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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25320007 | 2014 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : TNM stage II, III | - | Up-regulation | - | Overexpression of NFATc1 significantly increased the metastatic potential of colon cancer cells. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Endogenous ligands |
| Description | This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene's expression is associated with allergic rhinitis. [provided by RefSeq, Jul 2008] | Chromosome | 1 |
| Location | 1p13.1 |
| Start | 115828537 |
| End | 115880857 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 52321 |
| OMIM ID | 162030 |
| HGNC ID | HGNC:7808 |
| Unigene ID | Hs.2561 |
| Ensembl ID | ENSG00000134259 |
| PharmGKB ID | PA162397475 |
mRNA Information
| mRNA ID | NM_002506.2 |
|---|---|
| Exon | join(149..181,44635..44758,51578..52469) | mRNA Sequence | Download Select all |
| Length | 1052 |
Protein Information
| Protein ID | NP_002497.2 |
|---|---|
| Protein Name | nerve growth factor (beta polypeptide) |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 241 |
| Uniprot ID | P40337 |
| Ensembl Protein ID | ENSP00000256474 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 84;- |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 2 | A2M | 72 | NP_000005.2 | in vitro | 10681572 |
| 4316 | MMP7 | 1525 | NP_002414.1 | in vitro;in vivo | 11729324 |
| 4804 | NGFR | 1197 | NP_002498.1 | in vitro;in vivo | 14985763 |
| 4914 | NTRK1 | 1869 | NP_002520.2 | in vitro;in vivo | 1 049 003 014 985 760 |
| 5340 | PLG | 1417 | NP_000292.1 | in vitro;in vivo | 11729324 |
| 6272 | SORT1 | 3910 | NP_002950.3 | in vitro;in vivo | 14985763 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Apoptosis | hsa04210 |
| Inflammatory mediator regulation of TRP channels | hsa04750 |
| MAPK signaling pathway | hsa04010 |
| Neurotrophin signaling pathway | hsa04722 |
| PI3K-Akt signaling pathway | hsa04151 |
| Rap1 signaling pathway | hsa04015 |
| Ras signaling pathway | hsa04014 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam00243 | 125-239 | NGF |
| cl02481 | 125-239 | NGF superfamily |
| smart00140 | 129-232 | NGF |
Ontology Information
| HPRD ID | 1899 |
|---|---|
| Molecular Class | Growth factor |
| Molecular Function | Structural constituent of cytoskeleton (GO:0005200) |
| Biological Process | Cell growth and/or maintenance (GO:0008151) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P01138 | DB01407 | Clenbuterol | SmallMoleculeDrug |