate the cell division cycle 2, cyclin D1, and insulin-like growth factor-binding protein 5 genes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013]  
Chromosome 20
Location 20q13.1
Start 42295659  
End 42345136  
Strand +  
Gene Sequence

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Length 49478  
OMIM ID 601415   
HGNC ID HGNC:7548   
Unigene ID Hs.179718   
Ensembl ID ENSG00000101057   
PharmGKB ID PA31348   

mRNA Information


mRNA ID NM_002466.3
Exon join(1..285,6788..6881,14766..14837,15776..15868, 19834..20054,25139..25301,32739..33026,35472..35885, 38201..38340,42945..43044,44470..44583,45984..46088, 48116..48265,48941..49478)  
mRNA Sequence

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Length 2785  



CDS Information


   
Location266..2368
CDS Sequence

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CCDS ID CCDS13322.1



Protein Information


      
Protein IDNP_002457.1
Protein Namev-myb avian myeloblastosis viral oncogene homolog-like 2
Molecular Wt. (Da)43112
Protein Sequence

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Length 700  
Uniprot IDP29597
Ensembl Protein ID ENSP00000264818  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation282
TPhosphorylation266
SPhosphorylation393
TPhosphorylation405
TPhosphorylation440
TPhosphorylation444
SPhosphorylation452
TPhosphorylation487
TPhosphorylation494
TPhosphorylation515
TPhosphorylation518
TPhosphorylation520
SPhosphorylation577
SPhosphorylation393
SPhosphorylation241
SPhosphorylation600

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                      
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
142PARP11435NP_001609.2in vivo10744766   
595CCND11346NP_444284.1in vitro;in vivo10645009   
890CCNA2453NP_001228.1in vivo10871850   
898CCNE1455NP_001229.1in vitro;in vivo9012818   
997CDC34306NP_004350.1in vivo10871850   
1387CREBBP2534NP_004371.2in vitro;in vivo11423988   
5933RBL1312NP_002886.2in vitro;in vivo1   243   974   312   947   090   
8458TTF25280NP_003585.3yeast 2-hybrid12927788   
9611NCOR12911NP_006302.2in vitro;in vivo11997503   
9612NCOR22910NP_006303.3in vitro;in vivo11997503   


Pathway Information


      
Pathway Name Pathway ID
HTLV-I infection hsa05166


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd0016785-129  SANT
cl2149885-129  SANT superfamily
cd0016733-77  SANT
cl2149833-77  SANT superfamily
cd00167138-177  SANT
cl21498138-177  SANT superfamily
pfam09316451-605  Cmyb_C
cl07814451-605  Cmyb_C superfamily
pfam0024983-129  Myb_DNA-binding
pfam1392134-94  Myb_DNA-bind_6
pfam1392186-146  Myb_DNA-bind_6
pfam0024931-77  Myb_DNA-binding
pfam00249135-180  Myb_DNA-binding
pfam13921138-189  Myb_DNA-bind_6
cd1165979-125  SANT_CDC5_II
cd1166085-127  SANT_TRF
cd1166032-79  SANT_TRF
cd11659131-170  SANT_CDC5_II
cd1220386-136  GT1
smart0071783-131  SANT
smart0071731-79  SANT
smart00717135-182  SANT
PLN0309181-197  PLN03091
COG514780-195  REB1
PLN0321283-184  PLN03212
COG514724-181  REB1


Ontology Information


   
HPRD ID8931
Molecular ClassTranscription factor
Molecular FunctionStructural constituent of ribosome (GO:0003735)
Biological ProcessProtein metabolism (GO:0019538)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO