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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
NDRG1 10397 N-myc downstream regulated 1  8DRG1, RTP, TDD5, NDR1 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
23874544   2013Cell line : -

Source : -

Sample Type : CRC tumor and normal tissue

No. of Sample : 240

Stage : -

Immunohistochemistry, ImmunoblottingDown-regulation-NDRG1 is a novel favorable predictor for the prognosis in CRC patients.

NDRG1 expression was significantly decreased in most of CRC tissues compared to the paired non-tumor counterparts.


Gene Details



Chromosome 8 - NC_000008.11 (133237171..133297587, complement)

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Gene Type protein coding
Gene Family
Description This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein involved in stress responses, hormone responses, cell growth, and differentiation. The encoded protein is necessary for p53-mediated caspase activation and apoptosis. Mutations in this gene are a cause of Charcot-Marie-Tooth disease type 4D, and expression of this gene may be a prognostic indicator for several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.  
Chromosome 8
Location 8q24
Start 133237171  
End 133297587  
Strand -  
Gene Sequence

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Length 60417  
OMIM ID 605262   
HGNC ID HGNC:7679   
Unigene ID Hs.372914   
Ensembl ID ENSG00000104419   
PharmGKB ID -   

mRNA Information


mRNA ID NM_001258432.1
Exon join(284..454,32936..33041,35421..35541,38358..38420, 39162..39222,40725..40811,42993..43049,47045..47148, 48817..48873,49662..49713,50925..50972,53198..53233, 55514..55565,58469..60417)  
mRNA Sequence

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Length 3520  



CDS Information


   
Location join(13277..13339,17321..17356,32936..33041,35421..35541, 38358..38420,39162..39222,40725..40811,42993..43049, 47045..47148,48817..48873,49662..49713,50925..50972, 53198..53233,55514..55565,58469..58710)
CDS Sequence

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CCDS ID CCDS:CCDS34945.1



Protein Information


      
Protein IDNP_001128714.1
Protein NameN-myc downstream regulated 1
Molecular Wt. (Da)42705
Protein Sequence

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Length 394  
Uniprot IDP26006
Ensembl Protein ID ENSP00000007722  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation319
SPhosphorylation330
SPhosphorylation336
SPhosphorylation330
TPhosphorylation366
SPhosphorylation326;-
GPhosphorylation331;-
SPhosphorylation330;-
TPhosphorylation328;-
SPhosphorylation336;-
SPhosphorylation333;-
SPhosphorylation362;-
SPhosphorylation364;-
TPhosphorylation335;-
SPhosphorylation332;-
TPhosphorylation375;-
SPhosphorylation378;-
SPhosphorylation367;-
SPhosphorylation384
SAcetylation2

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
71ACTG117NP_001605.1in vivo17220478   
476ATP1A11662NP_000692.2in vivo17220478   
821CANX252NP_001737.1in vivo17220478   
999CDH11885BAA88957.1in vitro;in vivo17220478   
1173AP2M13014NP_004059.2in vivo17220478   
1213CLTC350NP_004850.1in vivo17220478   
1499CTNNB1286NP_001895.1in vitro;in vivo17220478   
1653DDX13158NP_004930.1in vivo17220478   
1655DDX51615NP_004387.1in vivo17220478   
1743DLST520NP_001924.2in vivo17220478   
1937EEF1G11745NP_001395.1in vivo17220478   
1938EEF2561NP_001952.1in vivo17220478   
1968EIF2S32155NP_001406.1in vivo17220478   
2130EWSR1592NP_053733.2in vivo17220478   
2181ACSL33845NP_004448.2in vivo17220478   
2194FASN2567NP_004095.4in vivo17220478   
3185HNRNPF3023NP_004957.1in vivo17220478   
3187HNRNPH13021NP_005511.1in vivo17220478   
3192HNRNPU4185NP_114032.2in vivo17220478   
3295HSD17B43514NP_000405.1in vivo17220478   
3309HSPA5682NP_005338.1in vivo17220478   
3320HSP90AA1777NP_001017963.2in vivo17220478   
3609ILF34420NP_060090.2in vivo17220478   
3646EIF3E3734NP_001559.1in vivo17220478   
3799KIF5B7214NP_004512.1in vivo17220478   
3939LDHA1025NP_005557.1in vivo17220478   
4128MAOA2400NP_000231.1in vivo17220478   
4311MME392NP_000893.2in vivo17220478   
4691NCL1245NP_005372.2in vivo17220478   
5315PKM21529NP_872270.1in vivo17220478   
5520PPP2R2A9223NP_002708.1in vivo17220478   
5701PSMC21105NP_002794.1in vivo17220478   
5702PSMC31733NP_002795.2in vivo17220478   
5708PSMD25870NP_002799.3in vivo17220478   
5976UPF13254Q92900in vivo17220478   
6122RPL316042NP_000958.1in vivo17220478   
6124RPL41607NP_000959.2in vivo17220478   
6152RPL2410365NP_000977.1in vivo17220478   
6185RPN21609NP_002942.2in vivo17220478   
6188RPS310941NP_000996.2in vivo17220478   
6194RPS61592NP_001001.2in vivo17220478   
6202RPS815969NP_001003.1in vivo17220478   
6217RPS164724NP_001011.1in vivo17220478   
6224RPS204728NP_001014.1in vivo17220478   
6231RPS264743NP_001020.2in vivo17220478   
6285S100B1505NP_006263.1in vitro;in vivo12493777   
6472SHMT2717NP_005403.2in vivo17220478   
6897TARS1762NP_689508.3in vivo17220478   
7090TLE32558NP_005069.2in vivo17220478   
7415VCP3013NP_009057.1in vivo17220478   
7520XRCC58935NP_066964.1in vivo17220478   
7711ZNF1554969NP_003436.2in vivo17220478   
9276COPB26103NP_004757.1in vivo17220478   
10053AP1M26296NP_005489.2in vivo17220478   
10484SEC23A6714NP_006355.2in vivo17220478   
10856RUVBL216070NP_006657.1in vivo17220478   
26986PABPC15247NP_002559.2in vivo17220478   
55748CNDP29893NP_060705.1in vivo17220478   


Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
pfam0309634-316  Ndr
pfam1269763-304  Abhydrolase_6
COG059688-311  MhpC
pfam0056189-306  Abhydrolase_1
TIGR0173852-309  bioH
TIGR0242782-310  protocat_pcaD
PRK1034983-189  PRK10349
TIGR0361145-164  RutD
TIGR0369584-167  menH_SHCHC
PLN02894130-235  PLN02894
TIGR0305682-164  bchO_mg_che_rel


Ontology Information


   
HPRD ID627
Molecular ClassUnclassified
Molecular FunctionReceptor activity (GO:0004872)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO