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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
NOTCH2 4853 notch 2  1- 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
19653042   2009Cell line : HT29,SW480

Source : Department of Gastroinestinal surgery of Xijing Hospital,The fourth military hospital Xi'an, China.

Sample Type : CRC tumor and adjacent normal tissue

No. of Sample : 216

Stage : -

Immunohistochemistry, real-timeRT-PCR, Western blottingDown-regulation-Notch2 expression correlated closely with CRC and may play a role in tumor inhibition in colon carcinogenesis.

24223455   2013Cell line : -

Source : Fujian Provincial Hospital (Fuzhou, China).

Sample Type : CRC tumor and adjacent normal tissue

No. of Sample : -

Stage : -

Immunohistochemistry, real time RT-PCR, Western blottingDown-regulation- Increased LEF1 coexpression and decreased Notch2 coexpression represent a risk factor for poor overall survival of CRC patients.

22905095   2012Cell line : -

Source : First Affiliated Hospital, College of Medicine of Xi'an Jiaotong University.

Sample Type : CRC tumor and adjacent normal tissue

No. of Sample : 184

Stage : -

RNA-sequencing ,real time RT-PCRGene fusion-Tumor-restricted gene fusion, PRTEN-NOTCH2, was detected and experimentally confirmed


Gene Details



NC_000001.10 (120454176..120639880, complement)

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Gene Type protein coding
Gene Family Ankyrin repeat domain containing
Description This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]  
Chromosome 1
Location 1p13-p11
Start 120454176  
End 120639880  
Strand -  
Gene Sequence

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Length 185705  
OMIM ID 600275   
HGNC ID HGNC:7882   
Unigene ID Hs.487360   
Ensembl ID ENSG00000134250   
PharmGKB ID PA31684   

mRNA Information


mRNA ID NM_024408.3
Exon join(1..370,39717..39798,64116..64375,72372..72707, 82622..82744,99960..100193,101472..101627,102083..102271, 103215..103328,104138..104251,105897..106130, 110202..110312,114472..114664,116016..116161, 118867..118980,120578..120697,121138..121290, 127950..128178,128948..129149,131694..131847, 132238..132422,134100..134232,140492..140728, 143093..143205,143894..144399,145720..146067, 146926..147068,147258..147468,147895..147991, 149307..149475,150091..150392,151151..151298, 151942..152039,153010..158151)  
mRNA Sequence

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Length 11474  



CDS Information


   
Location298..7713
CDS Sequence

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CCDS ID CCDS908.1



Protein Information


      
Protein IDNP_077719.2
Protein Namenotch 2
Molecular Wt. (Da)239547
Protein Sequence

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Length 2471  
Uniprot IDO43516
Ensembl Protein ID ENSP00000272746  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SProteolytic Cleavage1665
GProteolytic Cleavage1696
TPhosphorylation1808
SPhosphorylation2070
SPhosphorylation2078
TPhosphorylation2068
SPhosphorylation2070
TPhosphorylation2074
SPhosphorylation2093
SPhosphorylation1841;-
SPhosphorylation1842;-
SPhosphorylation1854;-
SPhosphorylation1855;-
SPhosphorylation1845;-
TPhosphorylation1716
SPhosphorylation1778
TPhosphorylation1802
SPhosphorylation1804
SPhosphorylation2081
TPhosphorylation2097
TPhosphorylation2296
YPhosphorylation2023
TPhosphorylation2077
TPhosphorylation2295
TPhosphorylation436

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                           
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
3516RBPJ920NP_005340.2in vitro;in vivo9032325   
4086SMAD13356NP_005891.1yeast 2-hybrid15231748   
5664PSEN22860NP_000438.2in vivo11518718   
55534MAML310066NP_061187.2in vivo12370315   
84441MAML29608NP_115803.1in vivo12370315   


Pathway Information


                        
Pathway Name Pathway ID
Dorso-ventral axis formation hsa04320
MicroRNAs in cancer hsa05206
Notch signaling pathway hsa04330
Thyroid hormone signaling pathway hsa04919


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd002041938-2062  ANK
cl025291938-2062  ANK superfamily
cd002041872-1997  ANK
cl025291872-1997  ANK superfamily
cd00054182-218  EGF_CA
cl21504182-218  EGF_CA superfamily
cd000541026-1061  EGF_CA
cl215041026-1061  EGF_CA superfamily
cd00054873-909  EGF_CA
cl21504873-909  EGF_CA superfamily
cd00054757-793  EGF_CA
cl21504757-793  EGF_CA superfamily
cd000541151-1185  EGF_CA
cl215041151-1185  EGF_CA superfamily
cd00054456-492  EGF_CA
cl21504456-492  EGF_CA superfamily
cd00054495-530  EGF_CA
cl21504495-530  EGF_CA superfamily
cd000541225-1262  EGF_CA
cl215041225-1262  EGF_CA superfamily
cd00054949-985  EGF_CA
cl21504949-985  EGF_CA superfamily
cd00054911-947  EGF_CA
cl21504911-947  EGF_CA superfamily
cd00054415-454  EGF_CA
cl21504415-454  EGF_CA superfamily
cd00054682-717  EGF_CA
cl21504682-717  EGF_CA superfamily
cd00054608-643  EGF_CA
cl21504608-643  EGF_CA superfamily
cd00054532-568  EGF_CA
cl21504532-568  EGF_CA superfamily
cd000541188-1223  EGF_CA
cl215041188-1223  EGF_CA superfamily
cd00054987-1022  EGF_CA
cl21504987-1022  EGF_CA superfamily
cd00054795-831  EGF_CA
cl21504795-831  EGF_CA superfamily
cd00054260-296  EGF_CA
cl21504260-296  EGF_CA superfamily
cd00054298-335  EGF_CA
cl21504298-335  EGF_CA superfamily
cd00054645-679  EGF_CA
cl21504645-679  EGF_CA superfamily
cd00054570-604  EGF_CA
cl21504570-604  EGF_CA superfamily
cd000541312-1343  EGF_CA
cl215041312-1343  EGF_CA superfamily
cd000541117-1147  EGF_CA
cl215041117-1147  EGF_CA superfamily
cd000541264-1302  EGF_CA
cl215041264-1302  EGF_CA superfamily
cd002041904-2030  ANK
pfam068161539-1595  NOD
cl084491539-1595  NOD superfamily
pfam119362380-2445  DUF3454
cl133872380-2445  DUF3454 superfamily
cd002041971-2066  ANK
cd002041820-1930  ANK
pfam076841617-1673  NODP
cl066391617-1673  NODP superfamily
pfam000661499-1534  Notch
cl024191499-1534  Notch superfamily
pfam000661420-1456  Notch
cl024191420-1456  Notch superfamily
smart000041418-1455  NL
smart00179182-219  EGF_CA
smart00179873-909  EGF_CA
smart000041496-1534  NL
smart001791025-1061  EGF_CA
smart001791151-1185  EGF_CA
smart00179682-711  EGF_CA
smart00179456-492  EGF_CA
smart00179757-793  EGF_CA
smart00179494-530  EGF_CA
smart00179949-985  EGF_CA
smart00179415-454  EGF_CA
smart001791225-1262  EGF_CA
smart001791187-1223  EGF_CA
smart00179608-643  EGF_CA
cd00053185-216  EGF
pfam000231877-1908  Ank
smart00179911-947  EGF_CA
smart00179532-568  EGF_CA
pfam000231976-2008  Ank
smart00179987-1022  EGF_CA
smart00179795-831  EGF_CA
pfam00008186-217  EGF
smart00179298-335  EGF_CA
pfam07645182-213  EGF_CA
pfam000232011-2041  Ank
cd000531152-1185  EGF
pfam053872292-2421  Chorion_3
cl051162292-2421  Chorion_3 superfamily
PHA02887629-681  PHA02887
cl20100629-681  PHA02887 superfamily
cd000531028-1061  EGF
smart00179260-296  EGF_CA
pfam000231943-1975  Ank
pfam000081032-1059  EGF
smart000041459-1496  NL
cl024191459-1496  Notch superfamily
pfam000661461-1497  Notch
cd00053876-905  EGF
cd00053760-789  EGF
cd00053497-527  EGF
cd000531228-1260  EGF
pfam136061877-1905  Ank_3
smart00181185-216  EGF
pfam07645298-330  EGF_CA
pfam127961948-2040  Ank_2
pfam127961832-1940  Ank_2
pfam127961881-2007  Ank_2
COG06661879-2066  ANKYR
PHA030951794-2030  PHA03095
COG06661869-2014  ANKYR
COG06661874-2042  ANKYR
PHA028751877-2037  PHA02875
PHA028781841-2038  PHA02878
pfam127961981-2062  Ank_2
PHA030951889-2035  PHA03095
PHA031001820-2008  PHA03100
PHA031001879-2062  PHA03100
PHA028761801-2058  PHA02876
PHA028741874-2046  PHA02874
pfam072232130-2422  DUF1421
PHA028761878-2035  PHA02876
PHA030951820-1998  PHA03095
pfam031542144-2422  Atrophin-1
PHA028741884-2035  PHA02874
PHA032472068-2422  PHA03247
PLN031921873-2011  PLN03192
pfam136371979-2030  Ank_4
PHA028741874-2059  PHA02874
COG06661819-1931  ANKYR
pfam127961821-1907  Ank_2
pfam031542140-2442  Atrophin-1
PHA032472068-2407  PHA03247
PHA031001857-2044  PHA03100
PHA033792100-2395  PHA03379
pfam138571963-2017  Ank_5
PHA028761881-2035  PHA02876
PHA028761862-2063  PHA02876
PHA028781968-2096  PHA02878
pfam138571896-1951  Ank_5
PHA028741927-2064  PHA02874
pfam138571862-1917  Ank_5
pfam136371880-1930  Ank_4
PHA028751822-2014  PHA02875
PTZ003221963-2032  PTZ00322
pfam097702269-2394  PAT1
PHA029461859-2016  PHA02946
PHA032472098-2403  PHA03247
PLN031921948-2062  PLN03192
pfam031542095-2422  Atrophin-1
PHA033782272-2424  PHA03378
pfam051092077-2390  Herpes_BLLF1
PRK102632296-2422  PRK10263
PRK123232273-2444  PRK12323
pfam072232204-2446  DUF1421
PTZ003221982-2070  PTZ00322
pfam136371944-1997  Ank_4
PLN031921874-2037  PLN03192
PTZ003221766-1942  PTZ00322
PRK070032269-2422  PRK07003
pfam138571996-2050  Ank_5
PHA029461942-2072  PHA02946
PTZ003221882-1975  PTZ00322
pfam06247777-938  Plasmod_Pvs28
PHA028761796-1970  PHA02876
PHA029461949-2015  PHA02946
pfam138571929-1984  Ank_5


Ontology Information


   
HPRD ID1276
Molecular ClassCell surface receptor
Molecular FunctionMolecular function unknown (GO:0005554)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO