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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| NFYC | 4802 | nuclear transcription factor Y, gamma | 1 | CBF-C, NF-YC |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22104449 | 2012 | Cell line : - Source : University Hospital of Patras. Sample Type : Formalin-fixed paraffin-embedded tissue No. of Sample : 92 Stage : Duke Stage A-D | qRT-PCR,Immunohistochemistry. | Up-regulation | - | NFY-C expression was elevated in adenocarcinomas. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes one subunit of a trimeric complex forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoters of a variety of genes. The encoded protein, subunit C, forms a tight dimer with the B subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008] | Chromosome | 1 |
| Location | 1p32 |
| Start | 41157242 |
| End | 41237275 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 80034 |
| OMIM ID | 605344 |
| HGNC ID | HGNC:7806 |
| Unigene ID | Hs.713051 |
| Ensembl ID | ENSG00000066136 |
| PharmGKB ID | PA31611 |
mRNA Information
| mRNA ID | XM_011542479.1 |
|---|---|
| Exon | complement(387..515) | mRNA Sequence | Download Select all |
| Length | 6851 |
Protein Information
| Protein ID | XP_011540781.1 |
|---|---|
| Protein Name | nuclear transcription factor Y, gamma |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 312 |
| Uniprot ID | P49767 |
| Ensembl Protein ID | ENSP00000480043 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1388 | ATF6B | 2992 | NP_004372.3 | in vitro;yeast 2-hybrid | 11158310 |
| 4087 | SMAD2 | 3221 | NP_005892.1 | in vivo | 12023901 |
| 4088 | SMAD3 | 4380 | NP_005893.1 | in vivo | 12023901 |
| 4609 | MYC | 1818 | NP_002458.2 | in vitro;in vivo | 1 044 620 311 282 020 |
| 4800 | NFYA | 1793 | NP_002496.1 | in vitro | 15243141 |
| 4801 | NFYB | 1794 | NP_006157.1 | in vitro | 9388234 |
| 22926 | ATF6 | 16118 | NP_031374.2 | in vitro;yeast 2-hybrid | 11158310 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Antigen processing and presentation | hsa04612 |
| Tuberculosis | hsa05152 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam00808 | 41-105 | CBFD_NFYB_HMF |
| cl00074 | 41-105 | H2A superfamily |
| COG5247 | 44-130 | BUR6 |
| pfam00125 | 36-105 | Histone |
| COG2036 | 41-106 | HHT1 |
| COG5262 | 44-132 | HTA1 |
| COG5208 | 17-123 | HAP5 |
Ontology Information
| HPRD ID | 475 |
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | Cytoskeletal anchoring activity (GO:0016343) |
| Biological Process | Cell growth and/or maintenance (GO:0008151) |
Drug Information
No matching records could be found.