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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23551578 | 2013 | Cell line : - Source : - Sample Type : CRC tumor and normal tissues No. of Sample : - Stage : - | - | Up-regulation | - | An increase in NRP1 and NRP2 epithelial/tumour expression, as well as in NRP1 vascular expression, may be associated with disease progression in colorectal cancer. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a member of the neuropilin family of receptor proteins. The encoded transmembrane protein binds to SEMA3C protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C} and SEMA3F protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F}, and interacts with vascular endothelial growth factor (VEGF). This protein may play a role in cardiovascular development, axon guidance, and tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008] | Chromosome | 2 |
| Location | 2q33.3 |
| Start | 206547184 |
| End | 206662857 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 115674 |
| OMIM ID | 602070 |
| HGNC ID | HGNC:8005 |
| Unigene ID | Hs.471200 |
| Ensembl ID | ENSG00000118257 |
| PharmGKB ID | PA31784 |
Protein Information
| Protein ID | NP_003863.2 |
|---|---|
| Protein Name | neuropilin 2 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 931 |
| Uniprot ID | O75475 |
| Ensembl Protein ID | ENSP00000370091 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 5228 | PGF | 3076 | NP_002623.2 | in vivo | 10748121 |
| 6405 | SEMA3F | 3079 | NP_004177.3 | in vitro;in vivo | 9883722 |
| 7422 | VEGFA | 1889 | NP_001020537.2 | in vivo | 10748121 |
| 7869 | SEMA3B | 3179 | NP_004627.1 | in vivo | 10196546 |
| 8829 | NRP1 | 3642 | NP_003864.4 | in vitro | 9856463 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00057 | 280-426 | FA58C |
| cl19067 | 280-426 | FA58C superfamily |
| cd06263 | 646-793 | MAM |
| cl18943 | 646-793 | MAM superfamily |
| cd00041 | 28-141 | CUB |
| cl00049 | 28-141 | CUB superfamily |
| cd00041 | 149-265 | CUB |
| cl00049 | 149-265 | CUB superfamily |
| cd00057 | 438-591 | FA58C |
| cl19067 | 438-591 | FA58C superfamily |
| smart00231 | 277-427 | FA58C |
| pfam00431 | 28-139 | CUB |
| smart00042 | 38-139 | CUB |
| pfam00431 | 149-264 | CUB |
| pfam11980 | 854-928 | DUF3481 |
| cl13423 | 854-928 | DUF3481 superfamily |
| pfam00754 | 292-424 | F5_F8_type_C |
| smart00042 | 158-264 | CUB |
| pfam00754 | 449-589 | F5_F8_type_C |
| smart00231 | 433-592 | FA58C |
| smart00137 | 641-794 | MAM |
| pfam00629 | 646-802 | MAM |
Ontology Information
| HPRD ID | 5945 |
|---|---|
| Molecular Class | Cell surface receptor |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Cell growth and/or maintenance (GO:0008151) |
Drug Information
No matching records could be found.