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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
MYO18B 84700 myosin XVIIIB  22BK125H2.1 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
15751041   2005Cell line : HT29,DLD 1

Source : -

Sample Type : -

No. of Sample : -

Stage : -

-Acetylation of histones H3 and H4.-Genetic and epigenetic inactivation of the MYO18B gene play an important role in colorectal carcinogenesis.


Gene Details



NC_000022.10 (26138117..26453345)

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Gene Type protein coding
Gene Family Myosins / Myosin superfamily : Class XVIII
Description The protein encoded by this gene may regulate muscle-specific genes when in the nucleus and may influence intracellular trafficking when in the cytoplasm. The encoded protein functions as a homodimer and may interact with F actin. Mutations in this gene are associated with lung cancer. [provided by RefSeq, Jul 2008]  
Chromosome 22
Location 22q12.1
Start 26138117  
End 26453345  
Strand +  
Gene Sequence

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Length 315229  
OMIM ID 607295   
HGNC ID HGNC:18150   
Unigene ID Hs.417959   
Ensembl ID ENSG00000133454   
PharmGKB ID PA38300   

mRNA Information


mRNA ID ?NM_032608.5
Exon  
mRNA Sequence

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Length  



CDS Information


   
Location
CDS Sequence

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CCDS ID CCDS54507.1



Protein Information


      
Protein IDNP_115997.5
Protein Namemyosin XVIIIB
Molecular Wt. (Da)0
Protein Sequence

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Length 2567  
Uniprot IDQ7Z408
Ensembl Protein ID ENSP00000241312  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation2494;-
SPhosphorylation164;-
SPhosphorylation1828
TPhosphorylation2452
TPhosphorylation2454
SPhosphorylation2246
SPhosphorylation202
TPhosphorylation1068

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                              
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
60ACTB32NP_001092.1in vivo12547197   
5705PSMC53400NP_002796.4in vitro;in vivo;yeast 2-hybrid16499872   


Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd01386585-1321  MYSc_Myo18
cl22853585-1321  Motor_domain superfamily
cd00124586-1321  MYSc
cd14890585-1321  MYSc_Myo29
cd14920585-1321  MYSc_Myh10
cd01383586-1276  MYSc_Myo8
cd14895586-1278  MYSc_Myo34
cd14888586-1206  MYSc_Myo27
cd14911585-1321  MYSc_Myh2_insects_mollusks
cd14883585-1321  MYSc_Myo22
cd14872586-1318  MYSc_Myo4
cd14903585-1277  MYSc_Myo42
cd14921585-1321  MYSc_Myh11
cd14879582-1320  MYSc_Myo17
cd14897586-1130  MYSc_Myo36
cd01377586-1321  MYSc_class_II
cd14892588-1321  MYSc_Myo31
cd01378632-1321  MYSc_Myo1
cd01379586-1205  MYSc_Myo3
cd01381585-1205  MYSc_Myo7
cd14913586-1321  MYSc_Myh3
cd14932585-1321  MYSc_Myh18
cd14902586-1273  MYSc_Myo41
cd14904586-1260  MYSc_Myo43
cd14909585-1321  MYSc_Myh1_insects_crustaceans
cd14929585-1321  MYSc_Myh15_mammals
cd14919585-1321  MYSc_Myh9
cd14934585-1321  MYSc_Myh16
cd14918587-1321  MYSc_Myh8
cd14930585-1321  MYSc_Myh14_mammals
cd01382586-1205  MYSc_Myo6
cd14917586-1321  MYSc_Myh7
cd14927585-1321  MYSc_Myh7b
cd14915586-1321  MYSc_Myh4
cd14873586-1321  MYSc_Myo10
cd01384587-1016  MYSc_Myo11
cd14912586-1321  MYSc_Myh2_mammals
cd14889587-1276  MYSc_Myo28
cd14916586-1321  MYSc_Myh6
cd14910586-1321  MYSc_Myh1_mammals
cd01380586-994  MYSc_Myo5
cd15896585-1321  MYSc_Myh19
cd14923586-1321  MYSc_Myh13
cd14901586-1320  MYSc_Myo40
cd14907585-1205  MYSc_Myo46
cd01385586-1321  MYSc_Myo9
cd01387585-1260  MYSc_Myo15
cd14896585-1276  MYSc_Myo35
cd14906586-1209  MYSc_Myo45
cd14891633-1063  MYSc_Myo30
cd14887635-1211  MYSc_Myo26
cd14878585-1289  MYSc_Myo16
cd14875631-1273  MYSc_Myo13
cd14900586-1205  MYSc_Myo39
cd14898586-996  MYSc_Myo37
cd14880585-1205  MYSc_Myo19
cd14876587-1321  MYSc_Myo14
cd14908586-1283  MYSc_Myo47
cd14886587-996  MYSc_Myo25
cd14893585-1274  MYSc_Myo32
cd14874585-1276  MYSc_Myo12
cd14881586-1053  MYSc_Myo20
cd14899585-1205  MYSc_Myo38
cd14882586-999  MYSc_Myo21
cd14937585-999  MYSc_Myo24A
cd14884586-1205  MYSc_Myo23
cd14905586-1057  MYSc_Myo44
cd01363633-723  Motor_domain
pfam112621878-1973  Tho2
cl128071878-1973  Tho2 superfamily
cd076101700-1791  FCH_F-BAR
cl120131700-1791  BAR superfamily
smart00242566-1333  MYSc
pfam067051709-1906  SF-assemblin
COG5022510-2086  COG5022
pfam00063573-1321  Myosin_head
PTZ00014551-1358  PTZ00014
pfam015761386-1980  Myosin_tail_1
COG11961414-2090  Smc
TIGR021681401-2086  SMC_prok_B
COG11961402-2058  Smc
COG11961401-2087  Smc
TIGR021691326-2095  SMC_prok_A
COG04191460-2087  SbcC
COG04191407-1999  SbcC
TIGR045231402-1957  Mplasa_alph_rch
TIGR021681408-2088  SMC_prok_B
TIGR006181384-2022  sbcc
PRK039181472-2102  PRK03918
TIGR021691394-2087  SMC_prok_A
COG11961731-2090  Smc
PRK039181402-1943  PRK03918
PTZ001211402-2086  PTZ00121
COG04191656-2095  SbcC
pfam054831703-2092  SCP-1
TIGR021681406-1785  SMC_prok_B
TIGR006181417-2098  sbcc
TIGR045231402-2087  Mplasa_alph_rch
pfam056221657-2087  HOOK
PTZ001211402-2069  PTZ00121
TIGR021691402-1782  SMC_prok_A
pfam024631540-2086  SMC_N
PTZ001211402-1891  PTZ00121
TIGR021691402-2096  SMC_prok_A
pfam121281435-2148  DUF3584
TIGR006061402-2086  rad50
pfam055571488-2071  MAD
TIGR045231479-2086  Mplasa_alph_rch
TIGR021681683-2103  SMC_prok_B
pfam121281408-2063  DUF3584
TIGR021691718-2096  SMC_prok_A
pfam054831403-2085  SCP-1
COG04191753-2088  SbcC
pfam055571405-1948  MAD
PRK022241655-2097  PRK02224
TIGR021691401-2080  SMC_prok_A
pfam121281402-1876  DUF3584
pfam101741397-2071  Cast
pfam015761653-2086  Myosin_tail_1
TIGR021691869-2112  SMC_prok_A
TIGR021691823-2101  SMC_prok_A
pfam054831403-1951  SCP-1
pfam057011924-2114  WEMBL
PRK022241404-1913  PRK02224
pfam078881823-2084  CALCOCO1
TIGR045231402-1909  Mplasa_alph_rch
pfam135141401-2086  AAA_27
TIGR006061386-2060  rad50
PRK039181828-2087  PRK03918
pfam101741414-2070  Cast
pfam0315763-499  Glutenin_hmw
TIGR021681325-1578  SMC_prok_B
pfam101741389-1949  Cast
pfam078881889-2086  CALCOCO1
pfam024631737-2082  SMC_N
COG43721800-2291  COG4372
PRK022241703-2090  PRK02224
pfam078881412-1788  CALCOCO1
pfam097301694-2072  BicD
TIGR030071894-2067  pepcterm_ChnLen
PRK039181402-1836  PRK03918
TIGR021691692-1957  SMC_prok_A
PRK011561408-2017  PRK01156
PRK022241812-2103  PRK02224
pfam061601402-1763  EzrA
PTZ004401418-2087  PTZ00440
pfam054831402-1777  SCP-1
PLN029391703-2028  PLN02939
TIGR021691528-1937  SMC_prok_A
COG47171516-2088  YhaN
PRK047781402-1763  PRK04778
pfam061601657-1964  EzrA
pfam101741525-2072  Cast
pfam040941820-2104  DUF390
TIGR006181623-2115  sbcc
pfam015761735-2095  Myosin_tail_1
pfam061601701-2036  EzrA
TIGR031851829-2074  DNA_S_dndD
pfam061601402-1888  EzrA
TIGR006181329-1762  sbcc
PRK047781708-2045  PRK04778
pfam056221655-2102  HOOK
PRK011561550-2085  PRK01156
TIGR018431859-2067  type_I_hlyD
pfam057011828-2101  WEMBL
pfam002611825-2059  Tropomyosin
pfam0315768-507  Glutenin_hmw
PRK048631408-1795  mukB
TIGR00927221-513  2A1904
pfam041111386-1561  APG6
TIGR006061680-2089  rad50
pfam055571694-2095  MAD
COG49421923-2086  EnvC
PRK1333587-218  PRK13335
COG44871657-1925  COG4487
PHA025621874-2096  46
pfam138511888-2080  GAS
COG30961415-1782  MukB
PRK048631402-1782  mukB
COG44771418-1748  EzrA
COG44771706-2087  EzrA
pfam0511068-295  AF-4
COG15791923-2086  COG1579
pfam146621800-1949  CCDC155
PTZ004401701-2098  PTZ00440
PRK047781707-2086  PRK04778
PHA03169324-506  PHA03169
pfam097891700-1916  DUF2353
pfam101741703-2095  Cast
PRK048631831-2082  mukB
COG49421402-1562  EnvC
pfam097311402-1504  Mitofilin
COG30961530-1957  MukB
COG47171416-1734  YhaN
pfam078881406-1673  CALCOCO1
COG30961426-2087  MukB
pfam150701726-2087  GOLGA2L5
pfam150701657-2053  GOLGA2L5
pfam03157255-507  Glutenin_hmw
TIGR042111851-1959  SH3_and_anchor
PRK004091830-1972  PRK00409
TIGR042111880-1961  SH3_and_anchor
COG24331424-1577  COG2433
pfam101741405-1729  Cast
pfam149921870-2074  TMCO5
PRK022241744-2102  PRK02224
pfam039622025-2142  Mnd1
pfam083171818-1982  Spc7
COG12691814-2086  NtpI
COG38831696-1957  CwlO1
pfam154501686-2084  DUF4631
COG15791402-1547  COG1579
COG32061408-1570  GumC
PHA03169261-514  PHA03169
PRK109291392-1764  PRK10929
TIGR037941661-1792  NHLM_micro_HlyD
TIGR033451711-1815  VI_ClpV1
pfam071111707-2085  HCR
pfam071111472-2054  HCR
pfam135141547-2102  AAA_27
COG13221362-1577  RmuC
COG47171660-2126  YhaN
PRK048631697-2086  mukB
COG43721441-1737  COG4372
COG13401831-2102  COG1340
smart007871371-1507  Spc7
pfam097551832-2059  DUF2046
COG49131859-2098  COG4913
PRK039181395-1747  PRK03918
TIGR042111413-1510  SH3_and_anchor
pfam059111811-2088  DUF869
pfam078881626-1953  CALCOCO1
COG49132029-2112  COG4913
pfam115591891-2000  ADIP
TIGR010691704-1782  mutS2
PRK004091400-1501  PRK00409


Ontology Information


   
HPRD ID16329
Molecular ClassMotor protein
Molecular FunctionMolecular function unknown (GO:0005554)
Biological ProcessBiological_process unknown (GO:0000004)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO