Search results:


General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
NRAS 4893 neuroblastoma RAS viral (v-ras) oncogene homolog  1N-ras 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
25975908   2015Cell line : -

Source : -

Sample Type : CRC tumor

No. of Sample : 200

Stage : -

PCR-based direct DNA sequencingMutation-Expanding the detection sites of KRAS gene combined with�NRAS�and BRAF genes may help to identify patients who will most likely benefit from targeted therapies.

26220423   2015Cell line : -

Source : -

Sample Type : CRC tumor

No. of Sample : 93

Stage : -

Mass spectrometry,next-generation sequencing ,Sanger sequencing, chip hybridization assayMutation-NRAS mutation in 2/93 (2 %) observed in CRC.


Gene Details



NC_000001.10 (115247085..115259515, complement)

View Larger Image
   
Gene Type protein coding
Gene Family -
Description This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia. [provided by RefSeq, Jun 2011]  
Chromosome 1
Location 1p13.2
Start 115247085  
End 115259515  
Strand -  
Gene Sequence

   Download   Select all

Length 12431  
OMIM ID 164790   
HGNC ID HGNC:7989   
Unigene ID Hs.486502   
Ensembl ID ENSG00000213281   
PharmGKB ID PA31768   

mRNA Information


mRNA ID NM_002524.4
Exon join(1..237,718..845,2917..3095,7167..7326,8241..8364, 8703..8741,8845..12431)  
mRNA Sequence

   Download   Select all

Length 4454  



CDS Information


   
Location 255..824
CDS Sequence

   Download   Select all

CCDS ID CCDS877.1



Protein Information


      
Protein IDNP_002515.1
Protein Nameneuroblastoma RAS viral (v-ras) oncogene homolog
Molecular Wt. (Da)0
Protein Sequence

   Download   Select all

Length 189  
Uniprot IDP09544
Ensembl Protein ID ENSP00000265441  



Post-translational Modification Information (Source : HPRD)


Residue Type site
CMethylation186
CPrenylation186

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                           
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
596BCL21045NP_000624.2in vivo10490827   
4089SMAD42995NP_005350.1in vivo15761153   
5894RAF11265NP_002871.1in vitro9488663   
51196PLCE17087NP_057425.3yeast 2-hybrid16169070   
64750SMURF26901NP_073576.1in vivo15761153   


Pathway Information


                                                                                                                                                                                                                                                                                                                                    
Pathway Name Pathway ID
Acute myeloid leukemia hsa05221
AGE-RAGE signaling pathway in diabetic complications hsa04933
Alcoholism hsa05034
Axon guidance hsa04360
B cell receptor signaling pathway hsa04662
Bladder cancer hsa05219
Central carbon metabolism in cancer hsa05230
Chemokine signaling pathway hsa04062
Choline metabolism in cancer hsa05231
Cholinergic synapse hsa04725
Chronic myeloid leukemia hsa05220
Endometrial cancer hsa05213
ErbB signaling pathway hsa04012
Estrogen signaling pathway hsa04915
Fc epsilon RI signaling pathway hsa04664
FoxO signaling pathway hsa04068
Gap junction hsa04540
Glioma hsa05214
GnRH signaling pathway hsa04912
Hepatitis B hsa05161
Hepatitis C hsa05160
HTLV-I infection hsa05166
Insulin signaling pathway hsa04910
Longevity regulating pathway - mammal hsa04211
Longevity regulating pathway - multiple species hsa04213
Long-term depression hsa04730
Long-term potentiation hsa04720
MAPK signaling pathway hsa04010
Melanogenesis hsa04916
Melanoma hsa05218
MicroRNAs in cancer hsa05206
Natural killer cell mediated cytotoxicity hsa04650
Neurotrophin signaling pathway hsa04722
Non-small cell lung cancer hsa05223
Oxytocin signaling pathway hsa04921
Pathways in cancer hsa05200
Phospholipase D signaling pathway hsa04072
PI3K-Akt signaling pathway hsa04151
Prolactin signaling pathway hsa04917
Prostate cancer hsa05215
Proteoglycans in cancer hsa05205
Rap1 signaling pathway hsa04015
Ras signaling pathway hsa04014
Regulation of actin cytoskeleton hsa04810
Renal cell carcinoma hsa05211
Serotonergic synapse hsa04726
Signaling pathways regulating pluripotency of stem cells hsa04550
Sphingolipid signaling pathway hsa04071
T cell receptor signaling pathway hsa04660
Thyroid cancer hsa05216
Thyroid hormone signaling pathway hsa04919
Tight junction hsa04530
VEGF signaling pathway hsa04370
Viral carcinogenesis hsa05203


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd041383-164  H_N_K_Ras_like
cl214553-164  P-loop_NTPase superfamily
smart0017316-166  RAS
smart0001016-166  small_GTPase
cd0087616-163  Ras
cd0414516-164  M_R_Ras_like
cd0413916-165  RalA_RalB
cd0414416-167  Ras2
cd041753-163  Rap1
cd041773-164  RSR1
cd041363-163  Rap_like
cd041413-170  Rit_Rin_Ric
cd041763-163  Rap2
cd0413716-189  RheB
cd0015416-161  Rab
smart0017516-163  RAB
cd0414616-165  RERG_RasL11_like
cd0186316-163  Rab18
cd0186916-164  Rab1_Ypt1
cd0186716-165  Rab8_Rab10_Rab13_like
cd0412316-163  Rab21
cd0015716-161  Rho
cd0414316-159  Rhes_like
cd0186816-163  Rab11_like
cd0186016-163  Rab5_related
cd041403-160  ARHI_like
cd0186216-161  Rab7
cd0414716-164  Ras_dva
cd0186116-156  Rab6
cd0414816-164  RGK
cd0411016-179  Rab35
cd0088216-161  Ras_like_GTPase
cd0412716-168  Rab27A
cd0411616-163  Rab9
smart0017416-161  RHO
cd0186616-163  Rab2
cd0411116-170  Rab39
cd0411516-165  Rab33B_Rab33A
cd0411316-163  Rab4
cd0186428-163  Rab19
cd0411242-164  Rab26
cd0412216-165  Rab14
cd0187516-163  RhoG
cd0410916-170  Rab28
cd0411716-164  Rab15
cd0413316-161  Rop_like
cd0411916-163  RJL
cd0410616-156  Rab23_like
cd0186553-160  Rab3
cd0410143-161  RabL4
cd0412042-163  Rab12
cd0412927-181  Rho2
cd041322-162  Rho4_like
cd0413016-156  Wrch_1
cd0187016-161  RhoA_like
cd0410713-163  Rab32_Rab38
cd0187116-163  Rac1_like
cd0413516-156  Tc10
cd0187416-156  Cdc42
cd0411442-163  Rab30
cd0087754-161  Ran
cd0413416-161  Rho3
cd0412144-161  Rab40
pfam0847716-119  Miro
cd0412422-167  RabL2
cd0414214-161  RRP22
cd0411816-159  Rab24
cd0410316-156  Centaurin_gamma
cd0413116-158  Rnd
cd0187316-161  RhoBTB
cd0410816-157  Rab36_Rab34
cd099143-162  RocCOR
cd0417216-157  Rnd3_RhoE_Rho8
cd01898110-166  Obg
cd0417313-185  Rnd2_Rho7
cd0189313-157  Miro1
cd0416479-166  trmE
COG22291-159  Srp102
cd01879109-166  FeoB
pfam02421108-163  FeoB_N
cd0189793-155  NOG
cd0087816-160  Arf_Arl
cd0187896-154  HflX
cd0188743-154  IF2_eIF5B
cd0412655-181  Rab20
cd0088013-166  Era_like
cd01890108-163  LepA
cd0185479-154  YjeQ_EngC
cd0188193-163  Obg_like
cd0185998-187  MJ1464
cd01849112-187  YlqF_related_GTPase
cd0412816-146  Spg1
pfam0000935-163  GTP_EFTU
cd0417416-150  Rnd1_Rho6
pfam0007116-165  Ras
PTZ003691-166  PTZ00369
TIGR0023116-161  small_GTP
COG110016-165  Gem1
PLN0310816-165  PLN03108
PLN0311816-165  PLN03118
PLN0311016-170  PLN03110
PTZ0013248-163  PTZ00132
PLN0307154-163  PLN03071
smart0017653-163  RAN
PTZ0009928-156  PTZ00099
PRK0529195-178  trmE
PRK00093110-174  PRK00093
COG053256-154  InfB
TIGR02729110-160  Obg_CgtA
PRK12299110-166  obgE
COG0370109-163  FeoB
PRK0530643-154  infB
PRK12297110-169  obgE
TIGR0391890-154  GTP_HydF
COG048635-178  MnmE
PRK00098108-154  PRK00098
TIGR03594110-174  GTPase_EngA
COG1161112-172  RbgA
COG0536110-166  Obg
PRK12298110-163  obgE
PRK0008998-166  era
TIGR0315696-153  GTP_HflX
TIGR0050351-124  prfC


Ontology Information


   
HPRD ID1293
Molecular ClassGTPase
Molecular FunctionReceptor binding (GO:0005102)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO