CoReCG

Search results:

General Information

Gene_Symbol	Gene_ID	Gene_Name	Chromosome	Alias
NOX1	27035	NADPH oxidase 1	X	MOX1; NOH1; NOH-1; GP91-2

Evidence
Gene
mRNA
CDS
Protein
PTM
Enzyme
PPi
Pathway
Structural
Domain
Ontology
SNP
Drug
External Links

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
15797632	2005	Cell line : - Source : Tokushima University Hospital. Sample Type : CRC tumor and normal tissue No. of Sample : 33 Stage : -	Immunohistochemistry	Up-regulation	-	Adenomas and well differentiated adenocarcinomas up-regulated Nox1 expression. Ki-67-negative, well differentiated tumor cells contained abundant Nox1, whereas Ki-67-positive, proliferating cells did not express it. Nuclear factor (NF)-kappaB was predominantly activated in adenoma and adenocarcinoma cells expressing abundant Nox1, suggesting that Nox1 may stimulate NF-kappaB-dependent antiapoptotic pathways in colon tumors.
18398843	2008	Cell line : - Source : Emory University, Human Tissue Procurement and Banking Center. Sample Type : CRC tumor and normal tissue No. of Sample : 24 Stage : TNM Stage I-IV	-	Up-regulation	-	Overexpression in model cells has been implicated in stimulation of mitogenesis and angiogenesis and inhibition of apoptosis. Nox1 mRNA and protein are overexpressed in colon cancer and are strongly correlated with activating mutations in K-Ras.
20715105	2010	Cell line : - Source : Steven F. Moss, M.D. and Lelia Simao (Rhode Island Hospital, Providence, RI). Sample Type : - No. of Sample : - Stage : -	real time RT-PCR, Immunoblotting, Immunohistochemistry, Cell culture, siRNA transfection and LPS treatment,	Up-regulation	-	Nox1 and Nox4 mRNA and protein levels were markedly elevated in a panel of primary human colon cancers, compared with their matched controls. The results provide the first evidence for a role of Nox1, Nox4 and NF?B in PhIP-induced colon carcinogenesis, including during the early stages before tumor onset.
21922590	2012	Cell line : - Source : - Sample Type : - No. of Sample : - Stage : -	-	Up-regulation	-	-
22552367	2012	Cell line : - Source : Charles River Laboratories, Inc , maintained at the University of Kentucky. Sample Type : Mouse model No. of Sample : - Stage : -	2-D Gel electrophoresis coupled with mass spectrometry.	Up-regulation	-	In vitro system, exposure of CRL-1807 to carcinogenic metals(As(III) or Cr(VI)) increased reactive oxygen species (ROS) generation, the expression of beta-catenin, phospho-GSK, and NOX1. Eighty five-week old C57BL/6 J mice were obtained from Charles River Laboratories, Inc were used.
23071493	2012	Cell line : SW 480, SW 620, CT 26 Source : ATCC Sample Type : - No. of Sample : - Stage : -	Flow cytometry, Western Blotting, Immunofluorescence and Microscopy, PCR, Adhesion assay	Up-regulation	-	Nox1 may represent a valuable target in which to prevent colon cancer metastasis. TLR-4 signalling accelerates colon cancer cell adhesion via NF-kappa B mediated transcriptional up-regulation of Nox-1.

Gene Details

Chromosome: X; NC_000023.10 (100098313..100129334, complement)
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Gene Type	protein coding
Gene Family	-
Description	This gene encodes a member of the NADPH oxidase family of enzymes responsible for the catalytic one-electron transfer of oxygen to generate superoxide or hydrogen peroxide. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012]
Chromosome	X
Location	Xq22
Start	100843324
End	100874345
Strand	+
Gene Sequence	>gi\|568815575:c100874345-100843324 Homo sapiens chromosome X, GRCh38.p2 Primary Assembly GCTGATAGCACAGTTCTGTCCAGAGAAGGAAGGCAGAATAAACTTATTCATTCCCAGGAACTCTTGGGGT AGGTGTGTGTTTTTCACATCTTAAAGGCTCACAGACCCTGCGCTGGACAAATGTTCCATTCCTGAAGGAC CTCTCCAGAATCCGGATTGCTGAATCTTCCCTGTTGCCTAGAAGGGCTCCAAACCACCTCTTGACAATGG GAAACTGGGTGGTTAACCACTGGTTTTCAGTTTTGTTTCTGGTAAGTGATGTTTGACTTCCTATTAATTA GGAAGGATTAAGGAGAAATCATGTTTTTTAATATTTGTAAAGCAATTTGAAAGAGAAAGATGATTCCATG CCGATTATTGGGCTCATCAAGACCAGTTAGTTAAAAAATACAACTGTGGGTCAGATGAGAGGACAGAGGC AAATAACATGCAATTGTTCATGTTGTCAAATCACAAGTATTTGGAATTTCAATCTGTTTTCATTTTCTGT CATCTCCCTTTCTCTTCCATCTCACTTCTAACTACTACCATGAGTGCTGATTTCTCTCTATCTTTCCTAT ACTGGTCCCATCAAGATTTCAAAAAGTCACTGAATGTTTGAGATGAAAGTGATCTTAGAGATCATCTGGC CCAGTACTGACCACTAGAAATATAGCAAACCACATAATGTAATTCCTAAATTTTCTAATACCTACACCGA AAAGGTAAAAATAAACAGGTGAAGTTAATATTTAACAATATAATTCATTTAACCCAACATATCAACAAAT CCTTTCAGTATGTATTCAATATTGAAAATATTAAGAAGCTAATTTACATATTTTTATTTTTACTGAGTCT TTCAAATCTGATGTGTATATATACCCACAGCACATCTCAGTGAGGACTAGCCACATTTCAAGTGCTCAGC AGCCCCATGTGGGTAGTGGCTGTGGCATTGCATAGTGCAGATGTAAACCAACTTATTGATTGTACAAAGG AAAATAAGACCTAGATGTCACACAATGAATTGACTGAATTGGCATCACTCGAACCCAGCTCCCCAATGAC GTTCAGGCCAGAACCCCTTTATCACCCTTTGTATGCACAATCCCTTTCTCCTAACACTCTAACACCTCTC TCCACTCTCATTCTTCCATTTCTGAGCCACAGTTGAGCCTGGGGCTCCCTGTGTCCTTTCTCACTTTCCT AGATCTTCATTCATTACTCTTTCTCTTTTCTCCTGTTTTGCTTTTGGGTCCCACAGGCAAAACAGAAGAG AGAAGGTGTGATGCTTCTTTTTATTCCTGTCTACCCCCCCGCCCCCCGACCAGGTGCTCCAGGGAAAAAT ATGTGGAGTTTCCCTGGAGGGTTGTTTGTTTTACATTTAACAAAAGTGCTTATTTTGTCAGGTTATCCCA TGACATATTTTAAATGCTCAATGCCTTATATTGAGTTCCTTTTGCACTATAATGGAAAGAACACTAGTTT AGGAGAAAGGGAACCTGGCAAGTACTTTGAATTCTGCTACTAACTGGGTGATCTCGATCAAATTATTTAT CCTCTCTAGACTTCAGGTCCTGTGGGTGTGTAGGTGGGGGGAATTGGGCAGGGGAGGGGAGCAGGGGATT AATAAAGTGACTAGATTAGATACAAATATAAGGGTGTTTCTAGCTCTAAAATCCACATTTACCTGCATTT TTTCCCCCTCTCTTATTTTTTGCTGGGAGAGTTTACCAGCTATGATGGTGACTCACATTTAACTCTCTAG CTTTGAATTTTCATCCCCCACCAAACCAGCTGGCAAGCTTAGACTTCTCATTATCTCTGACATATACTCC TATGCACTGATTTTTAAATAAAAAATAAATTACTTAAAAATAGTTTTATTCCTCCTTCCTCCCAGGTCTT GTAGTTTACCTTCTTTGACGTTCATAGTGGAGGAAATGACAGCTAAGATGGGGAATGGAATGCCTTACTC CTAGATATCACTGTATTTCATCATTTGCCTTGCCTACAATTGATGATGGGCTGACACAGTTATTTGCCCC TGTGTCTCTTTGCGATCCAGAAATATTTCTGCTCCCTCTAAATAAACTTCTCTCCTCTGTCTTCCAAATT CTTGAGGTGTCTGTGACTGTTGACTTTCTTTTCTTTCAAAGACGTTTCTCTGGAAGACACTCAGCTCTGG AAAAGGGTAACTGAGCAAAGGAGGCAGGAAGAAATTGATTGGTAAAGCAGGTTCGGTGGTGACACAACTC TGTAGCTAGCACTTATTGATCTCTTACTAAGCCCCAAGCATTGCATTAATCACTTTACACGCATTATCTG ACGTAAGCCTCATAGCATTACTATAAAGTAGGTCCTGTTATTATCCTCATTTTGCAGGTGAAGAAATTGA GGTTTAGAAAATTTAAATCATATGTCTGTCTGAGATTATAGAGCTATTAATTGGTGATGCTACAACTTGA CTCCAATATCACACTTTAAATCACTATATTATAGTACTAAAGGTGTGTGAGTGGTCTAGATCTAGGGAGT CTGAATAGGCCATGTCCTAGGCTAAAGGCCCTTTGCCTGTTGTGCTGAGATGGTTCTGACTCATACTGTG GGGCGAGGGATATATACTAGCGCCCTGGAGACCTGTCGAATTACAGACTAGCACCTCCACACTTGGGCTA GAGACCAGTTGGTTGGTCCTCAAGGCAATGGGCAGTGAGTTCCAAATTTCACCTTTAGCCAGTGCAGAGA CAGAACTTGGAACAGGCAAAAGCAGTCTTAAGAGCTCAAAAAAGTCCAAAGGAAAAATAGATTAATTTGA AAAAAGACTCACAATCTGAAAACAGAAAAATGTGTGTCAGGGTGTAATTAAAAAGGCAGGCCCATCTGGA ATGGTTTAGTTCTTTTCAGTTAGGTATTGTTATAGGTGCTAAATTTGTTCTTTGTTTCTTCAGATATCCA TTTATTCACTTATTGCCATCTTTTAGGTGCAACAGTTTGAATGCTCTAGTCCAAGAAATGGCAAATGTTT CTGTAAAAATCTAGATAGTACATATTTTAGGCTTTGCAAGCCATATGGTCTCTGTCCCAACTACTCTACT CCGTCATTGTATCACAAAAACAGCCATAAACAATACAAAAATGAGTAGCAGTGGCTAAGTTCCAATACCA CTTTATTTATGGTCACTGAAATTTGAATTTCATATAACTTTCACATGCCACAAAATATTCTTCTTTCGAT TTTCTCAACCATTAGCAAATTTGAAAATATAAAATATAAAAAACAATTCTGAGCTTGCAGGCTGTGGCAA AACAGGTAATGGGCCATGGGCCTCAGTTTGCTGACCCTGCTCTAGTCTAATGCATGTCTCAAAGTGCTAA CTCACTCTGAAAGCCAGTTAGATACTAGCAGGATTGCACTCATTTAAAATGAAAACAGGTAAACACAAAA TAGCCAAAACGGCGACACTATTGCTATCCCTATCCCTTATTTACTCCTTCCCATACTCAAATTTCACTTT ATTCTTTGCATGTTTTTTTTTCTTTCTCTAGGTTGTTTGGTTAGGGCTGAATGTTTTCCTGTTTGTGGAT GCCTTCCTGAAATATGAGAAGGCCGACAAATACTACTACACAAGAAAAATCCTTGGGGTGAGTATCACGG TTGTCACGGATAGAATCTCTATTGTTTTCCTTATCTCTGATTCCAGCTTCTTTGTGACCCAATGCCCTGA TATTCTCTAGGGCTAGGGTTGCCAGAAAAAGTACAGAATGCCCAACTGACTTTGAGTTTCAGATAAATGA CAAATTATTTTTTTATGTAAGTATGCTCCAAATACTGTATGAAACACAGGTATACTAAAATATTTATTTT AAAAAGTCTGAAGTTAAAATTTAGCTTAGCATCCTGTATTTTTATTAAATAAATCTGATAACCCCATCTA GGGCACACTACCCAGACCCAATAAAGGAAACATGCAATAAAGAAAACTATTAGGCAGTTGTTTTCAAACT GGTTTCCAGAAACTCAGGTGTTCCTACAGGGTATGAGGGGAAGGCTAACTGGGCAGTGCTCCTGCTCCTG CTCCTGCCCCTATTTCTTTTTTTTTTTTTTTTACAAGGAGGAACTGGTACCATTCTTCTGAAACTATTTC AATCAATAGAAAAAGAGGGAATCCTCCCTAACTCATTTTATGAGGCCAGCATCATTCTGATACCAAAGCC TGGCAGAGACACAACCAAAAAAGAGAATTTTAGACCAATATCCTTGATGAACATTGATGCAAAAATCCTC AATAAAATACTGGCAAACCGAATCCAGCAGCACATCAAAAAGCTTATCCACCATGATCAAGTGGGCTTCA TCCCTGGGATGCAAGGCTGGTTCAATATACACAAATCAATAAATGTAATCCAGCATATAAACAGAGCCAA AGACAAAAACCACATGATTATCTCAATAGATGCAGAAAAGGCCTTTGACAAAATTCAACAACCTTTCATG CTAAAAACTCTCAATAAATTAGGTATTGATGGGACATATTTCAAAATAATAAGAGCTATCTATGACAAAC CCACAGCCAATATCATACTGAATGGGCAAAAACTGGAAGCATTCCCTTTGAAAACTGGCACAAGACAGGG ATGCCCTCTCTCACCGCTCCTATTCAACATAGTGTTGGAAGTTCTGGCCAGGGCAATTAGGCAGGAGAAG GAAATAAAGGGTATTCAATTAGGAAAAGAGGAAGTCAAATTGTCCCTGTTTGCAGATGACATGATTGTAT ATCTAGAAAACCCCATCGTCTCAGCCCAAAATCTCCTTAAGCTAATAAGCAACTTCAGCAAAGTCTCAGG ATACAAAATCAATGTACAGAAATCACAAGCATTCTTATACACCAACAACAGACAAACAGAGAGCCAAATC ATGAGTGAACTCCCATTCACAATTGCTTCAAAGAGAATAAAATACCTAGGAATCCAACTTACAAGGGATG TGAAGGACCTCTTCAAGGAGAACTACAAACCGCTGCTCAAGGAAATAAAAGAGGATACAAACAAATGGAA GAACATTCCATACTCATGGATAGGAAGAATCAATATCGTGAAAATGGCCATACTGCCCAAGGTAATTTAC AGATTCAATGCCATCCCCATCAAGCTACCAATGCCTTTCTTCACAGAATTGGAAAAAACTACTTCAAAGT TCATATGGAACCAAAAAAGAGCCCGCATCGCCAAGTCAATCCTAAGCCAAAAGAACAAAGCTGGAGGCAT CACACTACCTCACTTCAAACTATACTACAAGGCTACAGTAACCAAAACAGCATGGTACTGGTACCAAAAC AGAGATATATATCAATGGAACAGAACAGAGCCCTCAGAAATAATGCCGCATATCTACAACTATCTGATCT TTGACAAACCTGAGAAAAACAAGCAATGGGGAAAGGATTCCCTATTTAATAAATGGTGCTGGGAAAACTG GCTAGCCATATGTAGAAAGCTGCAACTGGATCCCTTCCTTACACCTTATACAAAAATCAATTCAAGATGG ATTAATGCTCCTGCCCCTATTTCAACCAAAGCAGACTATATCTATCTATGAACACCTGCTTACAATTTTA AGAAAGAGTTTGGTTTTTTTTTAAAAAAAAGGAAAGTAAAAAAGAAAAAACAAACACAACTTGAAAACAC TGCTGTCATGGAAACATACCTCTCTATCAAATAGGAGGGATACTTAGGGGAGTCTCATGGGTGCTACAGA ATTCAAGGCCTGCAGAAAGGAGGGCTCAGGTCAAGGTTACAGAACCTGAGAAGCTTGGGGAAGTGGCAGA TCAAAAACAGAAGAGGGAGGGAGGGAGTGGGTAGGGCACAGGGGTGTGGAGGTGACCAGGAGGAAGCACG GAGTTGAGGATGGTTCTCTCACAGGCTGATGAACCCGGATGCTGCCTGGTTAGAAGAGCATATTTGACTG CTACCTCTAGTCTATTATGCAATAACAGATAGAGGATTTTAAATCACTTTCATCTTGACAGTGTCATTTT TTCAGTAGCTTTTGGTATCTTCCCAATGTACATGTTTAAAGACAGCTTGTCCTTTTAAAAAATGCTTTTT TCTCTCTCCATAATCAAAGAATCCATGTTGAGATCACAACTAATTTGAACGTTCTGTTCATGGTTTATTT CACCCTGCTGTTTTCCATTTTAAATGTTCATCCTTGATCCTTCTTTAGAAACTATAACTCCAAAGGAGGT ATTAATTTGCTTTAAAAATAGCTTTTTACTAAGAGAATGATGCAATAAATGTGACTAGTTATTAACAGCT TGATTACTACATGACCAAAATGTCAGCAGCACAAAAATAAATTATGCTGATGTCCCATGGACATTTTTTT TTCAAAATTATTTAAAAATTGTTTACATATGTAGGGGGTATAAGTGCAGGTCTCTTTCTTTCCTTCTTTC TTTTTTCTCTTTCTTCCTTTCTTTATTCTTCCTTCCTTTTCTTTCTCTTTCTTCTCTCTCTCTTTCTTTC CTTCCTTCCTTCCTTCTTTCCTTCTCTCTTTCTCTCTCTCTTTCTTCTTTTCTTTTCCTTCCTTCCTTCC TTCTTTCTTTCTTTGTTTTCATTCTTTTTATTTTGAGACAGGGTCTTTCTCTGTTACCCAGGCTGGCATG CAGTGGCATGATCATGGTTCACTGCAGCCTCGACTCTCCCAGGCTTCAGCTATCTTCCCACCTCAGCCTC CTGATTAGCTGGGACCACAGGTGTGCGCCACCAAGCCTGGCTAATTAATATGCCATAATTTATTTAAACA TTCCACAGTCATTAAAACATTTACCATCACTGCATAACTGCATAGAGCTCTCAGCCTTTTAAGAGAATAA CAATTCATTGCATTGATATGCCATAATTTATTTAAACATTCCACAGGTTATTTCTTAAATTCATGCTCAC CTTGGGAAAATACAGGGAACAATTTGATTCACTATGAAGTAGAGCAGATAAGCAGCAGAGGAAGAAGTTT AAATCCATAATTTAAAAACATTTTTTTGCCAGGCGCTGTGGCTCACGCCTGTAATCCCAGCACTTTGGGA GGCCGAGGCGGGCGGATCACGAGGTCAGGAGATCGAGACCACGGTGAAACCCCATCTCTACTAAAAATAC AAAAAATTAGCCAGGCGTGGTGGCGAGCGCCTGTAGTCCCAGCTACTCGGGAGACTGAGGCAGAAGAATG GCGTGAACCCAGAAGGCGGAGCTTGCAGTGAGCCGAGATCGCGCCACTGCACTCCAGCCTGGGCGACAGA GCCAGACTCTGTCTCAAAAATAAATACATAAATAAATAAATACTTTTTTTTTGTAGACATGAGGTCTCCG TGTTGCTCAGGCTAGTCTCAAAACTCCTGGGCTCAAGTAATATTCCCACCTCGGCCTCCCAAAGGCCGGG TATTACAGGTGTGAGCGACCATGCCCAGTCACAAGTGTAGGTTTCTTACATGCATATATTGCATAGTGAT GAAGTCTGGGTTTTTAGTTACCTATCACCTGAATAGTGAACATTGTACCCAGTGGGTCATTTTTCAACCC TCACTCCCCTCCCACCCTCCCACATTTTGTAGTCTCCAATATCCATTATTCCACTCTGTAGGACATTTCA TTTTTTAAATCCCTATTTTAAAACCTTAATTATCAATAATGCTGCTTCCAATGAGATCAAAGCACATATT AGTTTGGTGCAAAAATTATTGCTATTAAAACTGTTTGCAAAAACCGCAATTACTTTTGCACCAAGCGAAT AGAAGTGTATAAGTAAAATGTGAAAATCTCCCTCCCATCCTACTCCCCAGAGATACACACACACACACAC ACACACACACACACACAGGGACACACACACTGACATAAGCTCACAAATGTATCAGACACGCAGGTTTTGT TTTTGAGGTGGGTACTATCGTTTATTCACTTTTTCATTTTCATATAGTAAAATTTGCTGTTTTTTGGTAT ACAGTTCTATGAGTTTGGGTAAACACATATAATAAGACACACAGCTTTTTGTTTTAACCAAAAAAGGGAT CACTTTGTAGATATTGGCTGGAAATTGCTTATGTTAATATATCTCAGATATCTTTCTTTCTTTTTTTTTT TTTTGAGATGGAGTCTCACTCTGTCGCCCAGCCTGGAGTGCAGTGGCGCAATCTCTGCTCACTGCAACCT CCACCTCCTGGGATCAAGCGATTTTCCTGCCTCAGTCTCCCAAGTAGCAGGGGTTACATGTGCGAACTTT CATGGCTGGCTAATTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCATGTTGGCCAGGCTGATCTCAAA CTCCTGACCTCAAGTGATCCACCCGCTTTGGTCTCCCAAAGTGCTAGGATTACAGGCGTAAGCCACTGCT CCCAGCCTCAGATATCTTTCCATGTGAGTGCCTAACCAGTGGTGTGCTGAAACCAGCTCATACCAGGTTG CAATGCCAGTTGCGTGCATCTCTTCCCAACTCTGCATTCAGTGGTGTTCAATGACATCAAGTTAGTGTCT TGAAATCTGGCATGGTGGGAGTATTTACATCATCAAAATTGGCAAATGCTGGAAATCAGGAATCCCCTTC CTCCCAAAAAGCTAGTCATTAAAACATTTACCATCACTGCATCACTGCATAGAGCTCTCAGCCTTTTAAG AGAATAACAATTCATTGCATTGATATGCCATAATTTATTGAAACATTCCACAGGTTATTTCTTAAATTCA TGCTCTGCTCACCTTGGGAAAATACAGATAACAATTTGATTCGCTATGAAGTAGAGCAGATAAGCAGCAG AGGAAGAAGTTTAAATCCATAGTCAATTATGCATTAATGACAGCAGGAGTTCAATTATAACACCAGTGAG TGGAGATCTAGAGAAATGAACATACATTGGCATATTTAAATGTGCTGCAACGAGGAAAAAATGTTTTCTC TAAAAAGAATTCATCCTATACAGATAGCCACCACAGAATATGGAACTGTGAAATTATAGTCCTATATTTT CAATTCACTTGCCAATTTTAGCTTTAAGAAATCTCTGTGATTCAAATAAGCAAGTAGTGGGAACCAATGT GGAAATGCAGGATCTCTGAGATGAGCAGAGGAAATTTACTCAGAAGTGGAACAGGCTGTCTGTACCAAAA ACAGTCAGGGTGTGAGTCAGCAGAGGGAGAAAACACAGGTCATGTGGAAAAGCCAGAAATGGAAAACAGT AGGGCAGCTTTTGTTCACCACATTGCCTGACATTCTTAGCCATTATAGATACTAGGCAGATCTTGTCCTG GCTTATTAAACTAACATCACATGTTCCTGGGTTTACGATATAAGGAAAAATCAATTTTGTGCTTCATAGA TAATTACAAAAAGGCCAAGAAATTGTTAACCTTAACCCATACCCCTCCTTTTAGAAAGTCTTTGACAGGC ACACAATGTAAGGCTGGCCAGTCAGCAGAAGTGCAACAAAAATTGCCTGGCTGCTGCTGTCAGCTCCTCT GCTACAACATTGTCACACTCCATAGCAGTCCCAAGTTCATGAAGTAGACTCAGAGACCGGTTGTACAGAG TTGAGGAGAGAAGTCAGATTTAGCTGCCATGGAGTTAAGCATATTCTGTCCAGCTTATACCTAGTAAGGC CTGTTTTTTGGGGCTAAATGCTTCTTTGAAGCATTGATTCCTTGTCTCCTTTGCTAGCAGCTTCTACTGC TGGATCAGGTTGTTCTTGATTTATGCTGCCTGGCCACCCAAGGAAATCAGCTTAAAATTTTGCTCCTCTG AAGTTCTCCCTTCTCAAATATCTACCTGTTTAAAAATTTTGCTCCAAGAGGTTTGCTAGTCTTGACTAAA TTTATTCAATTTTTAAAGACATCTTAAATAGAATTGGTTAAAAATTTTAAGTGTTTTTATTATACAACTC TTATGTGCTTATAACTGCAATATTAGAAAATACAGAAAAGAATAAAATACCATCTGTAATTGTACCTCTA AGTATGAGCTTTATTTAAAATGCAAATAAAGGTATATATGATCCTTGGCCAGGCATGGTGGCTCACATCT GTAATCCCAGCACTTTGGGAGGCCAAAGCAGGCAGATCTCTTGAGCTCAGGAGTTCCAGACCAGCCTGGG CAACATGGCAAAACCCTGTCTCTACCAAAAATACAAAAATTGGCTGGGTATGGTGGTGCACGCCTGTAGT CCCAGCTACTCAGGAGGCTGAGGTGGGAGGATGGCTTGAGCCCAGGAGGCAGAGGATGCAGTGAGCCGAT ATCTCGCCACTGCACTCCAGCCTGGGCAATAGTGCCAGACCTTGTCTCAAAAAGAAAAATCTATATCTAT ATCTATATCTATATCTATATCTGATCCTTAGGACTCTTTTACAAGTGACAAATAACAAAATTATAATAAA GAGTATTAAGTAAAATGTTACAGCCATAGAATGTTTTGCTAACATGTAATCATTAAATCCTATTCTCTTT CATGTTAATAAATGTAGTCAAACATTTCCAAACTACTGTCATGGGAATTTCTCAACTCAATATTAAATTC AGTATGTTTTATGTATTTTGCAAACAGAGCCTGGCCTGATGGTGTTAGCTACTGAGAGAGAGGAGAGGCA GCTGTAGCCCTGTTCATTTGCAGGCCTCAGATGAGTGGGCTGGGTCAGTTGCTCACGTGCTAGATGGTGA AATGAAGCAGCTGATGGTCTCTTTTTCTCCTCTGCTGTAGTCAACATTGGCCTGTGCCCGAGCGTCTGCT CTCTGCTTGAATTTTAACAGCACGCTGATCCTGCTTCCTGTGTGTCGCAATCTGCTGTCCTTCCTGAGGG GCACCTGCTCAGTGAGTCCCAACCACTCCTAAGTCAACTTTCACATTAAAGAAGGAGACCCCAGACTCCT CAGTAGGACAGTCCAACACCATGCTCCTAGGAATGGAAGCTAGAAGTCTCCTTTGGTAGCTAAGGGGGTG GGTTAGTGCGGGTGAGTATTGGCATGCTATATGCAAGACATATTGGTTATGGGTTAGTGAATTTAATAAA GCTGGCTGGCGACATCTGACCATGATCATTCTACATTTGTAGTTTTGCAGCCGCACACTGAGAAAGCAAT TGGATCACAACCTCACCTTCCACAAGCTGGTGGCCTATATGATCTGCCTACATACAGGTAACTCAGGCAA TCCATGAATCTGCAGACTCCAGGGCATTCAGAATCTTGCTTCATTCATCCATCCATATGCACATTCAAAA AATATTTATCGAGCACTGGGCACTATTTGTCAGGCACTGTTCTTGGCCTGTTTTCATGGAGCTTAAGTTC TATTCCTTTGGGAACAGAGTAAATATAAAAAAGATCTCTCCGCAATCGAGGGTTTATTGGGCACCTTCTG TGCACTCAGCATTCTGCTAAGCACTATAATGTAGGATTCTTCTAGTCTAGTGGGGCACACCTGCCATGAT GTTGCTGAGATGCCTCTTAACATTTCTTTTCATCTTTCCATTTAGCTATTCACATCATTGCACACCTGTT TAACTTTGACTGCTATAGCAGAAGCCGACAGGCCACAGATGGCTCCCTTGCCTCCATTCTCTCCAGCCTA TCTCATGATGAGAAAAAGGGGGGTTCTTGGCTAAATCCCATCCAGTCCCGAAACACGGTGAGTTGACTTT CTAGCAAAGCATCTGAGATCTGGTCATGAGCAGGAAGTGCACAGGTGGACATTGTGTCAGGCTGACATTT CTCCTTTCACAGACAGTGGAGTATGTGACATTCACCAGCATTGCTGGTCTCACTGGAGTGATCATGACAA TAGCCTTGATTCTCATGGTAACTTCAGCTACTGAGTTCATCCGGAGGAGTTATTTTGAAGTCTTCTGGTA TACTCACCACCTTTTTATCTTCTATATCCTTGGCTTAGGGATTCACGGCATTGGGTAAGATCCTCGAACC CTCATTCTCATGCCCCAGCCCCTGACCTTGCATAATTCTTTGTCCCAAACCATCCTTCTTTGTCTATTTC AGTGGAATTGTCCGGGGTCAAACAGAGGAGAGCATGAATGAGAGTCATCCTCGCAAGTGTGCAGAGTCTT TTGAGATGTGGGATGATCGTGACTCCCACTGTAGGCGCCCTAAGTTTGAAGGGCATCCCCCTGAGGTAAG AGCCCTACGGGCAAGGACAGACTCTTGTTAGGAGCTGTTACTGTTATTATTCTTATTATTACTCTTATTG TTATTATCATCATTATTATTAGTTCAGTCCTGTGCTGGGTCTTATGAAGGATATCTATGGGGTTCCTACC TTTAAGAAACTTCCAGTATCACTGGCAACAGGCAATTACAAGGGGATCTTGAAGAGAAAAAACTAATAGT TCTTGCATGTTGTGAGACCCTCTGCAAAGGTAATAATGATAGCCCACATTATTAATTGTGTTTATCATCT GCCAGCCTTGCTGCATAATATGGATTATTTCATTTATATATAGCAATAGCCTATGAGATATTACTTCTTT TTTGTCTAAATTTTGAAACAAAAGGACAGGATTCCAAGAGATTAAGTAAACTGACAAGCTCTTACAGTAA GTAGTGGAGCTTGAATACAAACCCAGGCCTTTTGGATTCCAAAGGTTTGAACTCTTGACCACTATACTGT CCCAAAGCTCAGCCGTGATATTCCAGTCAAATTCTGGGGGGAAATAAAGCATTCTTGAAGTGGGCTTTCT TTGGTGTTCTAAGAATATGCTTGGAAATTTTTGTTAGATACTGGGTGATTATGAAACTGTGTTCTAGGGA ACTCAAGGTGTGCCCCAGGGTAATTCTTGCGGATATTATTATTTACCTTTGCTTGCTCACAAAATAGGTT ATATTGAGGAGTAAATGGAAGGGGAAGGTTGATTTGTGGTGCCTCAGAGTATTCTGAGAATGATTAAGGT CTTTAAATCAGATTCAGGATTAAGAGCAATAGCTTAGTTCTCATCTGGAACAGGAAAAATATATAAAACA AAAAGTCTTCTAAAGTTGGCATTTTAATTCAGCAGGAAAAGGATAAATGAATAATTTTTAGCACAATAAG ATCATCATCTGGGAAAAAAGCTATATCTTCATTTCACGCCTTGCACTAAAATATGAATCGAGGATACATG AAGCAAAAAAACCATAAAAGCACCTTAAGACCACGTGGGAAGTTTTTTTCTAATACTGAAGTGGAGGAAC ATGTTTCTAAATAAGATAAACCACCCTGAAGCCATAAAAGAAGAGATAATTTTGCATGGCAAAAGAAATC CCCATCGGGCCGGGCACGGTGGCTCACACCTGTAATCCCAGCAATTTGGGAGGCTGAGGTGGGTGGATTG CTTGAGCCCAGGAGTTTGAGACCAGCCTGGGCAACATGGCAAAACCCCATCTCTACAAAAAATACAAAAA TTAGTTGGGCATGGTGGTGTGGAGGGTGAGGTGAAAGGATTACTTGAGCCTGGGAGGCTGAGGCTGCAGT GAGCTGTAATCATGCCACTGCACTCCAGCCTGGGTGACAGTGAGATCCTGTGTCAAAATAAACAAACAAA TAAACAAAAATTCCCATTGTAAATAAAGATAGACAAAAAATTACCAAGTAGGAAAAGTATTTACAACTCA CAGGGCATGGACTAATTTTCTAATATATAAATAACTCCTAGAAATCAATAAGAAAAAGCCTAATAACATG ATAAAAAGAGAAACAGAAGATGTGAACAGAATAATCTCAGAAATGGAGATATATCCTTATCTTAAATATA TGAAATGATGCTTAATGTTATTCATAATGGAAAAAAATGCCAAATAAAACTACAAGAATCTGTTAACCTA ACAGATTAGCAAAGATTAAAAAACCTGCTAATGTATGGTGCTGGCAAGTGTGGAAAAATGCTCTTATGCA TTGCTGGTGAGAGTGTAAACCTATACAACTGCTTGTAGAGAGTGATTTGGCAGTAGCAATTAAGGTTTAA AACTCGACTTCCAATTTATTCCACAAATATACTTAAATATGTGTTAAATTACATGCATTAAGTTATTCAT TACAGCATTGTTGAATAGAAAAAAAGACTGGAAACAAGTGTCCATCAGTGGGGAACTAGTTACATTTTGG GACTTTCATGCAGTGGAATAGTCTGCAACCAGTAAAACGAAAGAGACAGTACCATAGACACTAATAGGGA CCAGTCTCTAAGATGTTAAATGCAAAAGGCAGGGCAGTGTGTAGAGTCTCCTATCATTTGCATTGAAAAG ATCATTTAAATGCATGTTCTCCAGAAGAATTCACAAAATAATAACATTACCTCTGGGGATCTGGAGGGGC AGGAGGATTTGCTTTTTACTATTGTACTGTTGTACTTTCAGATTTTGTACCATATACATATATTACCTAT TTAGAAAGTAATTTTCTAATAAGATAGATAGAATGCTAGCTACACAAATAAAGAATAGACCACTAGCTAC ACTAATAAAGAAAAAAGAGAGACAATCCAAAAAACACAATCAGAAATGGCAAAGAGGACATTATGACTGA CCGCACAGAAATTAAAAAAAAAAAAACCCTCAGAGACTACTATGAACATCTCTATGCACACAAACTAAAA AAAAAAACAACCTAGAAGAAATGGATAAATTCCTGGACACATACAACCTCGCAAGACCAGACCACGAAGA AATTTAATCCCTGAGCAGACCAATATTGAGTTCCAAAACTGAATCAGTAATAAAAAAGCCTACAACTAAA AAATGCCCAGGACCAGATAGATTCACAGCCAAATTCTTCCAGATGTACAAAGAAGATCTGGTACCATTCC TACTGAAACTATTGCAAAAAAATTGAGGAGGAGGGTCTCCTTCCTAACTCACTCTATGAGGCCAGCATCA TCCTGATACCAAAACGTGGCAGAGATACAACGAAAAAAGAAAACTTCAGGCCAATATCCCTGATGATCAT TCATTGATGAAAAAATCCTCGACAAAATACTGGCAAACTGAATCCAGCAGCACATCAAAAAGCTAATCCA CCACGATCAAGTAGGCTTTATCCCTGGGATGCAAGTTTGGTTCAACATATGCAAATCAATAAATGTGATT CATCACATAAAGAGAACTAAAGACAAAAATCATATGATCATCTCAGTAGATACACAAAAGGCTTTCAATA AAATTCAACATTCCTTCATATGAAAAACTCTCAGCAAACTAGGCATTGCTGGAACATATTTCAAAATAAC AAGAGCCATCTATGACAAACCCACAGCCAACATCATACTGAATGGGCAAAAGCTGGAGGCATTCCCCTTG AAAACTGGAAAAAGACAAGGATGCATTCTCTTACCACTCCTATTTAACATCGTGCTGGAAGTCCTGTCCA GAGCAATCAGGCAGGAGAAAGAAATAAAAGGCATCCAAATAGGAAGACAAAAAGTCAAACTATCCCTGTT TGCAGACAATATGATTCTATACCTAGAAAACCCCATAGTCTATGTCCAAAAGCTCCTAGATCTGATAAAC AGCTTCAGCAAAGTTTCAGGATACAAAATCAATATACAAAAATCAGTAGCATTGCTATACCCCAACAACA CCCAAGCTGAGAGCCAAATCAAGAATGCAATCCCATTCACAATAGCCACAAAAAAAATAAAATACCTAGG AATACAGCCAACTAGGGAGGTGAAAGATCTCTACAATGAGAGTTACAAAACACTGCTCAAAGAAATTAGA GATGACACAAACAAATGGAAAAACATTCCATACTAATGGATAGGAAGAATCAATATCATTAAAATGGCCC TACTGCCCAAATCAATTTACAGATTCAACACTATTCCTACCAAACTACCAATGACATTCTTCACAGAATA AGAAAAAAAAACTATTTCAAAATTCATATGAAACCAAAAAAGAGCCCAAATAGCCAAGGCAATCCTAAGC AAAAAGAACAAAGCTGGAGGCATCATGTTACCCAACTTCAAACTATACAAGGCTACAGCAACCAAAACAG CATAGTACTGGTATAAAAACAGACACACAGACTGATGGAACAGAATAGAGAGCCCAGAAATAATGTTGCA TATCCATGACCATGTGATCTTTAACAAAGTCAACAAAAATAAGCAATGGGGAAAGGACTCTGTTCAATAG GTGGTGCTGGGATAACCGGCTAGCCATATGAAGAAGATTGAAACTGGACTCTTTCCTTACACCATATACA AAAACCAACTCAAAATGGATTAAAGACTTAAATGTAAAACCCCAAACTATAAACACCGTAGAAGACAACC ACCCTGGAAGACAACCTAGGCAATACCATTCAGGACATAGGCCCTGGCAAAGATTTCATGATGAAGATAC CAAAAGCAAATGCAACAAAAATAAAAATTGATGAATGGGATCTAATTAAACTAAAGAGCTTCTGCACAGC AAAAGCAACTACCAAGAGAGTAAACAAACAACCTACAGAATGGGAGAAAATATTTGCAAACTACACATCC GACAAAGGTCTAATATCTAGCATCTATAAGGAACCTAAACAAATTAACAACAACAACAAAAAAACACAAA TTATCCCATAACAAAGTGTGCAAAGTCTCAAAAAAAAAAAAAAAGTGGGCAAAGGACATAAAGAAACACT TTTCAAAAGAAGACACACACGCAGCCAACAAGCATATGAAAAAATGCTCAACATCGCCGATCATTAGAGA AATGCAAATCCAAACCACAATGACACACCATCTCACGCCAGTCAGAATGGCTATTATTAAAAAGTCAAAA AATAACAGATGTTGGTGAGGTTGCAAGGAAAAGGGAGCACTTATACAGTGCTGGTGGAAATGTAAATTAG TTCAGCCATTGTGGAAAGCAGTGTGGTAATTCCTCAAAGAATTGAAAACAGATTACCGTTTGACCTAGCA ATCCCATTACTGAGTATATACCCAAAGGAATATAAATCATTCTATGACAAAGACACATGCACTTGTGTGT TCATTGCAGCACTATTCAAAACTGCAGACATGGAATCCACCTAAATGCCCATCAATGGTAGACTGGATAA AGAAAATGTGGTACATATATACCATGGAATACTACGCAGCCATAAAAAATAACAAGATCATGTCCTTTGC AGCAAGATGGATGGAGCTGGAGGCCATTATCCTAAGCAAACTAATGTAGAAACAGAAAACCAAATATCAC ATGTTCTCATTTATAAGTGATAGCTAAACATTGAGTACATATGCACACAAAGAAGGGAATAACACACTGG GGCCTACTTGAGAATGGAGAAAGGGTGGAGAGAGAGGATCAAAAAACTATCTAATGGGTAGTAGGCTTAT TACCTAGGTGATGAAATAATCTGTACACCAAACCCCTGTGACATGTAGTTTACCTGCAAACTGCACATGT ACCTCTGAACCTAAAATAGAAGTTAAAAAAAAAAGTAATTTTGGGTGGGGCACAGTGGCTCATGCCTGTA ATCCCAGCACTTTGGGAGGCTGAGGCAGGAGGATTGCTTGAGCTCAAGAGTTCGAGACCAATCTGAGCAA CATAGGAAGACCTTGTCTCTACAGAATATTAAAAAATTAGCCGGGCATGGTGGTGCACGACTCTGGTTCC AGCTACATGGGAGGCTGAGATGGGAGGATCACTTGAGCCCAGGAGATTGAGGCTGCAGTGAGCTGTGATG GCACCACCGCACTCCAGCCTGGTTGACAGAGAAAGACCCCATCTCAAAAAAAAAAAGTAATTTTGGAAGG ACATACCTGGGATATGTTAATAGCACATTTCATTTCTAAAGTCAGAGGAAATTATAAGATCATAACCAGG GATCTGTATTAGCGGACTAGTAGACAAGAGGACCTTAAAGATAGGGAGCTATTGCCTTTCCGCCCGTGTA CGCCACTGAAGAAGCATCGTTAAAGTCTCTCTTCTCCCTTCCATCTTGTCTAAGTCAGAGTCTCCTAAAG AGCTCAAACAGCTGAGGAAGCTCTTCATTGGAGATTTGAGCTTTGAAACAACTGACGAGAGCCTGAGGAG CCATTATGAGTGATGGGGAATGCTCACAGACTGTGTGGTAATGAGAGATCCAAACACCAAGCGCTCCAGG GGCTGTGGGTTTGTCACATACGCCACTGTGGAGGAGGTGGATGCAGCCACGAACGCAAGGCCACACAAGG TGGATGGAAAAGTTGTGGAACCAAAGAGAACTGTCTCAAGAGAAGATTCTCAAAGACCAGGTGCCCACTT AACTGTGAAAAAGATATTTGTTGGTGGCATTAAAGAAGACACGGAAGAACATCACCTAAGAGATTACTTT GAACAGTTTGGAAAAATGGAAGTGATTGAAATCATGACTGAGGCAGTGGCAAGAAAAGGGGCTTTGCCTT TGTAACTTTTGACGACCATGACTCCGTGGATAAGATTGTCATTCCGAAATACCATACTGTGAATGGCCAC AACTGTGAAGTTAGGAAAGCCCTGTCAAAGCAAGAGATGGCTAGTGCTTCATCCAGCCAAAGAGGTCGAA GTGGTCGTGGAGGTGGTTTTGGTGGGAATGAAAACTTTGGTTGTGGAGGAAACTTCAGTGGTCATGGTGG CTTTGGTGGCAGCCATGATGGTGGTGGATATGGTGGCAGTGGGGATGGCTATAATGGATTTGGTAATGAT GGTGGTTATCCAGGAGGCGGCCCTGGTTACTCTGGAGGAAGCAGAGGCTATGGAAGTGGTGGACAGGGTT GTGGAAATCAGGACAGTGGCTATGGCAGGAGTGGCAGCTATGACAGCTGTAACAAGGGAGGCAGAGGCGG CTTTGGCAGTGGTAGTGGAAGCAATTTTGGAGGTGGTGGAAGCTACAATGATTTTGGCAATTACAACAAT CAGTATTCAAATTTTGGACCCATGAAGGGAGGAAACTTTGGGGCAGACGCTCTGGCCCCTAGGGTGATGG AGGCCAATACTTTGCCAAACCACCAAACCACAGTGGCTATGGCGGTTCCAGTAGCAGCAGTAGCTATGGC AGTGGCAGAAGATGTTAATTGGGAATCAAAGCTTAGCAGGAGAGGAGAGCCAGAGAAGTGACAGAGAAGC TACAGGTTACAACAGATTCATGAACTCAGCCAAACACAGTGGTGGCAGGGCCTAGCTGCCACAAAGAAGA CATGTTTTATACAAATACTCATGTTTATGGGCAAAAAAGTCAAGGACTGTATTTGTGACTAATTGTATAA CAGGTTATTTTAGTTTCTGTTCTATGGAAAGTGTAAAGCATTCCAACAAAGGGTTTTAATGTAGATTTTT TTTGCACCCATGCAAAAAATTGCTATATGTGATAGTCTGATCATGACACTGAATAAATGTCTTTTTTTTT TAATGTGCTGTGTAAAGTTAGTCTACACTGAAGCCATCTTGGTAAATTTCCCCAACAGTGTGAAGTTAGC ATTCCTTCAGGGTGATGCCAGGTTCTATTTGGAATTTATATACAACCTGCTTGGGTGGAGAAGCCATTGT CTTCAGAAACCTTGGTGTAATTGAATTGATAGTTACTGTTGTGACCTGAAGTTCACCATTAAAAGGGACT ACCCAAGCAAAATCATGGAATTATTGGTTATAAAAATAATTGTTGGCACATCCTATGCAATATATCTACG TTGAATAATGGTACCAGATAAAATTATAGATGGGAATGAAGCTTGTGTATCATCCATTATCATGTGTAAT CAATAAACAATTTAATTCTCTTGAAAAAAAAGATAGGGAGCTATTTAAAGATTATTAGGAAAGCTTACTA GCTAAGATGGTTAATACCTTGTCTTATCTTGCACATCAGCTTCTGTCTTTTTCTCATCTATTACCTGAGT TAAGTTATAGTTGGTCTATTTGGTATCCTTAAAACTTAGGGGTTGCTTTGGTTGGTCGTGTAATACTCTA AGAGAGAGAATACCAGTTTTGCCACCTGAATGTATTGCTTTGTTTCTTCCATAAACATTTAAAAAATACT CTCTCCATATTCACCCCATTTAAAAATTAGAAAAATAATATACATTTATTGTAGAAAGTTTGGAAAATAC AAAAAATACTAGAAGTAAATAAAAAATTTCATAGAGTTCTACCACCTAGAGGAAATAATGTTTTTCCTTG ATTGATATAATGGATGCTTTCCTTTGAAACATTTTTTTTTGTTTTGAGACAGTCTCCCTCTGTTACTCAG GCTAGAGTGCAGTGGTGTGATCTTGTCTCACTGCAACCTCTGCCTCCTGGGTTCAAGTGATTCTCCTGCC TCAGCTTCCCAAGTAGCTGGGACTACAGGCGCGCACCACCACGCCCTGCTAATTTTTGTATATTTAGTAG AGACGGGGTTTTGCCACGTTGACCAGACTGGTCTCGAACTCCTGACCTCAGGTGATCCACCTGCCTTGGC TTCCCAAAGTGTTGGGATTACAGGCGTGAGCCACCGCACCCGGCCTTGAAACATTTGTTTTAAAATAGTT GGCCAGGAGTGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGTGGATCATTCGAGG CCAGCAGTTCCAGACCAGCCTGGCCAGCATGGTGAATCTCCATCTCTACTGAAAATGCAAAAATTCGCCA GGTGTGGTGGTGCATGCCTGTAGTTTTAGCTAATTGGGAGGCTGAGGCAGGTGGATCATTCGAGGCCAGC AGTTCCAGACCAGCCTGGCCAGCATGGTGAATCCCCATCTCTACTGAAAATGCAAAAATTCGCCAGGTGT GGTGGTGCATGCCTGTAGTTTTAGCTACTTGGGAGGCTGAAGCAGGAGAGTTGCTTGAACCCGGGAGGCG GGGGTTGCAGTGAGCCGAGACTGTGTGACTGCACGGAGTGAGACTCTGTCAAAAAAAAAAAAGAAAGAAA GAAAGGAAGGACGCAAGGAAGAAAGCAAGGAAGGAAGGAAGGAAGAAAAGAAAGAAAGAAAGAAAGAAAG AAAGAAAGAAAGAGAAAGAGAGAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAA AGAAAGAAAGAAAGGAAGGAAGGAAGGAAGGAAAGAAAGAAAAAGAAAGAAAGAGAAAGAGAAGGAAAAT ATGTGTATGGTATATATACCATTTTAATCATTTCTTAAAGTAAACATTGTGGCCATTACTTTACTCGTGC ATAATACTTTTTCACACCTTAATTATTTATCTTCATTTCCCAGAAGTGAAGTTCCAGGGTAAAAGAGAAG GAATGCTTTTGAGGCTATTGAGACATACTGCTCAACTGCTCTCTGGGAAGATGTTGCCAATTTGCATTTT CACCCCTGTGAAATGCATGTTCAATTTGCATGCCCACGTGAACACTCCCATTTCCCTGAATCCCAGTTAA TGCTGGGCATTATTAATTAAAATTGTTTTTCAATTTGAGAGACTAAAATGGTATCTTGTTTTAATATTTA TTACTCTGACTATTTCTGAGGCCAATATTTTTTTCACATTGTTATTATCCATTTCTTAAATATGTTTTTC CTCAAATTGAGCTGGGGAATTTTCTTCAAATAAGAAATAGCACTGAATTGCATAATGTTCACTCTGTTTG ATTTGTCCCATCTCTGCCTCTTCCTTCCCTAGAGATACTCAAGGAAGTTATTTGCTTGCACCAGCTTAAG AAACCTCACTTCACACAGTCCCAATGTATCACACTTGAGCAACTGTGCAAGAAAGGACATAATTTAGTAT TGCTAGGAAGTATATTTTTAGTAGTTCCTGTGCAGGTAGAAGCAAACTGCTGCTTTGCAAAGATCTCAGG GATAGAAAAGCTGCTTTATTTATTTATTTATTTTATTTATTTTGAGACGGAGTCTCACTCTGTCACCCAG GCTGGAATGCAGTGGCGCGACCTGGGCTCACTGCGACCTCCTGGGTTCGAGTGATTCTCCTTCCTCAGTC TCCCGAGTGTCTGGGATTACAGGCACCCACCACCACACTCGGCTAATTTTTGTATTTTTAGCAGAGATGG GGTTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGATCTCAAGTGATCCACCCGCCTTGGCTTCCCA AGGTGCTGGGATTACAGGCGTGAGCCACTGCGCCTGGCCAAAAAGCTGCCTTTAAAAAAAATGTAGACAA GGTAAAAAAGATATTACTATGTTAAATGTTTAAGCACTTGAGAAAGGAGGTGATGGATAAGTACTGAGTT TTATGTACCAGTAGCATCAGTCACATACTTTCCCTTTTTTGTGTTTGTTTTGTTTTTAATCATCTGCCTC TATTTCACATCTACTTTCTCTGTTGGTTTTTTAGATTGGACAAGCTGTCCTCGAAGACAGTCTTAGATTC TTAAAATTAAATCTTATTTTATTTTTTTGGAGACAGTGTCTTGCTCTGTTGCCCAGGCTGGAGTGCAGTG GTGTGATCTCAGCTCACTGCAACCTCTGCTGCCTCCTGGGTTCAAGCGATTCTTATGCCTCAGCATCCCA TGTGGCTGGAATTACAAGCATGCACCACCACGCGCAGCTAATTTTTTGTATTTTTAGTAGAGACAGGGTT TCGCTATGTTGCCCAGGCTAGGTCTCCAACTCCTGAGATCAGGCAGTCTGCCCGCCTCGGCCTCCTAAAG TGCTAGGATGAGCCACTGTGCCAGGCCTTAAAATTAAATTTTATATGTAATTTAAGAATAAGAATATTTA CCATGTGTTCCATTTCTGTGCTTTTCTCCTGCTTCTTGGTCAGACTTGTAAATTTTCAGGAAATGGTCTG TTTTATGAATAACAGATTAGCAAACGAAACCATTGTCCTTTATTTTTTCTATTTCCATCTTCCAGATTTG GTGAAATTAGTAGCTTAAAAATGATACACATTGGAGAACTCAGTAAAGAATGAAGGATGAACTGCTACAC AAATAAGTCCTAAACAAGAAATTAGTGTGTAATCTCATTCTTAACCCTGTCTCTGTGCAGTCTTGGAAGT GGATCCTTGCACCGGTCATTCTTTATATCTGTGAAAGGATCCTCCGGTTTTACCGCTCCCAGCAGAAGGT TGTGATTACCAAGGTAAAGAATATGCACTTTCCTCTTGCTGTGATAAGAGTTATCTTCTACCGGACTACA GAACTAAATTTTTATGTTGTCACCCTGAAAGAGGAACTTGGAAACTGGGCACAGTGGGTGGTAGTCCCAG CACTTTGGGAGGCCAAGGAGGGCAGATCTGTTGAGGTCAGGAGTTCGAGACCAGCCCGGCCAACATGGCG AAACCCCATCTCTAATAAAAAAAAAAAAATTAGCTGAGCGTGGTGGTGCCCACCTGTAATTCCAGCTACT TGGGAGGCTGAGGCGGGAGAATCGCTTGAACCCGGGAGGCAGAGGTTGCAGTGAGTTGAAATAGCGCCAC TGCACTCCAGCCTGGGTGACAGAGAGAGGCTCTGTCTCAAAAAAAAAAGAAGAAGAACTTGGGTTTGGCA TACCTCAGTTCCTCCAGCACTGGACAGAACTGGGAAAGAGGGGCTTGGCCGAAATCATCAGGATGAGTCT ATATCAGAGGTTGCAAACAGGCAGCCTGGGCCAGAGCTAGTTCACAGCTATATTTTGTTTGGTGCACACA ATGTTTGTTTATAAAGTTGAATTGGTTGCCAACATTTAAAAATCTGGATGGAAGCTTTCGTTTGATTTTT TAAAAGCTATTTCTTGCTTCTCTTGAAGAATCAGGAAACCTGATAACACTGTCATGGTTCCATATCGCAA CCACTGTCTGGAGCTAAGTAGCTGCTGCCCTCTTTAGAGAGGACTTGTGTTTGTAGTTCACCACTGTCAC CAGCCCTCCAGCTTCACTCATTTGCTTTATCTGCCTGTCCCTGTCGTCATTAGAGTTTGCTTTCTTTGGT CTATGTGCTTCATTCACAGGTTGTTATGCACCCATCCAAAGTTTTGGAATTGCAGATGAACAAGCGTGGC TTCAGCATGGAAGTGGGGCAGTATATCTTTGTTAATTGCCCCTCAATCTCTCTCCTGGAATGGCATCCTT TTACTTTGACCTCTGCTCCAGAGGAAGATTTCTTCTCCATTCATATCCGAGCAGCAGGGGACTGGACAGA AAATCTCATAAGGGCTTTCGAACAACAATATTCACCAATTCCCAGGTAGGTCCTTGAGACCAGGAGAGTC CCAGACCAGGATGCAGACTGGCAGAAAAGAGAAAGCAATTCTTCGTTGAATCTTAAGTTTGGTACAATAG AATAGGATTATAATAAATATGCAGAAGTCAGCCATGAGAACAACTATATTTCTGGGAGGATGTTTGAGGT TGGAGGTGGAGGGGAGTCTTCAGTTGCCCGTTATCTTCTGTCTTCTGCCAGGATTGAAGTGGATGGTCCC TTTGGCACAGCCAGTGAGGATGTTTTCCAGTATGAAGTGGCTGTGCTGGTTGGAGCAGGAATTGGGGTCA CCCCCTTTGCTTCTATCTTGAAATCCATCTGGTACAAATTCCAGTGTGCAGACCACAACCTCAAAACAAA AAAGGTATAATCCCGTATATCACTTTTCTTCTGGCCTGAGTCTGACAAGTCTATTGCCTTCTTGGGCTAA GCTCTTTACAATTGATAAGGGAGCAACCTATCCCTGGAGTTATGAGAATAAGTGATCACTTCTCTTGGCC AGGACATCCACTTCTACAGATTTATCATAAGAACAGGGTCTTCTTTTCAATTTGGAGTTTAAGATCACCC TGACCAAAGATGTTGGAAGGCTCGTTCCTAAGGAAAATTGTCAGAACTCTGAACATTCCTGCTGCCTAAA GTTTGCGGCTCTATAAATGTGACTTTTAAGGTCACCTAATAAGGCTATGTTCTCTCTTGCTGATTTCAGA TCTATTTCTACTGGATCTGCAGGGAGACAGGTGCCTTTTCCTGGTTCAACAACCTGTTGACTTCCCTGGA ACAGGAGATGGAGGAATTAGGCAAAGTGGGTTTTCTAAACTACCGTCTCTTCCTCACCGGATGGGACAGC AATATTGTGAGTCCAAATAACACACTAATTCCCCTACTAAACATAAGACGAATGTCAGACAAAGGATAGT GCATATGGATTAGAAGTTATTTCTTATGATTTCCTACCTGCCCTCACACTCACACACAAGTTTAAAAGTG GTGGAAAGAAGAGGCAGCTATCAGGACTTGGTTTTTCTTTTCTTTCTTTCTTCTTTTTTTTTTCTTTTTG AGACAGAGTTTCACTCTTGTTGCACAGGCTGGAGTGCAATGGTGCGATCTTGGCTCACCACAACCTCTGC CTCCTGGGTTTAAGCAATTCTCCTGCCTTAGCCTCCCGAGTAACTGGGATTACAGGCATGCGCCACCATG CCCAGCTAATTTTGAATTTTTAGTAGAGATGGGGGTCTCACCATGTTGGTCAGGCTAGTCTCGAACTCCT GACCTCAGGTGATCCACCCACCTCGGCCTCCCAAAGTATTGGGATTACAGGCGTGAGCCACGCACCCAGC CTAGGACTTGGTTTTTCTAACTTTTATTCCTCTGAATCCAGGTTGGTCATGCAGCATTAAACTTTGACAA GGCCACTGACATCGTGACAGGTCTGAAACAGAAAACCTCCTTTGGGAGACCAATGTGGGACAATGAGTTT TCTACAATAGCTACCTCCCACCCCAAGTAAGTATATTTTCCTCTAGTAAGATGAGTTTACAGGGGCCGTG CGTGGTGGCTTACTGCCTGTAATCTCAGCACTTTGGGAGGCCGAAGTGGGTGGATCACCTGAGGTCAGGA GTTCGAGACCAGTCTGGCCAACTTGGCAAAACCCCGTCACTACTAAAAATACAAAAATTAGCTAGGCGTG GTGGCACATGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAAGGAGAATTGCTTGAACCTGGGAGGCA GAGGTTGCAATGAGCTGAGATAGCGCCATTGCACTCCAGCCTGGGCAACAAGAGAGAAACTCTGTCTCAA AAGAAAAAAAAAAAGATGAGTGCGGAGTTAGGATTTAGGAAAGGTATTACAACATGTTGAACACTCTTAA GAAAAGATCTCTGGGGCAGAAATCTTTTGTGCCATTCTTAGATTCTTGGTGAAGACCGAGGAAATTTCAT CTGGGGTTTTAGAAAAATAGGGTCATGATCTTGAAAATGATGAAAAGAGGTTTTTTTGCCCCAGCAAACT CCATTCAAACAGTGAGGCAAGTGGACCCACTTCTGATCTATACTACCAAACAAACTAGAGAACTGGAGCA ATTCAAATGCATTTTTGCGGGGAGGGGACTCAATAATCTCTACTTAAAGTAACAAAGGTATTATCTAGTT TACTGGCCACCTGAGCTCAATCTTTCTGGAGGGTTTTGAGACATGTTACAGCACAAAAAATCCTGGTGCT ATGAAATCAGCCATTCCAATGGGAAGGAGATGAAGCTGAGATTCCCTGAACAAGTAGGGAGGTGATGATC AATTCAATGCTACAAATATTCTTGATTACCTTTTTTTTTTTTTTTTTTTGAGATGGAGTTTCGCTCTTGT CGCCCAGGCTGGAGTGCAGTGGTGCGATCTCTGCTTGCTGCAATCTCCGAATCCCGGGTTCAAGCGATTC TCCTGCCTCAGCCTCCCATGTAGCTGGGATTACAGGTGCCCACCACCATGCCCAGCTAATTTGTTGTATT TTTAGTAGAGATGGTGTTTCACCACGTTGGTCAGGCTAATCTCGAACTCCTGACCTCAGGTGATCCACCT GCCTCAGCCCCCAAAAGTGCTGAGATTACAGGCATGATCCACCAAGCCCCGCCTTGGTTACCTTTTATAA GCTCAGCTCTCACCATTCTAGAAGCTTTGGAGGTTGAAAGAGAAATAGGATATGGTTCTTGCCCACAAGG AACATACATTTGAATAAGAGATGCACACAATCACCTCAAAGCAGAATAATGCACTCCGTGAAAGAGGTTC ACGGATGCTGGAGGGAAGAAAAGTCTACGGCCACATGGGGTGATTAGGAAAGGCTTCAGGAAGGCAGTGG CTAGAGCACTTAGTGACTTGGATTCAGATGATCCTGGGTCCTCATGCTGGTTCTCTCTTTTTTTCTCGAG ACACAGTCTTGCTTTGTCACCCAGGCTGGAGTGCAATGGTGCCATCTCGGCTCACTGCAACCTCCGCCTC CTGGGTTCAAGCAGTTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCATCCACCACCACATCC AGCTAATTTTTTGTATTTTTAGTAGAGATGGGGTTTCGCCATATTGGCCAGGCTGGTCTCGAACTCCTGA CCTCAGGTGATTCACTCACCTCAGCCTCCCAAAGTGCTGGGATTACAGCATGAGCCACCATGCCCGGCCC TTATTCTGGTTCTGACACTTTCTAGTTATGAGACCTTGAACTTCTGAACTCTCTGATCTTGATTCCTCAT CTGTAAGACAAGGGTCATATTAGTGAATGCCTGCTCTACTCACTTGCAGGGTTGTTATGACAATTAAGTG AGACAATATATGAAAAAATGCTTTGTAAATTTTAAAGCAGCATATAAGCATAAAAGATGCTAATTATCAT GTTGAATGTAACTGAAGTTTTGAGAGAGTATGAGGTTGTCAGGAGAGAGAGAGAGAGGGAGGGAGAGAGA GAGACTAGCGAGGGACAGAGTACCAAGGAATGCTGCCTAGGTTATATGGGAAGGGAAAAAGACAAACCAG GGAAGAAATAGGAGTACACAGAGAAGTGGTGTCACAGAACCCAAGGGAGCAAATATTAGAGAAGCGTGGT CAATAGTGTTGGAAGAGTAGCAGGGTCAGGAAATGTTCATTTAGCTTAAGCATATTTATAGACAGAACAA GGACCAGTACATAAAATAAAATAAATACATGAAAGAGGGGAGAGGACTAAGATGGCCATAATAAAAGATG GACAATAGTATTGGCAAGGAAGTGGAGAAGTTGCAATCCTAGTACATTGCTTGTGGAAATGTGAAATGAT ACCACACTCGGGGAAAACTCTTTGGCAGTTCCTCAAAGTGTTAAACACAGTTTCCAGCTGGGCATGGTGG CTCGCGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCAGATGGATCACGAGGTCAGGAGTTCAAGACCA GCCTGGCCAACATAGTGAAACCTTGTCTCTACTAAAAATACAAAAAATTAGGCCGGGCGTGGTGGCTCAT GCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGTGGATCACGAGGTCAGGAGATCGAGACCATCCTG GCTAACACGGTGAAACCCTGTCTTTACTAAACATACAAAAAAAAATTAGCCGGGTGCGGTGGCGGGCGCC TGTAGTCCCAGCTACTTGGGAAGCTGAGGCAGGAGAGTGGCGTGAACCCAGGAGGCAGAGCTTGCAGTGA GCCAAGATCGTGCCACTGCGCTCCAGCCTGGGCGACAGCGAGATTCCATTAAAAAAAAAAAAGGTGAAAA GAATTAGCTGGGCATGGTGGCGGGCACCTGTAATCCCAGCTACTAGGGAGGCTGAGGCAGGAGAATCGCT TGAACCCGGGAGGTGGAGGTTGCAGTGACCCCAGATCATACCATTGTACTCCAGCCCGGGTGACAGTGCA AGACTCTGTCTCAAAAAAAAAAAAAAAAAAAAAACACATAGTTTCCATATGACCCAGCAATCCCACTCCT TGTTATACACCCAAGAGAAATGAAAATATATGTCTACACAAAAACTTGTACATGATGTACATAGCAGCAT TACTCATAATAGCCCCGAAGTGAAAACAAGCCAAGCATCCATCAATAGATGAATGGATGAAGCAAATGTA GTATATTCACATACTGGAATATTATTTAGCTATTAAAAAAAAAACAAAGTACTGAATCATGCTACAACAT GGACAAATCTTGAAAACATCATGCTGAAAAACACCAGACACCAAAGGCCATGTATTGTATGATTCCACTT ATGTGAAACATTCAGGATAGGCATACCCACAGAGACAGAAAGTAAAGTGATTGTCTTGGGTAGGACAGGG TAGTTGGGAGGAAATGAGGACTGCTAATGTGGATGGGGTTTCTTTGCGGATGATGAAAATGTTCTGGAAT TAGATAGTGGTGATGGTTGCATAACTTTGTGGCTGTGCTAAAAAGCACAAATTGCACACTTCAAAGGGGC GAATTTTATGGTATAGAAACTATACCATAATTATATTTTTAAAAAAGAGGGGGAGAGAAAGGTATGAGAG AAGGAAGAAGACGGTGAGACCCAGAGCATAGTTGGAAAGATTAGCTTTGGCAAGAAAGAACACTACCTCT CCACTAGGAGAAATTTTGAGGTAGGGATAAGCTCACAGTGGATGGGTTTAATGGGAGCTAATACATATGT ACTTGCTATGTGCCAGGCATTTTTCTAATTTATTTACATGTTCTTATTTAATCCTTAAAACAACCCTATG TGGTAAGTACTATTTTTATCCCCATTTTACAGGTGGGAAAGCTGAAACAGAGAGAGGTTAAGAAATTTTC CCTTGTCGGACATTGTGGCTCACGCCTGTAATCCCAGCACTTAGGGAGGCTGAGGCAGGCGGATCACTTG AGGTCAGGAGTTTGAGACCAGCCTGGCCAACATGGTGAAACCCCATCTCTAATAAAAATACAAAATTTAG CTGGGCATGCTGGTGCGTGCCTGTAGTCCCAGCTACTCAGGAGGCTGAGGCAGGAAAATTGCTTGAACCT GGGAGGTGGAGGTTGCAGTGAACCGAGATTGTGCCACTGCACTCCAGCTGGGGGACAGAGCAAGACTCCA TCTCAAAAAAAGAAAAGAAAAAAGAAAAAAAGAAATGTGCCCAAAGTCCCACAGGTGGGATAAATGTCAG AGCTGAGATTTGAGCCCAGACAACCCAGACAGACTGGCTGCACAGTCTGGCACTTAGCCACTGCACTGTC TTATGTCTGTCATCTGTGTTCTCAAAACAGGGAAGGCTGAGTGCTGAGAGTGTTAAGGGCTGAGAGCATA TTTGGGGTTTGTGCGCAGAAAAGGTTAAAAAACTACCATGAAGAACGTGGGAGTAAACAACCGAATTTTT ATTCAAGGTTCTTGGAAGTAGTAGAGGCCTAACAGAGGCAGTTTCTCCATTCTGTCATTGCTGCATTCTA GCCCTTACTATTGTTCTGTTCCTACAGGTCTGTAGTGGGAGTTTTCTTATGTGGCCCTCGGACTTTGGCA AAGAGCCTGCGCAAATGCTGTCACCGATATTCCAGTCTGGATCCTAGAAAGGTTCAATTCTACTTCAACA AAGAAAATTTTTGAGTTATAGGAATAAGGACGGTAATCTGCATTTTGTCTCTTTGTATCTTCAGTAATTT ACTTGGTCTCGTCAGGTTTGAGCAGTCACTTTAGGATAAGAATGTGCCTCTCAAGCCTTGACTCCCTGGT ATTCTTTTTTTGATTGCATTCAACTTCGTTACTTGAGCTTCAGCAACTTAAGAACTTCTGAAGTTCTTAA AGTTCTGAAGTTCTTAAAGCCCATGGATCCTTTCTCAGAAAAATAACTGTAAATCTTTCTGGACAGCCAT GACTGTAGCAAGGCTTGATAGCAGAGGTTTGGTGGTTCAGAGTTATACAACTAATCCCAGGTGATTTTAT CAATTCCAGTGTTACCATCTCCTGAGTTTTGGTTTGTAATCTTTTGTCCCTCCCACCCCCACAGAAGATT TCTAAGTAGGGTGACTTTTTAAATAAAAATTTATTGAATAATTAATGATAAAACATAATAATAAACATAA ATAATAAACAAAATTACCGAGAACCCCATCCCCATATAACACCAACAGTGTACATGTTTACTGTCACTTT TGATATGGTCTTATCCAGTGTGAACAGCAATTTATTCTTATTTTTGCTCATCAAAAAATAAAGGATTTTC TTCTTCACTTGA Download Select all
Length	31022
OMIM ID	300225
HGNC ID	HGNC:7889
Unigene ID	Hs.592227
Ensembl ID	ENSG00000007952
PharmGKB ID	-

mRNA Information

mRNA ID	NM_001271815.1
Exon	join(1..251,3532..3627,11103..11187,11526..11677, 11773..11954,12043..12175,23021..23113,23960..24195, 24412..24574,24920..25066,25592..25716,30268..31022)
mRNA Sequence	>27035 GCTGATAGCACAGTTCTGTCCAGAGAAGGAAGGCAGAATAAACTTATTCATTCCCAGGAACTCT TGGGGTAGGTGTGTGTTTTTCACATCTTAAAGGCTCACAGACCCTGCGCTGGACAAATGTTCCA TTCCTGAAGGACCTCTCCAGAATCCGGATTGCTGAATCTTCCCTGTTGCCTAGAAGGGCTCCAA ACCACCTCTTGACAATGGGAAACTGGGTGGTTAACCACTGGTTTTCAGTTTTGTTTCTGGTTGT TTGGTTAGGGCTGAATGTTTTCCTGTTTGTGGATGCCTTCCTGAAATATGAGAAGGCCGACAAA TACTACTACACAAGAAAAATCCTTGGGTTTTGCAGCCGCACACTGAGAAAGCAATTGGATCACA ACCTCACCTTCCACAAGCTGGTGGCCTATATGATCTGCCTACATACAGCTATTCACATCATTGC ACACCTGTTTAACTTTGACTGCTATAGCAGAAGCCGACAGGCCACAGATGGCTCCCTTGCCTCC ATTCTCTCCAGCCTATCTCATGATGAGAAAAAGGGGGGTTCTTGGCTAAATCCCATCCAGTCCC GAAACACGACAGTGGAGTATGTGACATTCACCAGCATTGCTGGTCTCACTGGAGTGATCATGAC AATAGCCTTGATTCTCATGGTAACTTCAGCTACTGAGTTCATCCGGAGGAGTTATTTTGAAGTC TTCTGGTATACTCACCACCTTTTTATCTTCTATATCCTTGGCTTAGGGATTCACGGCATTGGTG GAATTGTCCGGGGTCAAACAGAGGAGAGCATGAATGAGAGTCATCCTCGCAAGTGTGCAGAGTC TTTTGAGATGTGGGATGATCGTGACTCCCACTGTAGGCGCCCTAAGTTTGAAGGGCATCCCCCT GAGTCTTGGAAGTGGATCCTTGCACCGGTCATTCTTTATATCTGTGAAAGGATCCTCCGGTTTT ACCGCTCCCAGCAGAAGGTTGTGATTACCAAGGTTGTTATGCACCCATCCAAAGTTTTGGAATT GCAGATGAACAAGCGTGGCTTCAGCATGGAAGTGGGGCAGTATATCTTTGTTAATTGCCCCTCA ATCTCTCTCCTGGAATGGCATCCTTTTACTTTGACCTCTGCTCCAGAGGAAGATTTCTTCTCCA TTCATATCCGAGCAGCAGGGGACTGGACAGAAAATCTCATAAGGGCTTTCGAACAACAATATTC ACCAATTCCCAGGATTGAAGTGGATGGTCCCTTTGGCACAGCCAGTGAGGATGTTTTCCAGTAT GAAGTGGCTGTGCTGGTTGGAGCAGGAATTGGGGTCACCCCCTTTGCTTCTATCTTGAAATCCA TCTGGTACAAATTCCAGTGTGCAGACCACAACCTCAAAACAAAAAAGATCTATTTCTACTGGAT CTGCAGGGAGACAGGTGCCTTTTCCTGGTTCAACAACCTGTTGACTTCCCTGGAACAGGAGATG GAGGAATTAGGCAAAGTGGGTTTTCTAAACTACCGTCTCTTCCTCACCGGATGGGACAGCAATA TTGTTGGTCATGCAGCATTAAACTTTGACAAGGCCACTGACATCGTGACAGGTCTGAAACAGAA AACCTCCTTTGGGAGACCAATGTGGGACAATGAGTTTTCTACAATAGCTACCTCCCACCCCAAG TCTGTAGTGGGAGTTTTCTTATGTGGCCCTCGGACTTTGGCAAAGAGCCTGCGCAAATGCTGTC ACCGATATTCCAGTCTGGATCCTAGAAAGGTTCAATTCTACTTCAACAAAGAAAATTTTTGAGT TATAGGAATAAGGACGGTAATCTGCATTTTGTCTCTTTGTATCTTCAGTAATTTACTTGGTCTC GTCAGGTTTGAGCAGTCACTTTAGGATAAGAATGTGCCTCTCAAGCCTTGACTCCCTGGTATTC TTTTTTTGATTGCATTCAACTTCGTTACTTGAGCTTCAGCAACTTAAGAACTTCTGAAGTTCTT AAAGTTCTGAAGTTCTTAAAGCCCATGGATCCTTTCTCAGAAAAATAACTGTAAATCTTTCTGG ACAGCCATGACTGTAGCAAGGCTTGATAGCAGAGGTTTGGTGGTTCAGAGTTATACAACTAATC CCAGGTGATTTTATCAATTCCAGTGTTACCATCTCCTGAGTTTTGGTTTGTAATCTTTTGTCCC TCCCACCCCCACAGAAGATTTCTAAGTAGGGTGACTTTTTAAATAAAAATTTATTGAATAATTA ATGATAAAACATAATAATAAACATAAATAATAAACAAAATTACCGAGAACCCCATCCCCATATA ACACCAACAGTGTACATGTTTACTGTCACTTTTGATATGGTCTTATCCAGTGTGAACAGCAATT TATTCTTATTTTTGCTCATCAAAAAATAAAGGATTTTCTTCTTCACTTGA Download Select all
Length	2418

CDS Information

Location	join(207..251,3532..3627,11103..11187,11526..11677, 11773..11954,12043..12175,23021..23113,23960..24195, 24412..24574,24920..25066,25592..25716,30268..30394)
CDS Sequence	>lcl\|NM_001271815.1_cds_NP_001258744.1_1 [gene=NOX1] [protein=NADPH oxidase 1 isoform 3] [protein_id=NP_001258744.1] [location=207..1790] ATGGGAAACTGGGTGGTTAACCACTGGTTTTCAGTTTTGTTTCTGGTTGTTTGGTTAGGGCTGAATGTTT TCCTGTTTGTGGATGCCTTCCTGAAATATGAGAAGGCCGACAAATACTACTACACAAGAAAAATCCTTGG GTTTTGCAGCCGCACACTGAGAAAGCAATTGGATCACAACCTCACCTTCCACAAGCTGGTGGCCTATATG ATCTGCCTACATACAGCTATTCACATCATTGCACACCTGTTTAACTTTGACTGCTATAGCAGAAGCCGAC AGGCCACAGATGGCTCCCTTGCCTCCATTCTCTCCAGCCTATCTCATGATGAGAAAAAGGGGGGTTCTTG GCTAAATCCCATCCAGTCCCGAAACACGACAGTGGAGTATGTGACATTCACCAGCATTGCTGGTCTCACT GGAGTGATCATGACAATAGCCTTGATTCTCATGGTAACTTCAGCTACTGAGTTCATCCGGAGGAGTTATT TTGAAGTCTTCTGGTATACTCACCACCTTTTTATCTTCTATATCCTTGGCTTAGGGATTCACGGCATTGG TGGAATTGTCCGGGGTCAAACAGAGGAGAGCATGAATGAGAGTCATCCTCGCAAGTGTGCAGAGTCTTTT GAGATGTGGGATGATCGTGACTCCCACTGTAGGCGCCCTAAGTTTGAAGGGCATCCCCCTGAGTCTTGGA AGTGGATCCTTGCACCGGTCATTCTTTATATCTGTGAAAGGATCCTCCGGTTTTACCGCTCCCAGCAGAA GGTTGTGATTACCAAGGTTGTTATGCACCCATCCAAAGTTTTGGAATTGCAGATGAACAAGCGTGGCTTC AGCATGGAAGTGGGGCAGTATATCTTTGTTAATTGCCCCTCAATCTCTCTCCTGGAATGGCATCCTTTTA CTTTGACCTCTGCTCCAGAGGAAGATTTCTTCTCCATTCATATCCGAGCAGCAGGGGACTGGACAGAAAA TCTCATAAGGGCTTTCGAACAACAATATTCACCAATTCCCAGGATTGAAGTGGATGGTCCCTTTGGCACA GCCAGTGAGGATGTTTTCCAGTATGAAGTGGCTGTGCTGGTTGGAGCAGGAATTGGGGTCACCCCCTTTG CTTCTATCTTGAAATCCATCTGGTACAAATTCCAGTGTGCAGACCACAACCTCAAAACAAAAAAGATCTA TTTCTACTGGATCTGCAGGGAGACAGGTGCCTTTTCCTGGTTCAACAACCTGTTGACTTCCCTGGAACAG GAGATGGAGGAATTAGGCAAAGTGGGTTTTCTAAACTACCGTCTCTTCCTCACCGGATGGGACAGCAATA TTGTTGGTCATGCAGCATTAAACTTTGACAAGGCCACTGACATCGTGACAGGTCTGAAACAGAAAACCTC CTTTGGGAGACCAATGTGGGACAATGAGTTTTCTACAATAGCTACCTCCCACCCCAAGTCTGTAGTGGGA GTTTTCTTATGTGGCCCTCGGACTTTGGCAAAGAGCCTGCGCAAATGCTGTCACCGATATTCCAGTCTGG ATCCTAGAAAGGTTCAATTCTACTTCAACAAAGAAAATTTTTGA Download Select all
CCDS ID	CCDS65298.1

Protein Information

Protein ID	NP_001258744.1
Protein Name	NADPH oxidase 1
Molecular Wt. (Da)	60814
Protein Sequence	>27035 MGNWVVNHWFSVLFLVVWLGLNVFLFVDAFLKYEKADKYYYTRKILGFCSRTLRKQLDHNLTFH KLVAYMICLHTAIHIIAHLFNFDCYSRSRQATDGSLASILSSLSHDEKKGGSWLNPIQSRNTTV EYVTFTSIAGLTGVIMTIALILMVTSATEFIRRSYFEVFWYTHHLFIFYILGLGIHGIGGIVRG QTEESMNESHPRKCAESFEMWDDRDSHCRRPKFEGHPPESWKWILAPVILYICERILRFYRSQQ KVVITKVVMHPSKVLELQMNKRGFSMEVGQYIFVNCPSISLLEWHPFTLTSAPEEDFFSIHIRA AGDWTENLIRAFEQQYSPIPRIEVDGPFGTASEDVFQYEVAVLVGAGIGVTPFASILKSIWYKF QCADHNLKTKKIYFYWICRETGAFSWFNNLLTSLEQEMEELGKVGFLNYRLFLTGWDSNIVGHA ALNFDKATDIVTGLKQKTSFGRPMWDNEFSTIATSHPKSVVGVFLCGPRTLAKSLRKCCHRYSS LDPRKVQFYFNKENF Download Select all
Length	527
Uniprot ID	Q9BXW9
Ensembl Protein ID	ENSP00000287647

Post-translational Modification Information (Source : HPRD)

No matching records could be found.

Enzyme Information

EC	1.6.3.1
Name	NAD(P)H oxidase THOX2 ThOX dual oxidase p138tox thyroid NADPH oxidase thyroid oxidase thyroid oxidase 2 NADPH oxidase
Class	Oxidoreductases; Acting on NADH or NADPH; With oxygen as acceptor
Sysname	NAD(P)H:oxygen oxidoreductase
Substrate	NADH [CPD:C00004]; NADPH [CPD:C00005]; H+ [CPD:C00080]; O2
Product	NAD+ [CPD:C00003]; NADP+ [CPD:C00006]; H2O2
Reaction (IUBMB)

PPi Information

(Click to view network : Source STRING) View

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
1535	CYBA	1989	NP_000092.2	in vitro;in vivo	15322091

Pathway Information

Pathway Name	Pathway ID
AGE-RAGE signaling pathway in diabetic complications	hsa04933
HIF-1 signaling pathway	hsa04066
Leukocyte transendothelial migration	hsa04670
Osteoclast differentiation	hsa04380
Phagosome	hsa04145

Structure Information

No matching records could be found.

Domain Information

ID	Location	Description
cd06186	297-564	NOX_Duox_like_FAD_NADP
cl06868	297-564	FNR_like superfamily
pfam08030	395-544	NAD_binding_6
pfam08022	295-389	FAD_binding_8
cl21465	295-389	FAD_binding_6 superfamily
cd00322	296-542	FNR_like
cd06198	300-564	FNR_like_3
pfam01794	66-213	Ferric_reduct
cl01043	66-213	Ferric_reduct superfamily
cd06189	308-441	flavin_oxioreductase
cd06197	340-441	FNR_like_2
cd06196	307-428	FNR_like_1
cd06184	322-457	flavohem_like_fad_nad_binding
cd06220	317-416	DHOD_e_trans_like2
cd06187	295-414	O2ase_reductase_like
cd06192	322-415	DHOD_e_trans_like
cd06221	308-543	sulfite_reductase_like
cd06215	315-440	FNR_iron_sulfur_binding_1
pfam00970	303-387	FAD_binding_6
pfam00175	400-465	NAD_binding_1
cd06194	297-416	FNR_N-term_Iron_sulfur_binding
PLN02844	176-417	PLN02844
PLN02292	171-433	PLN02292
PLN02631	171-422	PLN02631
COG4097	285-547	COG4097
COG0543	297-491	Mcr1
PRK00054	314-465	PRK00054
COG1018	322-415	Fpr
PRK08345	315-440	PRK08345
PRK08051	317-442	fre

Ontology Information

HPRD ID	2567
Molecular Class	Enzyme: Oxidase
Molecular Function	Catalytic activity (GO:0003824)
Biological Process	Metabolism (GO:0008152); Energy pathways (GO:0006091)

SNP Information

View SNP Geneview Report

Drug Information

No matching records could be found.

External Links

ArrayExpress GO
ICGC GO
Cancer3D GO
COSMIC GO
NCG GO
TSGene GO
Tumor Gene Family of Databases GO
CCDB GO
G2SBC GO
Osteosarcoma Database GO
RCDB GO

ArrayExpress	GO
ICGC	GO
Cancer3D	GO
COSMIC	GO
NCG	GO
TSGene	GO
Tumor Gene Family of Databases	GO
CCDB	GO
G2SBC	GO
Osteosarcoma Database	GO
RCDB	GO