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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25738796 | 2015 | Cell line : HCT116 Source : - Sample Type : - No. of Sample : - Stage : - | real time RT-PCR, western blotting,MTT assay, colony formation assay and flow cytometry | Down-regulation | - | NIT2 may be an oncogene in human colon cancer and may thus serve as a promising therapeutic target for the treatment of colon cancer. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | - | Chromosome | 3 |
| Location | 3q12.3 |
| Start | 100053483 |
| End | 100075844 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 22362 |
| OMIM ID | - |
| HGNC ID | HGNC:29878 |
| Unigene ID | Hs.439152 |
| Ensembl ID | ENSG00000114021 |
| PharmGKB ID | PA134882857 |
Protein Information
| Protein ID | NP_064587.1 |
|---|---|
| Protein Name | nitrilase family, member 2 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 276 |
| Uniprot ID | P59510 |
| Ensembl Protein ID | ENSP00000374071 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| Y | Phosphorylation | 145;- |
| Y | Phosphorylation | 145;- |
| S | Phosphorylation | 266 |
| Y | Phosphorylation | 269 |
| T | Phosphorylation | 237 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Alanine, aspartate and glutamate metabolism | hsa00250 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd07572 | 5-265 | nit |
| cl11424 | 5-265 | nitrilase superfamily |
| cd07197 | 6-265 | nitrilase |
| COG0388 | 3-275 | YafV |
| cd07583 | 5-265 | nitrilase_5 |
| cd07581 | 7-265 | nitrilase_3 |
| cd07573 | 4-274 | CPA |
| PLN02798 | 5-270 | PLN02798 |
| cd07584 | 5-266 | nitrilase_6 |
| pfam00795 | 5-178 | CN_hydrolase |
| cd07585 | 5-269 | nitrilase_7 |
| cd07576 | 5-267 | R-amidase_like |
| TIGR03381 | 5-270 | agmatine_aguB |
| cd07580 | 5-269 | nitrilase_2 |
| PLN02747 | 6-275 | PLN02747 |
| cd07577 | 5-269 | Ph0642_like |
| cd07574 | 4-261 | nitrilase_Rim1_like |
| cd07564 | 4-256 | nitrilases_CHs |
| cd07568 | 5-276 | ML_beta-AS_like |
| cd07586 | 5-273 | nitrilase_8 |
| cd07579 | 5-276 | nitrilase_1_R2 |
| cd07578 | 4-268 | nitrilase_1_R1 |
| cd07582 | 18-255 | nitrilase_4 |
| cd07569 | 5-269 | DCase |
| cd07575 | 5-262 | Xc-1258_like |
| PLN02504 | 12-252 | PLN02504 |
| cd07565 | 6-246 | aliphatic_amidase |
| cd07571 | 28-240 | ALP_N-acyl_transferase |
| TIGR04048 | 23-248 | nitrile_sll0784 |
| cd07570 | 20-269 | GAT_Gln-NAD-synth |
| cd07567 | 28-179 | biotinidase_like |
| TIGR00546 | 2-231 | lnt |
| PRK10438 | 34-262 | PRK10438 |
| cd07587 | 5-204 | ML_beta-AS |
| PRK13286 | 54-256 | amiE |
| cd07566 | 5-178 | ScNTA1_like |
| PRK13981 | 4-247 | PRK13981 |
| PLN00202 | 23-270 | PLN00202 |
| COG0815 | 2-239 | Lnt |
| PRK00302 | 2-246 | lnt |
| PRK13287 | 6-237 | amiF |
Ontology Information
| HPRD ID | 10509 |
|---|---|
| Molecular Class | Enzyme: Hydrolase |
| Molecular Function | Ubiquitin-specific protease activity (GO:0004843) |
| Biological Process | Apoptosis (GO:0006915) |
Drug Information
No matching records could be found.