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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| MYD88 | 4615 | myeloid differentiation primary response 88 | 3 | - |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
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- Drug
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23235763 | 2012 | Cell line : - Source : - Sample Type : GC,CRC, Prostate tumor No. of Sample : 60 gastric, 60 coloretal and 107 prostate carcinomas. Stage : TNM Stage I-IV | Immunohistochemistry, SSCP | Down-regulation | - | MYD88 expression was significantly increased in gastric cancer cells compared with normal cells, whereas it was decreased in colorectal cancer cells compared with normal cells. |
| 24887488 | 2014 | Cell line : - Source : First Affiliated Hospital of Kunming Medical University. Sample Type : CRC tumor and normal tissue No. of Sample : 305 Stage : TNM Stage I-IV | realtime RT-PCR | Down-regulation | - | Aberrant mRNA expression of IDH1, DNMT3A, and MYD88 gene might be actively involved in the development of CRC. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010] | Chromosome | 3 |
| Location | 3p22 |
| Start | 38179969 |
| End | 38184513 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 4545 |
| OMIM ID | 602170 |
| HGNC ID | HGNC:7562 |
| Unigene ID | Hs.82116 |
| Ensembl ID | ENSG00000172936 |
| PharmGKB ID | PA31361 |
mRNA Information
| mRNA ID | NM_001172567.1 |
|---|---|
| Exon | join(1..551,1387..1521,1911..2115,2280..2371,2655..4545) | mRNA Sequence | Download Select all |
| Length | 2886 |
Protein Information
| Protein ID | NP_001166038.1 |
|---|---|
| Protein Name | myeloid differentiation primary response 88 |
| Molecular Wt. (Da) | 17687 |
| Protein Sequence | Download Select all |
| Length | 317 |
| Uniprot ID | P62987 |
| Ensembl Protein ID | ENSP00000396910 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 3554 | IL1R1 | 994 | NP_000868.1 | in vitro | 12659850 |
| 3654 | IRAK1 | 2235 | NP_001560.2 | in vivo | 10854325 |
| 3663 | IRF5 | 6240 | NP_001092099.1 | in vivo | 15665823 |
| 3665 | IRF7 | 5441 | NP_004022.2 | in vivo;yeast 2-hybrid | 15361868 |
| 7097 | TLR2 | 4323 | NP_003255.2 | yeast 2-hybrid | 16482509 |
| 7100 | TLR5 | 4326 | NP_003259.2 | yeast 2-hybrid | 16482509 |
| 8405 | SPOP | 16004 | NP_001007227.1 | yeast 2-hybrid | 16189514 |
| 55620 | STAP2 | 7430 | NP_060190.2 | in vivo | 16365431 |
| 81793 | TLR10 | 5884 | NP_112218.2 | in vivo | 15728506 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| African trypanosomiasis | hsa05143 |
| Apoptosis | hsa04210 |
| Chagas disease (American trypanosomiasis) | hsa05142 |
| Hepatitis B | hsa05161 |
| Herpes simplex infection | hsa05168 |
| Influenza A | hsa05164 |
| Legionellosis | hsa05134 |
| Leishmaniasis | hsa05140 |
| Malaria | hsa05144 |
| Measles | hsa05162 |
| NF-kappa B signaling pathway | hsa04064 |
| Pertussis | hsa05133 |
| Salmonella infection | hsa05132 |
| Toll-like receptor signaling pathway | hsa04620 |
| Toxoplasmosis | hsa05145 |
| Tuberculosis | hsa05152 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd08312 | 29-106 | Death_MyD88 |
| cl14633 | 29-106 | DD superfamily |
| smart00255 | 160-296 | TIR |
| cl22869 | 160-296 | TIR_2 superfamily |
| pfam01582 | 163-292 | TIR |
| pfam13676 | 164-275 | TIR_2 |
| pfam00531 | 34-105 | Death |
| smart00005 | 27-105 | DEATH |
| cd08311 | 30-101 | Death_p75NR |
| cd01670 | 36-105 | Death |
| cd08799 | 27-105 | Death_UNC5C |
| cd08310 | 29-100 | Death_NFkB-like |
| cd08309 | 25-97 | Death_IRAK |
| cd08318 | 41-101 | Death_NMPP84 |
| cd08781 | 25-103 | Death_UNC5-like |
| cd08782 | 29-101 | Death_DAPK1 |
| cd08802 | 25-103 | Death_UNC5B |
| cd08804 | 28-102 | Death_ank2 |
| cd08777 | 39-105 | Death_RIP1 |
Ontology Information
| HPRD ID | 1877 |
|---|---|
| Molecular Class | Adapter molecule |
| Molecular Function | Ubiquitin-specific protease activity (GO:0004843) |
| Biological Process | Protein metabolism (GO:0019538) |
Drug Information
No matching records could be found.