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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
NOTCH3 4854 notch 3  19CASIL 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
24525742   2014Cell line : -

Source : -

Sample Type : -

No. of Sample : -

Stage : -

-Up-regulation- NOTCH3-specific drugs could represent a valuable strategy to limit NOTCH signaling in the context of colorectal cancers overexpressing this receptor.

24728738   2014Cell line : -

Source : -

Sample Type : CRC tumor and normal tissue

No. of Sample : 305

Stage : TNM Stage II, III

ImmunohistochemistryUp-regulation-Nuclear Notch3 expression might be a novel predictive marker for recurrence in Stage II and III CRC.


Gene Details



NC_000019.9 (15270444..15311792, complement)

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Gene Type protein coding
Gene Family Ankyrin repeat domain containing
Description This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). [provided by RefSeq, Jul 2008]  
Chromosome 19
Location 19p13.2-p1
Start 15270444  
End 15311792  
Strand -  
Gene Sequence

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Length 41349  
OMIM ID 600276   
HGNC ID HGNC:7883   
Unigene ID Hs.8546   
Ensembl ID -   
PharmGKB ID PA31685   

mRNA Information


mRNA ID NM_000435.2
Exon join(1..194,3404..3482,8463..8605,8684..9022,9115..9237, 9325..9558,11554..11709,11808..11993,12634..12747, 12988..13101,13644..13877,13994..14104,15303..15495, 15574..15725,15963..16076,16532..16687,19181..19406, 19820..20021,20154..20301,20726..20910,21486..21618, 21700..21957,22041..22159,22892..23457,26582..26914, 30157..30311,30429..30651,30812..30896,33571..33733, 34891..35195,35467..35614,38420..38517,39268..41349)  
mRNA Sequence

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Length 8089  



CDS Information


   
Location77..7042
CDS Sequence

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CCDS ID CCDS12326.1



Protein Information


      
Protein IDNP_000426.2
Protein Namenotch 3
Molecular Wt. (Da)0
Protein Sequence

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Length 2321  
Uniprot IDQ15056
Ensembl Protein ID ENSP00000265753  



Post-translational Modification Information (Source : HPRD)


Residue Type site
DProteolytic Cleavage1628
GProteolytic Cleavage1661

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                           
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
1147CHUK2811NP_001269.3in vivo17289033   
3516RBPJ920NP_005340.2in vivo11404076   
5664PSEN22860NP_000438.2in vivo11518718   
55534MAML310066NP_061187.2in vivo12370315   
84441MAML29608NP_115803.1in vivo12370315   


Pathway Information


                        
Pathway Name Pathway ID
Dorso-ventral axis formation hsa04320
MicroRNAs in cancer hsa05206
Notch signaling pathway hsa04330
Thyroid hormone signaling pathway hsa04919


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd002041866-1992  ANK
cl025291866-1992  ANK superfamily
cd002041779-1892  ANK
cl025291779-1892  ANK superfamily
cd00054158-195  EGF_CA
cl21504158-195  EGF_CA superfamily
cd00054810-846  EGF_CA
cl21504810-846  EGF_CA superfamily
cd00054469-505  EGF_CA
cl21504469-505  EGF_CA superfamily
cd00054391-429  EGF_CA
cl21504391-429  EGF_CA superfamily
cd00054849-884  EGF_CA
cl21504849-884  EGF_CA superfamily
cd00054431-467  EGF_CA
cl21504431-467  EGF_CA superfamily
cd000541171-1203  EGF_CA
cl215041171-1203  EGF_CA superfamily
cd00054274-311  EGF_CA
cl21504274-311  EGF_CA superfamily
cd00054507-542  EGF_CA
cl21504507-542  EGF_CA superfamily
cd00054929-960  EGF_CA
cl21504929-960  EGF_CA superfamily
cd00054887-922  EGF_CA
cl21504887-922  EGF_CA superfamily
cd000541122-1158  EGF_CA
cl215041122-1158  EGF_CA superfamily
cd00054236-272  EGF_CA
cl21504236-272  EGF_CA superfamily
cd00054545-580  EGF_CA
cl21504545-580  EGF_CA superfamily
cd000541085-1120  EGF_CA
cl215041085-1120  EGF_CA superfamily
cd00054583-618  EGF_CA
cl21504583-618  EGF_CA superfamily
cd00054658-686  EGF_CA
cl21504658-686  EGF_CA superfamily
cd00054620-654  EGF_CA
cl21504620-654  EGF_CA superfamily
cd00054314-349  EGF_CA
cl21504314-349  EGF_CA superfamily
cd002041900-2024  ANK
pfam076841576-1639  NODP
cl066391576-1639  NODP superfamily
pfam068161505-1560  NOD
cl084491505-1560  NOD superfamily
pfam119362211-2273  DUF3454
cl133872211-2273  DUF3454 superfamily
smart00179158-195  EGF_CA
smart000041421-1458  NL
cl024191421-1458  Notch superfamily
pfam000661471-1500  Notch
cl024191471-1500  Notch superfamily
smart000041380-1417  NL
cl024191380-1417  Notch superfamily
pfam000661382-1418  Notch
smart000041473-1500  NL
pfam000661423-1459  Notch
smart00179391-429  EGF_CA
smart00179810-847  EGF_CA
smart00179469-505  EGF_CA
smart00179431-467  EGF_CA
smart00179849-884  EGF_CA
smart001791122-1158  EGF_CA
smart00179507-543  EGF_CA
smart001791171-1203  EGF_CA
cd00053161-192  EGF
smart00179274-311  EGF_CA
smart00179887-922  EGF_CA
smart00179657-686  EGF_CA
smart00179929-960  EGF_CA
pfam000231939-1969  Ank
pfam07645274-306  EGF_CA
pfam000231973-2003  Ank
smart001791084-1120  EGF_CA
smart00179545-580  EGF_CA
cd01475383-424  vWA_Matrilin
cl00057383-424  vWFA superfamily
smart00179236-272  EGF_CA
smart00179583-618  EGF_CA
pfam07645158-189  EGF_CA
pfam07645391-423  EGF_CA
pfam000231905-1937  Ank
pfam00008162-192  EGF
cd00053813-844  EGF
cd000531176-1201  EGF
pfam000081171-1201  EGF
pfam12947816-843  EGF_3
cd00053854-883  EGF
pfam127961910-2002  Ank_2
pfam138571858-1913  Ank_5
COG06661858-2024  ANKYR
PHA030951779-1992  PHA03095
COG06661866-2004  ANKYR
pfam127961876-1969  Ank_2
PHA028781809-1999  PHA02878
PHA028761858-1999  PHA02876
pfam127961943-2024  Ank_2
PHA030951858-1997  PHA03095
PHA028751858-2024  PHA02875
PHA028761732-1979  PHA02876
pfam136371941-1992  Ank_4
PHA032472045-2318  PHA03247
PHA028741858-1997  PHA02874
PLN031921835-1973  PLN03192
COG06661777-1893  ANKYR
PHA032472038-2319  PHA03247
PHA031001858-2002  PHA03100
PHA031001858-1997  PHA03100
pfam138571929-1979  Ank_5
PHA032472041-2316  PHA03247
PLN031921858-1992  PLN03192
PLN031921890-2024  PLN03192
PHA028741805-2021  PHA02874
PHA032472045-2318  PHA03247
pfam031542045-2314  Atrophin-1
pfam136371906-1959  Ank_4
PTZ003221874-1994  PTZ00322
PHA028781858-2024  PHA02878
PTZ003221944-2024  PTZ00322
PHA028761802-2025  PHA02876
pfam127961858-1902  Ank_2
PRK102632097-2319  PRK10263
TIGR016452115-2215  half-pint
PTZ003221808-1901  PTZ00322
PHA028741889-2024  PHA02874
PHA028751837-1967  PHA02875
PTZ004492199-2319  PTZ00449
PHA032472026-2315  PHA03247
pfam031542184-2311  Atrophin-1
PRK123232067-2273  PRK12323
PHA029461835-1978  PHA02946
pfam031542024-2309  Atrophin-1
TIGR008701866-2004  trp
PRK123232087-2321  PRK12323
PHA029461911-1977  PHA02946
PHA032472045-2300  PHA03247
PRK070032079-2273  PRK07003


Ontology Information


   
HPRD ID999
Molecular ClassCell surface receptor
Molecular FunctionReceptor binding (GO:0005102)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO