Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| NQO1 | 1728 | NAD(P)H dehydrogenase, quinone 1 | 16 | DHQU, QR1, DTD |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25276147 | 2014 | Cell line : - Source : Shanghai Huashan Hospital, China. Sample Type : CRC tumor No. of Sample : 76 Stage : - | Meta analysis | Polymorhpism | - | Meta-analysis suggest that the NQO1 C609T polymorphism significantly contributes to increased susceptibility to CRC in both Asians and Caucasians. |
| 24695690 | 2014 | Cell line : - Source : MEDLINE and EMBASE databases, CNKI database, China WanFang database, and the China Weipu database Sample Type : - No. of Sample : - Stage : - | Immunohistochemistry | Up-regulation | - | IHC stain showed that Nrf2, NQO1, MRP1, cmyc and p53 were highly expressed in CRC tissues compared with adjacent non-tumor tissues. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of this protein has been seen in many tumors and is also associated with Alzheimer's disease (AD). Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] | Chromosome | 16 |
| Location | 16q12-q22 |
| Start | 69743304 |
| End | 69760849 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 17546 |
| OMIM ID | 125860 |
| HGNC ID | HGNC:2874 |
| Unigene ID | Hs.406515 |
| Ensembl ID | ENSG00000181019 |
| PharmGKB ID | PA31744 |
mRNA Information
| mRNA ID | NM_001286137.1 |
|---|---|
| Exon | join(1..236,8135..8299,8416..8546,15388..17268) | mRNA Sequence | Download Select all |
| Length | 2423 |
Protein Information
| Protein ID | NP_001273066.1 |
|---|---|
| Protein Name | NAD(P)H dehydrogenase, quinone 1 |
| Molecular Wt. (Da) | 22662 |
| Protein Sequence | Download Select all |
| Length | 202 |
| Uniprot ID | P14618 |
| Ensembl Protein ID | ENSP00000320171 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| K | Acetylation | 262 |
| K | Acetylation | 228 |
| K | Acetylation | 224 |
| K | Acetylation | 59 |
| K | Acetylation | 59 |
| K | Acetylation | 59 |
| K | Acetylation | 209 |
| K | Acetylation | 175 |
| K | Acetylation | 171 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 7157 | TP53 | 1859 | NP_000537.3 | in vivo | 12529318 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Ubiquinone and other terpenoid-quinone biosynthesis | hsa00130 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam02525 | 5-212 | Flavodoxin_2 |
| cl00438 | 5-212 | FMN_red superfamily |
| COG2249 | 4-215 | MdaB |
| PRK09739 | 1-127 | PRK09739 |
| PRK00871 | 84-219 | PRK00871 |
| PRK04930 | 84-214 | PRK04930 |
| COG1182 | 36-215 | AzoR |
| PRK00170 | 36-151 | PRK00170 |
| pfam03358 | 53-154 | FMN_red |
| PRK13556 | 36-151 | PRK13556 |
| COG0655 | 90-165 | WrbA |
| PRK01355 | 91-131 | PRK01355 |
Ontology Information
| HPRD ID | 8986 |
|---|---|
| Molecular Class | Enzyme: Oxidoreductase |
| Molecular Function | Phospholipase activity (GO:0004620) |
| Biological Process | Metabolism (GO:0008152); Energy pathways (GO:0006091) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P15559 | DB00163 | Vitamin E | SmallMoleculeDrug |
| P15559 | DB00515 | Cisplatin | SmallMoleculeDrug |
| P15559 | DB00526 | Oxaliplatin | SmallMoleculeDrug |
| P15559 | DB00958 | Carboplatin | SmallMoleculeDrug |
| P15559 | DB00997 | Doxorubicin | SmallMoleculeDrug |
| P15559 | DB00170 | Menadione | SmallMoleculeDrug |
| P15559 | DB00266 | Dicoumarol | SmallMoleculeDrug |
| P15559 | DB03147 | Flavin adenine dinucleotide | SmallMoleculeDrug |