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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
NEDD9 4739 neural precursor cell expressed, developmentally down-regulated 9  6HEF1, CAS-L, CASS2 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
24966970   2014Cell line : -

Source : General surgery department in our hospital.

Sample Type : Tumor database

No. of Sample : 92

Stage : TNM Stage I-IV

Immunohistochemistry,Correlation analysis,multivariate analysisUp-regulation-NEDD9 expression level as a prognostic molecular marker and a target for new therapies for CRC patients.


Gene Details



NC_000006.11 (11183531..11382581, complement)

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Gene Type protein coding
Gene Family Cas scaffolding proteins
Description The protein encoded by this gene is a member of the CRK-associated substrates family. Members of this family are adhesion docking molecules that mediate protein-protein interactions for signal transduction pathways. This protein is a focal adhesion protein that acts as a scaffold to regulate signaling complexes important in cell attachment, migration and invasion as well as apoptosis and the cell cycle. This protein has also been reported to have a role in cancer metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]  
Chromosome 6
Location 6p25-p24
Start 11183531  
End 11382581  
Strand -  
Gene Sequence

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Length 199051  
OMIM ID 602265   
HGNC ID HGNC:7733   
Unigene ID Hs.37982   
Ensembl ID ENSG00000111859   
PharmGKB ID PA31538   

mRNA Information


mRNA ID NM_001142393.1
Exon join(1..210,76194..76357,168622..169068,188657..188758, 189903..190004,191144..192385,194042..194131, 196678..199051)  
mRNA Sequence

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Length 4745  



CDS Information


   
Location363..2867
CDS Sequence

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CCDS ID CCDS34340.1



Protein Information


      
Protein IDNP_001135865.1
Protein Nameneural precursor cell expressed, developmentally down-regulated 9
Molecular Wt. (Da)45086
Protein Sequence

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Length 834  
Uniprot IDO75795
Ensembl Protein ID ENSP00000320401  



Post-translational Modification Information (Source : HPRD)


Residue Type site
YPhosphorylation166
YPhosphorylation177
YPhosphorylation189
DProteolytic Cleavage363
YPhosphorylation92
YPhosphorylation92
YPhosphorylation317;-
YPhosphorylation345;-
YPhosphorylation164
YPhosphorylation168

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                                                                                                                                                                                                                                                       
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
25ABL11809NP_009297.2in vitro;in vivo88   792   098   668   148   
999CDH11885BAA88957.1in vitro15144564   
1103CHAT7510NP_065574.3in vivo10692442   
1398CRK1267NP_058431.2in vitro;in vivo887   920   993   664   059   000   000   
1399CRKL3596NP_005198.1in vitro;in vivo9   020   138   940   548   290   000   000   000   000   
2185PTK2B3131NP_004094.3in vivo9020138   
3398ID22664NP_002157.2in vivo;yeast 2-hybrid10502414   
3932LCK1080NP_005347.3in vitro8879209   
4067LYN1301NP_002341.1in vivo9020138   
4086SMAD13356NP_005891.1in vivo;yeast 2-hybrid1   111   821   115   231   740   
4087SMAD23221NP_005892.1in vivo11118211   
4088SMAD34380NP_005893.1in vitro;in vivo;yeast 2-hybrid150   517   261   111   821   000   000   000   
4690NCK12740NP_006144.1in vitro;in vivo108   081   248   879   209   
5747PTK22859NP_005598.3in vitro;in vivo;yeast 2-hybrid8   668   148   887   920   910   000   000   
5781PTPN111470NP_002825.3in vitro;in vivo8879209   
5782PTPN122513NP_002826.3in vitro9748319   
5829PXN3937BAA18998.1in vivo10455189   
6929TCF3918NP_003191.1yeast 2-hybrid10502414   
7205TRIP64242NP_003293.2yeast 2-hybrid11782456   
7791ZYX3592NP_003452.1in vitro;in vivo;yeast 2-hybrid11782456   
8412BCAR35268NP_003558.1in vivo12517963   
9564BCAR14248NP_055382.2in vivo;yeast 2-hybrid902   013   886   681   489   000   000   
10044SH2D3C5284NP_733745.1in vitro;in vivo10692442   
64780MICAL16183NP_073602.3in vitro;in vivo11827972   
83737ITCH7565Q96J02in vitro;in vivo;yeast 2-hybrid15051726   


Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd11550401-562  Serine_rich_NEDD9
cl07433401-562  Serine_rich_CAS superfamily
cd11570704-831  FAT-like_NEDD9_C
cl13463704-831  FAT-like_CAS_C superfamily
cd12002Jul-63  SH3_NEDD9
cl17036Jul-63  SH3 superfamily
pfam12026613-829  DUF3513
pfam08824404-562  Serine_rich
cd11549404-561  Serine_rich_CAS
cd11564704-829  FAT-like_CAS_C
cd11569699-828  FAT-like_BCAR1_C
cd11551404-558  Serine_rich_CASS4
cd11571703-832  FAT-like_EFS_C
cd11552404-558  Serine_rich_BCAR1
cd11844Jul-62  SH3_CAS
cd12001May-65  SH3_BCAR1
cd11568713-828  FAT-like_CASS4_C
cd12000Jun-62  SH3_CASS4
cd12003Jul-63  SH3_EFS
smart00326Jul-61  SH3
cd00174Aug-58  SH3
pfam14604Oct-61  SH3_9
cd11842Aug-62  SH3_Ysc84p_like
cd11805Aug-61  SH3_GRB2_like_C
pfam00018Sep-56  SH3_1
cd11952Oct-58  SH3_iASPP
cd11827Jul-60  SH3_MyoIe_If_like
cd11875Jul-62  SH3_CD2AP-like_3
cd12142Sep-60  SH3_D21-like
pfam07653Aug-61  SH3_2
cd11772Sep-60  SH3_OSTF1
cd11823Sep-60  SH3_Nostrin
cd11877Jul-62  SH3_PIX
cd11856Sep-58  SH3_p47phox_like
cd11824Jul-62  SH3_PSTPIP1
cd11810Sep-56  SH3_RUSC1_like
cd11819Aug-62  SH3_Cortactin_like
cd11763Aug-56  SH3_SNX9_like
cd11803Jul-63  SH3_Endophilin_A
cd11818Aug-58  SH3_Eve1_5
cd11762Jul-57  SH3_FCHSD_2
cd12059Oct-60  SH3_MLK1-3
cd12054Sep-63  SH3_CD2AP_2
cd12073Aug-63  SH3_HS1
cd11960Aug-62  SH3_Abp1_eu
cd1205720-63  SH3_CIN85_3
cd11864Aug-62  SH3_PEX13_eumet
cd11826Sep-60  SH3_Abi
cd11954Jul-62  SH3_ASPP1
cd11882Aug-62  SH3_GRAF-like
cd12058Oct-60  SH3_MLK4
cd11874Aug-62  SH3_CD2AP-like_2
cd11820Sep-61  SH3_STAM
cd11807Oct-58  SH3_ASPP
cd11800Oct-58  SH3_DNMBP_C2_like
cd11804Aug-58  SH3_GRB2_like_N
cd11953Oct-62  SH3_ASPP2
cd12056Jul-62  SH3_CD2AP_3
cd11843Sep-60  SH3_PACSIN
cd11858Jul-62  SH3_Myosin-I_fungi
cd11959Jul-62  SH3_Cortactin
cd11949Aug-61  SH3_GRB2_C
cd11758Sep-60  SH3_CRK_N
cd11876Oct-60  SH3_MLK
cd11771Aug-60  SH3_Pex13p_fungal
cd11950Jul-61  SH3_GRAP2_C
cd11775Jul-62  SH3_Sla1p_3
cd11808Oct-61  SH3_Alpha_Spectrin
cd11845Sep-58  SH3_Src_like
cd11873Aug-61  SH3_CD2AP-like_1
cd11786Aug-61  SH3_SH3RF_1
cd11948Aug-62  SH3_GRAP_N
cd11782Aug-61  SH3_Sorbs_2
cd11972Oct-66  SH3_Abi2
cd11961Jul-62  SH3_Abp1_fungi_C2
cd11781Aug-62  SH3_Sorbs_1
cd11866Jul-56  SH3_SKAP1-like
cd12061Jul-61  SH3_betaPIX
cd11916Sep-63  SH3_Sorbs1_3
cd11766Aug-60  SH3_Nck_2
cd11990Jul-62  SH3_Intersectin2_2
cd11840Sep-62  SH3_Intersectin_5
cd11812Oct-60  SH3_AHI-1
cd1207720-61  SH3_Tks5_2
cd11904Sep-62  SH3_Nck1_3
cd11976Aug-61  SH3_VAV1_2
cd11920Jun-56  SH3_Sorbs2_1
cd11855Aug-62  SH3_Sho1p
cd11849Jul-61  SH3_SPIN90
cd11817Aug-58  SH3_Eve1_4
cd11764Jul-58  SH3_Eps8
cd11947Aug-60  SH3_GRAP2_N
cd1201620-61  SH3_Tks_2
cd11796Aug-60  SH3_DNMBP_N3
cd11895Jul-56  SH3_FCHSD1_2
cd1201521-57  SH3_Tks_1
cd11821Aug-56  SH3_ASAP
cd11837Aug-62  SH3_Intersectin_2
cd11946Aug-62  SH3_GRB2_N
cd12012Oct-61  SH3_RIM-BP_2
cd11999Sep-60  SH3_PACSIN_like
cd1205220-61  SH3_CIN85_1
cd11828Aug-62  SH3_ARHGEF9_like
cd11995Oct-62  SH3_Intersectin1_5
cd11956Jun-56  SH3_srGAP4
cd12055Sep-61  SH3_CIN85_2
cd12060Jun-61  SH3_alphaPIX
cd11813Aug-62  SH3_SGSM3
cd11996Oct-62  SH3_Intersectin2_5
cd11894Sep-56  SH3_FCHSD2_2
cd11884Aug-60  SH3_MYO15
cd11951Aug-60  SH3_GRAP_C
cd12021Sep-56  SH3_p47phox_1
cd11841Aug-61  SH3_SH3YL1_like
cd11871Sep-58  SH3_p67phox_N
cd11851Jul-61  SH3_RIM-BP
cd11833Oct-60  SH3_Stac_1
cd11809Aug-56  SH3_srGAP
cd11767Aug-62  SH3_Nck_3
cd11903Jul-63  SH3_Nck2_3
cd11770Sep-56  SH3_Nephrocystin
cd12009Oct-60  SH3_Blk
cd11780Sep-61  SH3_Sorbs_3
cd11919Aug-63  SH3_Sorbs1_1
cd11778Oct-58  SH3_Bzz1_2
cd11974Aug-62  SH3_ASEF2
cd11830Aug-61  SH3_VAV_2
cd11878Sep-56  SH3_Bem1p_1
cd1183821-62  SH3_Intersectin_3
cd11836Sep-60  SH3_Intersectin_1
cd11971Oct-61  SH3_Abi1
cd11860Sep-57  SH3_DLG5
cd11906Oct-60  SH3_BTK
cd11769Oct-61  SH3_CSK
cd11935Sep-63  SH3_Nebulette_C
cd11958Sep-56  SH3_RUSC1
cd11898Aug-63  SH3_SNX9
cd12045Sep-56  SH3_SKAP2
cd11989Aug-62  SH3_Intersectin1_2
cd11783Oct-62  SH3_SH3RF_3
cd11975Aug-64  SH3_ARHGEF9
cd11773Jul-58  SH3_Sla1p_1
cd11912Aug-56  SH3_Bzz1_1
cd11774Aug-60  SH3_Sla1p_2
cd11854Jul-57  SH3_Fus1p
cd12044Sep-56  SH3_SKAP1
cd11962Aug-62  SH3_Abp1_fungi_C1
cd1195721-56  SH3_RUSC2
cd11806Oct-60  SH3_PRMT2


Ontology Information


   
HPRD ID1880
Molecular ClassAdhesion molecule
Molecular FunctionTranscription factor activity (GO:0003700)
Biological ProcessRegulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO