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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
NFATC2 4773 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2  20NF-ATP, NFATp, NFAT1 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
15632146   2005Cell line : Caco 2, HCT116, HT29.

Source : -

Sample Type : -

No. of Sample : -

Stage : -

real time RT-PCR,Immunoblotting,EMSA,Transfection, Luciferase AssaysUp-regulation--

22738913   2012Cell line : -

Source : -

Sample Type : BALB/c- and NFATc2-deficient mice

No. of Sample : -

Stage : -

Induction of colitis-associated cancer,Miniendoscopic analysis,Analysis of apoptosis,Immunohistochemistry,real time RT-PCRUp-regulation-NFATc2 in the establishment of inflammation-associated colorectal tumors mediated by control of IL-6 expression.


Gene Details



NC_000020.10 (50003494..50179370, complement)

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Gene Type protein coding
Gene Family Nuclear factor of activated T-cells
Description This gene is a member of the nuclear factor of activated T cells (NFAT) family. The product of this gene is a DNA-binding protein with a REL-homology region (RHR) and an NFAT-homology region (NHR). This protein is present in the cytosol and only translocates to the nucleus upon T cell receptor (TCR) stimulation, where it becomes a member of the nuclear factors of activated T cells transcription complex. This complex plays a central role in inducing gene transcription during the immune response. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Apr 2012]  
Chromosome 20
Location 20q13.2
Start 50003494  
End 50179370  
Strand -  
Gene Sequence

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Length 175877  
OMIM ID 600490   
HGNC ID HGNC:7776   
Unigene ID Hs.744148   
Ensembl ID ENSG00000101096   
PharmGKB ID PA31583   

mRNA Information


mRNA ID NM_001258295.1
Exon join(28..299,39263..39778,45904..46075,87199..87401, 88707..88879,108171..108311,127098..127153,127545..127671, 130103..130792,171408..175902)  
mRNA Sequence

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Length 6850  



CDS Information


   
Location 286..2406
CDS Sequence

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CCDS ID CCDS13437.1



Protein Information


      
Protein IDNP_001245224.1
Protein Namenuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
Molecular Wt. (Da)51341
Protein Sequence

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Length 706  
Uniprot IDP15498
Ensembl Protein ID ENSP00000469450  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation168
SPhosphorylation171
SPhosphorylation172
SPhosphorylation174
SPhosphorylation175
SPhosphorylation177
SPhosphorylation180
SPhosphorylation213
SPhosphorylation217
SPhosphorylation221
SPhosphorylation236
SPhosphorylation243
SPhosphorylation268
SPhosphorylation274
SPhosphorylation276
SPhosphorylation280
SPhosphorylation326
SPhosphorylation330
SPhosphorylation363
SPhosphorylation99
SPhosphorylation168
SPhosphorylation171
SPhosphorylation172
SPhosphorylation174
SPhosphorylation175
SPhosphorylation180
SPhosphorylation213
SPhosphorylation217
SPhosphorylation221
SPhosphorylation236
SPhosphorylation243
SPhosphorylation268
SPhosphorylation274
SDephosphorylation274
SPhosphorylation276
SPhosphorylation280
SPhosphorylation326
SPhosphorylation330
SPhosphorylation363
SPhosphorylation99
TDephosphorylation116
SDephosphorylation213
SDephosphorylation217
SDephosphorylation221
SDephosphorylation236
SDephosphorylation268
SDephosphorylation274
SDephosphorylation276
SDephosphorylation280
SDephosphorylation326
SDephosphorylation363
SDephosphorylation99
TDephosphorylation116
SDephosphorylation213
SDephosphorylation217
SDephosphorylation221
SDephosphorylation236
SDephosphorylation268
SDephosphorylation276
SDephosphorylation280
SDephosphorylation326
SDephosphorylation363
SDephosphorylation99
TPhosphorylation585
TPhosphorylation599
SPhosphorylation605
TPhosphorylation585
TPhosphorylation599
SPhosphorylation605
TPhosphorylation325
TPhosphorylation325
TPhosphorylation374
TPhosphorylation374
TPhosphorylation483
TPhosphorylation483
SPhosphorylation757
SPhosphorylation759
SPhosphorylation757
SPhosphorylation759
SPhosphorylation882
SPhosphorylation882
SPhosphorylation77
SPhosphorylation77

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                       
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
1387CREBBP2534NP_004371.2in vitro9625762   
1958EGR1549NP_001955.1in vitro12560487   
1961EGR4550NP_001956.3in vitro12560487   
5534PPP3R13195NP_000936.1in vivo16473827   
5590PRKCZ1504NP_002735.3in vivo12021260   
7431VIM1899NP_003371.2yeast 2-hybrid16169070   
10971YWHAQ886NP_006817.1in vitro10611249   
50943FOXP32242NP_054728.2in vivo15790681   
51003MED3114382NP_057144.1yeast 2-hybrid16169070   


Pathway Information


                                                                  
Pathway Name Pathway ID
Axon guidance hsa04360
B cell receptor signaling pathway hsa04662
cGMP-PKG signaling pathway hsa04022
Hepatitis B hsa05161
HTLV-I infection hsa05166
Natural killer cell mediated cytotoxicity hsa04650
Osteoclast differentiation hsa04380
Oxytocin signaling pathway hsa04921
T cell receptor signaling pathway hsa04660
VEGF signaling pathway hsa04370
Wnt signaling pathway hsa04310


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd07881398-572  RHD-n_NFAT
cl08275398-572  RHD-n superfamily
cd01178577-677  IPT_NFAT
cl15674577-677  IPT superfamily
cd07927408-571  RHD-n_NFAT_like
cd07882409-571  RHD-n_TonEBP
cd07827408-571  RHD-n
cd00602578-677  IPT_TF
pfam00554410-570  RHD
smart00429577-676  IPT
cd00102578-677  IPT
PHA032474-442  PHA03247
PHA032474-407  PHA03247


Ontology Information


   
HPRD ID1900
Molecular ClassTranscription factor
Molecular FunctionCytoskeletal protein binding (GO:0008092)
Biological ProcessCell growth and/or maintenance (GO:0008151)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO