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General Information
- Evidence
- Gene
- mRNA
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- Protein
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- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20089989 | 2010 | Cell line : - Source : VU University Medical Center, Amsterdam, The Netherlands. Sample Type : CRC tumor and normal tissue No. of Sample : - Stage : TNM Stage II | Biochemical isolation to nano-LC-MS/MS analysis | Unknown | - | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a member of the FG-repeat containing nucleoporins that functions as a soluble cofactor in importin-alpha:beta-mediated nuclear protein import. Pseudogenes of this gene are found on chromosomes 5, 6, and 14. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] | Chromosome | 22 |
| Location | 22q13.31 |
| Start | 45163845 |
| End | 45188011 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 24167 |
| OMIM ID | 604646 |
| HGNC ID | HGNC:8065 |
| Unigene ID | Hs.475103 |
| Ensembl ID | ENSG00000093000 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_007172.3 |
|---|---|
| Exon | join(1..452,4324..4402,7756..7839,12050..12236, 14394..15056,17442..17523,19558..19676,20609..24167) | mRNA Sequence | Download Select all |
| Length | 5225 |
CDS Information
| Location | join(4334..4402,7756..7839,12050..12236,14394..15056, 17442..17523,19558..19676,20609..20811) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS14062.1 |
Protein Information
| Protein ID | NP_009103.2 |
|---|---|
| Protein Name | Nucleoporin 50kDa |
| Molecular Wt. (Da) | 50013 |
| Protein Sequence | Download Select all |
| Length | 468 |
| Uniprot ID | P28715 |
| Ensembl Protein ID | ENSP00000347978 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 221;- |
| S | Phosphorylation | 193;- |
| S | Phosphorylation | 223;- |
| S | Phosphorylation | 195;- |
| T | Phosphorylation | 219 |
| T | Phosphorylation | 191 |
| K | Acetylation | 83 |
| K | Acetylation | 55 |
| K | Acetylation | 275 |
| K | Acetylation | 247 |
| S | Phosphorylation | 141 |
| S | Phosphorylation | 142 |
| S | Phosphorylation | 113 |
| S | Phosphorylation | 114 |
| T | Phosphorylation | 246 |
| T | Phosphorylation | 218 |
| T | Phosphorylation | 259 |
| T | Phosphorylation | 231 |
| S | Phosphorylation | 263 |
| S | Phosphorylation | 235 |
| S | Phosphorylation | 270 |
| S | Phosphorylation | 242 |
| S | Phosphorylation | 296 |
| S | Phosphorylation | 268 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1027 | CDKN1B | 2867 | NP_004055.1 | in vitro;yeast 2-hybrid | 10891500 |
| 3837 | KPNB1 | 4114 | NP_002256.2 | in vitro;in vivo | 12176322 |
| 3838 | KPNA2 | 2818 | NP_002257.1 | in vitro | 12176322 |
| 5901 | RAN | 3109 | NP_006316.1 | in vitro;in vivo | 12176322 |
| 7514 | XPO1 | 3975 | NP_003391.1 | in vitro;in vivo | 10891499 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| RNA transport | hsa03013 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd13170 | 350-466 | RanBD_NUP50 |
| cl17171 | 350-466 | PH-like superfamily |
| pfam08911 | Feb-67 | NUP50 |
| cl07486 | Feb-67 | NUP50 superfamily |
| cd00835 | 350-466 | RanBD_family |
| cd13181 | 355-466 | RanBD_NUP2 |
| cd13180 | 354-464 | RanBD_RanBP3 |
| smart00160 | 344-464 | RanBD |
| pfam00638 | 351-466 | Ran_BP1 |
| cd13171 | 355-468 | RanBD1_RanBP2_insect-like |
| cd13172 | 355-466 | RanBD2_RanBP2_insect-like |
| cd13173 | 353-414 | RanBD3_RanBP2_insect-like |
| cd13179 | 342-414 | RanBD_RanBP1 |
| cd13176 | 354-464 | RanBD_RanBP2-like |
Ontology Information
| HPRD ID | 3390 |
|---|---|
| Molecular Class | Transport/cargo protein |
| Molecular Function | Transcription factor activity (GO:0003700) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.