CoReCG

Search results:

General Information

Gene_Symbol	Gene_ID	Gene_Name	Chromosome	Alias
NOS3	4846	Nitric oxide synthase 3 (endothelial cell)	7	eNOS; ECNOS

Evidence
Gene
mRNA
CDS
Protein
PTM
Enzyme
PPi
Pathway
Structural
Domain
Ontology
SNP
Drug
External Links

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
21706163	2012	Cell line : - Source : Tumor Bank Network established at the Centro Nacional de Investigaciones Oncologicas (CNIO). Sample Type : - No. of Sample : - Stage : -	PCR-RFLP	Polymorhpism	-	NOS3 Glu298Asp polymorphism might be associated with the risk and progression of colorectal cancer in Turkish population.
23137631	2013	Cell line : - Source : Istanbul Research and Education Hospital, Surgery Clinic. Sample Type : CRC tumor and normal tissue No. of Sample : 84 colorectal cancer patients and 99 non-malignant healthy subjects Stage : -	PCR-RFLP	Polymorhpism	-	eNOS -786T>C and 894G>T polymorphisms may be associated with the development of CRC in the Korean population.
17848589	2007	Cell line : - Source : CHA Bundang Medical Center (Seongnam, South Korea). Sample Type : CRC tumor and normal tissue No. of Sample : 509 healthy controls and 528 patients with CRC Stage : -	Antibody Microarrays,Protein Labeling and Microarray Assay,Tissue Microarray Design and Immunohistochemistry	Up-regulation	1.639	-

Gene Details

Chromosome: 7; NC_000007.13 (150688144..150711687)
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Gene Type	protein coding
Gene Family	-
Description	Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. Nitric oxide is synthesized from L-arginine by nitric oxide synthases. Variations in this gene are associated with susceptibility to coronary spasm. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
Chromosome	7
Location	7q36
Start	150991056
End	151014599
Strand	+
Gene Sequence	>gi\|568815591:150991056-151014599 Homo sapiens chromosome 7, GRCh38.p2 Primary Assembly ACTGAAACTAGGGGCAAGGAGACGAAGAGAACATGAAAGTTAAACTTTAAGATGAAGAACAAAGCTGAAC ATACTGATGCATTGGATCTTTGGAGAGGATCTCAGAACTCATTGTACTTAATTTACAGGCTAAAACCTTA GAAGAGGAATTTATTATATCCTACACAAGACTCCAGGGAAGCACATGGCCTTGGACTGAAGGCTGGCATC TGGAAGCTGTCAGCCACCAGCACCTTCTGCAGCAGGTACCTGCTCTCTAAGAGGGAGGCCTGGGTGGTGC ACCTCCAGAGCTGCCCAGGCTGGGCCTCAAGGAAGAAAAAGATTTTCATTTGTCAGAGGCGGAAGGGAGA GGTGGAGGGAACAGCACAGCAGCGGCCCAGGGGCAGGGAAGCACAGGACCATTAGGGAGACACGAGAAAG CCCATTTGTCTAGAACAGAGGATTCAAGCAGTGCACCAAGGAAAATGAGGGCCAGGCCAATGTGCTGGAG TGGCTTTGTTCTTGGCTGAGGGTTTTGGGTAGTGCCAAAGCGTAAGGTAAGCCCTGCTTTCCAGAAGAAT CTAGCAGAGTGTGGAGCCCAGATGGGACTGGAAGGCCTGGGAGGGGTCAGGTGGCCACAGGGACGGGCCA CAGCCAGTGGTGCAGGCAAGAAGACAATGGCCATCCATGGTGGCTCACACCTGGAATCCCAGCCCATTGG GAGGTCGAGGCAGGTGGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGGTCAACATGGTGAAACCCTG TCTCTAATAAAATTATAAAAATTAGCCGGGCGTGGTGGTGGGTACCTGTAATCTCAGCTACTCAGGAGGC TGGGTCAGGAGAATCGCTTGAACCCAGGAGGCGGAGGTTACAGTGAGCTGAGATAGCACCATTGCATTCC AGCCTGGACAACAAAAGCGAGACTCTGTCTCAAAAAAAAAAAAAAATTAGCCAGGCGTGGTGGTGGGTGC CTGTCGTCCTCGGGAGGCTGAGGCATGAGAATCACTCCGGGAGGCAGAGGTTGCAATGAACCAAGATCAC ACCACTGCACTCCAGCCTGGGTGACAGAGCAAGACTCTGTCTAAAAAAAAAAAAAAGACAGAAGGATGTC AGCATCTGATGCTGCCTGTCACCTTGACCCTGAGGATGCCAGTCACAGCTCCATTAACTGGGACCTAGGA AAATGAGTCATCCTTGGTCATGCACATTTCAAATGGTGGCTTAATATGGAAGCCAGACTTGGGATCTGTT GTCTCCTCCAGCATGGTAGAAGATGCCTGAAAAGTAGGGGCTGGATCCCATCCCCTGCCTCACTGGGAAG GCGAGGTGGTGGGGTGTGGTGGGGCCTCAGGCTTGGGGTCATGGGACAAAGCCCAGGCTGAATGCCGCCC TTCCATCTCCCTCCTCCTGAGACAGGGGCAGCAGGGCACACTAGTGTCCAGGAGCAGCTTATGAGGCCCC TTCACCCTCCATCCTCCAAAACTGGCAGACCCCACCTTCTTGGTGTGACCCCAGAGCTCTGAGCACAGCC CGTTCCTTCCGCCTGCCGGCCCCCCACCCAGGCCCACCCCAACCTTATCCTCCACTGCTTTTCAGAGGAG TCTGGCCAACACAAATCCTCTTGTTTGTTTGTCTGTCTGTCTGCTGCTCCTAGTCTCTGCCTCTCCCAGT CTCTCAGCTTCCGTTTCTTTCTTAAACTTTCTCTCAGTCTCTGAGGTCTCGAAATCACGAGGCTTCGACC CCTGTGGACCAGATGCCCAGCTAGTGGCCTTTCTCCAGCCCCTCAGATGGCACAGAACTACAAACCCCAG CATGCACTCTGGCCTGAAGTGCCTGGAGAGTGCTGGTGTACCCCACCTGCATTCTGGGAACTGTAGTTTC CCTAGTCCCCCATGCTCCCACCAGGGCATCAAGCTCTTCCCTGGCCGGCTGACCCTGCCTCAGCCCTAGT CTCTCTGCTGACCTGCGGCCCCGGGAAGCGTGCGTCACTGAATGACAGGGTGGGGGTGGAGGCACTGGAA GGCAGCTTCCTGCTCTTTTGTGTCCCCCACTTGAGTCATGGGGGTGTGGGGGTTCCAGGAAATTGGGGCT GGGAGGGGAAGGGATACCCTAATGTCAGACTCAAGGACAAAAAGTCACTACATCCTTGCTGGGCCTCTAT CCCCAAGAACCCAAAAGGACTCAAGGGTGGGGATCCAGGAGTTCTTGTATGTATGGGGGGAGGTGAAGGA GAGAACCTGCATGACCCTAGAGGTCCCTGTGGTCACTGAGAGTGTGGGCTGCCATCCCCTGCTACAGAAA CGGTGCTCACCTTCTGCCCAACCCTCCAGGGAAAGGCACACAGGGGTGAGGCCGAAGGCCCTTCCGTCTG GTGCCACATCACAGAAGGACCTTTATGACCCCCTGGTGGCTCTACCCTGCCACTCCCCAATGCCCCAGCC CCCATGCTGCAGCCCCAGGGCTCTGCTGGACACCTGGGCTCCCACTTATCAGCCTCAGTCCTCACAGCGG AACCCAGGCGTCCGGCCCCCCACCCTTCAGGCCAGCGGGCGTGGAGCTGAGGCTTTAGAGCCTCCCAGCC GGGCTTGTTCCTGTCCCATTGTGTATGGGATAGGGGCGGGGCGAGGGCCAGCACTGGAGAGCCCCCTCCC ACTGCCCCCTCCTCTCGGTCCCCTCCCTCTTCCTAAGGAAAAGGCCAGGGCTCTGCTGGAGCAGGCAGCA GAGTGGACGCACAGTAACATGGGCAACTTGAAGAGCGTGGCCCAGGAGCCTGGGCCACCCTGCGGCCTGG GGCTGGGGCTGGGCCTTGGGCTGTGCGGCAAGCAGGGCCCAGCCACCCCGGCCCCTGAGCCCAGCCGGGC CCCAGCATCCCTACTCCCACCAGCGCCAGAACACAGGTAAGGGCCAGGCAGCTAGGAGCAGGTGGGCAAC AAGGGTGGTGTCAAGGCCTGAAGCCTGGGGCTGGGAAGGTCTGGAACTTGTAGCTGAGTCGGGAGGGCCA GGTCACAAATGCAAAAGGGCTATTAATGTGCATAGAACAGGACAGTCTGGGAGGCTCAGAAAGGAGACCA GGATCAGAGTCGGCAGGTGAAAGCTGGGAGTAAGGGTGCCAGCTATAGAATCTGGCCAGGGTTTGAATGC TGCTCTGCCGCCAGGAGCTGTTTGACTTTGAGCAAGTTACTTAATCTCTCTGAACCTCCATTTATATAAA ACGAGATATGGCAATACTTACTCCATGGGGAAGTAAGTTTCTAGCTCACAGCAAGCCTTCAACAGCAGCG ATGATTATTTAGCTGGAGAAGAAAGGAGCTGACAGCAGTGGTTACAGGAGTGAGAAAGTGGGGTCTCCCA GAAGAGGGAGAGAGTTGGGCAGGAAACTCGGGCCCTTGGGGTAAGCAGGCTGAGAAGACAGAGCCACCAG GCTTTTTTCCCCTGCTCCAGCCCCCTCTCCTCGTGGCTGTCACCCGAAAACTGGACCATGCAGTTCCCAC AAGAGTCCTCCCGGGGGTAGAGGTCCCAGGAGGGAGGAAAGACCCGGAGGCCTGGTGGGGTGCCAGGCCG GGGGCAGGCTGGGGCTGCAGGCAGCTATGCAGGGAAGGCTGAGGGCCGGGGCCCTGCTGCTCAGGCGCAC CCTTGGCCTGAGTCCCTCCCTTCCTCCCTGCCGCTGGTGGCTCTGGGAGGAAGTGATAAGGCCTGCGAGG CTTCCCTTCACACATGGGGCTGCTGTCAGGAGGGGTTGTGAGTGCGGAGGGAAATCAGAGCTGAGGAATC CCTGCAGGGCTTCCCTCCACTCAAGCACCAGGCTCTGTCCCCCTCAGGGTAGGGCTTATAGCAGCTTTGC GGGGGGTGGACACCCCATCTCCAGAAGAGGTGAGGTGGGCGCTGCAGGTGGGATGCGAACTTAGCCTCGG GTCAGGGGCTCAGGAGCTCAGCACCAGCAGCCCCTGCAGCCCAGGACCCTGGTCTATAAACGGAGGCACA GCTCGCCTCTAGCTCCTAAGGCATGGGGAACGCCAGAAGGCATGCGGCAGGTGGGCTGTGAGATCGCCAG TGCTGTAACAGGGGCCTCCGGGTGACATCTGGGAAGGCTGAAAGGAAACAAACCCTTCCTGATGACCCTA TCCCTGGCTCCCAACAGCCCCCCGAGCTCCCCGCTAACCCAGCCCCCAGAGGGGCCCAAGTTCCCTCGTG TGAAGAACTGGGAGGTGGGGAGCATCACCTATGACACCCTCAGCGCCCAGGCGCAGCAGGTAAGGCCGGC ATGCCCTGTCCCCATCGTCTCCAGGGAAAGGGTGGGTAAGGCCTGGCCTCAGATGGGGCCGGAGAGGGAA GCTCAACCCTTCTTTGAATTGGTCCCTTGTTTCCAAAAAGAGGAGAGGACTGGGAAGAACCAGAGGAGTT GAGGGACATGCACGGGACTTGGGTGACCCTCAGCCTCCAGCCTTACCCCCAACCCTGGCTCAAACTCTCC CCCATCCCACCCCTGCACCCCTTTCCCCCCTCCCACCCCTGCACCCTTCCTCCCTCTCCCCCCGTCCCCT GCCTGCATTCCTCCTCCCTCTCCCCATCTCACCCCTGCACCCCTCTTCCCTCTCCCACCCCTGCACCCCT CCTCCCTCTCCCCGTCCCACCCTGCACTCCCGCCCTCTCCAGCGTCCCACCCCTACACCCCTCCTCCCTC TGCCCCATTCCACCCCTGCACCCCCTCCTCCCTCTGCCCCGACCCACCCCTGCACCCCTCCTCCCTCTCC CCCGTCCCACCCCTGCATCCCTCCTCCCTCTGCCCCGTCCCACCCCTACACCCCTCCTCCCTCTCCCCCA TCCCACCCCTAAACCCCTCCTCCCTCTCCCCTGTCCCATCCCTGCACCCTTCCTCCCTCTCCCCGTCCCA TCCCTGCACCCTTCCTCCCTCTCCCCGTCCCATCCCTGCACCCCTCCTCCCTCTGCTCCCATCCCACCCC TGCACCCCTCCTCCCTCTGCCCCTACCCCACCTCTGCACCCCTCCTCCTTCTCCCCATCCCACCCCTGCA CCCCTCCTCCCTCTGCCCCTACCCCACCCCTGCACCCCTCCTCCTTCTCCCCATCCCACCTCTGCACCCC TCCTCCCTCTCCCCTCTCCCACCCCTGTACCCTTCCTCCTTCTCCCCGTCCCACCCCTGCACTTCTCCTC CCTCTCACCCATCCCACCCCTGCACCCTTCTTCCCTCTCCCCCATCCCACCACTGCACCCCTCCTCCCTC TCCCCCTGTTCCACCCCTGCACCCCTCCTCCCTGCCCCCAACTCCCATCCCACCCCTGCACCCTGGCCTG TCCTGACCTTTGCACTCCCTCGACCCAGGATGGGCCCTGCACCCCAAGACGCTGCCTGGGCTCCCTGGTA TTTCCACGGAAACTACAGGGCCGGCCCTCCCCCGGCCCCCCGGCCCCTGAGCAGCTGCTGAGTCAGGCCC GGGACTTCATCAACCAGTACTACAGCTCCATTAAGAGGTGACAGCTTCCCGGACGCCACAGCCTCCCTTG TCCCACTGAGGCCCCAGAAACCCCGTGACGACCTTCCCATGACCCCCTCCCTTCCCAGATCCTAACACCA CGTGGGCCCCTCCCGCCCTCCCCCAGCACTTGCACAAAGCCTGGAGGAGGGCCTCCCTGTCCCACACAAC TTCCTGCTTGTCCCCTTCCCACCCCTCTCCTCCCCAGGAGCGGCTCCCAGGCCCACGAACAGCGGCTTCA AGAGGTGGAAGCCGAGGTGGCAGCCACAGGCACCTACCAGCTTAGGGAGAGCGAGCTGGTGTTCGGGGCT AAGCAGGCCTGGCGCAACGCTCCCCGCTGCGTGGGCCGGATCCAGTGGGGGAAGCTGCAGGTGCGGCTGG CCAGCGACTGAGAGACCCGGGCGCTACCAAAAGGGGAGCGGGGTGGCGGGGCAGTTCCTAAGGCTTCCCG GGGGCTGGGAGGTCCCAAACTGTGGGGGAGATCCTTGCCTTTTCCCTTAGAGACTGGAAAGGTAGGGGGA CTGCCCCACCCTCAGCACCCAGGGGAACCTCAGCCCAGTAGTGAAGACCTGGTTATCAGGCCCTATGGTA GTGCCTTGGCTGGAGGAGGGGAAAGAAGTCTAGACCTGCTGCAGGGGTGAGGAAGTCTAGACCTGCTGCA GGGGTGAGGAAGTCTAGACCTGCTGCAGGGGTGAGGAAGTCTAGACCTGCTGCGGGGGTGAGGAAGTCTA GACCTGCTGCGGGGGTGAGGACAGCTGAGCGGAGCTTCCCTGGGCGGTGCTGTCAGTAGCAGGAGCAGCC TCCTGGAAAAGCCCTGGCTGCTGCTTCTCCCCCAAGAGAGAAGGCTTCTCCCGCCAGGCCAGTCCAGTGC AGCCCCTCACCCACACCCACTGCTACCCCAGTTCCCCTGCTTCGGCCCGCACCCTCCCTCACACCCCAGC CCACAGACTCGGGGCTGGCCTTAGTTACTGGAACGCCTGTGACCACAGCACTAAGAGAAGCAAGCTGCCC CATGGGGGACTTGGTCCCATGGCCTTGGCCTCCTTCACCATCACTGGCCGCCAAAGAGTTTGAAATAAAG CCACGTGCCCAGTGAATCCCAAAGGAACCTCAACTAAAATAAAAACAATCCTATCTGACACTTGCCTGAC CCTCTAAGTCATTCAAAGCTTTAGCTCAACTTCGATCCATCTGAGCTGCCATAGTGGACCCCACTCAGAG CTGCGTCCCTCCCTTGACCCCAGGTTGGTCCCTGCCACTCCCCTGCCCCTGTCACTGACACATGTTTCCT CCTCCCTCAGGCAGGAGTGGGACCTCCCAGCCTCCTCCTGGGGCCTCCACTCAGAATGTCAGGATGAGCA GGGTCCTAGGAGGCCTCTGGTGCAGCCTTCCCTTCCCACCATCCATGTGCTCAAAGAGAATCACCCGTCC TTTCTTGAATGCCATGGATCATGGGGGATTTGCTGCCCACACTCCTAGGCGGCCTCTTAGACATCCGTTG GTGCCTAACCCAAGCATCAGTTTGGCAGAGGCCGAGTCCCTCCTCTGTACTGGATACCAAGTCAGCTTCC ATAGGGATGGGGAGACACCTGGCCCAGGGAGGAGATGAGAAGCAGCCCGGATGGTGCTACATATGTCAGA GAGCAGGGCAGGAAGGGATCAGTGTGGCTGCCAATGGTCAGGAGGGCGCCATGGAGTGAACCATGGCCCC TGCCTCCTCACCAGCAGCTCCTCTGGAGCTGATACTCAAGACCCCCCGTCTCTCTCCTCACCCTCCTCTC CCGCTGCCTCGGCTGGCTCAGGTGTTCGATGCCCGGGACTGCAGGTCTGCACAGGAAATGTTCACCTACA TCTGCAACCACATCAAGTATGCCACCAACCGGGGCAACCTTCGGTGAGTGCCCCCCACCATGCCAGGCCC CAGCCTTCTTCCCCAAGGCAGGGAAGGCGGGGCTCTGACCAGCTCTTTCCCCATGCGTGCCAGCTCGGCC ATCACAGTGTTCCCGCAGCGCTGCCCTGGCCGAGGAGACTTCCGAATCTGGAACAGCCAGCTGGTGCGCT ACGCGGGCTACCGGCAGCAGGATGGCTCTGTGCGGGGGGACCCAGCCAACGTGGAGATCACCGAGGTGGG CACCGAGGGCCACCCATGAGGGTGTCCCCAAGGTGGAGAATGAGGAAACCAGTGGGAGAAGGCTCGGGGG ATCCAGGCAGGAAGAGGGGAGCCTCGGTGAGATAAAGGATGAAAAACACCAAAGGAGGGGTGCCTGGGTG GTCACGGAGACCCAGCCAATGAGGGACCCTGGAGATGAAGGCAGGAGACAGTGGATGGAGGGGTCCCTGA GGAGGGCATGAGGCTCAGCCCCAGAACCCCCTCTGGCCCACTCCCCACAGCTCTGCATTCAGCACGGCTG GACCCCAGGAAACGGTCGCTTCGACGTGCTGCCCCTGCTGCTGCAGGCCCCAGATGATCCCCCAGAACTC TTCCTTCTGCCCCCCGAGCTGGTCCTTGAGGTGCCCCTGGAGCACCCCACGTGAGCACCAAAGGGATTGA CTGGGTGGGATGGAGGGGGCCATCCCTGAGCCTCTCAAGAAGGGCCTGCAAGGGGGTGCTGATCCCACAC CCCAACACCCCCAGGCTGGAGTGGTTTGCAGCCCTGGGCCTGCGCTGGTACGCCCTCCCGGCAGTGTCCA ACATGCTGCTGGAAATTGGGGGCCTGGAGTTCCCCGCAGCCCCCTTCAGTGGCTGGTACATGAGCACTGA GATCGGCACGAGGAACCTGTGTGACCCTCACCGCTACAACATCCTGGAGGTGAGGTGCGGGATGGGGCTC GGGCACCGAATGCACCTGTCCAAGGCAGGAGTCTGGCTCTCACTCCATCCCCAAAATGCCAGCCACGGGG ACAATCAGAGCAGGTCCAGGGTTGCCTCCTAAATGGGAACTGAGGACAAGCTCTAGAACCACTGAAGCAA AGGGGTAGGGGGTGGCAGGGGTGTGTGTGGGGGTGTGAGTGGGTGAGTGTGAGAGTGTGGGTTTCTGGGG TGTGCAGTGGGTGAGAGTGTGGGCTTGTGGGGTGTGTAGTGGGTGTGAGACTGTGGGTTTGTAGGGGTGG GTGAGTGTGGGTGTGTGGGGGTAGGTGGGTGTGGGTTTGTGGGTGTGTATAGGCAGTGACTGTGAGACTG TGGGTTTGTGGGGGTAGGTGACTGTGGGTTTGTGGGGTGTGTAGGGGTGAGTGTGTGTGGGTTTGTAGGG GTAGGCGAGTGTGGGTTTGTGGGGTGTGTAGGGGTGAGTGTGTGTGAGTTTGTAGGGGTAGGCGAGTGTG GGTTTGTGGGGTGTGTAGGGGTGAGTGTGTGTGAGTTTGTAGGGGTAGGTGAGTGTGGGTTTGTGGGGTG TGTAGGGGGTGTGTGTGGGCTTGTAGGGGTAGGCGAGTGTGGGTTTGTGGGGTGTGTAGGGGCGAGTGTG AGAGTGTAGGTATGTGGGTGTGAGTGTGGATGTGTGTAGGCGGTGAGTGTGAAATTGTGGGTTTGTGGGG GTGGGTGGGTGTGAGTGTGTGGGTTTGTGGGTGGGTGTGGGTGTGAGTGGGTGGGTGAGGGGGGCATGGG GATGGGTGTGAACATGTAGTTGTTCTTTCAGGCATAGGACCCATAGCTCTAGAGCTTTCATCAGATTCTC AAAGGGGACCTTGACTCGGCAAAGGTTAAGACCCATTTTAGAGATGAGAAATTAAAGCCTGGAGCTGAGG AGCGACTGGCCCAAAGTCCCTCTCTGCTCTGAGGTGCCTTCGCAGGCAAAAACCTGAACCAGCCCCCTAG GCAGCCAGGCCTCCCAATGGACACCACTCACCTCACTCCTTCCAGCCATGTACGGGAAACAGAGATAGTC TCCCCACCCCACCCCCGTGATCACCTCTGTCCCTACCGATGCCACACACCCTTCTGCCCCAGGATGTGGC TGTCTGCATGGACCTGGATACCCGGACCACCTCGTCCCTGTGGAAAGACAAGGCAGCAGTGGAAATCAAC GTGGCCGTGCTGCACAGTTACCAGGTGCAGAGGCCCAGACTGGCCAGGAAGGCAAAGGGTTTGCATACGG GGGCAGCAGGGGCGGGGGATGGAGGAGAGGCAGCCATTTAGAAACTAGGGCAGGATTTGGACAGGCAGAA GAAGTTCCGTAGTCCCAGTGCCATGGCGCACACTGGCCTGCGGTTCGGGGACAGGGCAGGTACTATTCCA GGCGCTGTCATCTGGTGGCTTACTGTGTGCCAGGGACCTTGCTGTTTACTGCATGCCCAGTCATGCTGAT TCTCAGGGCATATTGGGTATTGCAGTTTGTGGGACCCGCTGGATCCTGGAAACAAATACCAGGATCAAGG GCACACCAGGAGTCGTAGTTTGAGGAAGCCGGGGCCTGCTGAGAATTTCTGTGGGCTATTTGGTTTGGGG ACCAGGCATGCAGATGCTGGAGATTAGAGCTGCTTGTTGCATGTTGAACCTGCAGCATGACCATGCATGA TGTGGTTTGGGGTGAGGGTGACATTGTGGTTTGAGGGGACACAGGGTGTGTTAGATATGGGGTAATCGAG GGCACATGTGGTTTGGGGTGACCGGAGTGGTGGAGGAAGAATGGGCGAGGTCTGTGGGTCTGGTTTGAGC CTCTCCCCCTCTCTCTCCCTTCCAGCTAGCCAAAGTCACCATCGTGGACCACCACGCCGCCACGGCCTCT TTCATGAAGCACCTGGAGAATGAGCAGAAGGCCAGGGGGGGCTGCCCTGCAGACTGGGCCTGGATCGTGC CCCCCATCTCGGGCAGCCTCACTCCTGTTTTCCATCAGGAGATGGTCAACTATTTCCTGTCCCCGGCCTT CCGCTACCAGGTGCCCACCCTAACTGGCTCTGCCAGCCTGGGCCCAGCTCTAATTCTAAGCAGCCCCTGG GGACCTCTAACCTTTCCTTTTCTTTACCTCCCCTCCCAACCCCATCATCTCTCTGCAGCCAGACCCCTGG AAGGGGAGTGCCGCCAAGGGCACCGGCATCACCAGGAAGAAGACCTTTAAAGAAGTGGCCAAGTGGGTCC CCTGGGAGCCCCGCTCTCCCACACACACCCTGGGGGCCCCACTCTCCCCCACACACCCTGGGGGACCCTG CCCCAGCAGTGTTCTGGGCCTACCACTCAGTATCCCAAAACCCTGTTGTGAGGGGGTTGGACCCTTGCCT GGGGAGGCCCTGCCTCTGTGCACCCAGGACACCCTCACACCTTCCTCTCCCGCAGCGCCGTGAAGATCTC CGCCTCGCTCATGGGCACGGTGATGGCGAAGCGAGTGAAGGCGACAATCCTGTATGGCTCCGAGACCGGC CGGGCCCAGAGCTACGCACAGCAGCTGGGGAGACTCTTCCGGAAGGCTTTTGATCCCCGGGTAGGGCTGA GCCCAGGGGAGCAGGGAGCTAGAAAGAGGGGGCTCTATCAGCATCTTCAGGGGTGCCCTGGAGGACAGGA AGTGTTACAAGTCAGGACTCATGAGGAACCCGGAACCACAGGTGTTCAGAGATCAAGTTGGGGCCTGAAT CTTGCACTGCCAGGGAGGCCAGAGTGAGGAGGGCAGGGCCTCCGGGGGCCACAGCACCCAGGACATCTGT CTTCCCACCCACAGGTCCTGTGTATGGATGAGTATGACGTGGTGTCCCTCGAACACGAGACGCTGGTGCT GGTGGTAACCAGCACATTTGGGAATGGGGATCCCCCGGAGAATGGAGAGGTGAGAACTTCCAGGAAAGGG GCTGCTGGGAATGAGGAGAGACTCAGAATTGGAGTGACTGGGCAGGAACCTCTGCCCAACACACACACAC ACACACACACACACACACACACACACACACACACACACACACACACACACACACACACGCCAGGATGGAA AGGGAGATGCTAAGAGACCCCTGGAGCCTGAAACCCCACACAAGCTACGCTCCCAGCCCACCCATGTGGC TGCCTCCCTGCAAGCACATTTGCTTAACTGCGCGTCCCCAAGTCATTTCCATTATCAGTGCAAGTTTTTA ATACAAGGAAGGCACATCCTGGCTGACCAAGAGGTTAGACTGTGCTCGGGCACTGACAAGAAAAACAGGG ATACGTCACTGAGGGCGGCTTCTAGGATGCGGGTAATGTTTCTTAATGGGATACTGGTTACACAGGTGTG TTCAGTTTGTAAAAATCCACAGAGCTGTACATTTACAACATGTGCAACACTATTCCAGCATTTTATTTTA TTTGTTTTATTTATTTTGAGAACCTATTTACGTTGCCCAGGCTGGCCTTGAACTCCTAGCCTCAAGAGAT CCTCCTGCCGCAGGCTCCTTTTTCAAAAGAAGAAATTGAGCGCTGTTTAGATGCCAACATAGATTAAATA ACTTCACTTTTTAAAAAGAAACACAAAGCTAGAGTACCATCATTGAATTCCTTCTCTTGCAAGCTTAGGT ATCTCTGAGGTGCCCCAGGCTAGGCTCATTTCTGAGTCTTACCTGCTCCAGCTTCTAGGTGTTAAAGGCC TTATTAGCACTAAGTACTTCCTCAGTACTCTTTTTTCTTTTTTCCTTTGAGACAGGGTCTCACTTTGTGG CCCAGGCTGGAGTGCAGTAGTACAATCACGGCTCACTGCAGCCTCAACCTCCTAGACTCAAGCAATCCTC CCACTTCAACCTCCCAAGTAGTTGGGACTACAGGCGCATGCCATGATGCCTAGCTAATTTTTGTATTTTT TATAGAGATGGGGTTTCGCCATGTTGCCCAGGCTGGTCTCTAACTCCTGGGTTCAAGCAATCCACCTGCC TCGGCCTCCCAAAGTGCTGCGATTATAGACGTGAGCCACTGCACCTGGCCCTCAGTATCTTAAGCAAGTT GGAATCTCGTGAAACCCTTTTTGCTGCCTTAGTGTCCGTTTCAGCCCTCATTCTGACCTACCTTTTCAAG AAAAATAGCACCAGCAATTGACTTTTTTTTAGCATAAAGGTGTATAGACACCCATATAACCTACAGCCTT CACAAGGCATAGCACATTTTCACCACCCTGGAAAGTTCCCTCATCAGTTCCTCACGTGAATCCCTTCCCA GTCTGTCTCCCTGCCAGAAGTGTCTGTCACCACAGAATAGTTTCGCCTGCTCTAGAACGGCACCTAGATG GAAGCACGCAGTGTTGCGGCGTCTCCTGCTGAGGCTGTTTTTGAGGCGCACTCGTGTTGCTGCGTGACTC AGTATTTCACTCATTCTGCTGCTGAGTGCCGTTCATTGTGTGAATATCCCCAGTTTGTTTACCCATTCTC TTGTTGGTGACACTTGGGCTGTTTCCAGGTCGGGGCTATTATGAATAAACCTGTTATGAACATTCTTGTA CCCGGCTTTTGTGGGCTTATGTTTTTATTTCTCTTGGGTAAATACCTAGGAGTAGAATTGGTAGGTCATA GGGTAGATGCATGTTTAATCTTTCACTTTTTTAAAAAATAAAACTGCCAGGCCAGGCGCGGTGGCTCACG CCTGTGATCCCAGCACTTTGGGAGGCCCAGGTGGGTGGATCACTTGAGGTCAGAAGCTCAAGACCAGCCT GGCCAACATGGCAAAACCCTGTCTCTACTAAAAATACAAAAATTAGCTGGGCATGGTGGCGCACGCCTAT AGTCCTAGCTACTCAGGAGGCTAGGCGGGAGAATTGCTTGAACCTGGGAGGTGGAGGTTGCAGTGAGCCG AGATCACGCCACTGCACTCCAGCCTGGGTGACAGAGCAAGAATTCTACTTAAAATAAAATACAAATAAAT AAAATAAAACTGTCAAACAGCAAAGCAAATTAAACTGCCCTTTAACATCTGTGCAGTTCAATGTATGTTA ATTTTATCCCAAATTTTTAACAAATCTAGGAATACAGCTCACAGAAAATGGGGTATATTCACTAAAAATA AGGAATATTTATAGCAAATTTGTTTGTAATACCCCACACTGGAAACAATTCAAATGACCATCGACAAATA CTGATAAATTGTGGTATATTCAAGTGCCATATCGCACTAAGTGTGAACGAAACACAACCACACACAACAG TGCAGGTGAATCTCAAAAAATGTGAAGAGAAGAAAAAGCCAGACCAAAGAATACATACTGTACTACAGGG TTCACTTTATATAAAGTTCAGAAACAGGCAGAACTAATCCACGGAGTTAGAAATTAGGAGAGGAGTTAGT CACTGGGATGGGGGTGGCAGTGACAGGAAGAAGGCACGAAGTTGGCTTCTAGGATGCGGGTAATGTTTGT TTGTTTGTTTGTTTGTTTGTTTTTGTTTTTGAGCTGGAGTCTCACTCTGTTGCCCAGGCTGGAGTGCAAT GGCGTGATCTCGGCTCACTGCAACCTCCGCCTCCCCGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCGAG TAGCTGGGATTACAGGTGCCCGCCACCATGGCCAGCTAATTTTTGTGTTTTTAGTAGAGACGCGGTTTCA CCATGTTGGCCAGGCTGGTCTTGAATCCCTGACCTCAGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGC CACCACGCCCAGCCACGGGTAATGTTTCTCGATGGGATGCTGGTTGCACAGGTGTGTTCAGTTTGTGAAA ACTTACAGAGTTGTACATTTACAACATGTGTGCACCTCTGGACTTGTGTTGCACGTTGACAAAACATTCA AAAATGAAATTCAAATCGTTCTTGCTAACTCTGGCGCACTTGGGAACCAGCACCCAGAGGCATCTGCAGT TGAGCACCAGATGCAGTTCCTTCCAGCTTCCTTCCCCCTGGGAGGTCCGCTTGATGCCACTTCTTCATGG CAGCACAAACAAGGCCATGGTCTTCTGAGGAGGGCAACCTGCACAATGTCTGCTAGTGACCAGGACACTG CTGAAGGAACTGAGAGTTTGTCCACCCATGAAATCCACTAAAACAGGAAAGATTTTGCTCTAGCCGTTGT TAGCCAGGAGTGAGGAAAGAGCTGTGCCCTCCCCTGCAGCTGCGAGGACGATCTGCCTGCCCCAACAAGT GGGGATTCAGCAACTCCACTTCTAAGGATTACCCAGCTGAAGCATTTAAAAGTGGGAGCAAGGCACACGT ACAAGGGCGTTTGAGAGAGCACCTGTTCCCAGACCACCGAGCTGCCCTTCAGTCTCAGTGAAGTACAATG TAGCCACTAAAAAGACTGAGGTCATGTTTTGGAAAGTCCAGGCCGGAGGATCGCTTGAGCCCAGGAGTTC AAGGCCAGACTGAACAACACAGCGAGACTCCATCTCTTCAGAAAATTTAAAAATTAACCAAGAGTGGTGG CACGCACCTATAGATCTAGCTACTAGGAAGGCAGAAAAATCCCTTAAGCCCAGGAGTCTGAGGTTACAGT GAATGATGATGGAGCCACTGCACCCCAACCTGGGCGACAGAGCAAGACCCATATCTAAAAACAATACTAC TACTTACGTCAATATTGTTGTATTGACCTGGAGGGATGTCTGCAATAAATTATTGATTAAAACCAAGGAA GTACAGTATGGTACCACTTTTACTTAAAAAAAAACTATAAATATGCACATGCACGTAAGTTCAAGGAAAA AGGGCTGGAAGGTTAACACCTGTCAATGGCGCATATGCCCGGAGGGAAGATGGGGTGGTCTTTGTCTTAT CACTTTACACATTTCTGTAATGTCATTTTTCAAAAACATCAGATCGCTTTTGAAATTTTCAAAACAAATA AAAATTAAGTTACAAATCAATAATAATGAGGATCAGCTGGTACAGTTTTAAACTTCTATGTAGTTTGAAA TGAAACAAAACTAACCCTGATGCAAACACTCCCCTCGCCAGAGCTTTGCAGCTGCCCTGATGGAGATGTC CGGCCCCTACAACAGCTCCCCTCGGCCGGAACAGCACAAGTGAGTTGGGTGAGAGTTTGGGGGAGCTGGG GGAGCTGATGCATTTGGAGACACAAACAGAAAGGGGGTCTGAAAAGCTCTCCCTCTGTGCCTCAAGTCGT TTTCCCACCAAAAGCCAGGGCTCCAGGATGCCCTCCATTCCAGGCTGCAATGGCAGTCCAGACCTGCCTG CTTCTGAGAGCCGGGACAGTCCTGAGGTCTTCAGAGATGGGGGTGTGGTGTGTCAGGGCCCCAGGCTCGG AACCCCAGGGATGCTGGCCCTCAGCCCCTCCCAAGGGCAGGGCCTTTCCTGTCCCAGAGGCAGAGACCCT GAAGCCGTCCCTGGGGCTGGGGCTGGGCCTAGCCTGTATCCCCAGGGCCCTGTGACAACCTTGTCTTTGT CCTCTCTTGCCAGGAGTTATAAGATCCGCTTCAACAGCATCTCCTGCTCAGACCCACTGGTGTCCTCTTG GCGGCGGAAGAGGAAGGAGTCCAGTAACACAGACAGTGCAGGGGCCCTGGGCACCCTCAGGTCAGGGCCT CACCAAGAGGGGTGCAACGGGTGGGCAAGCTGCCTGGGCAAACGTGGCCTGCAAAGGGAGCTCCACTGAC GACCCCTGCACCCCAGGTTCTGTGTGTTCGGGCTCGGCTCCCGGGCATACCCCCACTTCTGCGCCTTTGC TCGTGCCGTGGACACACGGCTGGAGGAACTGGGCGGGGAGCGGCTGCTGCAGCTGGGCCAGGGCGACGAG CTGTGCGGCCAGGAGGAGGCCTTCCGAGGCTGGGCCCAGGCTGCCTTCCAGGTGAGCCCAGCCCAGCCCC TGCTCTGACTCCTGCCCCCTGGGATGCCTCCTCCTGCCTCACTCTGCCCTGATTCTGTTTGGTTCTTTGG TCCCTTCCTGTTCCTTCCAAAATCCACCCTCATCTCTCCATGGCATAGCCAGCTCTTCTGGGTCAGGGGC AGAGGATGACATGGCCCTGCCGACCACAGGGGTGCCTAGCCCAGGCAGAAGTGCAGCCGAAAGAGAGCAG GCAGGGCCCTGGCAGGAGGGAGCTTCAGCCAGGCACAGGCTGGGCCTCACAAGTGGGCGCACAAAGGGAG GGGGTGCAGGGCAGGGCAGGGGACCCCACCCAGGATGGGCAGGATGGAGGGAGAAGGAAGGGACAGAGAG AAGGTCAGACAGAGGCAAGGGCTGAAGCTGAGGCCAGCACAGAAGCCACAGGAAGCCAGAGGCCAGACAG CCTGGGGCGGTGCCTGCACCGCAGAACTGGTCCCGGGCCGGGCAAGCAAGCACAGGGAGAGGTGGATCCC TGGGGGCTGTGGCTTTTTAAGCCTGGGCTTCCTCAGGGGCAGTGCTGCCTGTCTGGGGATCATGTCTGCA GTTGACAAGGGCTCGGTCTCCCCAGTGCCACACTGTTCAGGGCAGTGCTGCTGTCCCGGGGCCCAGGCTG GAGCTCAGCAGATTTGCCTTGATTGGAGGAGGAGGGCATCCTAGGAGGAGAGGGAGTGGGGGCTACCTCA GGGACGGGGAGGTCAGGCTGCAGAAACACATAGGCCCTGATTGGGAAGAAGGGAACGGAAAATAAGACTT AAAGAATTTAAACAAAAAGAGCCATTGCAGCGGGATGAGACCACATCATCAGGTTTTGGGAATAGGACTT TAGAGGCGTAGGATCCATTACAGCATCACCGAACCAGAAGCAGGAAGGCTGAGCTAAGCAGAGCAGCAGC AGTGGAGATAGGAAGGAAGGGAGGGAGGGGCCGAGGAAGGAAGGAAGAGATATAAGACTTCACACGCACC ACAAAAGAAAGATTAACGGGACTTGGTGATATGAGGCTCAGCCAATCACGGGTGAGCCCTGCATTTCAAG CCTGGGACTGGCCCAGCAGTTTTCCAGCTGTGTGCCTGACCAGGAGTAGACGGGATCCACACCCTCCCAG GGATCTGCCCCGTGGGGTCCCCTCTGCCGCCCGAATTGTGCGTCCCTTCCCAGGAGCACTTACTATCTGC ACGCACTTTGTGGAAAGCTAAGGGCTTTACATAAAGTATCTCATTTAATCTTCACCAGAACACAATGAGG TGTAAAGATGGGGAAACTGAGGCATGTCACTGTAAGTACGGGATTCGGAATTTGAATGCAGGTCTGAACA CACAGACGCCTTCACAGAGCTACCGTGTGCCAAGCACTATGCTTCTCGGATCACGGGATTAACACGCACC AGATAAGGAACGATGCACCAATCAGGACGTGCAGAGAAAGAGCCAGCCGGGTCCCTGGGCCCAGCGGCCA ATCCATGAAATGGGCTGGCGGAAAAGGTGCTGTCCTTGGCGCCGGCCTCAGCCACTGGGGCTGCCAACCC CCCAGGAGCAAGACGCAGTGAAGCCGCCCAGGCGCCTCACTAGGGCGACCCCTGGTGGCGGGAGGTCCTC AGCCCTCACCGGCCTGTCCCGCAGGCCGCCTGTGAGACCTTCTGTGTGGGAGAGGATGCCAAGGCCGCCG CCCGAGACATCTTCAGCCCCAAACGGAGCTGGAAGCGCCAGAGGTACCGGCTGAGCGCCCAGGCCGAGGG CCTGCAGTTGCTGCCAGGTGGGCCCTGCCCTCACCCTAACCCGGCTGGTTCTCTGAGGCCCCCACACCCC GGGACTAAAGCACTCTGGGGCCAGGCCCTGCTCCCTAGCTCAGGCTGCCTCATTTGCCCCTCCCCGCCCC CAGGTCTGATCCACGTGCACAGGCGGAAGATGTTCCAGGCTACAATCCGCTCAGTGGAAAACCTGCAAAG CAGCAAGTCCACGTGAGGACGACGGCTTTACCGCCCCCCCACCCCTGTCCTGAACACCCTGACCCTGGAC CCTCCTCCTCCCACATTCTCCCGCCCCCACCCCTCTCTGACTCCCCATAAGTGCCCCTCTCCCCACCCCC AGGAGGGCCACCATCCTGGTGCGCCTGGACACCGGAGGCCAGGAGGGGCTGCAGTACCAGCCGGGGGACC ACATAGGTGTCTGCCCGCCCAACCGGCCCGGCCTTGTGGAGGCGCTGCTGAGCCGCGTGGAGGACCCGCC GGCGCCCACTGAGCCCGTGGCAGTAGAGCAGCTGGAGAAGGGCAGCCCTGGTGAGGGGCAGCCTGGGAAG CAACAGGGCACACCAGCCCCATGCCCAGCCCCACCCCCGGCCCCAGGCCTCCAGGAGCTCAGGACCCGAC CCAGGGGGTGGCCACCTCCTCCACAGCTCAGCAGGCAGGCTCAGAGCTGGCTGTGCTGCCCACTGCCGGG CTGGCCTTGTTGCTGGACCATCCCCACACCCTCAAATGCACCCCCACCAAAAGGCTGTCCCCTCCCTCTG GGCTCCTCTCCGAGGCTCCCCTAGCAATCTAGCTTGCTCTGGAGCTGGCACTGGGGCTATTTGCTGCCAC ATCAATGCCTGGGCTTTATTTAAAATAAGGGGGTGGAGTCAGAGGCAGAGGAGCCCAGACCAACCCAGTC CGGCCAGGGGCCCCCGAACAATACACTGAGGCTACCTAGACAGGCCGACCCCGCTGCTCAAGGGCAGGCT CTCTAACAGTCACCAAAACACAAACATCAGCCCAGGTACTGCAGTCCTGCTGGGCCCTGTCCTCAGAGCT CCCTGTGCACTATCCCCAGGTGGCCCTCCCCCCGGCTGGGTGCGGGACCCCCGGCTGCCCCCGTGCACGC TGCGCCAGGCTCTCACCTTCTTCCTGGACATCACCTCCCCACCCAGCCCTCAGCTCTTGCGGCTGCTCAG CACCTTGGCAGAAGAGCCCAGGGAACAGCAGGAGCTGGAGGCCCTCAGCCAGGTTGGGGGCCACCCCAAT GAGGCACAGGGGCTAGAGAGACGGGATGAGCTGGGGGGACCCCAGTGGCAGGAAACCCCCATGCAAAGTC CCCCCTGGACTTTCTTCTCCTGGCCGACATGCACTGGTGCTTTAAGACCCAGCTCCTCAGGGAGGAATTC ATGGCTGGATTCTCCAGGTCTTAGAGAAAACTCTATTGGCCTGAACTGAGCAGGGAGAAACCCTAAAGAG GCTCAGTGGGGGAGGGGTCAAGAAGGGAGGTTACTAGGAAGGGCTATGGGGCCTCCAACCCACTGCATCC TGCCCCGCCAGGATCCCCGACGCTACGAGGAGTGGAAGTGGTTCCGCTGCCCCACGCTGCTGGAGGTGCT GGAGCAGTTCCCGTCGGTGGCGCTGCCTGCCCCACTGCTCCTCACCCAGCTGCCTCTGCTCCAGCCCCGG TACTACTCAGTCAGCTCGGCACCCAGCACCCACCCAGGAGAGATCCACCTCACTGTAGCTGTGCTGGCAT ACAGGACTCAGGGTGAGGCAACAAGCAGGAGCAGGCCTGGCCACAGCAGGGTTGGGACCGGCCCCTCTCT GGCCCCTCACCGGCCTCTCCTTCCCACCCCCAGATGGGCTGGGCCCCCTGCACTATGGAGTCTGCTCCAC GTGGCTAAGCCAGCTCAAGCCCGGAGACCCTGTGCCCTGCTTCATCCGGGGGTAAGTGAGATGGAAGACT TGGTGGGGAGCTGCCCAGGGTCAGGGTGGCAGCTTTGGTGAGGAGTGTCACTGGTGAGGGGTGTCACTGG AAACAGGAAGGAGCTCTGTAACATGTCAAGGGTGTGGTGTCATTAGGTCACTTCAGAACTCTGGCTAAGC TTTGGCTCTCTCATTCATTTAGACTCAGAGTTCTGCCCTGAAACTATAGCTCCCAGAGCCAGAGCTGGGA TCAAACCGGCTGGCCCTGTGGCTTTCTGAAAGCTTCTGTGTTCCTCTCTATGTCCCTGGGCTGTCTGATG TTGGGCAGCATGGCACCTGGGAACTACAGTCACTAAATCCTCACTCAATCCAGGGAGAACTACTAGTTAG GGTTAAGACCACCCTTGGCCTTGGTGTCACCAAGGACTCAAAGAAGGTGAAGGTTTTGGTTTTTTTTTCC CCCAGAGATGGAGTCTTGCTCTGTCGCCCAGGCTGGAGTGCAGTGGTACGATCTCGGCTTACTGCAACCT CCGCCTCCCGGGTTCAAGAGATTCTCCTATGGCGTGAACCTGGGAGGTGGAGCTTGCAGTGAGCCAAGAT TGTGCCACTGCACTCCAGCCTGGGCGACAGAGCCAGACTCTGTCTCAAAAAAAAAAAAAAAAATATTCTC CTGTCTCAGCCTCCTGAGTAGCTGGGATTACAGGCACCCACCACCACGCCCAGCTAATTTTTGTATTTTT AGTAGAGACGGTGTTTCACTATGTTGGCCAGGCTGGTCTCGAGCTCCTGACCTCACGATCCTCCCACCTC CGCCTCCCAAAGTCTTGGGATTACAGGTGTGAGCCACCGCGCCCGGACCGAGGGTGAAGGATTTTAAGAG ACCCTTCCTTCATGCTGTGTCCAGAAGTCTTGCCCGCTCTCGCAGCCAGGAACCAAAAGTCCTGGTAGGA CTGAGAACAGTTCCTAGGCTGCCATCAGCTGGGCCTGGTGATTCAAATCCACCCAGGTGGCTAAACTACA AATAAACCGTACCCATCTACTGAACATAAACTAAATACCACTATTAAGGATACTTAAAATAAACACACTT AGTGAACCCATTATGAACTGAAAGTGTCTTTCACCCTTCCCACGTTTTCTAAATCCCCTGAGTCATCTAA GTATTCTTCAATCCAAAATGAACTATATTTCCTTTGGTGCAATCTCCAGAAACCACAGATCCAAGGAGTT TCAGCAAGTAGAGTTGTTTTTTGTTTTTTGTTTTTTTTTTAATTTTTTTTTGAGATGGGAAGAACTTGGG TCCTCCTTGCTCCACCCACCCTGCATGGTGAGAATGGTGGAGCAGGAAAGGCAAAGGGGACCTGATGGAG TGTCTCTCCTGCCAGGGCTCCCTCCTTCCGGCTGCCACCCGATCCCAGCTTGCCCTGCATCCTGGTGGGT CCAGGCACTGGCATTGCCCCCTTCCGGGGATTCTGGCAGGAGCGGCTGCATGACATTGAGAGCAAAGGTG AGGCTGGGGACTAAAGGACTGCCTGAAGGGAGTCACACAATCTAGGGACAGAGGGGTGGGGCTGGAAGGC AGGAAATAGGAAAGAGAGGGCAGGAAACAAAGTCCACAAAGCTGAAAAGACGCTCATGAGACCAAGGGGA GGGCAGGTACCAAAGGCAAGGGCTGGGCCCTGAGCTTCTGGCTTCCTGGTGCCTGGTACATAGTAGGTGT TGACTGGATTGAGGACAAAGGAAAATAGAATTTTCAAAGGGATTAGGGCTAAGACTCAAAGAAGAACTGC CCAAGGTGGATTCTTGACTGTGCCAGAGCTGACCGAGGTCTGTCCAAGACCTAAGGATGCTACAAGGTGT TCATATTGAGCATGGGGTGCCCAGGGTGGTCTGTCAATCAAAAGAAGAGGGCTGTGACTGGGAGGAGAGT TATAAGTATGGGAGAATATGAAGTGGGAGCGGGGAAGGGGACTGCGATGTCACACAATGCAAAGGGCATG GAATTCTGAGTCCGAAGCCGCGCATTCTAGCGCAGCTCCACCAGGGGCCACCACCTCACCCGCGCTTCCC TTCCCTCTGTAAATCAGGGCTGTGCAGGGTCTCTGTGAAAGCATTCTACACTCTCTTAGAGATGAAACAG CCAAAGTAATGGTGGTTTCAGCCCAAAACGCTGGGCTGCCAGGCTGGGCGACGGTGGCCTGTGGGGAGGC CCCACTAGCACTGTGCCCCGGAGAAGAGCCTTCCCAAGCGCGGGGTTGCTTGCAGGGCTGCAGCCCACTC CCATGACTTTGGTGTTCGGCTGCCGATGCTCCCAACTTGACCATCTCTACCGCGACGAGGTGCAGAACGC CCAGCAGCGCGGGGTGTTTGGCCGAGTCCTCACCGCCTTCTCCCGGGAACCTGACAACCCCAAGGTGTGA GACCCTGAGGGCGCAATGGTAACCTGAAGATAGGGAGAGAGGGGAGGACTCGCGCTCTCCAGCGGGGCAC ACCAACCACGGCCCTCCCGTGGCCTCCCACGACCACTCAGCCACCCCTGCACACTCTGGCCCACCCTTGT GCCCCGGCCCCTCTAGGCCCGCCTCCTCCCGCCCCTGCCCCGCCCCTTTGGCTCTGCCCCTGTTGACACC GCCCCAGGGCACGCAGGCCCCACCAGGCCCGCTCCGGAGACTTTCACGTCCAGGGCCAGCCAGCAGCCCC GGGCTGCGCCCCCGCGCCCACCCCCACCAGGGCCCGCCCTAACCCCGCCGCCCCGCAGACCTACGTGCAG GACATCCTGAGGACGGAGCTGGCTGCGGAGGTGCACCGCGTGCTGTGCCTCGAGCGGGGCCACATGTTTG TCTGCGGCGATGTTACCATGGCAACCAACGTCCTGCAGACCGTGCAGCGCATCCTGGCGACGGAGGGCGA CATGGAGCTGGACGAGGCCGGCGACGTCATCGGCGTGCTGCGGGTGCGGAGGGGCGGGCCGGGCCTGAGC GTGCGGGGTTCCTGCTAAGGTCTCCGAGTCGGGTTCTGATCCACTGTGCTCTTTTCCGACAGGATCAGCA ACGCTACCACGAAGACATTTTCGGGCTCACGCTGCGCACCCAGGAGGTGACAAGCCGCATACGCACCCAG AGCTTTTCCTTGCAGGAGCGTCAGTTGCGGGGCGCAGTGCCCTGGGCGTTCGACCCTCCCGGCTCAGACA CCAACAGCCCCTGAGAGCCGCCTGGCTTTCCCTTCCAGTTCCGGGAGAGCGGCTGCCCGACTCAGGTCCG CCCGACCAGGATCAGCCCCGCTCCTCCCCTCTTGAGGTGGTGCCTTCTCACATCTGTCCAGAGGCTGCAA GGATTCAGCATTATTCCTCCAGGAAGGAGCAAAACGCCTCTTTTCCCTCTCTAGGCCTGTTGCCTCGGGC CTGGGTCCGCCTTAATCTGGAAGGCCCCTCCCAGCAGCGGTACCCCAGGGCCTACTGCCACCCGCTTCCT GTTTCTTAGTCGAATGTTAGATTCCTCTTGCCTCTCTCAGGAGTATCTTACCTGTAAAGTCTAATCTCTA AATCAAGTATTTATTATTGAAGATTTACCATAAGGGACTGTGCCAGATGTTAGGAGAACTACTAAAGTGC CTACCCCAGCTCATGTGGATTACA Download Select all
Length	23544
OMIM ID	163729
HGNC ID	HGNC:7876
Unigene ID	Hs.647092
Ensembl ID	ENSG00000164867
PharmGKB ID	PA254

mRNA Information

mRNA ID	NM_000603.4
Exon	join(1..245,2698..2906,4148..4259,5349..5497,5708..5870, 7302..7393,7484..7625,7891..8030,8135..8309,9443..9544, 10176..10370,10489..10562,10766..10910,11145..11249, 15372..15439,15834..15950,16047..16221,17875..18007, 18134..18212,18343..18530,19060..19232,19542..19752, 19844..19931,21296..21417,22176..22324,22669..22863, 22953..23544)
mRNA Sequence	>4846 ACTGAAACTAGGGGCAAGGAGACGAAGAGAACATGAAAGTTAAACTTTAAGATGAAGAACAAAG CTGAACATACTGATGCATTGGATCTTTGGAGAGGATCTCAGAACTCATTGTACTTAATTTACAG GCTAAAACCTTAGAAGAGGAATTTATTATATCCTACACAAGACTCCAGGGAAGCACATGGCCTT GGACTGAAGGCTGGCATCTGGAAGCTGTCAGCCACCAGCACCTTCTGCAGCAGGAAAAGGCCAG GGCTCTGCTGGAGCAGGCAGCAGAGTGGACGCACAGTAACATGGGCAACTTGAAGAGCGTGGCC CAGGAGCCTGGGCCACCCTGCGGCCTGGGGCTGGGGCTGGGCCTTGGGCTGTGCGGCAAGCAGG GCCCAGCCACCCCGGCCCCTGAGCCCAGCCGGGCCCCAGCATCCCTACTCCCACCAGCGCCAGA ACACAGCCCCCCGAGCTCCCCGCTAACCCAGCCCCCAGAGGGGCCCAAGTTCCCTCGTGTGAAG AACTGGGAGGTGGGGAGCATCACCTATGACACCCTCAGCGCCCAGGCGCAGCAGGATGGGCCCT GCACCCCAAGACGCTGCCTGGGCTCCCTGGTATTTCCACGGAAACTACAGGGCCGGCCCTCCCC CGGCCCCCCGGCCCCTGAGCAGCTGCTGAGTCAGGCCCGGGACTTCATCAACCAGTACTACAGC TCCATTAAGAGGAGCGGCTCCCAGGCCCACGAACAGCGGCTTCAAGAGGTGGAAGCCGAGGTGG CAGCCACAGGCACCTACCAGCTTAGGGAGAGCGAGCTGGTGTTCGGGGCTAAGCAGGCCTGGCG CAACGCTCCCCGCTGCGTGGGCCGGATCCAGTGGGGGAAGCTGCAGGTGTTCGATGCCCGGGAC TGCAGGTCTGCACAGGAAATGTTCACCTACATCTGCAACCACATCAAGTATGCCACCAACCGGG GCAACCTTCGCTCGGCCATCACAGTGTTCCCGCAGCGCTGCCCTGGCCGAGGAGACTTCCGAAT CTGGAACAGCCAGCTGGTGCGCTACGCGGGCTACCGGCAGCAGGATGGCTCTGTGCGGGGGGAC CCAGCCAACGTGGAGATCACCGAGCTCTGCATTCAGCACGGCTGGACCCCAGGAAACGGTCGCT TCGACGTGCTGCCCCTGCTGCTGCAGGCCCCAGATGATCCCCCAGAACTCTTCCTTCTGCCCCC CGAGCTGGTCCTTGAGGTGCCCCTGGAGCACCCCACGCTGGAGTGGTTTGCAGCCCTGGGCCTG CGCTGGTACGCCCTCCCGGCAGTGTCCAACATGCTGCTGGAAATTGGGGGCCTGGAGTTCCCCG CAGCCCCCTTCAGTGGCTGGTACATGAGCACTGAGATCGGCACGAGGAACCTGTGTGACCCTCA CCGCTACAACATCCTGGAGGATGTGGCTGTCTGCATGGACCTGGATACCCGGACCACCTCGTCC CTGTGGAAAGACAAGGCAGCAGTGGAAATCAACGTGGCCGTGCTGCACAGTTACCAGCTAGCCA AAGTCACCATCGTGGACCACCACGCCGCCACGGCCTCTTTCATGAAGCACCTGGAGAATGAGCA GAAGGCCAGGGGGGGCTGCCCTGCAGACTGGGCCTGGATCGTGCCCCCCATCTCGGGCAGCCTC ACTCCTGTTTTCCATCAGGAGATGGTCAACTATTTCCTGTCCCCGGCCTTCCGCTACCAGCCAG ACCCCTGGAAGGGGAGTGCCGCCAAGGGCACCGGCATCACCAGGAAGAAGACCTTTAAAGAAGT GGCCAACGCCGTGAAGATCTCCGCCTCGCTCATGGGCACGGTGATGGCGAAGCGAGTGAAGGCG ACAATCCTGTATGGCTCCGAGACCGGCCGGGCCCAGAGCTACGCACAGCAGCTGGGGAGACTCT TCCGGAAGGCTTTTGATCCCCGGGTCCTGTGTATGGATGAGTATGACGTGGTGTCCCTCGAACA CGAGACGCTGGTGCTGGTGGTAACCAGCACATTTGGGAATGGGGATCCCCCGGAGAATGGAGAG AGCTTTGCAGCTGCCCTGATGGAGATGTCCGGCCCCTACAACAGCTCCCCTCGGCCGGAACAGC ACAAGAGTTATAAGATCCGCTTCAACAGCATCTCCTGCTCAGACCCACTGGTGTCCTCTTGGCG GCGGAAGAGGAAGGAGTCCAGTAACACAGACAGTGCAGGGGCCCTGGGCACCCTCAGGTTCTGT GTGTTCGGGCTCGGCTCCCGGGCATACCCCCACTTCTGCGCCTTTGCTCGTGCCGTGGACACAC GGCTGGAGGAACTGGGCGGGGAGCGGCTGCTGCAGCTGGGCCAGGGCGACGAGCTGTGCGGCCA GGAGGAGGCCTTCCGAGGCTGGGCCCAGGCTGCCTTCCAGGCCGCCTGTGAGACCTTCTGTGTG GGAGAGGATGCCAAGGCCGCCGCCCGAGACATCTTCAGCCCCAAACGGAGCTGGAAGCGCCAGA GGTACCGGCTGAGCGCCCAGGCCGAGGGCCTGCAGTTGCTGCCAGGTCTGATCCACGTGCACAG GCGGAAGATGTTCCAGGCTACAATCCGCTCAGTGGAAAACCTGCAAAGCAGCAAGTCCACGAGG GCCACCATCCTGGTGCGCCTGGACACCGGAGGCCAGGAGGGGCTGCAGTACCAGCCGGGGGACC ACATAGGTGTCTGCCCGCCCAACCGGCCCGGCCTTGTGGAGGCGCTGCTGAGCCGCGTGGAGGA CCCGCCGGCGCCCACTGAGCCCGTGGCAGTAGAGCAGCTGGAGAAGGGCAGCCCTGGTGGCCCT CCCCCCGGCTGGGTGCGGGACCCCCGGCTGCCCCCGTGCACGCTGCGCCAGGCTCTCACCTTCT TCCTGGACATCACCTCCCCACCCAGCCCTCAGCTCTTGCGGCTGCTCAGCACCTTGGCAGAAGA GCCCAGGGAACAGCAGGAGCTGGAGGCCCTCAGCCAGGATCCCCGACGCTACGAGGAGTGGAAG TGGTTCCGCTGCCCCACGCTGCTGGAGGTGCTGGAGCAGTTCCCGTCGGTGGCGCTGCCTGCCC CACTGCTCCTCACCCAGCTGCCTCTGCTCCAGCCCCGGTACTACTCAGTCAGCTCGGCACCCAG CACCCACCCAGGAGAGATCCACCTCACTGTAGCTGTGCTGGCATACAGGACTCAGGATGGGCTG GGCCCCCTGCACTATGGAGTCTGCTCCACGTGGCTAAGCCAGCTCAAGCCCGGAGACCCTGTGC CCTGCTTCATCCGGGGGGCTCCCTCCTTCCGGCTGCCACCCGATCCCAGCTTGCCCTGCATCCT GGTGGGTCCAGGCACTGGCATTGCCCCCTTCCGGGGATTCTGGCAGGAGCGGCTGCATGACATT GAGAGCAAAGGGCTGCAGCCCACTCCCATGACTTTGGTGTTCGGCTGCCGATGCTCCCAACTTG ACCATCTCTACCGCGACGAGGTGCAGAACGCCCAGCAGCGCGGGGTGTTTGGCCGAGTCCTCAC CGCCTTCTCCCGGGAACCTGACAACCCCAAGACCTACGTGCAGGACATCCTGAGGACGGAGCTG GCTGCGGAGGTGCACCGCGTGCTGTGCCTCGAGCGGGGCCACATGTTTGTCTGCGGCGATGTTA CCATGGCAACCAACGTCCTGCAGACCGTGCAGCGCATCCTGGCGACGGAGGGCGACATGGAGCT GGACGAGGCCGGCGACGTCATCGGCGTGCTGCGGGATCAGCAACGCTACCACGAAGACATTTTC GGGCTCACGCTGCGCACCCAGGAGGTGACAAGCCGCATACGCACCCAGAGCTTTTCCTTGCAGG AGCGTCAGTTGCGGGGCGCAGTGCCCTGGGCGTTCGACCCTCCCGGCTCAGACACCAACAGCCC CTGAGAGCCGCCTGGCTTTCCCTTCCAGTTCCGGGAGAGCGGCTGCCCGACTCAGGTCCGCCCG ACCAGGATCAGCCCCGCTCCTCCCCTCTTGAGGTGGTGCCTTCTCACATCTGTCCAGAGGCTGC AAGGATTCAGCATTATTCCTCCAGGAAGGAGCAAAACGCCTCTTTTCCCTCTCTAGGCCTGTTG CCTCGGGCCTGGGTCCGCCTTAATCTGGAAGGCCCCTCCCAGCAGCGGTACCCCAGGGCCTACT GCCACCCGCTTCCTGTTTCTTAGTCGAATGTTAGATTCCTCTTGCCTCTCTCAGGAGTATCTTA CCTGTAAAGTCTAATCTCTAAATCAAGTATTTATTATTGAAGATTTACCATAAGGGACTGTGCC AGATGTTAGGAGAACTACTAAAGTGCCTACCCCAGCTCATGTGGATTACAAAAAAAA Download Select all
Length	4345

CDS Information

Location	join(2749..2906,4148..4259,5349..5497,5708..5870, 7302..7393,7484..7625,7891..8030,8135..8309,9443..9544, 10176..10370,10489..10562,10766..10910,11145..11249, 15372..15439,15834..15950,16047..16221,17875..18007, 18134..18212,18343..18530,19060..19232,19542..19752, 19844..19931,21296..21417,22176..22324,22669..22863, 22953..23114)
CDS Sequence	>gi\|231571207:297-3908 Homo sapiens nitric oxide synthase 3 (endothelial cell) (NOS3), transcript variant 1, mRNA ATGGGCAACTTGAAGAGCGTGGCCCAGGAGCCTGGGCCACCCTGCGGCCTGGGGCTGGGGCTGGGCCTTG GGCTGTGCGGCAAGCAGGGCCCAGCCACCCCGGCCCCTGAGCCCAGCCGGGCCCCAGCATCCCTACTCCC ACCAGCGCCAGAACACAGCCCCCCGAGCTCCCCGCTAACCCAGCCCCCAGAGGGGCCCAAGTTCCCTCGT GTGAAGAACTGGGAGGTGGGGAGCATCACCTATGACACCCTCAGCGCCCAGGCGCAGCAGGATGGGCCCT GCACCCCAAGACGCTGCCTGGGCTCCCTGGTATTTCCACGGAAACTACAGGGCCGGCCCTCCCCCGGCCC CCCGGCCCCTGAGCAGCTGCTGAGTCAGGCCCGGGACTTCATCAACCAGTACTACAGCTCCATTAAGAGG AGCGGCTCCCAGGCCCACGAACAGCGGCTTCAAGAGGTGGAAGCCGAGGTGGCAGCCACAGGCACCTACC AGCTTAGGGAGAGCGAGCTGGTGTTCGGGGCTAAGCAGGCCTGGCGCAACGCTCCCCGCTGCGTGGGCCG GATCCAGTGGGGGAAGCTGCAGGTGTTCGATGCCCGGGACTGCAGGTCTGCACAGGAAATGTTCACCTAC ATCTGCAACCACATCAAGTATGCCACCAACCGGGGCAACCTTCGCTCGGCCATCACAGTGTTCCCGCAGC GCTGCCCTGGCCGAGGAGACTTCCGAATCTGGAACAGCCAGCTGGTGCGCTACGCGGGCTACCGGCAGCA GGATGGCTCTGTGCGGGGGGACCCAGCCAACGTGGAGATCACCGAGCTCTGCATTCAGCACGGCTGGACC CCAGGAAACGGTCGCTTCGACGTGCTGCCCCTGCTGCTGCAGGCCCCAGATGATCCCCCAGAACTCTTCC TTCTGCCCCCCGAGCTGGTCCTTGAGGTGCCCCTGGAGCACCCCACGCTGGAGTGGTTTGCAGCCCTGGG CCTGCGCTGGTACGCCCTCCCGGCAGTGTCCAACATGCTGCTGGAAATTGGGGGCCTGGAGTTCCCCGCA GCCCCCTTCAGTGGCTGGTACATGAGCACTGAGATCGGCACGAGGAACCTGTGTGACCCTCACCGCTACA ACATCCTGGAGGATGTGGCTGTCTGCATGGACCTGGATACCCGGACCACCTCGTCCCTGTGGAAAGACAA GGCAGCAGTGGAAATCAACGTGGCCGTGCTGCACAGTTACCAGCTAGCCAAAGTCACCATCGTGGACCAC CACGCCGCCACGGCCTCTTTCATGAAGCACCTGGAGAATGAGCAGAAGGCCAGGGGGGGCTGCCCTGCAG ACTGGGCCTGGATCGTGCCCCCCATCTCGGGCAGCCTCACTCCTGTTTTCCATCAGGAGATGGTCAACTA TTTCCTGTCCCCGGCCTTCCGCTACCAGCCAGACCCCTGGAAGGGGAGTGCCGCCAAGGGCACCGGCATC ACCAGGAAGAAGACCTTTAAAGAAGTGGCCAACGCCGTGAAGATCTCCGCCTCGCTCATGGGCACGGTGA TGGCGAAGCGAGTGAAGGCGACAATCCTGTATGGCTCCGAGACCGGCCGGGCCCAGAGCTACGCACAGCA GCTGGGGAGACTCTTCCGGAAGGCTTTTGATCCCCGGGTCCTGTGTATGGATGAGTATGACGTGGTGTCC CTCGAACACGAGACGCTGGTGCTGGTGGTAACCAGCACATTTGGGAATGGGGATCCCCCGGAGAATGGAG AGAGCTTTGCAGCTGCCCTGATGGAGATGTCCGGCCCCTACAACAGCTCCCCTCGGCCGGAACAGCACAA GAGTTATAAGATCCGCTTCAACAGCATCTCCTGCTCAGACCCACTGGTGTCCTCTTGGCGGCGGAAGAGG AAGGAGTCCAGTAACACAGACAGTGCAGGGGCCCTGGGCACCCTCAGGTTCTGTGTGTTCGGGCTCGGCT CCCGGGCATACCCCCACTTCTGCGCCTTTGCTCGTGCCGTGGACACACGGCTGGAGGAACTGGGCGGGGA GCGGCTGCTGCAGCTGGGCCAGGGCGACGAGCTGTGCGGCCAGGAGGAGGCCTTCCGAGGCTGGGCCCAG GCTGCCTTCCAGGCCGCCTGTGAGACCTTCTGTGTGGGAGAGGATGCCAAGGCCGCCGCCCGAGACATCT TCAGCCCCAAACGGAGCTGGAAGCGCCAGAGGTACCGGCTGAGCGCCCAGGCCGAGGGCCTGCAGTTGCT GCCAGGTCTGATCCACGTGCACAGGCGGAAGATGTTCCAGGCTACAATCCGCTCAGTGGAAAACCTGCAA AGCAGCAAGTCCACGAGGGCCACCATCCTGGTGCGCCTGGACACCGGAGGCCAGGAGGGGCTGCAGTACC AGCCGGGGGACCACATAGGTGTCTGCCCGCCCAACCGGCCCGGCCTTGTGGAGGCGCTGCTGAGCCGCGT GGAGGACCCGCCGGCGCCCACTGAGCCCGTGGCAGTAGAGCAGCTGGAGAAGGGCAGCCCTGGTGGCCCT CCCCCCGGCTGGGTGCGGGACCCCCGGCTGCCCCCGTGCACGCTGCGCCAGGCTCTCACCTTCTTCCTGG ACATCACCTCCCCACCCAGCCCTCAGCTCTTGCGGCTGCTCAGCACCTTGGCAGAAGAGCCCAGGGAACA GCAGGAGCTGGAGGCCCTCAGCCAGGATCCCCGACGCTACGAGGAGTGGAAGTGGTTCCGCTGCCCCACG CTGCTGGAGGTGCTGGAGCAGTTCCCGTCGGTGGCGCTGCCTGCCCCACTGCTCCTCACCCAGCTGCCTC TGCTCCAGCCCCGGTACTACTCAGTCAGCTCGGCACCCAGCACCCACCCAGGAGAGATCCACCTCACTGT AGCTGTGCTGGCATACAGGACTCAGGATGGGCTGGGCCCCCTGCACTATGGAGTCTGCTCCACGTGGCTA AGCCAGCTCAAGCCCGGAGACCCTGTGCCCTGCTTCATCCGGGGGGCTCCCTCCTTCCGGCTGCCACCCG ATCCCAGCTTGCCCTGCATCCTGGTGGGTCCAGGCACTGGCATTGCCCCCTTCCGGGGATTCTGGCAGGA GCGGCTGCATGACATTGAGAGCAAAGGGCTGCAGCCCACTCCCATGACTTTGGTGTTCGGCTGCCGATGC TCCCAACTTGACCATCTCTACCGCGACGAGGTGCAGAACGCCCAGCAGCGCGGGGTGTTTGGCCGAGTCC TCACCGCCTTCTCCCGGGAACCTGACAACCCCAAGACCTACGTGCAGGACATCCTGAGGACGGAGCTGGC TGCGGAGGTGCACCGCGTGCTGTGCCTCGAGCGGGGCCACATGTTTGTCTGCGGCGATGTTACCATGGCA ACCAACGTCCTGCAGACCGTGCAGCGCATCCTGGCGACGGAGGGCGACATGGAGCTGGACGAGGCCGGCG ACGTCATCGGCGTGCTGCGGGATCAGCAACGCTACCACGAAGACATTTTCGGGCTCACGCTGCGCACCCA GGAGGTGACAAGCCGCATACGCACCCAGAGCTTTTCCTTGCAGGAGCGTCAGTTGCGGGGCGCAGTGCCC TGGGCGTTCGACCCTCCCGGCTCAGACACCAACAGCCCCTGA Download Select all
CCDS ID	CCDS5912.1

Protein Information

Protein ID	NP_000594.2
Protein Name	Nitric oxide synthase 3 (endothelial cell)
Molecular Wt. (Da)	133144
Protein Sequence	>4846 MGNLKSVAQEPGPPCGLGLGLGLGLCGKQGPATPAPEPSRAPASLLPPAPEHSPPSSPLTQPPE GPKFPRVKNWEVGSITYDTLSAQAQQDGPCTPRRCLGSLVFPRKLQGRPSPGPPAPEQLLSQAR DFINQYYSSIKRSGSQAHEQRLQEVEAEVAATGTYQLRESELVFGAKQAWRNAPRCVGRIQWGK LQVFDARDCRSAQEMFTYICNHIKYATNRGNLRSAITVFPQRCPGRGDFRIWNSQLVRYAGYRQ QDGSVRGDPANVEITELCIQHGWTPGNGRFDVLPLLLQAPDDPPELFLLPPELVLEVPLEHPTL EWFAALGLRWYALPAVSNMLLEIGGLEFPAAPFSGWYMSTEIGTRNLCDPHRYNILEDVAVCMD LDTRTTSSLWKDKAAVEINVAVLHSYQLAKVTIVDHHAATASFMKHLENEQKARGGCPADWAWI VPPISGSLTPVFHQEMVNYFLSPAFRYQPDPWKGSAAKGTGITRKKTFKEVANAVKISASLMGT VMAKRVKATILYGSETGRAQSYAQQLGRLFRKAFDPRVLCMDEYDVVSLEHETLVLVVTSTFGN GDPPENGESFAAALMEMSGPYNSSPRPEQHKSYKIRFNSISCSDPLVSSWRRKRKESSNTDSAG ALGTLRFCVFGLGSRAYPHFCAFARAVDTRLEELGGERLLQLGQGDELCGQEEAFRGWAQAAFQ AACETFCVGEDAKAAARDIFSPKRSWKRQRYRLSAQAEGLQLLPGLIHVHRRKMFQATIRSVEN LQSSKSTRATILVRLDTGGQEGLQYQPGDHIGVCPPNRPGLVEALLSRVEDPPAPTEPVAVEQL EKGSPGGPPPGWVRDPRLPPCTLRQALTFFLDITSPPSPQLLRLLSTLAEEPREQQELEALSQD PRRYEEWKWFRCPTLLEVLEQFPSVALPAPLLLTQLPLLQPRYYSVSSAPSTHPGEIHLTVAVL AYRTQDGLGPLHYGVCSTWLSQLKPGDPVPCFIRGAPSFRLPPDPSLPCILVGPGTGIAPFRGF WQERLHDIESKGLQPTPMTLVFGCRCSQLDHLYRDEVQNAQQRGVFGRVLTAFSREPDNPKTYV QDILRTELAAEVHRVLCLERGHMFVCGDVTMATNVLQTVQRILATEGDMELDEAGDVIGVLRDQ QRYHEDIFGLTLRTQEVTSRIRTQSFSLQERQLRGAVPWAFDPPGSDTNSP Download Select all
Length	1203
Uniprot ID	O00299
Ensembl Protein ID	ENSP00000364934

Post-translational Modification Information (Source : HPRD)

Residue	Type	site
C	Palmitoylation	15
C	Palmitoylation	26
G	Myristoylation	2
S	Phosphorylation	1177
S	Dephosphorylation	1177
T	Dephosphorylation	495
Y	Phosphorylation	81;-
T	Phosphorylation	1175
S	Phosphorylation	633

Enzyme Information

EC	1.14.13.39
Name	nitric-oxide synthase (NADPH dependent) nitric oxide synthetase endothelium-derived relaxation factor-forming enzyme endothelium-derived relaxing factor synthase NO synthase NADPH-diaphorase
Class	Oxidoreductases; Acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2; With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
Sysname	L-arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming)
Substrate	L-arginine [CPD:C00062]; NADPH [CPD:C00005]; H+ [CPD:C00080]; O2 [CPD:C00007]; Nomega-hydroxy-L-arginine
Product	L-citrulline [CPD:C00327]; nitric oxide [CPD:C00533]; NADP+ [CPD:C00006]; H2O [CPD:C00001]; Nomega-hydroxy-L-arginine
Reaction (IUBMB)

PPi Information

(Click to view network : Source STRING) View

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
185	AGTR1	107	NP_114038.1	in vitro	10510297
624	BDKRB2	213	NP_000614.1	in vitro	1 068 150 110 510 290
627	BDNF	214	NP_001137282.1	in vitro	10493752
3320	HSP90AA1	777	NP_001017963.2	in vitro;in vivo;yeast 2-hybrid	117 442 391 212 422 000 000 000

Pathway Information

Pathway Name	Pathway ID
AGE-RAGE signaling pathway in diabetic complications	hsa04933
Arginine and proline metabolism	hsa00330
Arginine biosynthesis	hsa00220
Calcium signaling pathway	hsa04020
cGMP-PKG signaling pathway	hsa04022
Estrogen signaling pathway	hsa04915
HIF-1 signaling pathway	hsa04066
Insulin resistance	hsa04931
Metabolic pathways	hsa01100
Oxytocin signaling pathway	hsa04921
PI3K-Akt signaling pathway	hsa04151
Platelet activation	hsa04611
Sphingolipid signaling pathway	hsa04071
VEGF signaling pathway	hsa04370

Structure Information

No matching records could be found.

Domain Information

ID	Location	Description
cd00795	68-480	NOS_oxygenase_euk
cl00254	68-480	NOS_oxygenase superfamily
pfam02898	115-480	NO_synthase
cd00575	122-477	NOS_oxygenase
cd06202	762-1164	Nitric_oxide_synthase
cl06868	762-1164	FNR_like superfamily
cd00794	123-477	NOS_oxygenase_prok
COG4362	118-480	COG4362
cd06204	759-1159	CYPOR
cd06182	938-1160	CYPOR_like
pfam00667	752-979	FAD_binding_1
cl19189	752-979	FAD_binding_1 superfamily
cd06207	763-1155	CyPoR_like
cd06199	762-1160	SiR
cd06203	778-1159	methionine_synthase_red
cd06206	762-1160	bifunctional_CYPOR
pfam00258	522-698	Flavodoxin_1
cl00438	522-698	FMN_red superfamily
cd06201	938-1160	SiR_like2
cd00322	938-1140	FNR_like
cd06208	938-1156	CYPOR_like_FNR
cd06200	938-1160	SiR_like1
pfam00175	1011-1120	NAD_binding_1
cd06195	938-1119	FNR1
cd06216	938-1135	FNR_iron_sulfur_binding_2
cd06217	938-1120	FNR_iron_sulfur_binding_3
cd06209	938-1095	BenDO_FAD_NAD
cd06183	938-1119	cyt_b5_reduct_like
PRK08105	514-680	PRK08105
cd06188	938-1060	NADH_quinone_reductase
PRK09004	519-679	PRK09004
cd06184	938-1135	flavohem_like_fad_nad_binding
cd06191	938-1080	FNR_iron_sulfur_binding
PRK06703	519-677	PRK06703
cd06215	938-1067	FNR_iron_sulfur_binding_1
cd06187	938-1120	O2ase_reductase_like
cd06218	979-1135	DHOD_e_trans
cd06198	940-1129	FNR_like_3
cd06221	941-1082	sulfite_reductase_like
cd06194	974-1119	FNR_N-term_Iron_sulfur_binding
cd06211	938-1084	phenol_2-monooxygenase_like
cd06189	938-1060	flavin_oxioreductase
COG0369	512-1159	CysJ
TIGR01931	521-1160	cysJ
PRK06214	760-1160	PRK06214
PRK10953	521-1160	cysJ
TIGR03224	938-1156	benzo_boxA
PLN03116	970-1136	PLN03116
PLN03115	938-1135	PLN03115
COG1018	938-1183	Fpr
COG0543	938-1077	Mcr1
COG2871	938-1065	NqrF
PHA03247	34-121	PHA03247
PRK08345	974-1084	PRK08345
PHA03247	28-124	PHA03247
TIGR01941	938-1144	nqrF
pfam12526	34-70	DUF3729

Ontology Information

HPRD ID	351
Molecular Class	Enzyme: Synthase
Molecular Function	Structural molecule activity (GO:0005198)
Biological Process	Cell growth and/or maintenance (GO:0008151)

SNP Information

View SNP Geneview Report

Drug Information

Uniprot ID DrugBank ID Name Type
P29474 DB00997 Doxorubicin SmallMoleculeDrug
P29474 DB00125 L-Arginine SmallMoleculeDrug
P29474 DB00155 L-Citrulline SmallMoleculeDrug
P29474 DB00360 Tetrahydrobiopterin SmallMoleculeDrug
P29474 DB01110 Miconazole SmallMoleculeDrug
P29474 DB05676 Apremilast SmallMoleculeDrug

External Links

ArrayExpress GO
ICGC GO
Cancer3D GO
COSMIC GO
NCG GO
TSGene GO
Tumor Gene Family of Databases GO
CCDB GO
G2SBC GO
Osteosarcoma Database GO
RCDB GO

Uniprot ID	DrugBank ID	Name	Type
P29474	DB00997	Doxorubicin	SmallMoleculeDrug
P29474	DB00125	L-Arginine	SmallMoleculeDrug
P29474	DB00155	L-Citrulline	SmallMoleculeDrug
P29474	DB00360	Tetrahydrobiopterin	SmallMoleculeDrug
P29474	DB01110	Miconazole	SmallMoleculeDrug
P29474	DB05676	Apremilast	SmallMoleculeDrug

ArrayExpress	GO
ICGC	GO
Cancer3D	GO
COSMIC	GO
NCG	GO
TSGene	GO
Tumor Gene Family of Databases	GO
CCDB	GO
G2SBC	GO
Osteosarcoma Database	GO
RCDB	GO