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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
NUMB 8650 numb homolog (Drosophila)  14- 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
26074693   2015Cell line : -

Source : Department of Surgery, Shanghai Jiao Tong University Affiliated Sixth People�s Hospital�

Sample Type : CRC tumor and normal tissue

No. of Sample : 40

Stage : TNM Stage I-IV.

real time RT-PCR,PCR-RFLPAlternative splicing--


Gene Details



NC_000014.8 (73741858..73925288, complement)

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Gene Type protein coding
Gene Family -
Description The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]  
Chromosome 14
Location 14q24.3
Start 73741858  
End 73925288  
Strand -  
Gene Sequence

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Length 183431  
OMIM ID 603728   
HGNC ID HGNC:8060   
Unigene ID Hs.525443   
Ensembl ID -   
PharmGKB ID PA31845   

mRNA Information


mRNA ID ?NM_001005743.1
Exon join(1..477,213580..213801,247462..247605,270849..270952, 298544..298724,304067..304234,306618..306782, 329035..329226,329898..330242,333000..333087, 342415..342583,346247..346480,364015..364164, 366150..366314,378879..379057,379812..386707)  
mRNA Sequence

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Length 9879  



CDS Information


   
Location 354..3149
CDS Sequence

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CCDS ID CCDS32115.1



Protein Information


      
Protein IDNP_001005743.1
Protein Namenumb homolog (Drosophila)
Molecular Wt. (Da)137204
Protein Sequence

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Length 651  
Uniprot IDQ15311
Ensembl Protein ID ENSP00000019317  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation7
SPhosphorylation295
SPhosphorylation7
SPhosphorylation295
SPhosphorylation276;-
SPhosphorylation276;-
SPhosphorylation265;-
SPhosphorylation265;-
TPhosphorylation436;-
TPhosphorylation388;-
TPhosphorylation377;-
TPhosphorylation425;-
SPhosphorylation284;-
SPhosphorylation284;-
SPhosphorylation438;-
SPhosphorylation390;-
SPhosphorylation379;-
SPhosphorylation427;-
SPhosphorylation240
SPhosphorylation241
SPhosphorylation244
SPhosphorylation240
SPhosphorylation241
SPhosphorylation244
SPhosphorylation229
SPhosphorylation230
SPhosphorylation233
SPhosphorylation229
SPhosphorylation230
SPhosphorylation233
SPhosphorylation634
SPhosphorylation586
SPhosphorylation575
SPhosphorylation623
SPhosphorylation20
SPhosphorylation20
SPhosphorylation20
SPhosphorylation20

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                                                                                                                               
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
160AP2A13016AAH14214.1in vivo12942088   
161AP2A26256NP_036437.1in vivo17203073   
351APP100NP_000475.1in vitro;in vivo12011466   
1808DPYSL23914NP_001377.1in vitro;in vivo1   294   208   811   121   440   
3689ITGB22506NP_000202.2in vitro12606711   
3690ITGB31428NP_000203.2in vitro12606711   
3693ITGB5949NP_002204.2in vitro12606711   
3897L1CAM2394NP_000416.1in vivo12942088   
4193MDM21272NP_002383.2in vitro;yeast 2-hybrid126   462   529   632   782   
4851NOTCH11827NP_060087.3in vitro;in vivo126   820   598   755   477   
5578PRKCA1498NP_002728.1in vitro17203073   
5579PRKCB1499NP_002729.2in vitro17203073   
5580PRKCD1501NP_006245.2in vitro17203073   
5581PRKCE1500NP_005391.1in vitro17203073   
5582PRKCG1502NP_002730.1in vitro17203073   
5583PRKCH5669NP_006246.2in vitro17203073   
6477SIAH13736NP_001006611.1in vitro;in vivo;yeast 2-hybrid11752454   


Pathway Information


      
Pathway Name Pathway ID
Notch signaling pathway hsa04330


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd0126823-168  PTB_Numb
cl1717123-168  PH-like superfamily
pfam06311258-339  NumbF
cl05682258-339  NumbF superfamily
pfam0064039-172  PID
smart0046237-175  PTB
cd0093437-162  PTB
cd1316139-167  PTB_TK_HMTK
cd0127335-162  PTB_CED-6
cd1315938-162  PTB_LDLRAP-mammal-like
cd0121530-131  PTB_Dab
cd0127424-148  PTB_Anks
cd1316038-144  PTB_LDLRAP_insect-like
cd0120925-144  PTB_Shc
cd0127238-144  PTB1_Fe65
pfam0841640-172  PTB
cd0127038-175  PTB_CAPON-like
cd1315839-161  PTB_APPL
cd1315738-144  PTB_tensin-related
PRK10263343-524  PRK10263
PRK12323418-622  PRK12323
PHA03247339-574  PHA03247
PRK07003347-522  PRK07003


Ontology Information


   
HPRD ID6715
Molecular ClassUnclassified
Molecular FunctionAuxiliary transport protein activity (GO:0015457)
Biological ProcessTransport (GO:0006810)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO