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General Information

• Evidence
• Gene
• mRNA
• CDS
• Protein
• PTM
• Enzyme
• PPi
• Pathway
• Structural
• Domain
• Ontology
• SNP
• Drug
• External Links

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
26379350	2015	Cell line : RKO, DLD 1 Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 27 Stage : -	MTT assay,matrigel transwell assay, wound healing assay	Down-regulation	-	NDRG2 overexpression inhibits proliferation and invasive potential of SW48 cells, which likely occurs via suppression of MMP-9 activity.
26250123	2015	Cell line : SW48 Source : - Sample Type : - No. of Sample : - Stage : -	Colony formation, cell viability, proliferation, invasion and migration assays	Methylation	-	Epigenetic silencing of NDRG2 induce proliferation and invasion of CRC and may be associated with proximal CRC and advanced T stage. NDRG2 methylation might serve as novel biomarker of CRC.

Gene Details

NC_000014.8 (21484922..21539098, complement)
View Larger Image   

Gene Type	protein coding
Gene Family	-
Description	This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein that may play a role in neurite outgrowth. This gene may be involved in glioblastoma carcinogenesis. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
Chromosome	14
Location	14q11.2
Start	21484922
End	21539098
Strand	-
Gene Sequence	Download   Select all
Length	54177
OMIM ID	605272
HGNC ID	HGNC:14460
Unigene ID	Hs.525205
Ensembl ID	ENSG00000165795
PharmGKB ID	PA31483

mRNA Information

mRNA ID	?NM_001282211.1
Exon
mRNA Sequence	Download   Select all
Length

CDS Information

   

Location
CDS Sequence	Download   Select all
CCDS ID	CCDS61384.1

Protein Information

      

Protein ID	NP_001269140.1
Protein Name	NDRG family member 2
Molecular Wt. (Da)	0
Protein Sequence	Download   Select all
Length	371
Uniprot ID	Q8NFU7
Ensembl Protein ID	ENSP00000362748

Post-translational Modification Information (Source : HPRD)

Residue	Type	site
S	Phosphorylation	328
T	Phosphorylation	330
S	Phosphorylation	338
S	Phosphorylation	314
T	Phosphorylation	316
S	Phosphorylation	324
S	Phosphorylation	314
T	Phosphorylation	316
S	Phosphorylation	324
S	Phosphorylation	328
T	Phosphorylation	330
S	Phosphorylation	338
S	Phosphorylation	314
T	Phosphorylation	316
S	Phosphorylation	324
S	Phosphorylation	328
T	Phosphorylation	330
S	Phosphorylation	338
S	Phosphorylation	328
T	Phosphorylation	330
S	Phosphorylation	338
S	Phosphorylation	314
T	Phosphorylation	316
S	Phosphorylation	324
S	Phosphorylation	332
S	Phosphorylation	318
S	Phosphorylation	318
S	Phosphorylation	332
S	Phosphorylation	318
S	Phosphorylation	332
S	Phosphorylation	332
S	Phosphorylation	318
T	Phosphorylation	348
S	Phosphorylation	350
S	Phosphorylation	353
T	Phosphorylation	334
S	Phosphorylation	336
S	Phosphorylation	339
T	Phosphorylation	334
S	Phosphorylation	336
S	Phosphorylation	339
T	Phosphorylation	348
S	Phosphorylation	350
S	Phosphorylation	353
T	Phosphorylation	334
S	Phosphorylation	336
S	Phosphorylation	339
T	Phosphorylation	348
S	Phosphorylation	350
S	Phosphorylation	353
T	Phosphorylation	348
S	Phosphorylation	350
S	Phosphorylation	353
T	Phosphorylation	334
S	Phosphorylation	336
S	Phosphorylation	339
S	Phosphorylation	352
S	Phosphorylation	338
S	Phosphorylation	338
S	Phosphorylation	352
S	Phosphorylation	338
S	Phosphorylation	352
S	Phosphorylation	352
S	Phosphorylation	338
S	Phosphorylation	346
S	Phosphorylation	332
S	Phosphorylation	332
S	Phosphorylation	346
S	Phosphorylation	332
S	Phosphorylation	346
S	Phosphorylation	346
S	Phosphorylation	332
S	Phosphorylation	355
S	Phosphorylation	341
S	Phosphorylation	341
S	Phosphorylation	355
S	Phosphorylation	341
S	Phosphorylation	355
S	Phosphorylation	355
S	Phosphorylation	341
S	Phosphorylation	335
S	Phosphorylation	321
S	Phosphorylation	321
S	Phosphorylation	335
S	Phosphorylation	321
S	Phosphorylation	335
S	Phosphorylation	335
S	Phosphorylation	321
T	Phosphorylation	334
T	Phosphorylation	320
T	Phosphorylation	320
T	Phosphorylation	334
T	Phosphorylation	320
T	Phosphorylation	334
T	Phosphorylation	334
T	Phosphorylation	320
S	Phosphorylation	326
S	Phosphorylation	312
S	Phosphorylation	312
S	Phosphorylation	326
S	Phosphorylation	312
S	Phosphorylation	326
S	Phosphorylation	326
S	Phosphorylation	312

Enzyme Information

No matching records could be found.

PPi Information

(Click to view network : Source STRING)      View   

               

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
81532	-	17581	NP_443731.2	in vitro;in vivo	15067004

Pathway Information

No matching records could be found.

Structure Information

No matching records could be found.

Domain Information

ID	Location	Description
pfam06522	140-186	B12D
cl05835	140-186	B12D superfamily
pfam03096	40-318	Ndr
pfam12697	84-306	Abhydrolase_6
COG0596	119-313	MhpC
pfam00561	97-264	Abhydrolase_1
TIGR02427	119-312	protocat_pcaD
PLN02894	136-202	PLN02894
TIGR02240	59-168	PHA_depoly_arom
TIGR03611	87-173	RutD

Ontology Information

   

HPRD ID	16207
Molecular Class	Enzyme: Hydrolase
Molecular Function	Signal transducer activity (GO:0004871)
Biological Process	Cell communication (GO:0007154); Signal transduction (GO:0007165)

SNP Information

View SNP Geneview Report   

Drug Information

No matching records could be found.

External Links

                                 

ArrayExpress	GO
ICGC	GO
Cancer3D	GO
COSMIC	GO
NCG	GO
TSGene	GO
Tumor Gene Family of Databases	GO
CCDB	GO
G2SBC	GO
Osteosarcoma Database	GO
RCDB	GO