Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| MYOD1 | 4654 | Myogenic differentiation 1 | 11 | PUM; MYF3; MYOD; bHLHc1 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22591756 | 2012 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 8 adenocarcinoma and 5 adenoma Stage : - | COBRA technique (Combined Bisulphite Modified Restriction Enzyme Analysis) and PCR | Hypermethylation | - | Promoter gene hypermethylation of the MYOD-1 gene increases significantly with age in normal individuals and thus may offer potential as a putative biomarker for colorectal cancer. |
| 9066689 | 1997 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 80 colorectal cancer and 74 adjacent normal tissues Stage : TNM Stage I-IV | - | Methylation | - | Regional hypermethylation of this gene therefore appears to be an early event in human colorectal neoplasia. |
| 14767572 | 2004 | Cell line : - Source : Saudi Arabian patients Sample Type : CRC tumor and normal tissue No. of Sample : 120 Stage : - | MethyLight assay | Methylation | - | MYOD1 hypermethylation plays an important role in colorectal cancer and may be a novel prognostic factor. |
| 23010642 | 2012 | Cell line : - Source : BORICC study Sample Type : CRC tumor and normal tissue No. of Sample : 218 CRC Stage : - | DNA methylation frequency study, K-means clustering analysis | Methylation | - | Can be potentially used as a new biomarker for the classification and prognosis of CRC tumors along with other polycomb group target genes. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Basic helix-loop-helix proteins |
| Description | This gene encodes a nuclear protein that belongs to the basic helix-loop-helix family of transcription factors and the myogenic factors subfamily. It regulates muscle cell differentiation by inducing cell cycle arrest, a prerequisite for myogenic initiation. The protein is also involved in muscle regeneration. It activates its own transcription which may stabilize commitment to myogenesis. [provided by RefSeq, Jul 2008] | Chromosome | 11 |
| Location | 11p15.4 |
| Start | 17719563 |
| End | 17722131 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 2569 |
| OMIM ID | 159970 |
| HGNC ID | HGNC:7611 |
| Unigene ID | Hs.181768 |
| Ensembl ID | ENSG00000129152 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_002478.4 |
|---|---|
| Exon | join(1..850,1340..1418,1693..2569) | mRNA Sequence | Download Select all |
| Length | 1823 |
CDS Information
| Location | join(221..850,1340..1418,1693..1946) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS7826.1 |
Protein Information
| Protein ID | NP_002469.2 |
|---|---|
| Protein Name | Myogenic differentiation 1 |
| Molecular Wt. (Da) | 34370 |
| Protein Sequence | Download Select all |
| Length | 320 |
| Uniprot ID | O14757 |
| Ensembl Protein ID | ENSP00000412504 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 200 |
| T | Phosphorylation | 115 |
| K | Acetylation | 102 |
| K | Acetylation | 99 |
| K | Acetylation | 102 |
| K | Acetylation | 99 |
| K | Acetylation | 102 |
| K | Acetylation | 104 |
| K | Acetylation | 99 |
| K | Acetylation | 104 |
| K | Acetylation | 104 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 801 | CALM1 | 241 | NP_008819.1 | in vitro | 10757985 |
| 805 | CALM2 | 242 | NP_001734.1 | in vitro | 10757985 |
| 808 | CALM3 | 243 | NP_005175.2 | in vitro | 10757985 |
| 997 | CDC34 | 306 | NP_004350.1 | in vitro | 9710583 |
| 1019 | CDK4 | 447 | NP_000066.1 | in vitro;in vivo | 1 060 102 010 022 830 |
| 3320 | HSP90AA1 | 777 | NP_001017963.2 | in vitro | 1406681 |
| 3400 | ID4 | 8995 | NP_001537.1 | yeast 2-hybrid | 11756408 |
| 4089 | SMAD4 | 2995 | NP_005350.1 | yeast 2-hybrid | 15231748 |
| 6774 | STAT3 | 26 | NP_644805.1 | in vitro;in vivo | 12947115 |
| 6929 | TCF3 | 918 | NP_003191.1 | in vitro;in vivo | 900 121 191 841 581 000 000 |
| 7026 | NR2F2 | 139 | NP_066285.1 | in vitro;in vivo | 9826778 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00083 | 109-165 | HLH |
| cl00081 | 109-165 | HLH superfamily |
| smart00520 | 19-114 | BASIC |
| cl11603 | 19-114 | Basic superfamily |
| pfam01586 | 23-109 | Basic |
| pfam12232 | 191-259 | Myf5 |
| cl13642 | 191-259 | Myf5 superfamily |
| pfam00010 | 110-161 | HLH |
| smart00353 | 115-166 | HLH |
Ontology Information
| HPRD ID | 300 |
|---|---|
| Molecular Class | Unknown |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.