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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
NFKB1 4790 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1  4KBF1, p105, NFKB-p50, p50, NF-kappaB, NFkappaB, NF-kB1 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
22530801   2012Cell line : -

Source : China population

Sample Type : Population based case control study

No. of Sample : 388 CRC and 390 controls

Stage : -

GenotypingPolymorhpism-Significant combined effect of rs3774959 and rs3774964 in the NFKB1 gene with rs2228991 in the REST gene on CRC risk was observed.

23806437   2013Cell line : -

Source : Hospital Universiti Sains Malaysia, Kubang Kerian, Kelantan, (2) Hospital Raja Perempuan Zainab II, Kota Bharu, Kelantan, and (3) Hospital Sultanah Bahiyah.

Sample Type : Population based case control study

No. of Sample : 237 histopathologically confirmed CRC patients and 237 cancer-free controls

Stage : -

RFLP-PCR,DNA sequencingPolymorhpism-NFKB1 -94 ins/del ATTG (rs28362491) polymorphism is associated with higher risk of sporadic CRC in Malaysian population.

25705893   2015Cell line : -

Source : Denmark population

Sample Type : Population based case control study

No. of Sample : 1010 CRC and 1829 control

Stage : -

GenotypingPolymorhpism-Del-carriers of the NFKB1/rs28362491 polymorphism had a 17% (95%CI: 1.03-1.34; P = 0.02) increased risk of CRC compared to homozygous carriers of the ins-allele.

20836841   2010Cell line : -

Source : -

Sample Type : Danish Diet, Cancer and Health study, an ongoing prospective cohort study

No. of Sample : -

Stage : -

GenotypingPolymorhpism-A polymorphism in NFkB was associated with CRC risk.


Gene Details



NC_000004.11 (103422486..103538459)

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Gene Type protein coding
Gene Family Ankyrin repeat domain containing
Description This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Alternative splicing results in multiple transcript variants encoding different isoforms, at least one of which is proteolytically processed. [provided by RefSeq, Feb 2016]  
Chromosome 4
Location 4q24
Start 103422486  
End 103538459  
Strand +  
Gene Sequence

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Length 115974  
OMIM ID 164011   
HGNC ID HGNC:7794   
Unigene ID Hs.618430   
Ensembl ID ENSG00000109320   
PharmGKB ID PA248   

mRNA Information


mRNA ID XM_011532467.1
Exon complement(<1..563)  
mRNA Sequence

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Length 1062  



CDS Information


   
Location 1..708
CDS Sequence

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CCDS ID CCDS3657.1



Protein Information


      
Protein IDXP_011530769.1
Protein Namenuclear factor of kappa light polypeptide gene enhancer in B-cells 1
Molecular Wt. (Da)96547
Protein Sequence

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Length 235  
Uniprot IDP18206
Ensembl Protein ID ENSP00000211998  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation922
SPhosphorylation924
TPhosphorylation932
SPhosphorylation933
SPhosphorylation338
SPhosphorylation924
SPhosphorylation900
SPhosphorylation904
SPhosphorylation908
SPhosphorylation928
SPhosphorylation928
SPhosphorylation894;-
TPhosphorylation940
SPhosphorylation942
SPhosphorylation852
TPhosphorylation944

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                                                                                                                                                                                                                                                       
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
602BCL3179NP_005169.2in vitro;in vivo;yeast 2-hybrid1   036   235   284   285   800   000   000   000   000   000   
672BRCA1218NP_009231.2in vitro;in vivo12700228   
1147CHUK2811NP_001269.3in vitro;in vivo11976329   
2908NR3C1679NP_001019265.1in vitro78   239   598   290   595   
3146HMGB11228NP_002119.1in vitro12604365   
3559IL2RA986NP_000408.1in vitro;in vivo2497520   
3659IRF1961NP_002189.1in vitro8746784   
3660IRF2962NP_002190.2in vitro8550813   
3839KPNA33536NP_002258.2in vitro14743216   
4066LYL11046NP_005574.2in vitro;in vivo;yeast 2-hybrid10023675   
4221MEN1564NP_000235.2in vitro;in vivo11526476   
4791NFKB21239NP_001070962.1in vitro14743216   
4792NFKBIA1235NP_065390.1in vitro;in vivo95   668   839   865   693   
4793NFKBIB7260NP_002494.2in vitro;in vivo14743216   
4794NFKBIE5181NP_004547.2in vitro;in vivo931   567   914   743   216   
5966REL1286NP_002899.1in vitro;in vivo1   514   318   217   962   800   
5970RELA1241NP_068810.3in vivo11   970   949   824   699   700   000   000   000   000   000   000   000   
5971RELB6886NP_006500.2in vitro;in vivo1   474   321   617   962   800   
6774STAT326NP_644805.1in vitro;in vivo12057007   
7323UBE2D34269NP_871622.1in vitro10835356   
8517IKBKG2217NP_001093326.2in vitro;in vivo14743216   
8837CFLAR4671NP_003870.4in vivo;yeast 2-hybrid13679070   
8945BTRC4596NP_378663.1in vitro;in vivo1   248   299   110   835   350   
22984PDCD1118752NP_055791.1in vitro;yeast 2-hybrid14624448   
23291FBXW117294NP_036432.2in vitro;in vivo12482991   


Pathway Information


                                                                                                                                                                                                                                                                                                                        
Pathway Name Pathway ID
Acute myeloid leukemia hsa05221
Adipocytokine signaling pathway hsa04920
AGE-RAGE signaling pathway in diabetic complications hsa04933
Amoebiasis hsa05146
Apoptosis hsa04210
B cell receptor signaling pathway hsa04662
cAMP signaling pathway hsa04024
Chagas disease (American trypanosomiasis) hsa05142
Chemokine signaling pathway hsa04062
Chronic myeloid leukemia hsa05220
Cocaine addiction hsa05030
Cytosolic DNA-sensing pathway hsa04623
Epithelial cell signaling in Helicobacter pylori infection hsa05120
Epstein-Barr virus infection hsa05169
Hepatitis B hsa05161
Hepatitis C hsa05160
Herpes simplex infection hsa05168
HIF-1 signaling pathway hsa04066
HTLV-I infection hsa05166
Inflammatory bowel disease (IBD) hsa05321
Influenza A hsa05164
Insulin resistance hsa04931
Legionellosis hsa05134
Leishmaniasis hsa05140
Longevity regulating pathway - mammal hsa04211
MAPK signaling pathway hsa04010
Measles hsa05162
MicroRNAs in cancer hsa05206
Neurotrophin signaling pathway hsa04722
NF-kappa B signaling pathway hsa04064
NOD-like receptor signaling pathway hsa04621
Non-alcoholic fatty liver disease (NAFLD) hsa04932
Osteoclast differentiation hsa04380
Pancreatic cancer hsa05212
Pathways in cancer hsa05200
Pertussis hsa05133
PI3K-Akt signaling pathway hsa04151
Prolactin signaling pathway hsa04917
Prostate cancer hsa05215
Ras signaling pathway hsa04014
RIG-I-like receptor signaling pathway hsa04622
Salmonella infection hsa05132
Shigellosis hsa05131
Small cell lung cancer hsa05222
Sphingolipid signaling pathway hsa04071
T cell receptor signaling pathway hsa04660
TNF signaling pathway hsa04668
Toll-like receptor signaling pathway hsa04620
Toxoplasmosis hsa05145
Transcriptional misregulation in cancer hsa05202
Tuberculosis hsa05152
Viral carcinogenesis hsa05203


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd0793542-243  RHD-n_NFkB1
cl0827542-243  RHD-n superfamily
cd01177250-351  IPT_NFkappaB
cl15674250-351  IPT superfamily
cd08797815-890  Death_NFkB1_p105
cl14633815-890  DD superfamily
cd00204576-705  ANK
cl02529576-705  ANK superfamily
cd0788342-243  RHD-n_NFkB
pfam0055444-242  RHD
cd0793442-243  RHD-n_NFkB2
cd0782742-243  RHD-n
cd0793342-243  RHD-n_c-Rel
cd0788742-243  RHD-n_Dorsal_Dif
cd00602250-351  IPT_TF
cd0788442-243  RHD-n_Relish
cd0788542-243  RHD-n_RelA
cd0788642-243  RHD-n_RelB
cd00204539-671  ANK
cd08310815-889  Death_NFkB-like
cd00204645-732  ANK
smart00429249-350  IPT
smart00005813-891  DEATH
cd00102250-351  IPT
cd08798819-888  Death_NFkB2_p100
pfam00531818-892  Death
cd08781815-889  Death_UNC5-like
pfam00023583-613  Ank
cd0792742-116  RHD-n_NFAT_like
cd08782815-888  Death_DAPK1
pfam00023650-680  Ank
cd01178252-351  IPT_NFAT
smart00248584-608  ANK
pfam12796586-680  Ank_2
pfam12796520-612  Ank_2
pfam13857670-726  Ank_5
COG0666555-710  ANKYR
pfam12796547-637  Ank_2
PHA02878575-726  PHA02878
COG0666538-654  ANKYR
pfam12796655-732  Ank_2
COG0666499-705  ANKYR
PHA03100575-727  PHA03100
PHA03095575-725  PHA03095
PHA03095538-723  PHA03095
PHA02875544-708  PHA02875
PLN03192583-723  PLN03192
COG0666585-732  ANKYR
PHA03095512-733  PHA03095
PHA02874542-726  PHA02874
PHA02876511-726  PHA02876
pfam13637651-705  Ank_4
PHA02736612-733  PHA02736
PHA02874563-730  PHA02874
pfam13637584-635  Ank_4
PHA03100569-670  PHA03100
pfam13857634-692  Ank_5
TIGR00870575-679  trp
PTZ00322583-637  PTZ00322
PHA02741615-726  PHA02741
PHA02743645-726  PHA02743
PHA03100525-613  PHA03100
PHA02878585-726  PHA02878
TIGR00870543-658  trp
PHA02875516-678  PHA02875
pfam13637685-733  Ank_4
pfam13637615-671  Ank_4
PHA03095512-636  PHA03095
pfam13857601-658  Ank_5
PHA02876554-730  PHA02876
PHA02875584-732  PHA02875
pfam13857572-622  Ank_5
PHA02874518-624  PHA02874
pfam13637543-602  Ank_4
PHA02876540-679  PHA02876
pfam13857539-589  Ank_5


Ontology Information


   
HPRD ID3237
Molecular ClassTranscription factor
Molecular FunctionGrowth factor activity (GO:0008083)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


View SNP Geneview Report   

Drug Information


Uniprot ID DrugBank ID Name Type
P19838DB00945Acetylsalicylic acidSmallMoleculeDrug
P19838DB01041ThalidomideSmallMoleculeDrug
P19838DB01411PranlukastSmallMoleculeDrug
P19838DB08814TriflusalSmallMoleculeDrug

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO