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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
NCOA3 8202 nuclear receptor coactivator 3  20RAC3, AIB1, ACTR, p/CIP, TRAM-1, CAGH16, TNRC16, KAT13B, bHLHe42, SRC-3, SRC3 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
22371647   2012Cell line : -

Source : Department of General Surgery, Henan Province Tumor Hospital.

Sample Type : CRC Tumor and normal tissue

No. of Sample : 142

Stage : -

real time RT-PCRAmplification-Expression level of NCOA3 mRNA was also enhanced in the CRC samples with unaltered copy numbers.

16084947   2005Cell line : -

Source : -

Sample Type : CRC tumor and normal tissue

No. of Sample : 85

Stage : TNM Stage I-IV

Immunohistochemistry and FISHUp-regulation-Findings suggest a possible convergence of AIB1 with a pathway involving p53, which might induce chromosomal instability and affect the clinical phenotype of a subset of CRCs.


Gene Details



NC_000020.10 (46130601..46285621)

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Gene Type protein coding
Gene Family Chromatin-modifying enzymes / K-acetyltransferases, "Basic helix-loop-helix proteins"
Description The protein encoded by this gene is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has histone acetyltransferase activity and recruits p300/CBP-associated factor and CREB binding protein as part of a multisubunit coactivation complex. This protein is initially found in the cytoplasm but is translocated into the nucleus upon phosphorylation. Several transcript variants encoding different isoforms have been found for this gene. In addition, a polymorphic repeat region is found in the C-terminus of the encoded protein. [provided by RefSeq, Mar 2010]  
Chromosome 20
Location 20q12
Start 46130601  
End 46285621  
Strand +  
Gene Sequence

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Length 155021  
OMIM ID 601937   
HGNC ID HGNC:7670   
Unigene ID Hs.592142   
Ensembl ID ENSG00000124151   
PharmGKB ID PA31472   

mRNA Information


mRNA ID ?NM_001174088.1
Exon join(1..163,81327..81405,120373..120474,122055..122227, 123525..123625,125146..125320,125705..125893, 126066..126167,131640..131780,132162..132339, 133466..133857,134035..134906,135792..135927, 137152..137346,137766..137966,138069..138195, 140357..140528,145217..145510,147149..147241, 149126..149420,150550..150724,151075..151216, 151550..155021)  
mRNA Sequence

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Length 7969  



CDS Information


   
Location262..4509
CDS Sequence

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CCDS ID CCDS13406.1



Protein Information


      
Protein IDNP_001167559.1
Protein Namenuclear receptor coactivator 3
Molecular Wt. (Da)143102
Protein Sequence

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Length 1424  
Uniprot IDQ9Y6D6
Ensembl Protein ID ENSP00000262215  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation857
TPhosphorylation24
SPhosphorylation505
SPhosphorylation543
SPhosphorylation860
SPhosphorylation867
SPhosphorylation857
TPhosphorylation24
SPhosphorylation505
SPhosphorylation543
SPhosphorylation860
SPhosphorylation867
SPhosphorylation857
SPhosphorylation857
SPhosphorylation214;-
SPhosphorylation214;-
SPhosphorylation551
SPhosphorylation551
SPhosphorylation728
SPhosphorylation728
SPhosphorylation1326
SPhosphorylation1330
KAcetylation687
KAcetylation687
SPhosphorylation274
TPhosphorylation282
SPhosphorylation284
SPhosphorylation287
SPhosphorylation288
SPhosphorylation274
TPhosphorylation282
SPhosphorylation284
SPhosphorylation287
SPhosphorylation288
SPhosphorylation694
SPhosphorylation694
SPhosphorylation863
SPhosphorylation863
SPhosphorylation429
SPhosphorylation429
SPhosphorylation866
SPhosphorylation866
SPhosphorylation1325
SPhosphorylation1329

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
367AR2437NP_000035.2in vitro;yeast 2-hybrid1   096   591   715   563   460   
595CCND11346NP_444284.1in vivo9832502   
654BMP6211NP_001709.1in vivo10504300   
655BMP7212NP_001710.1in vivo7791754   
1147CHUK2811NP_001269.3in vitro;in vivo11971985   
1387CREBBP2534NP_004371.2in vitro1   182   386   494   454   750   000   000   
1869E2F11806NP_005216.1in vitro;in vivo15169882   
2099ESR1589NP_000116.2in vitro110   501   741   514   544   000   000   000   
2100ESR23390NP_001428.1in vitro;in vivo1   068   159   111   389   580   
2101ESRRA7210NP_004442.3yeast 2-hybrid15604093   
3164NR4A1744NP_002126.2in vitro12082103   
3725JUN1302NP_002219.1in vitro;in vivo11477071   
5300PIN13031NP_006212.1in vitro;in vivo;yeast 2-hybrid16227615   
5468PPARG3288NP_056953.2yeast 2-hybrid15604093   
5914RARA6769NP_000955.1in vitro;in vivo;yeast 2-hybrid126   655   831   645   654   000   000   000   
5915RARB7183NP_000956.2in vitro12665583   
5916RARG1573NP_000957.1in vitro;in vivo;yeast 2-hybrid126   655   831   645   654   000   000   000   
5970RELA1241NP_068810.3in vivo16456540   
6256RXRA1577NP_002948.1in vitro;in vivo9267036   
6257RXRB1578NP_068811.1in vitro;in vivo9267036   
6908TBP2511NP_003185.1in vitro9267036   
7341SUMO13554NP_003343.1in vivo16760465   
7376NR1H22660NP_009052.3yeast 2-hybrid15604093   
7533YWHAH215NP_003396.1in vitro11266503   
8517IKBKG2217NP_001093326.2in vitro11971985   
8856NR1I24346NP_071285.1yeast 2-hybrid16219912   
9612NCOR22910NP_006303.3in vitro9267036   
10062NR1H37211NP_005684.2yeast 2-hybrid15604093   
10197PSME35500NP_789839.1in vitro;in vivo16439211   
10521DDX1710532NP_001091974.1yeast 2-hybrid11250900   


Pathway Information


      
Pathway Name Pathway ID
Thyroid hormone signaling pathway hsa04919


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd00130121-186  PAS
cl21578121-186  PAS superfamily
cd0008334-87  HLH
cl0008134-87  HLH superfamily
pfam088151045-1092  Nuc_rec_co-act
cl074271045-1092  Nuc_rec_co-act superfamily
pfam074691291-1348  DUF1518
cl064851291-1348  DUF1518 superfamily
pfam08832618-704  SRC-1
cl07440618-704  SRC-1 superfamily
smart00091116-173  PAS
smart0035334-88  HLH
pfam14598264-375  PAS_11
pfam00989117-166  PAS
pfam13426125-192  PAS_9
pfam096061096-1417  Med15
pfam097701096-1247  PAT1
pfam096061077-1419  Med15
TIGR00229125-166  sensory_box


Ontology Information


   
HPRD ID9214
Molecular ClassTranscription regulatory protein
Molecular FunctionAuxiliary transport protein activity (GO:0015457)
Biological ProcessTransport (GO:0006810)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO