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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
MYH11 4629 myosin, heavy chain 11, smooth muscle  16SMMHC, SMHC 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
17950328   2008Cell line : -

Source : Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine,Seoul, Korea.

Sample Type : CRC tumor and normal tissue

No. of Sample : 5112

Stage : TNM Stage I-IV

Microsatellite Analysis,Modified Differential Display PCR ,ACP-Based GeneFishing PCR,Cloning and Sequencing, real time RT-PCRDown-regulation-Reg I, MLCK, and MYH11 in tumors of MSS HNPCC showed significant differences in gene expression pattern compared with the adjacent pathologically normal tissues. Reg I and DMBT1, were upregulated in the cancer tissues, MLCK and MYH11, were down-regulated in the cancer tissues.

25227818   2014Cell line : -

Source : Department of Colorectal Surgery in Fudan University Shanghai Cancer Center

Sample Type : CRC tumor and normal tissue

No. of Sample : 58

Stage : Stage II,III

Immunohistochemistry,real time RT-PCR,multivariate analysisDown-regulation--


Gene Details



NC_000016.9 (15796992..15950887, complement)

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Gene Type protein coding
Gene Family Myosins / Myosin superfamily : Class II
Description The protein encoded by this gene is a smooth muscle myosin belonging to the myosin heavy chain family. The gene product is a subunit of a hexameric protein that consists of two heavy chain subunits and two pairs of non-identical light chain subunits. It functions as a major contractile protein, converting chemical energy into mechanical energy through the hydrolysis of ATP. The gene encoding a human ortholog of rat NUDE1 is transcribed from the reverse strand of this gene, and its 3' end overlaps with that of the latter. The pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript that encodes a protein consisting of the first 165 residues from the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Alternative splicing generates isoforms that are differentially expressed, with ratios changing during muscle cell maturation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]  
Chromosome 16
Location 16p13.11
Start 15796992  
End 15950887  
Strand -  
Gene Sequence

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Length 153896  
OMIM ID 160745   
HGNC ID HGNC:7569   
Unigene ID Hs.460109   
Ensembl ID ENSG00000133392   
PharmGKB ID PA31367   

mRNA Information


mRNA ID NM_001143979.1
Exon complement(<130681..132843)  
mRNA Sequence

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Length 3936  



CDS Information


   
Location827..1834
CDS Sequence

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CCDS ID CCDS10565.1



Protein Information


      
Protein IDNP_001137451.1
Protein Namemyosin, heavy chain 11, smooth muscle
Molecular Wt. (Da)45243
Protein Sequence

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Length 335  
Uniprot IDP09936
Ensembl Protein ID ENSP00000284440  



Post-translational Modification Information (Source : HPRD)


Residue Type site
TPhosphorylation604
TPhosphorylation604
TPhosphorylation611
TPhosphorylation611
SPhosphorylation1814
TPhosphorylation1815
SPhosphorylation1814
TPhosphorylation1815
SPhosphorylation1821
TPhosphorylation1822
SPhosphorylation1821
TPhosphorylation1822
SPhosphorylation1954
SPhosphorylation1961

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

No matching records from HPRD source could be found.

Pathway Information


            
Pathway Name Pathway ID
Tight junction hsa04530
Vascular smooth muscle contraction hsa04270


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd1492199-771  MYSc_Myh11
cl2285399-771  Motor_domain superfamily
cd0137799-771  MYSc_class_II
cd1492099-771  MYSc_Myh10
cd1493299-771  MYSc_Myh18
cd1491999-771  MYSc_Myh9
cd1589699-771  MYSc_Myh19
cd1491199-771  MYSc_Myh2_insects_mollusks
cd1493099-771  MYSc_Myh14_mammals
cd0012499-771  MYSc
cd1492799-771  MYSc_Myh7b
cd14913100-771  MYSc_Myh3
cd1490999-771  MYSc_Myh1_insects_crustaceans
cd1493499-771  MYSc_Myh16
cd01380100-771  MYSc_Myo5
cd1492999-771  MYSc_Myh15_mammals
cd14917100-771  MYSc_Myh7
cd14918101-771  MYSc_Myh8
cd14923100-771  MYSc_Myh13
cd14910100-771  MYSc_Myh1_mammals
cd14916100-771  MYSc_Myh6
cd14912100-771  MYSc_Myh2_mammals
cd14915100-771  MYSc_Myh4
cd14883100-771  MYSc_Myo22
cd01383100-771  MYSc_Myo8
cd01378100-771  MYSc_Myo1
cd0138499-771  MYSc_Myo11
cd0138199-771  MYSc_Myo7
cd0138299-771  MYSc_Myo6
cd1487299-771  MYSc_Myo4
cd1489099-771  MYSc_Myo29
cd0138799-771  MYSc_Myo15
cd1489799-771  MYSc_Myo36
cd1490199-769  MYSc_Myo40
cd0138599-771  MYSc_Myo9
cd1490399-771  MYSc_Myo42
cd1488899-732  MYSc_Myo27
cd01379100-771  MYSc_Myo3
cd1487399-771  MYSc_Myo10
cd1489299-771  MYSc_Myo31
cd14889101-771  MYSc_Myo28
cd1490799-734  MYSc_Myo46
cd1489199-771  MYSc_Myo30
cd14900100-737  MYSc_Myo39
cd1490299-728  MYSc_Myo41
cd14895100-771  MYSc_Myo34
cd1490499-771  MYSc_Myo43
cd1489699-771  MYSc_Myo35
cd0138699-771  MYSc_Myo18
cd1490899-757  MYSc_Myo47
cd1487699-769  MYSc_Myo14
cd1488099-732  MYSc_Myo19
cd1490699-767  MYSc_Myo45
cd1487599-771  MYSc_Myo13
cd1488699-771  MYSc_Myo25
cd1489999-728  MYSc_Myo38
cd1488799-771  MYSc_Myo26
cd1487996-770  MYSc_Myo17
cd1487899-771  MYSc_Myo16
cd14898100-735  MYSc_Myo37
cd1493799-771  MYSc_Myo24A
cd14881100-758  MYSc_Myo20
cd1488499-723  MYSc_Myo23
cd14905100-724  MYSc_Myo44
cd1487499-731  MYSc_Myo12
cd14882100-771  MYSc_Myo21
cd14893102-729  MYSc_Myo32
cd01363121-255  Motor_domain
cd14938100-769  MYSc_Myo24B
cd14894105-712  MYSc_Myo33
pfam0273633-75  Myosin_N
cl0368633-75  Myosin_N superfamily
cd01363657-681  Motor_domain
pfam100791111-1222  DUF2317
cl195111111-1222  DUF2317 superfamily
pfam12325977-1083  TMF_TATA_bd
cl22438977-1083  TMF_TATA_bd superfamily
TIGR034951780-1867  phage_LysB
cl200641780-1867  phage_LysB superfamily
pfam0006387-771  Myosin_head
pfam015761073-1930  Myosin_tail_1
COG1340858-1149  COG1340
smart0024280-783  MYSc
COG502236-1191  COG5022
PTZ0001464-814  PTZ00014
COG11961001-1907  Smc
COG1196863-1674  Smc
TIGR02168863-1677  SMC_prok_B
COG11961101-1912  Smc
TIGR021681104-1913  SMC_prok_B
TIGR02168971-1705  SMC_prok_B
COG1196851-1566  Smc
TIGR02168851-1544  SMC_prok_B
TIGR02169981-1826  SMC_prok_A
TIGR021681052-1882  SMC_prok_B
COG1196977-1819  Smc
TIGR02168829-1606  SMC_prok_B
COG11961229-1933  Smc
TIGR021681201-1934  SMC_prok_B
TIGR02169851-1706  SMC_prok_A
COG0419849-1420  SbcC
COG11961185-1915  Smc
COG11961249-1930  Smc
TIGR021691113-1926  SMC_prok_A
TIGR02169844-1604  SMC_prok_A
TIGR021691138-1922  SMC_prok_A
TIGR04523977-1556  Mplasa_alph_rch
TIGR04523848-1467  Mplasa_alph_rch
pfam121281036-1696  DUF3584
COG1196846-1175  Smc
TIGR021681326-1933  SMC_prok_B
PTZ001211170-1924  PTZ00121
TIGR02169846-1452  SMC_prok_A
PTZ00121853-1600  PTZ00121
COG1196850-1217  Smc
pfam02463849-1705  SMC_N
PRK02224989-1566  PRK02224
PTZ00121849-1568  PTZ00121
TIGR02168846-1167  SMC_prok_B
PRK03918851-1399  PRK03918
pfam135141078-1836  AAA_27
COG04191069-1688  SbcC
TIGR021691192-1933  SMC_prok_A
PRK02224851-1392  PRK02224
COG04191272-1897  SbcC
PRK03918875-1481  PRK03918
COG11961583-1934  Smc
PRK022241185-1707  PRK02224
PTZ00121828-1482  PTZ00121
TIGR00606850-1805  rad50
TIGR00618833-1432  sbcc
PRK022241315-1933  PRK02224
pfam121281296-1929  DUF3584
TIGR045231028-1681  Mplasa_alph_rch
TIGR006181135-1876  sbcc
COG0419848-1340  SbcC
PRK039181085-1671  PRK03918
pfam024631074-1915  SMC_N
COG1196845-1130  Smc
pfam05483860-1459  SCP-1
TIGR045231277-1927  Mplasa_alph_rch
pfam02463850-1598  SMC_N
pfam02463942-1820  SMC_N
TIGR006061110-1908  rad50
PTZ001211125-1929  PTZ00121
pfam121281171-1855  DUF3584
COG04191337-1930  SbcC
PTZ001211458-1955  PTZ00121
TIGR00606846-1591  rad50
pfam10174901-1668  Cast
pfam12128846-1370  DUF3584
TIGR02168764-1123  SMC_prok_B
PRK02224848-1230  PRK02224
PRK03918840-1290  PRK03918
TIGR00618992-1707  sbcc
PRK039181290-1889  PRK03918
PTZ001211330-1961  PTZ00121
PTZ00121803-1396  PTZ00121
pfam10174851-1581  Cast
pfam135141153-1972  AAA_27
pfam13514811-1578  AAA_27
pfam05483851-1377  SCP-1
pfam13514846-1235  AAA_27
pfam05483941-1678  SCP-1
TIGR00618844-1630  sbcc
TIGR00606846-1661  rad50
PRK048631069-1863  mukB
TIGR04523846-1282  Mplasa_alph_rch
pfam054831210-1883  SCP-1
COG04191526-1913  SbcC
pfam055571215-1854  MAD
COG4717980-1573  YhaN
pfam101741016-1707  Cast
COG43721103-1327  COG4372
pfam13514852-1706  AAA_27
pfam055571311-1896  MAD
pfam04094997-1337  DUF390
COG51851043-1447  HEC1
PRK04863997-1738  mukB
TIGR031851017-1344  DNA_S_dndD
PRK04863887-1706  mukB
pfam078881285-1635  CALCOCO1
PRK01156763-1437  PRK01156
pfam07111847-1479  HCR
PRK039181504-1912  PRK03918
COG49421044-1277  EnvC
pfam056221179-1585  HOOK
pfam078881525-1893  CALCOCO1
PRK04863846-1611  mukB
pfam12128884-1216  DUF3584
PHA025621175-1448  46
pfam13514856-1264  AAA_27
pfam131661069-1429  AAA_13
pfam05622871-1358  HOOK
pfam078881165-1486  CALCOCO1
TIGR01612977-1915  235kDa-fam
COG43721592-1896  COG4372
pfam000381037-1345  Filament
TIGR018431158-1352  type_I_hlyD
pfam101741126-1881  Cast
pfam122521140-1432  SidE
COG32641159-1357  MscK
pfam05557846-1348  MAD
PRK112811045-1455  PRK11281
COG43721243-1479  COG4372
TIGR00606999-1410  rad50
PRK011561253-1886  PRK01156
TIGR021681726-1961  SMC_prok_B
COG15111059-1399  YhgE
pfam10174846-1407  Cast
TIGR018431646-1859  type_I_hlyD
TIGR00618802-1218  sbcc
PRK04863850-1490  mukB
pfam12128846-1157  DUF3584
pfam055571138-1700  MAD
COG43721183-1409  COG4372
TIGR026801049-1797  TIGR02680
COG04971239-1441  RecN
pfam10174842-1450  Cast
COG44771191-1561  EzrA
PRK112811101-1466  PRK11281
PRK047781173-1481  PRK04778
PTZ004401004-1923  PTZ00440
pfam061601048-1481  EzrA
COG32641761-1924  MscK
COG3206980-1266  GumC
pfam13166972-1285  AAA_13
TIGR021691600-1934  SMC_prok_A
TIGR026801069-1367  TIGR02680
COG49421754-1930  EnvC
PRK10246867-1363  PRK10246
COG43721666-1910  COG4372
TIGR01843966-1098  type_I_hlyD
COG4913936-1314  COG4913
pfam09726977-1188  Macoilin
COG0497858-1111  RecN
TIGR006181529-1916  sbcc
PRK011561373-1905  PRK01156
TIGR026801529-1906  TIGR02680
PRK02224847-1298  PRK02224
TIGR006061450-1912  rad50
COG30961069-1369  MukB
COG49421082-1351  EnvC
PRK00409852-1055  PRK00409
TIGR018431784-1930  type_I_hlyD
COG43721289-1575  COG4372
pfam05622849-1098  HOOK
pfam07888872-1224  CALCOCO1
COG4942851-1118  EnvC
pfam078881594-1912  CALCOCO1
pfam02463840-1200  SMC_N
pfam055571506-1929  MAD
PRK090391069-1208  PRK09039
COG3206964-1177  GumC
COG4372846-1029  COG4372
PRK10246844-1443  PRK10246
pfam097261095-1369  Macoilin
pfam056221374-1894  HOOK
COG4372841-1085  COG4372
COG1579874-1053  COG1579
COG3096849-1456  MukB
pfam15070939-1440  GOLGA2L5
pfam122521075-1371  SidE
PLN03229985-1357  PLN03229
pfam041561317-1432  IncA
TIGR01612873-1472  235kDa-fam
pfam097261305-1462  Macoilin
COG3096864-1695  MukB
COG15791036-1212  COG1579
pfam078881484-1849  CALCOCO1
PRK127041141-1316  PRK12704
COG52811654-1900  COG5281
pfam05557846-1264  MAD
PRK03918852-1080  PRK03918
pfam014961194-1445  V_ATPase_I
TIGR01612977-1553  235kDa-fam
pfam05622853-1232  HOOK
COG04191626-1933  SbcC
COG15791007-1187  COG1579
PRK109291046-1446  PRK10929
PTZ004911763-1934  PTZ00491
pfam101741316-1936  Cast
PRK004091020-1141  PRK00409
pfam059111045-1363  DUF869
COG15791070-1222  COG1579
COG4942939-1194  EnvC
pfam078881650-1929  CALCOCO1
pfam04111968-1087  APG6
PRK112811635-1924  PRK11281
COG15791229-1402  COG1579
COG30961037-1858  MukB
TIGR006341239-1441  recN
PRK116371308-1482  PRK11637
COG49421234-1485  EnvC
COG49131068-1735  COG4913
pfam055571367-1930  MAD
TIGR042111781-1902  SH3_and_anchor
pfam150661243-1461  CAGE1
PHA025621278-1530  46
COG49421532-1796  EnvC
PRK048631529-1930  mukB
pfam07888995-1315  CALCOCO1
PRK090391081-1251  PRK09039
TIGR042111068-1175  SH3_and_anchor
TIGR029711239-1401  heterocyst_DevB
pfam09731965-1210  Mitofilin
pfam143621040-1198  DUF4407
COG43721638-1905  COG4372
pfam041111789-1908  APG6
TIGR033191147-1316  RNase_Y
pfam05557878-1484  MAD
pfam056221506-1933  HOOK
pfam071111195-1884  HCR
pfam040941474-1687  DUF390
COG15791529-1655  COG1579
PRK11281872-1356  PRK11281
TIGR031851171-1461  DNA_S_dndD
COG30961186-1909  MukB
pfam040941647-1901  DUF390
PRK127041221-1412  PRK12704
PHA02562978-1185  46
PHA02562876-1126  46
TIGR030071749-1905  pepcterm_ChnLen
COG43721004-1266  COG4372
pfam06160844-1328  EzrA
TIGR006061211-1930  rad50
pfam056671076-1353  DUF812
PRK004091143-1275  PRK00409
PRK053061789-1946  infB
pfam097261733-1887  Macoilin
pfam06548855-1214  Kinesin-related
TIGR03185866-1207  DNA_S_dndD
pfam057011527-1924  WEMBL
TIGR006181529-1928  sbcc
COG5271850-1300  MDN1
pfam01576860-1099  Myosin_tail_1
pfam131661725-1907  AAA_13
COG32061219-1465  GumC
PHA025621413-1640  46
COG43721277-1482  COG4372
COG5281946-1225  COG5281
TIGR042111805-1915  SH3_and_anchor
pfam071111337-1919  HCR
TIGR00634842-1166  recN
PRK048631215-1685  mukB
pfam005291072-1265  HlyD
COG43721537-1799  COG4372
pfam09730883-1264  BicD
COG47171095-1738  YhaN
pfam078881208-1479  CALCOCO1
COG24331410-1645  COG2433
pfam055571675-1933  MAD
pfam056671263-1464  DUF812
COG47171310-1915  YhaN
TIGR04211964-1093  SH3_and_anchor
pfam056671734-1922  DUF812
PRK050351545-1841  PRK05035
pfam14817971-1362  HAUS5
pfam056671180-1463  DUF812
pfam097261357-1571  Macoilin
COG49421682-1927  EnvC
COG06431033-1330  CheA
TIGR018431047-1209  type_I_hlyD
COG3064847-1055  TolA
pfam131661219-1556  AAA_13
pfam05622850-1263  HOOK
COG11961729-1936  Smc
pfam041561084-1214  IncA
PRK057711277-1484  PRK05771
PRK116371064-1277  PRK11637
TIGR00618839-1169  sbcc
PTZ001081318-1785  PTZ00108
PTZ00440976-1259  PTZ00440
COG1579979-1130  COG1579
COG0466995-1188  Lon
COG5185863-1239  HEC1
COG5185836-1162  HEC1
PRK090391004-1136  PRK09039
PRK09510846-982  tolA
pfam041111820-1930  APG6
smart007871002-1152  Spc7
PLN02939980-1290  PLN02939
pfam097301086-1490  BicD
PRK05771971-1233  PRK05771
COG52831750-1972  COG5283
pfam05911855-1161  DUF869
PRK127041523-1688  PRK12704
pfam059111068-1797  DUF869
COG38831009-1220  CwlO1
PRK127041780-1905  PRK12704
COG38831645-1851  CwlO1
COG04971016-1283  RecN
TIGR018431270-1485  type_I_hlyD
PRK127041820-1930  PRK12704
COG49421468-1704  EnvC
PRK004091819-1916  PRK00409
pfam15450853-1268  DUF4631
TIGR03185853-1165  DNA_S_dndD
TIGR042111529-1611  SH3_and_anchor
COG15791110-1268  COG1579
pfam04111851-923  APG6
pfam06705981-1213  SF-assemblin
pfam05911866-1609  DUF869
PRK090391784-1925  PRK09039
TIGR042111313-1424  SH3_and_anchor
pfam079021137-1330  Gp58
pfam149151069-1354  CCDC144C
pfam054831475-1921  SCP-1
pfam041111506-1606  APG6
COG4477939-1301  EzrA
pfam136541001-1127  AAA_32
pfam093111196-1269  Rab5-bind
COG01721795-1896  SerS
pfam097891254-1483  DUF2353
TIGR006341043-1266  recN
TIGR042111726-1833  SH3_and_anchor
PRK054311638-1707  PRK05431
pfam05701995-1329  WEMBL
pfam054781277-1475  Prominin
TIGR033191211-1357  RNase_Y
pfam014421137-1267  Apolipoprotein
smart007871081-1267  Spc7
pfam041561041-1160  IncA
COG1293983-1231  YloA
COG1196836-1048  Smc
COG32061535-1799  GumC
TIGR006181405-1934  sbcc
TIGR023021000-1364  aProt_lowcomp
pfam00038967-1128  Filament
pfam009011818-1929  Orbi_VP5
COG49421507-1775  EnvC
PRK124721659-1825  PRK12472
COG30641750-1916  TolA
pfam041111033-1132  APG6
pfam149151192-1482  CCDC144C
PRK035981632-1706  PRK03598
COG51851278-1611  HEC1
COG49131014-1450  COG4913
TIGR030071001-1235  pepcterm_ChnLen
COG51851772-1930  HEC1
COG4913757-1084  COG4913
pfam15066980-1212  CAGE1
PRK114481817-1906  hsdR
pfam083171290-1410  Spc7
pfam04156996-1099  IncA
pfam146621381-1568  CCDC155
PLN03188998-1204  PLN03188
COG32061629-1879  GumC
PRK127041007-1173  PRK12704
pfam12252888-1280  SidE
pfam066371810-1943  PV-1
pfam138701285-1410  DUF4201
COG5281941-1317  COG5281
TIGR042111178-1288  SH3_and_anchor


Ontology Information


   
HPRD ID4535
Molecular ClassStructural protein
Molecular FunctionCatalytic activity (GO:0003824)
Biological ProcessMetabolism (GO:0008152); Energy pathways (GO:0006091)  



SNP Information


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Drug Information


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External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO