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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 19535783 | 2009 | Cell line : - Source : Department of Pathology of the Maastricht University Medical Center Sample Type : - No. of Sample : - Stage : - | real time RT-PCR and immunohistochemistry, methylation-specific PCR,bisulfite sequencing | Methylation | - | NDRG4 promoter methylation is a potential biomarker for the noninvasive detection of colorectal cancer in stool samples. NDRG4 is a candidate tumor suppressor gene in colorectal cancer whose expression is frequently inactivated by promoter methylation. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | |
| Description | This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein that is required for cell cycle progression and survival in primary astrocytes and may be involved in the regulation of mitogenic signalling in vascular smooth muscles cells. Alternative splicing results in multiple transcripts encoding different isoforms.[ | Chromosome | 16 |
| Location | 16q21-q22. |
| Start | 58463645 |
| End | 58513619 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 49975 |
| OMIM ID | 614463 |
| HGNC ID | HGNC:14466 |
| Unigene ID | Hs.322430 |
| Ensembl ID | ENSG00000103034 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_020465.3 |
|---|---|
| Exon | join(1..153,24112..24206,31320..31364,40154..40259, 40510..40630,40715..40777,40945..41005,42743..42829, 42914..42970,43268..43371,44164..44220,44304..44355, 45318..45365,45510..45545,45657..45708,47778..49975) | mRNA Sequence | Download Select all |
| Length | 3581 |
CDS Information
| Location | join(787..823,24112..24206,31320..31364,37344..37433, 40154..40259,40510..40630,40715..40777,40945..41005, 42743..42829,42914..42970,43268..43371,44164..44220, 44304..44355,45318..45365,45510..45545,45657..45708, 47001..47039,47778..47932) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | - |
Protein Information
| Protein ID | NP_065198.1 |
|---|---|
| Protein Name | NDRG family member 4 |
| Molecular Wt. (Da) | 40514 |
| Protein Sequence | Download Select all |
| Length | 371 |
| Uniprot ID | P56470 |
| Ensembl Protein ID | ENSP00000302100 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 336 |
| S | Phosphorylation | 336 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam03096 | 8-290 | Ndr |
| pfam12697 | 56-278 | Abhydrolase_6 |
| COG0596 | 62-285 | MhpC |
| TIGR02427 | 18-284 | protocat_pcaD |
| TIGR03056 | 19-138 | bchO_mg_che_rel |
| pfam00561 | 62-236 | Abhydrolase_1 |
| TIGR02240 | 18-136 | PHA_depoly_arom |
| TIGR03611 | 55-141 | RutD |
Ontology Information
| HPRD ID | 3528 |
|---|---|
| Molecular Class | Enzyme: Hydrolase |
| Molecular Function | Carbohydrate binding (GO:0030246); Chemokine activity (GO:0008009); Cell adhesion molecule activity (GO:0005194) |
| Biological Process | Apoptosis (GO:0006915); Immune response (GO:0006955); Cell maturation (GO:0048469); Inflammatory response (GO:0006954); Cell adhesion (GO:0007155) |
Drug Information
No matching records could be found.