Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| NEUROG1 | 4762 | Neurogenin 1 | 5 | AKA; ngn1; Math4C; bHLHa6; NEUROD3 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 17372756 | 2007 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | PCR; MethyLight technology | Methylation | - | Methylation in CACNA1G, IGF2, MLH1, NEUROG1, RUNX3, MINT31, and WRN were associated with worse survival. |
| 17591929 | 2007 | Cell line : - Source : - Sample Type : Case control study No. of Sample : 920 colorectal cancers from two large prospective cohort studies Stage : - | MethyLight assays | Methylation | - | Based on sensitivity, specificity, and false positives and negatives, the eight markers were ranked for methylation in order as: RUNX3, CACNA1G, IGF2, MLH1, NEUROG1, CRABP1, SOCS1, and CDKN2A. |
| 21326223 | 2011 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : UICC stages I,II | Methylation-specific RT- PCR | Methylation | - | HLTF, HPP1/TPEF, and NEUROG1 DNA methylation was detectable in at least 50% of patients with colorectal cancers. NEUROG1 shows a higher sensitivity for colorectal cancer at UICC stages I and II. |
| 21738611 | 2013 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | - | Methylation | - | - |
| 23034738 | 2012 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 322 Stage : TNM Stage II,III | - | Methylation | - | Concurrent methylation of NEUROG1 and CDKN2A (p16) is associated with recurrence following adjuvant FOLFOX in Stages II/III colorectal cancer. NEUROG1 can used as Prognostic marker for CRC |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Basic helix-loop-helix proteins |
| Description | - | Chromosome | 5 |
| Location | 5q23-q31 |
| Start | 135534282 |
| End | 135535949 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 1668 |
| OMIM ID | 601726 |
| HGNC ID | HGNC:7764 |
| Unigene ID | Hs.248149 |
| Ensembl ID | ENSG00000181965 |
| PharmGKB ID | - |
Protein Information
| Protein ID | NP_006152.2 |
|---|---|
| Protein Name | Neurogenin 1 |
| Molecular Wt. (Da) | 25587 |
| Protein Sequence | Download Select all |
| Length | 237 |
| Uniprot ID | Q05315 |
| Ensembl Protein ID | ENSP00000221804 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1387 | CREBBP | 2534 | NP_004371.2 | in vivo | 11239394 |
| 4086 | SMAD1 | 3356 | NP_005891.1 | in vivo | 11239394 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Signaling pathways regulating pluripotency of stem cells | hsa04550 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00083 | 90-149 | HLH |
| cl00081 | 90-149 | HLH superfamily |
| smart00353 | 98-149 | HLH |
| pfam00010 | 93-144 | HLH |
Ontology Information
| HPRD ID | 1706 |
|---|---|
| Molecular Class | Transcription regulatory protein |
| Molecular Function | Complement activity (GO:0003811) |
| Biological Process | Immune response (GO:0006955) |
Drug Information
No matching records could be found.