CoReCG

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General Information

Gene_Symbol	Gene_ID	Gene_Name	Chromosome	Alias
MYL6	4637	Myosin, light chain 6, alkali, smooth muscle and non-muscle	1	LC17; ESMLC; LC17A; LC17B; MLC-3; MLC1SM; MLC3NM; MLC3SM; LC17-GI; LC17-NM

Evidence
Gene
mRNA
CDS
Protein
PTM
Enzyme
PPi
Pathway
Structural
Domain
Ontology
SNP
Drug
External Links

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
20089989	2010	Cell line : - Source : VU University Medical Center, Amsterdam, The Netherlands. Sample Type : CRC tumor and normal tissue No. of Sample : - Stage : -	Biochemical isolation to nano-LC-MS/MS analysis and using spectral counting combined with statistics	Up-regulation	-	This genes are differenitially expressed between colorectal adenoma and Colorectal cancer tissue.

Gene Details

Chromosome: 12; NC_000012.11 (56552045..56555366)
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Gene Type	protein coding
Gene Family	Myosins / Light chain, EF-hand domain containing
Description	Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light chain that is expressed in smooth muscle and non-muscle tissues. Genomic sequences representing several pseudogenes have been described and two transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Chromosome	1
Location	12q13.2
Start	56158261
End	56161582
Strand	+
Gene Sequence	>gi\|568815586:56158261-56161582 Homo sapiens chromosome 12, GRCh38.p2 Primary Assembly TCGTCTGCATAAACCCAGGCCACGGTTCCTATTGGCTGAGTCCTCTGAGGGTGACGTCATCGGGACGTAC TAAGACTAGGGTTGGGCCGAGAGTCGGAGCCATTACTGCAGGAAAAGGTCCCGGAGAGCTGAGCAGTCAA GATGGTGGGGCCCAGGTCTTGGGAGACGGGCAGGATTGGGGACGAGAGGCAGGAAGAGACGGGTGGGGGG CGAGGAGAAGGCAGGGGTAGGAGGCAAAGGGAATCTGAGGACCCGAAAGGTTGGAGGTGGGGTTGGAAAG ACTGGGGCCCTGCGGGGAAGCGAGTCTGCAGCCTGAAACAGGAGTTTGTGGGTCAGAGTTTGTGGGTCAG AGTTTGTGGGGCTGGGATAGAAACTCGGGGGATTGGCGTTCAGATGCTGACCACTTCCCTCTTCTCTGAG CAGTGTGACTTCACCGAAGACCAGACCGCAGGTAGGTTATCTCTGATCCCTACCGAGGTCACCCTTAGGG AGAGGGACACCCTCCCCCCAGCACCTATCCTCTAATCTTAATCTGTCATCTCTTTAGCACCCCCATGAGA TTACCCCCTGGATTATTTTCTCTTCTTCTGGATCCTCCATTTTCTTTTCTCACTTTCTTCCTCCCTCCCC TTCCACTCTAGATCTGATCCCAAGCACTGGGTGAGTTTTAGGTGGTGTGGGTATGTGAAAAAACTTGGTC ACTTAATGCCTGCTGTGTGTGGGGTCTCGGGAGGGTGTATAAAGCTGCCTGCTTTCCTTTGTCCTTTAAT CAGCTACTTCTGCCTCTTTTCTCCTCTTGTGATAACTGTCCCCGCCCTCCCAGCTTGCAGTTGTGAAGAT TGTAGAGCAGTGACCTGATATTCTGTGCAGATGGGGACAAGACAGGGGAGTTTGCTAAGGATATGACTGT AGCTATACCCTCTGGAAGTTCTCTTTATACTGGAGGGGTGCGAAGTGGCAGGTTGGGATGACCCTAGTCC CAGGCTGCTGCTCCCACTTCCTTATAAGGACAGGACTGAGACTGGGCGGTGGCGAATTCCTGCCCTGAGA AGTGTAGTAGCAGCAGTGGAGATTGGCAGGCCTGCCGCAGGCAGAGGGGTTGTGTAAATGGATGTTACCA GGCTGCCAGAAGGGGAGGAAGCCTCTATATAGAACACTTGAGTTGGGAGGAAGAGAAATAGAGCCCTCTT AAGTAGACTTTGGTGTACAGTTTGGTGCAGATATCTCGTTTCCTCAGCATGATCAAAGTTGAATGGGCAG CAGAGCTCTGAGGTAGGGTTTGGATTAACCCTCAAATCCTGTGTTGACATTCATCTGAATCCTCAGAGTT CAAGGAGGCCTTCCAGCTGTTTGACCGAACAGGTGATGGCAAGATCCTGTACAGCCAGTGTGGGGATGTG ATGAGGGCCCTGGGCCAGAACCCTACCAACGCCGAGGTGCTCAAGGTCCTGGGGAACCCCAAGAGTGATG GTGAGGGGCCTAAAGAACAACTCCTCAGTGTGGTCATGGGCCCACAGTTCTTCAGCTAAGAGCTTCCCTT TATCTTCATAGGCCCCAAACTCAAGCAAGTCTGGATTAGCAAATCCCATGGATTTCCTTGCTTTTAGTGG GGAGTCATCTGTCATCTCTCTGTTCAGTTGAGGTCTCTATAATCCCCTGTCCTGAGAACTTGTGTTACTT CTCTGGCCTGACACTTCCACCTCCTTTATGGCAGAGATGAATGTGAAGGTGCTGGACTTTGAGCACTTTC TGCCCATGCTGCAGACAGTGGCCAAGAACAAGGACCAGGGCACCTATGAGGATTATGTCGAAGGACTTCG GGTGTTTGACAAGGAAGGAAATGGCACCGTCATGGGTGCTGAAATCCGGCATGTTCTTGTCACACTGGGT AAGGTTCTGTGTCCTTGTCCTTGAGCTGAGATGGCACCCTGAGGTACCTCACTTGTCACCCAATTCCAAA AATGCTTTCTTTCCCCCTGCAGGTGAGAAGATGACAGAGGAAGAAGTAGAGATGCTGGTGGCAGGGCATG AGGACAGCAATGGTTGTATCAACTATGAAGGTAAGAGGTGAACTGCGCTTTCTCAGAGAAAGCAGCCATA TGGGGCAGGTCAAGTATAGTGTCTGGGGCTTTCCCTATCCCTGGACTTGGGCTCCAAAAAGAGCCAGGAG GCAAGGTGCAGGGCCCTGCCCAGCCCAGCCCAGGAGTGGGAGGTCAGGGCGGTATAACAGGAAAGGAAGG GGGTAGTATTGTAGAGGGTGGGAAGGAATGAGAAGTGAAATAATGGAATGTCTGTCCCCACTGCCTGACC CCTCACCCCATGTCTTTGTCTTGTCTTCACCATGAATGTCTCTTCCTTCCTGCAGCGTTTGTGAGGCATA TCCTGTCGGGGTGACGGGCCCATGGGGCGGGTACGGCTCCTCCCAGCCTCTCCTCTAGTTGATCTCCCCA GTGTTTCTTTTTTCCCCAACCTGTGCTCTTTATCCCCTGCCCTTACCCTACTACCATCTGACTTCCTCCT GGCATGTTTCTGCATGGAGCTGACTAGGGAGGGGAGGGATTCCTCAAAGAGGAAGACAACCTGGGGGTAC AGTACCTCCTTACCTCTAGAATGGGCCCTGAGGTTTTACTTATGCGGCCCTGGGTGCTGGTGTCTGGGAA CTCTCACCAGCCTGTATACCAGTCTTGCTTTAGGGTGACCTTCTGGCCCTGGAGCATGGGTAGCTGGCAT AGAGGGGTATGGGTTGCCTGCCCCATTCTGCTGCTATAGCTGAACAGTCCTTTCCCCTTCCCTCGCTGGG CAGCTTGGAGGTACCCTAACCCAAAACTCTGTCCTCTCCTCCCGCCAGTGGCTGACAGTAGCTGTAGGTG TAGTGGAGAACTTTTCTGCCTCTGCTGTGTTCTTGCTGCTTAGGTTTGGGTGGGGGACTAACAGCTGCTG GGAGGGGAGCTAGGGGCATGGAGAACTGGTCAGACTCAAGGTGGCTCCTCTGCAAACTGACCCCAGGGTT GGTTGCTGTGGGCATGTTCCCGCTTATGCTACCTTTGCAGTCTGGTAGTCCCCTGGCCCTTGGCGTACCC CTCCACAGCCCTGTTCCCTGGCTCATCCCACCTTTCCTTTCCACAGAGCTCGTCCGCATGGTGCTGAATG GCTGAGGACCTTCCCAGTCTCCCCAGAGTCCGTGCCTTTCCCTGTGTGAATTTTGTATCTAGCCTAAAGT TTCCCTAGGCTTTCTTGTCTCAGCAACTTTCCCATCTTGTCTCTCTTGGATGATGTTTGCCGTCAGCATT CACCAAATAAACTTGCTCTCTGGGCCCTCGGT Download Select all
Length	3322
OMIM ID	609931
HGNC ID	HGNC:7587
Unigene ID	Hs.632717
Ensembl ID	ENSG00000092841
PharmGKB ID	-

mRNA Information

mRNA ID	NM_021019.4
Exon	join(1..144,424..451,1327..1470,1715..1888,1983..2060, 2366..2410,3127..3322)
mRNA Sequence	>4637 TCGTCTGCATAAACCCAGGCCACGGTTCCTATTGGCTGAGTCCTCTGAGGGTGACGTCATCGGG ACGTACTAAGACTAGGGTTGGGCCGAGAGTCGGAGCCATTACTGCAGGAAAAGGTCCCGGAGAG CTGAGCAGTCAAGATGTGTGACTTCACCGAAGACCAGACCGCAGAGTTCAAGGAGGCCTTCCAG CTGTTTGACCGAACAGGTGATGGCAAGATCCTGTACAGCCAGTGTGGGGATGTGATGAGGGCCC TGGGCCAGAACCCTACCAACGCCGAGGTGCTCAAGGTCCTGGGGAACCCCAAGAGTGATGAGAT GAATGTGAAGGTGCTGGACTTTGAGCACTTTCTGCCCATGCTGCAGACAGTGGCCAAGAACAAG GACCAGGGCACCTATGAGGATTATGTCGAAGGACTTCGGGTGTTTGACAAGGAAGGAAATGGCA CCGTCATGGGTGCTGAAATCCGGCATGTTCTTGTCACACTGGGTGAGAAGATGACAGAGGAAGA AGTAGAGATGCTGGTGGCAGGGCATGAGGACAGCAATGGTTGTATCAACTATGAAGCGTTTGTG AGGCATATCCTGTCGGGGTGACGGGCCCATGGGGCGGAGCTCGTCCGCATGGTGCTGAATGGCT GAGGACCTTCCCAGTCTCCCCAGAGTCCGTGCCTTTCCCTGTGTGAATTTTGTATCTAGCCTAA AGTTTCCCTAGGCTTTCTTGTCTCAGCAACTTTCCCATCTTGTCTCTCTTGGATGATGTTTGCC GTCAGCATTCACCAAATAAACTTGCTCTCTGGGCCCTCGGTAAAAAAAAAAAAAAAAAA Download Select all
Length	827

CDS Information

Location	join(142..144,424..451,1327..1470,1715..1888,1983..2060, 3127..3155)
CDS Sequence	>gi\|314122163:142-597 Homo sapiens myosin, light chain 6, alkali, smooth muscle and non-muscle (MYL6), transcript variant 1, mRNA ATGTGTGACTTCACCGAAGACCAGACCGCAGAGTTCAAGGAGGCCTTCCAGCTGTTTGACCGAACAGGTG ATGGCAAGATCCTGTACAGCCAGTGTGGGGATGTGATGAGGGCCCTGGGCCAGAACCCTACCAACGCCGA GGTGCTCAAGGTCCTGGGGAACCCCAAGAGTGATGAGATGAATGTGAAGGTGCTGGACTTTGAGCACTTT CTGCCCATGCTGCAGACAGTGGCCAAGAACAAGGACCAGGGCACCTATGAGGATTATGTCGAAGGACTTC GGGTGTTTGACAAGGAAGGAAATGGCACCGTCATGGGTGCTGAAATCCGGCATGTTCTTGTCACACTGGG TGAGAAGATGACAGAGGAAGAAGTAGAGATGCTGGTGGCAGGGCATGAGGACAGCAATGGTTGTATCAAC TATGAAGCGTTTGTGAGGCATATCCTGTCGGGGTGA Download Select all
CCDS ID	CCDS31834.1

Protein Information

Protein ID	NP_066299.2
Protein Name	Myosin, light chain 6, alkali, smooth muscle and non-muscle
Molecular Wt. (Da)	16799
Protein Sequence	>4637 MCDFTEDQTAEFKEAFQLFDRTGDGKILYSQCGDVMRALGQNPTNAEVLKVLGNPKSDEMNVKV LDFEHFLPMLQTVAKNKDQGTYEDYVEGLRVFDKEGNGTVMGAEIRHVLVTLGEKMTEEEVEML VAGHEDSNGCINYEAFVRHILSG Download Select all
Length	151
Uniprot ID	Q14839
Ensembl Protein ID	ENSP00000349508

Post-translational Modification Information (Source : HPRD)

Residue	Type	site
Y	Phosphorylation	92;-
Y	Phosphorylation	95;-
Y	Phosphorylation	89;-
Y	Phosphorylation	86;-
Y	Phosphorylation	89;-
Y	Phosphorylation	86;-
Y	Phosphorylation	51;-
Y	Phosphorylation	54;-
Y	Phosphorylation	29;-
Y	Phosphorylation	29;-
Y	Phosphorylation	35;-
S	Phosphorylation	135
K	Acetylation	87
K	Acetylation	81
K	Acetylation	81
K	Acetylation	46
T	Phosphorylation	109
T	Phosphorylation	103
T	Phosphorylation	103
T	Phosphorylation	68

Enzyme Information

No matching records could be found.

PPi Information

(Click to view network : Source STRING) View

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
25843	MOBKL3	10165	NP_056202.2	yeast 2-hybrid	16169070

Pathway Information

Pathway Name	Pathway ID
Oxytocin signaling pathway	hsa04921
Vascular smooth muscle contraction	hsa04270

Structure Information

No matching records could be found.

Domain Information

ID	Location	Description
cd00051	94-148	EFh
cl08302	94-148	EFh superfamily
smart00054	Nov-39	EFh
cl23347	Nov-39	EFh superfamily
pfam13405	Nov-40	EF-hand_6
cl23634	Nov-40	EF-hand_6 superfamily
cd00051	Nov-75	EFh
cl08302	Nov-75	EFh superfamily
PTZ00184	5-150	PTZ00184
COG5126	4-150	FRQ1
PTZ00183	3-146	PTZ00183
pfam13499	94-146	EF-hand_7

Ontology Information

HPRD ID	423
Molecular Class	Cytoskeletal protein
Molecular Function	Catalytic activity (GO:0003824)
Biological Process	Metabolism (GO:0008152); Energy pathways (GO:0006091)

SNP Information

View SNP Geneview Report

Drug Information

No matching records could be found.

External Links

ArrayExpress GO
ICGC GO
Cancer3D GO
COSMIC GO
NCG GO
TSGene GO
Tumor Gene Family of Databases GO
CCDB GO
G2SBC GO
Osteosarcoma Database GO
RCDB GO

ArrayExpress	GO
ICGC	GO
Cancer3D	GO
COSMIC	GO
NCG	GO
TSGene	GO
Tumor Gene Family of Databases	GO
CCDB	GO
G2SBC	GO
Osteosarcoma Database	GO
RCDB	GO