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General Information
- Evidence
- Gene
- mRNA
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- Protein
- PTM
- Enzyme
- PPi
- Pathway
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- Domain
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 12149448 | 2002 | Cell line : HCT 15,Colo 205, DLD 1,HCT 116 Source : Cancer Cell Repository, Tohoku University, Sendai, Japan,Health Science Research Resources Bank, Osaka and ATCC, Tumors at Miyagi Prefectural Cancer Center Sample Type : CRC tumor and normal tissue No. of Sample : 50 Stage : - | Transfection,RT-PCR,In Situ Hybridization,Sialidase Activity Assay,Sialidase Activity Assay | Up-regulation | - | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene product belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from glycoproteins and glycolipids. It is localized in the plasma membrane, and its activity is specific for gangliosides. It may play a role in modulating the ganglioside content of the lipid bilayer. [provided by RefSeq, Jul 2008] | Chromosome | 11 |
| Location | 11q13.5 |
| Start | 74699950 |
| End | 74718743 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 18794 |
| OMIM ID | 604617 |
| HGNC ID | HGNC:7760 |
| Unigene ID | Hs.191074 |
| Ensembl ID | - |
| PharmGKB ID | PA31562 |
Protein Information
| Protein ID | NP_006647.3 |
|---|---|
| Protein Name | sialidase 3 (membrane sialidase) |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 428 |
| Uniprot ID | O14917 |
| Ensembl Protein ID | ENSP00000367151 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 342 |
| S | Phosphorylation | 450 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 857 | CAV1 | 3028 | NP_001744.2 | in vivo | 12011038 |
| 2885 | GRB2 | 150 | NP_002077.1 | in vivo | 12730204 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Other glycan degradation | hsa00511 |
| Sphingolipid metabolism | hsa00600 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd15482 | 11-403 | Sialidase_non-viral |
| cl21531 | 11-403 | Sialidase superfamily |
| pfam13088 | 37-384 | BNR_2 |
Ontology Information
| HPRD ID | 8388 |
|---|---|
| Molecular Class | Neuraminidase |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Cell growth and/or maintenance (GO:0008151) |
Drug Information
No matching records could be found.