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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
NFKB2 4791 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)  10LYT-10, p52, p105, NF-kB2 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
21471518   2011Cell line : -

Source : Tokushima University Hospital.

Sample Type : CRC Tumor

No. of Sample : 17

Stage : TNM Stage I-IV

Focused DNA microarray, immunohistochemistryPolymorhpism1.63 Fold NF-?B2/p52 is necessary for the development of colitis, whilst c-Rel-mediated signalling regulates colonic epithelial cell turnover following DNA damage.


Gene Details



NC_000010.10 (104153867..104162286)

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Gene Type protein coding
Gene Family Ankyrin repeat domain containing
Description This gene encodes a subunit of the transcription factor complex nuclear factor-kappa-B (NFkB). The NFkB complex is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function. The protein encoded by this gene can function as both a transcriptional activator or repressor depending on its dimerization partner. The p100 full-length protein is co-translationally processed into a p52 active form. Chromosomal rearrangements and translocations of this locus have been observed in B cell lymphomas, some of which may result in the formation of fusion proteins. There is a pseudogene for this gene on chromosome 18. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]  
Chromosome 10
Location 10q24
Start 104153867  
End 104162286  
Strand +  
Gene Sequence

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Length 8420  
OMIM ID 164012   
HGNC ID HGNC:7795   
Unigene ID Hs.73090   
Ensembl ID ENSG00000077150   
PharmGKB ID PA31600   

mRNA Information


mRNA ID NM_001288724.1
Exon join(1..491,1779..1871,2144..2225,2340..2380,2616..2714, 2795..2946,3193..3299,3418..3576,3872..3976,4103..4188, 4276..4414,4630..4755,5179..5388,5468..5609,5971..6085, 6169..6382,6546..6715,6838..6940,7071..7222,7340..7409, 7636..7808,7939..8050,8146..8420)  
mRNA Sequence

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Length 3416  



CDS Information


   
Location 564..3263
CDS Sequence

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CCDS ID CCDS41564.1



Protein Information


      
Protein ID NP_001275653.1
Protein Namenuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
Molecular Wt. (Da)35478
Protein Sequence

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Length 899  
Uniprot IDP15692
Ensembl Protein ID ENSP00000361148  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation865
SPhosphorylation869
SPhosphorylation22
SPhosphorylation22
SPhosphorylation22
SPhosphorylation23
SPhosphorylation23
SPhosphorylation23
SPhosphorylation222
SPhosphorylation222
SPhosphorylation222
TPhosphorylation429
TPhosphorylation429
TPhosphorylation429
KSumoylation90
KSumoylation298
KSumoylation689
KSumoylation90
KSumoylation298
KSumoylation689
KSumoylation90
KSumoylation298
KSumoylation863
SPhosphorylation866
SPhosphorylation870
SPhosphorylation226
SPhosphorylation226
SPhosphorylation226
SPhosphorylation277
SPhosphorylation277
SPhosphorylation277
TPhosphorylation759
SPhosphorylation762
TPhosphorylation759
SPhosphorylation762
TPhosphorylation759
SPhosphorylation762
TPhosphorylation811
TPhosphorylation811
TPhosphorylation811
SPhosphorylation816
SPhosphorylation816
SPhosphorylation816
SPhosphorylation220
SPhosphorylation220
SPhosphorylation220

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                                                                                                                                                             
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
602BCL3179NP_005169.2in vivo11   707   390   845   366   700   000   000   
1147CHUK2811NP_001269.3in vitro;in vivo1   474   321   618   617   890   
1326MAP3K81863NP_005195.2in vitro14743216   
1654DDX3X2154NP_001347.3in vitro14743216   
2734GLG12855NP_036333.2in vitro14743216   
2908NR3C1679NP_001019265.1in vitro;in vivo7823959   
2969GTF2I3399NP_127492.1in vitro;in vivo14743216   
3551IKBKB4462NP_001547.1in vitro14743216   
4221MEN1564NP_000235.2in vitro;in vivo11526476   
4793NFKBIB7260NP_002494.2in vitro14743216   
5966REL1286NP_002899.1in vitro;in vivo81   528   121   474   321   600   000   000   
6128RPL64745NP_000961.2in vitro14743216   
6156RPL301595NP_000980.1in vitro14743216   
6207RPS131604NP_001008.1in vitro14743216   
8517IKBKG2217NP_001093326.2in vitro14743216   
9099USP25287NP_004196.4in vitro14743216   
9759HDAC45610NP_006028.2in vitro;in vivo12917325   
10014HDAC59246NP_001015053.1in vitro;in vivo12917325   
79155TNIP218207NP_077285.3in vitro;in vivo14743216   


Pathway Information


                                                
Pathway Name Pathway ID
Epstein-Barr virus infection hsa05169
HTLV-I infection hsa05166
Legionellosis hsa05134
MAPK signaling pathway hsa04010
NF-kappa B signaling pathway hsa04064
Osteoclast differentiation hsa04380
Pathways in cancer hsa05200
Viral carcinogenesis hsa05203


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd0793438-221  RHD-n_NFkB2
cl0827538-221  RHD-n superfamily
cd01177228-327  IPT_NFkappaB
cl15674228-327  IPT superfamily
cd08798774-849  Death_NFkB2_p100
cl14633774-849  DD superfamily
cd00204483-620  ANK
cl02529483-620  ANK superfamily
cd00204597-705  ANK
cl02529597-705  ANK superfamily
cd0788338-221  RHD-n_NFkB
pfam0055440-220  RHD
cd0782738-221  RHD-n
cd0793538-221  RHD-n_NFkB1
cd0788738-221  RHD-n_Dorsal_Dif
cd00602228-327  IPT_TF
cd0793338-221  RHD-n_c-Rel
cd0788438-221  RHD-n_Relish
cd0788538-221  RHD-n_RelA
cd0788638-221  RHD-n_RelB
cd00204521-654  ANK
cd08310774-848  Death_NFkB-like
cd00204458-582  ANK
smart00429227-326  IPT
cd00102228-327  IPT
cd08797776-848  Death_NFkB1_p105
smart00005772-850  DEATH
cd0792738-139  RHD-n_NFAT_like
cd01178230-327  IPT_NFAT
pfam00531776-848  Death
pfam00023668-699  Ank
cd00204662-700  ANK
pfam00023528-558  Ank
pfam13606668-696  Ank_3
cd08799776-844  Death_UNC5C
cd08802782-842  Death_UNC5B
smart00248668-696  ANK
pfam12796605-698  Ank_2
pfam12796531-629  Ank_2
pfam13637488-547  Ank_4
PHA03095459-705  PHA03095
COG0666481-588  ANKYR
pfam12796492-586  Ank_2
COG0666482-675  ANKYR
PHA02878539-707  PHA02878
PHA02878523-675  PHA02878
PHA03100490-694  PHA03100
pfam12796489-557  Ank_2
PHA02876485-705  PHA02876
PHA02874480-694  PHA02874
COG0666530-698  ANKYR
PHA02875526-739  PHA02875
PHA03100508-699  PHA03100
PTZ00322528-601  PTZ00322
PHA03095482-569  PHA03095
PHA02875489-656  PHA02875
PHA02876427-632  PHA02876
PHA02874492-702  PHA02874
PHA02874490-705  PHA02874
pfam13857513-567  Ank_5
PHA02876556-750  PHA02876
TIGR00870520-699  trp
PHA02878491-759  PHA02878
PHA02743592-675  PHA02743
PHA02878485-628  PHA02878
TIGR00870488-688  trp
pfam12796638-705  Ank_2
pfam13637529-582  Ank_4
pfam13857653-705  Ank_5
PLN03192534-742  PLN03192
COG0666462-548  ANKYR
PHA03100483-632  PHA03100
pfam13637634-688  Ank_4
pfam13857473-534  Ank_5
pfam13637560-620  Ank_4
PHA02946521-705  PHA02946
PHA03100461-552  PHA03100
PHA02875486-625  PHA02875
PTZ00322659-705  PTZ00322
PHA02736604-692  PHA02736
pfam13857590-641  Ank_5
pfam12796458-521  Ank_2
pfam13637603-650  Ank_4
PHA02878459-569  PHA02878


Ontology Information


   
HPRD ID3317
Molecular ClassTranscription factor
Molecular FunctionGrowth factor activity (GO:0008083)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


View SNP Geneview Report   

Drug Information


Uniprot ID DrugBank ID Name Type
Q00653DB00945Acetylsalicylic acidSmallMoleculeDrug
Q00653DB01296GlucosamineSmallMoleculeDrug

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO