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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22562535 | 2012 | Cell line : - Source : - Sample Type : - No. of Sample : 360 CRC cases Stage : - | Immunohistochemistry and RT-PCR | Up-regulation | - | Nanog protein may be a potential biomarker for postoperative liver metastasis of colorectal cancer. Nanog were expressed significantly higher in CD133+ tumor cells compared to CD133- tumor cells. It was observed that 72 (20.00 %) of the 360 cases positively expressed Nanog. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Homeoboxes / ANTP class : NKL subclass |
| Description | - | Chromosome | 12 |
| Location | 12p13.31 |
| Start | 7788426 |
| End | 7796061 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 7636 |
| OMIM ID | 607937 |
| HGNC ID | HGNC:20857 |
| Unigene ID | Hs.635882 |
| Ensembl ID | ENSG00000111704 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | XM_011520851.1 |
|---|---|
| Exon | join(1..149,1195..1340,4525..4787,6032..6118,6254..6892) | mRNA Sequence | Download Select all |
| Length | 2055 |
CDS Information
| Location | join(1190..1340,4525..4787,6032..6118,6254..6670) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS31736.1 |
Protein Information
| Protein ID | NP_079141.2 |
|---|---|
| Protein Name | Nanog homeobox |
| Molecular Wt. (Da) | 34489 |
| Protein Sequence | Download Select all |
| Length | 305 |
| Uniprot ID | O00182 |
| Ensembl Protein ID | ENSP00000306228 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Proteoglycans in cancer | hsa05205 |
| Signaling pathways regulating pluripotency of stem cells | hsa04550 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00086 | 97-154 | homeodomain |
| cl00084 | 97-154 | homeodomain superfamily |
| pfam00046 | 97-152 | Homeobox |
| smart00389 | 95-151 | HOX |
| COG5576 | 74-191 | COG5576 |
Ontology Information
| HPRD ID | 8869 |
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | Cytokine activity (GO:0005125) |
| Biological Process | Biological_process unknown (GO:0000004) |
Drug Information
No matching records could be found.