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General Information
- Evidence
- Gene
- mRNA
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- Protein
- PTM
- Enzyme
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- Domain
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24289328 | 2013 | Cell line : - Source : Human samples collected from gastrointestinal endoscopy units of several academic hospitals. Sample Type : Tissue specimens from patients with adenoma, carcinoma and ulcerative colitis. No. of Sample : - Stage : TNM Stage I-IV | methylation specific PCR amplification,Bisulfite genomic sequencing | Methylation | - | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Endogenous ligands |
| Description | This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. The neuropeptide functions through G protein-coupled receptors to inhibit adenylyl cyclase, activate mitogen-activated protein kinase (MAPK), regulate intracellular calcium levels, and activate potassium channels. A polymorphism in this gene resulting in a change of leucine 7 to proline in the signal peptide is associated with elevated cholesterol levels, higher alcohol consumption, and may be a risk factor for various metabolic and cardiovascular diseases. The protein also exhibits antimicrobial activity against bacteria and fungi. [provided by RefSeq, Oct 2014] | Chromosome | 7 |
| Location | 7p15.3 |
| Start | 24323807 |
| End | 24331484 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 7678 |
| OMIM ID | 162640 |
| HGNC ID | HGNC:7955 |
| Unigene ID | Hs.1832 |
| Ensembl ID | ENSG00000122585 |
| PharmGKB ID | PA255 |
mRNA Information
| mRNA ID | NM_000905.3 |
|---|---|
| Exon | join(1..88,1054..1241,5312..5392,7476..7678) | mRNA Sequence | Download Select all |
| Length | 576 |
Protein Information
| Protein ID | NP_000896.1 |
|---|---|
| Protein Name | neuropeptide Y |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 97 |
| Uniprot ID | P04275 |
| Ensembl Protein ID | ENSP00000261405 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| E | Proteolytic Cleavage | 38 |
| E | Proteolytic Cleavage | 43 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 4160 | MC4R | 1116 | NP_005903.2 | in vitro;in vivo | 12015205 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Adipocytokine signaling pathway | hsa04920 |
| Alcoholism | hsa05034 |
| cAMP signaling pathway | hsa04024 |
| Regulation of lipolysis in adipocytes | hsa04923 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00126 | 29-64 | PAH |
| cl00111 | 29-64 | PAH superfamily |
| smart00309 | 29-64 | PAH |
| pfam00159 | 29-64 | Hormone_3 |
Ontology Information
| HPRD ID | 11940 |
|---|---|
| Molecular Class | Unclassified |
| Molecular Function | Translation regulator activity (GO:0045182) |
| Biological Process | Protein metabolism (GO:0019538) |
Drug Information
No matching records could be found.