Search results:


General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
NOS1 4842 nitric oxide synthase 1 (neuronal)  12nNOS 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
11989855   2002Cell line : -

Source : -

Sample Type : -

No. of Sample : -

Stage : -

 Pre-embedding peroxidase-anti-peroxidase and post-embedding immunoelectron microscopic triple gold labelling techniquesDown-regulation-These data suggest that metastatic tumour vessel endothelium is characterized by increased expression of NOS2 and ET-1 and by decreases in NOS1 and NOS3.


Gene Details



NC_000012.11 (117645921..117799607, complement)

View Larger Image
   
Gene Type protein coding
Gene Family -
Description The protein encoded by this gene belongs to the family of nitric oxide synthases, which synthesize nitric oxide from L-arginine. Nitric oxide is a reactive free radical, which acts as a biologic mediator in several processes, including neurotransmission, and antimicrobial and antitumoral activities. In the brain and peripheral nervous system, nitric oxide displays many properties of a neurotransmitter, and has been implicated in neurotoxicity associated with stroke and neurodegenerative diseases, neural regulation of smooth muscle, including peristalsis, and penile erection. This protein is ubiquitously expressed, with high level of expression in skeletal muscle. Multiple transcript variants that differ in the 5' UTR have been described for this gene but the full-length nature of these transcripts is not known. Additionally, alternatively spliced transcript variants encoding different isoforms (some testis-specific) have been found for this gene.[provided by RefSeq, Feb 2011]  
Chromosome 12
Location 12q24.22
Start 117645921  
End 117799607  
Strand -  
Gene Sequence

   Download   Select all

Length 153687  
OMIM ID 163731   
HGNC ID HGNC:7872   
Unigene ID Hs.654410   
Ensembl ID ENSG00000089250   
PharmGKB ID PA252   

mRNA Information


mRNA ID NM_000620.4
Exon join(1..291,30314..31458,50211..50337,71377..71505, 73584..73729,75537..75699,76471..76562,80937..81078, 83705..83844,89244..89418,93659..93760,96293..96487, 97829..97914,101194..101338,102673..102777,103348..103406, 108049..108165,114281..114455,118368..118506, 119098..119176,127045..127238,129672..129841, 134162..134372,135033..135120,136666..136787, 138940..139088,141534..141728,143639..143757, 146479..153661)  
mRNA Sequence

   Download   Select all

Length 12189  



CDS Information


   
Location 712..5016
CDS Sequence

   Download   Select all

CCDS ID CCDS41842.1



Protein Information


      
Protein IDNP_000611.1
Protein Namenitric oxide synthase 1 (neuronal)
Molecular Wt. (Da)0
Protein Sequence

   Download   Select all

Length 1434  
Uniprot IDP04004
Ensembl Protein ID ENSP00000226218  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation1417
SPhosphorylation852
SPhosphorylation852
SPhosphorylation852
SPhosphorylation852
SPhosphorylation852
SPhosphorylation746
TPhosphorylation396

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                       
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
146ADRA1D79NP_000669.1in vivo12184796   
147ADRA1B80NP_000670.1in vivo12184796   
148ADRA1A81NP_150646.3in vivo12184796   
153ADRB1181NP_000675.1in vivo12184796   
154ADRB2187NP_000015.1in vivo12184796   
493ATP2B4159NP_001675.3in vitro;in vivo11591728   
624BDKRB2213NP_000614.1in vivo10681501   
3162HMOX1782NP_002124.1in vivo11849436   
55697VAC147660NP_060522.3in vitro;in vivo17161399   


Pathway Information


                                                            
Pathway Name Pathway ID
Alzheimer's disease hsa05010
Amyotrophic lateral sclerosis (ALS) hsa05014
Arginine and proline metabolism hsa00330
Arginine biosynthesis hsa00220
Calcium signaling pathway hsa04020
Circadian entrainment hsa04713
Long-term depression hsa04730
Metabolic pathways hsa01100
Phagosome hsa04145
Salivary secretion hsa04970


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd00795305-716  NOS_oxygenase_euk
cl00254305-716  NOS_oxygenase superfamily
cd062021001-1404  Nitric_oxide_synthase
cl068681001-1404  FNR_like superfamily
cd0099215-98  PDZ_signaling
cl0011715-98  PDZ superfamily
pfam02898351-716  NO_synthase
cd00575358-713  NOS_oxygenase
cd00794359-713  NOS_oxygenase_prok
COG4362356-718  COG4362
cd062041013-1399  CYPOR
cd061821001-1400  CYPOR_like
pfam00667991-1219  FAD_binding_1
cl19189991-1219  FAD_binding_1 superfamily
cd062071008-1395  CyPoR_like
cd061991001-1400  SiR
cd06206996-1400  bifunctional_CYPOR
cd062031026-1399  methionine_synthase_red
cd003221177-1380  FNR_like
pfam00258762-935  Flavodoxin_1
cl00438762-935  FMN_red superfamily
cd062011177-1400  SiR_like2
cd062001177-1400  SiR_like1
cd062081177-1396  CYPOR_like_FNR
pfam001751251-1365  NAD_binding_1
pfam0059517-96  PDZ
smart0022814-100  PDZ
cd061951178-1369  FNR1
PRK08105754-923  PRK08105
cd0098825-110  PDZ_CTP_protease
cd0013626-98  PDZ
cd062171178-1365  FNR_iron_sulfur_binding_3
cd0098926-107  PDZ_metalloprotease
cd061871177-1366  O2ase_reductase_like
cd062161178-1363  FNR_iron_sulfur_binding_2
cd062091178-1359  BenDO_FAD_NAD
PRK09004801-916  PRK09004
PRK06703759-937  PRK06703
cd061881178-1367  NADH_quinone_reductase
cd0098741-99  PDZ_serine_protease
cd061911178-1400  FNR_iron_sulfur_binding
COG0716759-942  FldA
cd061941177-1359  FNR_N-term_Iron_sulfur_binding
cd062151178-1400  FNR_iron_sulfur_binding_1
cd062111177-1381  phenol_2-monooxygenase_like
pfam1318026-123  PDZ_2
cd061841177-1401  flavohem_like_fad_nad_binding
cd061891178-1366  flavin_oxioreductase
cd061831178-1380  cyt_b5_reduct_like
COG0369759-1399  CysJ
TIGR01931761-1400  cysJ
PRK10953761-1400  cysJ
PRK062141000-1400  PRK06214
TIGR032241178-1396  benzo_boxA
PLN031161177-1400  PLN03116
PLN031151178-1381  PLN03115
COG10181178-1406  Fpr
COG079322-123  CtpA
COG05431178-1366  Mcr1
pfam11035119-232  SnAPC_2_like
TIGR0022526-102  prc
TIGR0203741-123  degP_htrA_DO
PLN0004949-144  PLN00049
COG026541-123  DegQ
COG28711178-1365  NqrF


Ontology Information


   
HPRD ID3835
Molecular ClassEnzyme: Synthase
Molecular FunctionCytoskeletal protein binding (GO:0008092)
Biological ProcessCell growth and/or maintenance (GO:0008151)  



SNP Information


View SNP Geneview Report   

Drug Information


Uniprot ID DrugBank ID Name Type
P29475DB00997DoxorubicinSmallMoleculeDrug
P29475DB00155L-CitrullineSmallMoleculeDrug
P29475DB03147Flavin adenine dinucleotideSmallMoleculeDrug

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO