CoReCG

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
24962792	2014	Cell line : AU 565, COLO205, G 361, HCT 116, HCT15, HPAC, HT 29, KU812, LoVo, Malme3M, MCF7, MDA MB 436, MDA MB 468, Mewo, NCI H2087, NCIeH2228, NCIeH929, PANC 1, SK MEL 2, SKMEL 3, SK MEL 5, SK N SH, SW48, TF1, TF1a, TT, U 138MG, DSMZ (697, CAL-148, CAL-51, CAPAN-1, CL-11, COLO-320, COLO 800, DLD-1, EVSA-T, GRANTA-519, HCC-78, HEL, IGR-39, Jurkat, KARPAS-299, MEC-1, OPM-2, RPMI-7951, RS4-11, SH-SY5Y, SKM-1, SK-N-MC, SW480, THP-1), from ECACC (A2780, A375, BxPC-3, HuP-T3, K-562, MDA-MB-231, MIA-PaCa-2, PSN1, RPMI-8226, U-937), from (COLO-741, IST-MEL1, IST-MEL2, SW1417, KMS 11, MZ CRC 1, TPC1,K M12, LOX IMVI, M14, MDA MB435, SF539, SK MEL 28, U251, UACC 257, UACC 62 Source : Istituto Nazionale Tumori of Milan,ATCC, Interlab Cell Line Collection (ICLC),NCI , Sample Type : - No. of Sample : - Stage : -	PCR, sequencing, Immunoprecipitation and western blotting,Immunohistochemistry	Mutation(Translocation)	-	Identified the TPM3-NTRK1 rearrangement in a CRC clinical sample.
25926053	2015	Cell line : - Source : ATCC Sample Type : - No. of Sample : - Stage : -	MSI Analysis, real time RT-PCR,RNA-seq,Immunohistochemistry,FISH analysis	Mutation(Translocation)	-	Genomic rearrangements (translocations) involving the ALK and NTRK1 genes are associated with the overexpression of the corresponding proteins in CRC specimens.
26001971	2015	Cell line : KM 12, DLD 1 Source : Centre Hospitalier Universitaire de Toulouse, F-31300 France, NCI (National Cancer Institute) (Frederick, USA) and ATCC Sample Type : Tissue microarray No. of Sample : 408 Stage : -	Tumor tissue microarrays,Immunohistochemistry,PCR, sequencing	Mutation(Translocation)	-	Translocations in the NTRK1 gene are recurring events in colorectal cancer, although occurring at a low frequency (around 0.5%).

Gene Details

NC_000001.10 (156785542..156851642)
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Gene Type	protein coding
Gene Family	Immunoglobulin superfamily / Immunoglobulin-like domain containing
Description	This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. [provided by RefSeq, Jul 2008]
Chromosome	1
Location	1q21-q22
Start	156785542
End	156851642
Strand	+
Gene Sequence	Download Select all
Length	66101
OMIM ID	191315
HGNC ID	HGNC:8031
Unigene ID	Hs.406293
Ensembl ID	ENSG00000198400
PharmGKB ID	PA31817

mRNA Information

mRNA ID	XM_011510113.1
Exon	complement(join(257..363,926..1113))
mRNA Sequence	Download Select all
Length	1664

CDS Information

Location	155..1330
CDS Sequence	Download Select all
CCDS ID	CCDS1161.1

Protein Information

Protein ID	XP_011508415.1
Protein Name	neurotrophic tyrosine kinase, receptor, type 1
Molecular Wt. (Da)	95342
Protein Sequence	Download Select all
Length	391
Uniprot ID	Q9Y6F9
Ensembl Protein ID	ENSP00000233948

Post-translational Modification Information (Source : HPRD)

Residue	Type	site
Y	Phosphorylation	640
Y	Phosphorylation	644
Y	Phosphorylation	645
Y	Phosphorylation	721
Y	Phosphorylation	670
Y	Phosphorylation	674
Y	Phosphorylation	675
Y	Phosphorylation	751
Y	Phosphorylation	460
Y	Phosphorylation	755
Y	Phosphorylation	490
Y	Phosphorylation	785

Enzyme Information

No matching records could be found.

PPi Information

(Click to view network : Source STRING) View

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
25	ABL1	1809	NP_009297.2	in vitro;in vivo;yeast 2-hybrid	1 067 977 110 708 750
2885	GRB2	150	NP_002077.1	in vivo	1 173 353 410 748 050
4804	NGFR	1197	NP_002498.1	in vivo	9927421
5295	PIK3R1	1381	NP_852664.1	in vitro;in vivo	8384556
5335	PLCG1	1398	NP_002651.2	in vivo	17 156 908 384 556
5595	MAPK3	3479	NP_002737.2	in vitro;in vivo	1463607
5770	PTPN1	1477	NP_002818.1	in vitro	12237455
5906	RAP1A	1545	NP_002875.1	in vivo	11466412
5921	RASA1	745	NP_002881.1	in vitro;in vivo	8384556
6464	SHC1	2780	NP_001123512.1	in vitro;in vivo	82 268 088 155 326 700 000 000 000 000
8878	SQSTM1	3319	NP_003891.1	in vivo	1 124 408 810 747 020
9093	DNAJA3	9758	NP_005138.3	in vitro;in vivo;yeast 2-hybrid	15753086
10603	SH2B2	16097	NP_066189.3	in vitro	9856458
23327	NEDD4L	5903	NP_001138439.1	in vitro;in vivo	16701206

Pathway Information

Pathway Name	Pathway ID
Apoptosis	hsa04210
Central carbon metabolism in cancer	hsa05230
Endocytosis	hsa04144
Inflammatory mediator regulation of TRP channels	hsa04750
MAPK signaling pathway	hsa04010
Neurotrophin signaling pathway	hsa04722
Pathways in cancer	hsa05200
Thyroid cancer	hsa05216
Transcriptional misregulation in cancer	hsa05202

Structure Information

No matching records could be found.

Domain Information

ID	Location	Description
cd05092	504-783	PTKc_TrkA
cl21453	504-783	PKc_like superfamily
cd04971	299-379	Ig_TrKABC_d5
cl11960	299-379	Ig superfamily
cd04972	195-282	Ig_TrkABC_d4
cl11960	195-282	Ig superfamily
cd05049	504-783	PTKc_Trk
cd05094	504-789	PTKc_TrkC
cd05093	504-793	PTKc_TrkB
cd00192	515-782	PTKc
cd05048	515-784	PTKc_Ror
cd05050	507-782	PTKc_Musk
cd05051	507-782	PTKc_DDR
cd05032	505-783	PTKc_InsR_like
cd05036	503-783	PTKc_ALK_LTK
cd05090	515-783	PTKc_Ror1
cd05095	507-782	PTKc_DDR2
cd05044	516-783	PTKc_c-ros
cd05096	507-781	PTKc_DDR1
cd05053	505-775	PTKc_FGFR
cd05097	507-781	PTKc_DDR_like
cd05059	515-771	PTKc_Tec_like
cd05046	516-781	PTK_CCK4
cd05061	505-777	PTKc_InsR
cd05091	515-783	PTKc_Ror2
cd05148	507-783	PTKc_Srm_Brk
cd05034	516-771	PTKc_Src_like
cd05033	509-784	PTKc_EphR
cd05068	505-782	PTKc_Frk_like
cd05039	505-784	PTKc_Csk_like
cd05056	505-786	PTKc_FAK
cd05062	505-777	PTKc_IGF-1R
cd05041	516-782	PTKc_Fes_like
cd05038	516-785	PTKc_Jak_rpt2
cd05060	515-781	PTKc_Syk_like
cd05099	507-794	PTKc_FGFR4
cd05052	505-784	PTKc_Abl
cd05055	512-785	PTKc_PDGFR
cd05045	509-784	PTKc_RET
cd05084	515-782	PTKc_Fes
cd05040	515-771	PTKc_Ack_like
cd05063	504-784	PTKc_EphR_A2
cd13999	516-781	STKc_MAP3K-like
cd05113	505-775	PTKc_Btk_Bmx
cd05066	516-784	PTKc_EphR_A
cd05112	505-773	PTKc_Itk
cd05098	505-777	PTKc_FGFR1
cd05101	507-777	PTKc_FGFR2
cd05106	513-771	PTKc_CSF-1R
cd05054	513-771	PTKc_VEGFR
cd05100	505-777	PTKc_FGFR3
cd05058	516-784	PTKc_Met_Ron
cd05114	515-777	PTKc_Tec_Rlk
cd05072	505-771	PTKc_Lyn
cd05065	516-784	PTKc_EphR_B
cd05075	516-789	PTKc_Axl
cd05057	516-792	PTKc_EGFR_like
cd05035	516-773	PTKc_TAM
cd05074	505-784	PTKc_Tyro3
cd05064	510-781	PTKc_EphR_A10
cd05085	516-783	PTKc_Fer
cd05083	516-782	PTKc_Chk
cd14204	505-789	PTKc_Mer
cd05082	505-782	PTKc_Csk
cd14203	515-782	PTKc_Src_Fyn_like
cd05115	507-783	PTKc_Zap-70
cd05089	509-794	PTKc_Tie1
cd05067	505-771	PTKc_Lck_Blk
cd05047	516-786	PTKc_Tie
cd14205	506-782	PTKc_Jak2_rpt2
cd05107	505-771	PTKc_PDGFR_beta
cd05104	513-782	PTKc_Kit
cd05043	505-782	PTK_Ryk
cd05103	513-787	PTKc_VEGFR2
cd05081	516-784	PTKc_Jak3_rpt2
cd00180	516-777	PKc
cd14207	505-784	PTKc_VEGFR1
cd05102	516-786	PTKc_VEGFR3
cd05116	515-782	PTKc_Syk
cd05080	515-784	PTKc_Tyk2_rpt2
cd05079	515-784	PTKc_Jak1_rpt2
cd05042	515-781	PTKc_Aatyk
cd14206	515-781	PTKc_Aatyk3
cd05073	505-782	PTKc_Hck
cd05070	505-782	PTKc_Fyn
cd05071	505-782	PTKc_Src
cd05105	507-784	PTKc_PDGFR_alpha
cd05069	505-782	PTKc_Yes
cd05111	516-792	PTK_HER3
cd05087	515-781	PTKc_Aatyk1
cd05109	516-792	PTKc_HER2
cd05088	509-793	PTKc_Tie2
cd05108	516-796	PTKc_EGFR
cd05110	516-796	PTKc_HER4
cd14014	515-783	STKc_PknB_like
cd05086	515-781	PTKc_Aatyk2
cd14061	516-784	STKc_MLK
cd06606	516-771	STKc_MAPKKK
cd13978	516-781	STKc_RIP
cd14066	516-784	STKc_IRAK
cd14146	516-784	STKc_MLK4
cd14058	516-786	STKc_TAK1
cd14059	516-777	STKc_MAP3K12_13
cd05037	516-781	PTK_Jak_rpt1
cd14060	517-784	STKc_MLTK
cd14148	516-784	STKc_MLK2
cd08215	515-780	STKc_Nek
cd14145	509-784	STKc_MLK1
cd14147	508-784	STKc_MLK3
cd06627	515-775	STKc_Cdc7_like
cd05122	515-775	PKc_STE
cd14008	516-777	STKc_LKB1_CaMKK
cd14007	516-777	STKc_Aurora
cd14154	516-785	STKc_LIMK
cd14003	516-779	STKc_AMPK-like
cd14065	516-773	PKc_LIMK_like
cd14069	509-777	STKc_Chk1
cd14062	516-782	STKc_Raf
cd06623	509-771	PKc_MAPKK_plant_like
cd14025	514-777	STKc_RIP4_like
cd05855	299-379	Ig_TrkB_d5
cd06625	516-776	STKc_MEKK3_like
cd06632	516-771	STKc_MEKK1_plant
cd14027	516-780	STKc_RIP1
cd14158	516-784	STKc_IRAK4
cd07840	515-742	STKc_CDK9_like
cd14221	516-784	STKc_LIMK1
cd14009	516-776	STKc_ATG1_ULK_like
cd13992	537-777	PK_GC
cd08529	509-777	STKc_FA2-like
cd06614	516-773	STKc_PAK
cd14222	516-785	STKc_LIMK2
cd06629	516-771	STKc_Bck1_like
cd07829	516-722	STKc_CDK_like
cd06628	516-737	STKc_Byr2_like
cd05117	515-777	STKc_CAMK
cd14150	510-787	STKc_A-Raf
cd14080	516-777	STKc_TSSK-like
cd06631	516-773	STKc_YSK4
cd14149	505-789	STKc_C-Raf
cd14664	516-748	STK_BAK1_like
cd08222	516-777	STKc_Nek11
cd14131	516-774	PKc_Mps1
cd14026	516-790	STKc_RIP2
cd08225	516-780	STKc_Nek5
cd05118	516-777	STKc_CMGC
cd08530	510-777	STKc_CNK2-like
cd05078	516-775	PTK_Jak2_rpt1
cd14151	510-787	STKc_B-Raf
cd13996	516-777	STKc_EIF2AK
cd14064	516-784	PKc_TNNI3K
cd14000	516-783	STKc_LRRK
cd14002	517-771	STKc_STK36
cd06626	517-771	STKc_MEKK4
cd06620	505-780	PKc_Byr1_like
cd13979	515-774	STKc_Mos
cd14159	516-784	STKc_IRAK1
cd07832	516-720	STKc_CCRK
cd07866	516-722	STKc_BUR1
cd14077	509-777	STKc_Kin1_2
cd13987	516-781	STKc_SBK1
cd14063	509-788	PK_KSR
cd14155	543-784	PKc_TESK
cd07830	515-722	STKc_MAK_like
cd06612	509-776	STKc_MST1_2
cd05582	516-771	STKc_RSK_N
cd06611	515-771	STKc_SLK_like
cd14156	522-786	PKc_LIMK_like_unk
cd14053	519-786	STKc_ACVR2
cd14054	516-784	STKc_BMPR2_AMHR2
cd14056	515-784	STKc_TGFbR_I
cd14208	516-777	PTK_Jak3_rpt1
cd06624	516-736	STKc_ASK
cd14119	516-777	STKc_LKB1
cd13993	516-776	STKc_Pat1_like
cd13998	517-784	STKc_TGFbR-like
cd14165	508-778	STKc_TSSK1_2-like
cd07841	516-719	STKc_CDK7
cd07838	515-721	STKc_CDK4_6_like
cd05579	519-742	STKc_MAST_like
cd06643	515-771	STKc_SLK
cd08224	515-778	STKc_Nek6_7
cd05123	516-779	STKc_AGC
cd14073	516-777	STKc_NUAK
cd08220	516-779	STKc_Nek8
cd06642	516-777	STKc_STK25
cd06641	515-777	STKc_MST3
cd05581	515-777	STKc_PDK1
cd14081	516-778	STKc_BRSK1_2
cd06651	516-737	STKc_MEKK3
cd08219	516-780	STKc_Nek3
cd07864	501-742	STKc_CDK12
cd06652	516-737	STKc_MEKK2
cd08221	516-777	STKc_Nek9
cd08217	515-776	STKc_Nek2
cd14116	516-777	STKc_Aurora-A
cd14117	516-791	STKc_Aurora-B_like
cd06653	516-737	STKc_MEKK3_like_u1
cd14201	507-771	STKc_ULK2
cd13994	516-777	STKc_HAL4_like
cd07833	515-722	STKc_CDKL
cd06605	515-775	PKc_MAPKK
cd07834	516-722	STKc_MAPK
cd07836	515-722	STKc_Pho85
cd07862	515-770	STKc_CDK6
cd14045	537-771	PK_GC_unk
cd14042	539-781	PK_GC-A_B
cd06610	515-731	STKc_OSR1_SPAK
cd14161	516-777	STKc_NUAK2
cd14121	516-776	STKc_ULK3
cd06644	515-773	STKc_STK10
cd13997	516-774	PKc_Wee1_like
cd06640	516-720	STKc_MST4
cd14099	516-777	STKc_PLK
cd05619	509-775	STKc_nPKC_theta
cd08218	516-777	STKc_Nek1
cd06630	516-776	STKc_MEKK1
cd14079	516-718	STKc_AMPK_alpha
cd08228	509-778	STKc_Nek6
cd06609	515-776	STKc_MST3_like
cd07870	515-721	STKc_PFTAIRE2
cd14133	510-722	PKc_DYRK_like
cd08223	516-777	STKc_Nek4
cd14074	512-777	STKc_SNRK
cd14162	516-727	STKc_TSSK4-like
cd06621	516-720	PKc_Pek1_like
cd07863	515-736	STKc_CDK4
cd14188	516-777	STKc_PLK2
cd14098	516-749	STKc_Rad53_Cds1
cd05570	516-771	STKc_PKC
cd06917	513-777	STKc_NAK1_like
cd07844	516-722	STKc_PCTAIRE_like
cd14137	517-722	STKc_GSK3
cd05580	515-729	STKc_PKA_like
cd07835	516-727	STKc_CDK1_CdkB_like
cd14120	516-776	STKc_ULK1_2-like
cd14072	516-718	STKc_MARK
cd14048	516-749	STKc_EIF2AK3_PERK
cd14142	508-785	STKc_ACVR1_ALK1
cd14202	507-776	STKc_ULK1
cd07843	518-740	STKc_CDC2L1
cd05572	516-727	STKc_cGK
cd13990	516-788	STKc_TLK
cd14071	516-718	STKc_SIK
cd06655	515-777	STKc_PAK2
cd14047	515-777	STKc_EIF2AK2_PKR
cd13983	515-776	STKc_WNK
cd07839	515-725	STKc_CDK5
cd06659	515-777	STKc_PAK6
cd07846	516-722	STKc_CDKL2_3
cd07860	515-722	STKc_CDK2_3
cd05077	535-771	PTK_Jak1_rpt1
cd05578	517-777	STKc_Yank1
cd06633	515-777	STKc_TAO3
cd05589	516-771	STKc_PKN
cd14067	538-771	STKc_LRRK1
cd06647	515-777	STKc_PAK_I
cd05076	541-777	PTK_Tyk2_rpt1
cd13989	516-733	STKc_IKK
cd14031	515-777	STKc_WNK3
cd07845	516-722	STKc_CDK10
cd06648	515-777	STKc_PAK_II
cd14052	516-777	PTKc_Wee1_fungi
cd13985	508-782	STKc_GAK_like
cd07865	509-742	STKc_CDK9
cd14033	515-777	STKc_WNK4
cd14055	516-785	STKc_TGFbR2_like
cd08229	515-729	STKc_Nek7
cd14097	516-743	STKc_STK33
cd06613	515-719	STKc_MAP4K3_like
cd14030	515-782	STKc_WNK1
cd14044	537-781	PK_GC-C
cd05612	516-750	STKc_PRKX_like
cd06635	515-792	STKc_TAO1
cd14189	516-777	STKc_PLK3
cd07871	515-722	STKc_PCTAIRE3
cd14186	516-777	STKc_PLK4
cd07842	517-723	STKc_CDK8_like
cd07852	504-725	STKc_MAPK15-like
cd14046	516-747	STKc_EIF2AK4_GCN2_rpt2
cd06634	515-771	STKc_TAO2
cd14068	516-783	STKc_LRRK2
cd14078	512-776	STKc_MELK
cd14050	516-777	PKc_Myt1
cd06607	515-776	STKc_TAO
cd14143	516-720	STKc_TGFbR1_ACVR1b_ACVR1c
cd14103	516-716	STKc_MLCK
cd05592	516-771	STKc_nPKC_theta_like
cd14210	504-722	PKc_DYRK
cd07831	516-740	STKc_MOK
cd14144	516-771	STKc_BMPR1
cd07847	516-722	STKc_CDKL1_4
cd07854	516-725	STKc_MAPK4_6
cd14164	516-777	STKc_TSSK6-like
cd14075	515-777	STKc_NIM1
cd07873	515-722	STKc_PCTAIRE1
cd13995	518-777	STKc_MAP3K8
cd06622	515-773	PKc_PBS2_like
cd13968	516-670	PKc_like
cd14038	516-728	STKc_IKK_beta
cd14190	516-743	STKc_MLCK2
cd06619	509-771	PKc_MKK5
cd14043	637-778	PK_GC-2D
cd14191	516-741	STKc_MLCK1
cd05595	516-771	STKc_PKB_beta
cd05616	516-771	STKc_cPKC_beta
cd07837	515-729	STKc_CdkB_plant
cd07869	515-720	STKc_PFTAIRE1
cd14084	516-744	STKc_Chk2
cd14012	541-771	PK_eIF2AK_GCN2_rpt1
cd06650	515-755	PKc_MEK1
cd14094	555-777	STKc_CASK
cd05620	516-771	STKc_nPKC_delta
cd06654	515-790	STKc_PAK1
cd06656	515-777	STKc_PAK3
cd14041	516-771	STKc_TLK2
cd14032	515-777	STKc_WNK2_like
cd14160	516-722	PK_IRAK3
cd07861	515-730	STKc_CDK1_euk
cd14211	516-721	STKc_HIPK
cd05611	515-744	STKc_Rim15_like
cd14039	516-730	STKc_IKK_alpha
cd05615	502-771	STKc_cPKC_alpha
cd07872	515-720	STKc_PCTAIRE2
cd14229	516-721	STKc_HIPK3
cd05573	516-763	STKc_ROCK_NDR_like
cd06615	515-727	PKc_MEK
cd14209	516-729	STKc_PKA
cd06638	514-777	STKc_myosinIIIA_N
cd05604	516-776	STKc_SGK3
cd14152	516-786	STKc_KSR1
cd06608	513-715	STKc_myosinIII_N_like
cd14010	545-771	STKc_ULK4
cd05610	508-722	STKc_MASTL
cd14167	516-749	STKc_CaMKI_alpha
cd05584	516-771	STKc_p70S6K
cd14036	516-787	STKc_GAK
cd14006	516-776	STKc_MLCK-like
cd07855	516-732	STKc_ERK5
cd05587	516-771	STKc_cPKC
cd14153	516-786	PK_KSR2
cd14086	512-729	STKc_CaMKII
cd14187	516-777	STKc_PLK1
cd14049	516-773	STKc_EIF2AK1_HRI
cd14040	516-778	STKc_TLK1
cd14663	516-779	STKc_SnRK3
cd14199	512-728	STKc_CaMKK2
cd14169	512-773	STKc_CaMKI_beta
cd07879	516-725	STKc_p38delta
cd05609	519-771	STKc_MAST
cd05602	504-776	STKc_SGK1
cd14057	541-771	PK_ILK
cd14200	512-728	STKc_CaMKK1
cd06639	514-780	STKc_myosinIIIB_N
cd14083	512-749	STKc_CaMKI
cd14194	515-776	STKc_DAPK1
cd07851	516-722	STKc_p38
cd14118	515-777	STKc_CAMKK
cd14228	516-721	STKc_HIPK1
cd14192	516-740	STKc_MLCK3
cd13988	516-728	STKc_TBK1
cd13975	515-786	PKc_Dusty
cd14096	516-743	STKc_RCK1-like
cd13982	541-777	STKc_IRE1
cd07856	516-720	STKc_Sty1_Hog1
cd14193	516-740	STKc_MLCK4
cd14166	507-749	STKc_CaMKI_gamma
cd14089	509-729	STKc_MAPKAPK
cd07849	516-722	STKc_ERK1_2_like
cd06657	515-777	STKc_PAK4
cd14665	515-728	STKc_SnRK2-3
cd07848	516-720	STKc_CDKL5
cd13986	516-784	STKc_16
cd14157	518-722	STKc_IRAK2
cd06658	515-777	STKc_PAK5
cd08528	516-777	STKc_Nek10
cd07877	516-722	STKc_p38alpha
cd14076	516-728	STKc_Kin4
cd14070	516-722	STKc_HUNK
cd06646	505-720	STKc_MAP4K5
cd14185	516-718	STKc_DCKL3
cd14001	542-722	PKc_TOPK
cd05603	516-771	STKc_SGK2
cd05577	516-780	STKc_GRK
cd14163	516-718	STKc_TSSK3-like
cd05622	506-729	STKc_ROCK1
cd05593	499-771	STKc_PKB_gamma
cd14219	508-792	STKc_BMPR1b
cd06649	515-727	PKc_MEK2
cd14176	512-722	STKc_RSK2_C
cd14175	511-721	STKc_RSK1_C
cd06645	507-742	STKc_MAP4K3
cd14104	512-744	STKc_Titin
cd14220	515-784	STKc_BMPR1a
cd05594	499-771	STKc_PKB_alpha
cd07880	515-722	STKc_p38gamma
cd14004	515-777	STKc_PASK
cd14105	515-743	STKc_DAPK
cd14212	516-721	PKc_YAK1
cd06636	516-756	STKc_MAP4K4_6_N
cd14111	515-744	STKc_SPEG_rpt2
cd14198	625-742	STKc_DRAK2
cd14168	512-749	STKc_CaMKI_delta
cd14227	516-721	STKc_HIPK2
cd14135	516-725	STKc_PRP4
cd07857	633-730	STKc_MPK1
cd05624	504-735	STKc_MRCK_beta
cd14136	505-722	STKc_SRPK
cd14113	515-735	STKc_Trio_C
cd14178	512-721	STKc_RSK3_C
cd14141	519-768	STKc_ACVR2a
cd14005	515-777	STKc_PIM
cd05621	516-729	STKc_ROCK2
cd14091	512-718	STKc_RSK_C
cd14134	505-722	PKc_CLK
cd14090	516-729	STKc_Mnk
cd05623	505-745	STKc_MRCK_alpha
cd07853	516-741	STKc_NLK
cd14184	516-749	STKc_DCKL2
cd14102	633-777	STKc_PIM3
cd07859	516-725	STKc_TDY_MAPK
cd14082	516-741	STKc_PKD
cd05590	516-771	STKc_nPKC_eta
cd14177	512-728	STKc_RSK4_C
cd14181	522-744	STKc_PhKG2
cd14093	551-718	STKc_PhKG
cd14195	515-741	STKc_DAPK3
cd14196	515-741	STKc_DAPK2
cd05598	516-736	STKc_LATS
cd07858	516-742	STKc_TEY_MAPK
cd06618	640-771	PKc_MKK7
cd07878	516-721	STKc_p38beta
cd05630	516-730	STKc_GRK6
cd13991	510-780	STKc_NIK
cd14019	515-737	STKc_Cdc7
cd05614	516-783	STKc_MSK2_N
cd05574	516-727	STKc_phototropin_like
cd06616	515-728	PKc_MKK4
cd07876	541-720	STKc_JNK2
cd14172	516-734	STKc_MAPKAPK3
cd14170	516-792	STKc_MAPKAPK2
cd14037	516-723	STKc_NAK_like
cd14108	515-722	STKc_SPEG_rpt1
cd06617	508-728	PKc_MKK3_6
cd14018	633-773	STKc_PINK1
cd14114	515-776	STKc_Twitchin_like
cd14140	519-722	STKc_ACVR2b
cd14087	516-728	STKc_PSKH1
cd05625	516-735	STKc_LATS1
cd14011	633-771	PK_SCY1_like
cd07850	516-720	STKc_JNK
cd14226	516-722	PKc_DYRK1
cd14130	511-745	STKc_TTBK1
cd05605	585-727	STKc_GRK4_like
cd14016	516-682	STKc_CK1
cd05632	516-728	STKc_GRK5
cd14183	516-718	STKc_DCKL1
cd14180	516-795	STKc_MSK2_C
smart00082	148-190	LRRCT
cl15307	148-190	LRRCT superfamily
cd05596	516-729	STKc_ROCK
cd06637	516-720	STKc_TNIK
cd05597	516-735	STKc_DMPK_like
cd05631	516-793	STKc_GRK4
cd14101	516-777	STKc_PIM2
cd14223	585-771	STKc_GRK2
cd14138	515-670	PTKc_Wee1a
cd05575	516-771	STKc_SGK
cd13977	515-718	STKc_PDIK1L
cd14109	559-744	PK_Unc-89_rpt1
cd14197	633-728	STKc_DRAK1
cd14107	512-776	STKc_obscurin_rpt1
cd05633	585-771	STKc_GRK3
cd00096	301-374	Ig
cd05583	516-727	STKc_MSK_N
cd14179	516-796	STKc_MSK1_C
cd14095	558-718	STKc_DCKL
cd07875	516-724	STKc_JNK1
cd07874	541-720	STKc_JNK3
cd14110	554-715	STKc_obscurin_rpt2
pfam07714	510-781	Pkinase_Tyr
pfam13855	93-150	LRR_8
pfam07679	198-282	I-set
smart00221	510-781	STYKc
smart00219	510-781	TyrKc
smart00220	515-779	S_TKc
pfam00069	516-777	Pkinase
COG0515	512-776	SPS1
PLN00034	462-773	PLN00034
PTZ00024	505-722	PTZ00024
PHA03209	560-725	PHA03209
PTZ00263	495-771	PTZ00263
PTZ00283	587-775	PTZ00283
PRK13184	505-789	pknD
PTZ00266	515-746	PTZ00266
PHA02988	648-777	PHA02988
PTZ00426	505-729	PTZ00426
PTZ00267	560-771	PTZ00267
PHA03211	541-719	PHA03211
PHA03207	492-750	PHA03207
PLN00009	515-722	PLN00009
TIGR03903	541-722	TOMM_kin_cyc
TIGR00864	121-196	PCC
PHA03212	554-722	PHA03212
pfam07679	305-374	I-set
pfam13855	115-151	LRR_8
pfam13855	66-127	LRR_8

Ontology Information

HPRD ID	3573
Molecular Class	Receptor tyrosine kinase
Molecular Function	Receptor binding (GO:0005102)
Biological Process	Cell communication (GO:0007154); Signal transduction (GO:0007165)

SNP Information

View SNP Geneview Report

Uniprot ID	DrugBank ID	Name	Type
P04629	DB00321	Amitriptyline	SmallMoleculeDrug
P04629	DB00619	Imatinib	SmallMoleculeDrug
P04629	DB08896	Regorafenib	SmallMoleculeDrug