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General Information
- Evidence
- Gene
- mRNA
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- Protein
- PTM
- Enzyme
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- Domain
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23124703 | 2013 | Cell line : 2 human colon cancer cells lines: wild-type (low expression of NT-4) and NT-4 (overexpression of NT-4) LS174 cells. Source : - Sample Type : - No. of Sample : - Stage : - | - | Down-regulation | - | NT-4 may hold therapeutic potential in the treatment of colorectal cancer growth and major metastatic sites. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Netrins |
| Description | NTN4 belongs to a family of proteins related to laminins (see LAMA1, MIM 150320) Koch et al. (2000) [PubMed 11038171].[supplied by OMIM, Mar 2008] | Chromosome | 12 |
| Location | 12q22 |
| Start | 96051583 |
| End | 96184565 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 132983 |
| OMIM ID | 610401 |
| HGNC ID | HGNC:13658 |
| Unigene ID | Hs.201034 |
| Ensembl ID | ENSG00000074527 |
| PharmGKB ID | PA31815 |
Protein Information
| Protein ID | NP_067052.2 |
|---|---|
| Protein Name | netrin 4 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 628 |
| Uniprot ID | Q9BT81 |
| Ensembl Protein ID | ENSP00000301921 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 54507 | ADAMTSL4 | 18237 | NP_061905.2 | yeast 2-hybrid | 16189514 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Axon guidance | hsa04360 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd03578 | 516-626 | NTR_netrin-4_like |
| cl02512 | 516-626 | NTR_like superfamily |
| cd00055 | 394-445 | EGF_Lam |
| cl22875 | 394-445 | EGF_Lam superfamily |
| cd00055 | 261-320 | EGF_Lam |
| cl22875 | 261-320 | EGF_Lam superfamily |
| cd00055 | 332-381 | EGF_Lam |
| cl22875 | 332-381 | EGF_Lam superfamily |
| smart00136 | 28-260 | LamNT |
| cl02806 | 28-260 | Laminin_N superfamily |
| pfam00055 | 34-260 | Laminin_N |
| cd03523 | 517-626 | NTR_like |
| pfam01759 | 519-624 | NTR |
| smart00643 | 517-624 | C345C |
| cd03581 | 524-619 | NTR_Sfrp3_like |
| smart00180 | 395-446 | EGF_Lam |
| pfam00053 | 395-449 | Laminin_EGF |
| cd03579 | 517-626 | NTR_netrin-1_like |
| pfam00053 | 332-385 | Laminin_EGF |
| pfam00053 | 262-321 | Laminin_EGF |
| smart00180 | 332-381 | EGF_Lam |
| cd03574 | 524-611 | NTR_complement_C345C |
| smart00180 | 287-317 | EGF_Lam |
Ontology Information
| HPRD ID | 9555 |
|---|---|
| Molecular Class | Extracellular matrix protein |
| Molecular Function | Cytoskeletal protein binding (GO:0008092) |
| Biological Process | Cell growth and/or maintenance (GO:0008151) |
Drug Information
No matching records could be found.