CoReCG

Search results:

General Information

Gene_Symbol	Gene_ID	Gene_Name	Chromosome	Alias
NUP88	4927	Nucleoporin 88kDa	17	-

Evidence
Gene
mRNA
CDS
Protein
PTM
Enzyme
PPi
Pathway
Structural
Domain
Ontology
SNP
Drug
External Links

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
20089989	2010	Cell line : - Source : VU University Medical Center, Amsterdam, The Netherlands. Sample Type : - No. of Sample : - Stage : -	Biochemical isolation to nano-LC-MS/MS analysis and using spectral counting combined with statistics	Down-regulation	-	This genes are differenitially expressed between colorectal adenoma and Colorectal cancer tissue. CRC tissue was collected at the VU University Medical Center, Amsterdam, The Netherlands.
21863385	2012	Cell line : - Source : - Sample Type : Serum sample No. of Sample : 118 pre-operative serum samples, 66 post-operative and 96 healthy controls Stage : -	Sandwich ELISA, DNA sequencing	Up-regulation	-	Serum Nup88 might be a candidate for a new biomarker implicated in the development and aggressiveness of CRCs. the level of pre-operative serum Nup88 was significantly higher than that of post-operative Nup88 (P = 0.021).

Gene Details

Chromosome: 17; NC_000017.10 (5289346..5323059, complement)
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Gene Type	protein coding
Gene Family	-
Description	The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins, a family of 50 to 100 proteins, are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene belongs to the nucleoporin family and is associated with the oncogenic nucleoporin CAN/Nup214 in a dynamic subcomplex. This protein is also overexpressed in a large number of malignant neoplasms and precancerous dysplasias. [provided by RefSeq, Jul 2008]
Chromosome	17
Location	17p13.2
Start	5386026
End	5419739
Strand	-
Gene Sequence	>gi\|568815581:c5419739-5386026 Homo sapiens chromosome 17, GRCh38.p2 Primary Assembly ATTGGCCGAAACAGTGAGTGGACGGCCGCGGATTGGCTGTGCTCAGCGGCGGGCTGAGCAACTGGAGTGA GGGGAGCAGTTGGGCCAAGATGGCGGCCGCCGAGGGACCGGTGGGCGACGGCGAGCTGTGGCAGACCTGG CTTCCTAACCACGTCGTGTTCTTGCGGCTCCGGGAGGGACTGAAAAACCAGAGTCCAACCGAAGCTGAGA AACCAGCTTCTTCGTCGTTGCCTTCGTCGCCGCCGCCGCAGTTGCTGACGAGAAACGTGGTCTTTGGCCT CGGCGGAGAGCTTTTCCTGTGGGACGGAGAAGACAGCTCCTTCTTAGTCGTTCGCCTTCGGGGCCCCAGC GGCGGCGGCGAAGAGCCCGCCCTGTCCCAGTACCAGGTAATGCCAGGCCGATCTTGGAAGTGACCCTCAC CGGGATCGGAACCAGTCTTTTTTGTTCCTTGCTCCTCTTGGCTGTTTTTCATCTTGTGGCAGGCGTTCCA GCGGATTGACTCCGACGCTGCCATACGCGGTCGCGGGGACTCAGGCTCTCTCGATGCTTACGGCCTGGAG GCCTGGGAGGAAGGAAAGGGTCATTGAATATTCAATAAAAATACTAGTGACGGATGAGTGCTCTGGAGAA AAACAAAGCGGGCTAAAGGGGTTGAGAACGAGTGGGCGGAGTTGCTATTTTTAGTTTCGTCGAGAGAAAC CTGTTTCCTGATGTGACGCTTATAATAGGTTAGATCGTAACTTTCTCTTGCGTTGTGCACAGCAAGTCAG GTTGCAGGTTTCAAAGCACCACGCTTCATGCTTGACATGGAGGAGGAAGTCTCTGTTAATTCTTACCCCC GTAACGCCCGCTTTAGAAAATAAAGCCATACCCAAAATGGGGATTTTTGTTTTTGATTAGCCGACAGCAT GTGAAAATGGGTGTGATCCAGAAAGTATTACACACTTGCCGTGGTCAAATATTGGTTTATGGAAATGTTT ATTTGTAATACACAGATTCTCTTAAAGATGAAAAAGAGCTTGGTACTCATTCTAAGGTATGACATCTGTT GTGTGCCCGGTCCAATTCTTGTTACCGAGAAGTGATTTAATTTTAATAAGACGCTAGCAATGCTTCTGCA GTTTTGAAAATAGGGCAGGAGTCTACAGTCTACTTATTTACCCAATTTCAGTTAAAAAGAATTATGAAGG CCGGGCGCGGTGGCTCACGCCTGCAGTCCCAACACTGGGAGGCAGAGGCAGGTGGATCACCTGAAGTCAG GAATTCGAGACCAGCCTGGCCAACATGGTGAAACCCCGTCTCTACTAAAAATACAAAAATTAGCCAGGTG TAGTGGCGCGCCCTTGTAATCCCAGCTACTCAGGTGCCTGAGGCAGGAGAATCGCTTGAACCTGGGAGGA GGAGGTTGCAGTGAGCTGAGATCACGCCCCTGCACTACAGCCTGGGCAACAGAGCAAGACTGTGTCTCAA AAAATAATAATAATTACCAAATGTGCAGCACGCAGTATTCTAATAACATTCTATACTGCTGTGTAGCATT TGACATAATCATAACTTAATTATTTATAATTATTTTGTGTCTTTTTTTTTTTTTTGAGATGGAGTTTCGC TCTTGTTGCCCAGGCTGGAGTGCAATGGCGCCATCTCGGCTCACCGCAACCTCCACCTTCCAGTTTCAAG CGATTCTTCTGCCTCAGCCCCCCCCGCGAGTAGCTGGGATTACAGGTATCTGCCACCACGCCCGACTAAT TTTTGTGTTTTTAGTAGAGACGGGGTTTCGCCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCGTGA TCTGCTGGCTTTGGCCTCCCAAAGTGTTGGGATTACAGGCGTGAGCCACTGCGCCCGGCTGTTTTTGTTT TGTTTTGTTTTGAGGCAGGATCTCGCTCTGTTGCCCAGGCTGGAGTGCAGTGGTGCAATCTCAGCTAACT GCAACCTCCACCTCATGGATTCAAGCGATTCTCCTGCCTCAGCCTCTTGAGTAGTTGGGATTACAGGCCC ACTCCACCGTACCCGGCTACTTTTTGTATTTTTAGTGGAGACGGGGTTTCACCATGTTAACCAGGCTGAT CTGGAACTCCTGGCCTCAGGTGATCCACCCGTCTTGGCCTCCCAAAGTGCTGGCATTTCAGCCGTGAGCC ATGGCACTCTGCCTCTGTCTTCTTTTCTAGACTGTAAGCTCCAAGGCAGGGGCTGGGTCTGCCCTTGTCA TTTTTTAAAAACGTATTTTATTTTTTATTTTTGAAATGGGGTCTTTCTCTGTTGCCCAGGCTGGAGTGCA GTGGTGTGATCACGGCTCATTGGAGCCTCTACTGTCAGGGGTCGAGTGATCCTCCCACCTCAGCGCCTGG AAGTAGCTGGGACTACAGGCATGTGCCACCACGCCTGGCTATTTACTTATTTTTGTATGTCCAGCATACA GAAATGCTGGAGTGCCCAGAATTTATAAGCTTTCAGTAAATATTGGTGACTATCTCAATAACCTTCACTC CTCCAAAATCTCAAAACCTTAGAGATGGGGAAGAAAGCAGCTTATCATGAGTTGTAACTTTGGATGTTAA AAGCAAGCATGAGTAAGCTGGGTGTGGTAGCTGTAGCCTATAATCAGCACTTTAGGAGGCCAAGGTGGAG GCAGGTGGATCTTGTGAGCACGGGAACAGGTGTTCAGACCAGCCTGGGCAACATGACGAAACCCCCATCT CTACAAAAAAAACCTTTTTAATTAGCTGGGAGTGATGGTGCACACCTGTAGTCCCAGCTCCTCTGGAAGC TGAGGTGGGGAGGACACTTGAACCCCCATAGTAAAGTCTGCAGTGGGCTGCCACTGCACTCCAGCCTGGG TGACAGCAAGACTCTGTCTCAAAAAAAAAAAAAAAAATTTGTGAGTTAATGGTACAAGTGTGAGTACTTA TCCAGAGTTTTATTATCCTATAATTGTAGTAAACTAAGTATTACTGTGATTTCAAGTAACTGCCACCTAT ATTTAAATTAAAATTAACTATGTTGACTGGTTTGCTCTAATTTTCAGAGATTGCTTTGCATAAATCCACC CCTGTTTGAAATCTATCAAGTCTTGTTAAGCCCAACACAACATCATGTAGCACTTATAGGAATAAAAGGA CTTATGGTATTAGAATTACCTAAAAGATGGGGGAAGAATTCTGAATTTGAAGGTGGAAAATCAACAGTGA ATTGTAGGTAAGTTGTATACTATTTATCTGTATAATTTATTATATATACAGAAAATTGTTCAAGACTAGT GGTTCTTAAGCATGTTTAGTATACTACTCTTAAAACATTAAAACACTCCTCGTGGTCTGCAGACTGGCTT CTGTGTTATCAATGTTCATAGTATATGTGTAATTGATTGTACTTTATTCTGCCTGAAGTACCACGTTGCT GTCTCATTTGAGGCTAGGCCATTCTTTCGATTAGGTAGAAGTAAGATTTTGTAAAACCAGTTATCTGTCA GCCAGAAGTTTGCCAGAAGTGTAAGTATTTTATGTGTGTGTGTGTGTGTGTATGTGTGTATATATATATA TACTTTTTTTTTTTTTTTTTTTTTTGAGATGGAGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGCAC AATCTCGGCTCACTGCAAGCTCCGCCTCCTGGATTCAAGCGATTCTTCTGCCTCAGCCTCCCGAGTAACT GGGATTACAGGCAAGCGCTACCATGCCCAGCTAATTTTTGTATTTTTAGTAGAGACGGGGTTTCACCATG TTGACCAAGCTGGTCTTGAACTCCTGACCTCAAGTGATCCACCCACCTTAGCCTCCCAAAGTGCCGGGGT TATAGGTGTGAGCCACCGCACCTGGCCTATTTTTATATAATTTCTTTTTCAACAAATCCAGAAAAGTGAA TCTGAAAGATCTACTGAAAAGAGTACAGATGCTTTTCAACTTACGATTGGGTTATGTCCCGATAAACCCA GTGTAAGTTGAAAATGGATTTATTGCTGACAACACAGCAGAGGATCCCCGATTTAGGATGGTTCAACGTA GGATTTTTCAACATTATGATGGGTAACCCCATCATAAGTCGTAAGGAGCTCCTCAGTTTATGTTGGCTTA TGTACTGGTAAACCCATTGTAAAGTTGGGGATCATCTGTATAAGGTAGAAACTGCTTTTAGCTCCGCAAC TTATAAGTTGAGTCCCCTTAAACTGTTTACCTTCTAAATCTGTTTCCTCATTTTAAAAATAGGATTGATA ATATCTGCCCTTGTAATTTCCTTACAGGGTTAGTAAAAAGATCAAATGAGATACTATATCTGAAAACACT TGTACTGTATAAATATGTATCAATCCTAAGTCAAACCATCCTAAAATGTATATATACGTATGAAATATGC TATAATTTGGAGCCAGGCACGATGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGGTGGA TCACCTGAGCTCAGGAGCTTGAGACCACCCTGGGCAACATGGTGAAACCTCATTTCTACTAAAATACAAA AAATAAGTGGGGTGTGGTGGCACACGCCTGTAGTCCCAGCTACTCAGGAGGTTAAGGCACAAGTATTGAT TAAATCCAGGAGGCGGAGGTTGCAGTGAGCAAAGATCACGCCACTGCACTCCAGCTTGGGCCACAGAGTG AGACTTCATCTCAAATAAATAAACAAATAAAATTTAAATAAATAATTTAAATTATTAAAATAAATAAATT ATTTATTTATTTTGAGACAGAGTCTGGCTCTGTAGCCCAAGCTGGAGTGCAGTGGCGTGATCTCAGCTCA CTGCAACCTCCTCAGCCCGGGCTGGAGTGCAGTGGCACAAGCTCAGCTCACTGCAGCCTCCACCTCCTGG GTTCCAGCGATTCTTCTGCCTCAGCCTCACGGGTAACGGGTTACAGGCATGTGCCACCACACTTGCCTAA TTCTTGTATTTTTAGTGGAGACGGGGTTTTACCATGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAGG TGATCCACCTGCCTTGGCCTCCCAAAGTGCTAAGATAGGCGTGAGCCATTGCGCCCAGCCAGTGTGCTAT AATTTAGAAGATATTTTTATTTCAATTCTTTGATATTGATTGAATAGATGCCTTGAATGTCCTCTCAGCA TGATTTCAGGGAAATAAATCTGAAGGAAAGAGAATCAAAGAGTGTTAAAATAGAAATTTCTTCAGGGCCT GGCGTGGTGGCTCATGCCTGTAATCCCAGCACTTTGCGAGGCCGAGGTGGGCAGATCACCTGAGGTCGGG AGTTTGAGACCAGCCTGACCAACATGGAGAAACCCCCTCTCTACTGAAAATACAAAGTTCGCTGGGCGAG GTGGCAGGTGCCTGTAATCCCAGCTACTTGAAAGACTGAGGCAGGAGAATCACTTGAACCTGGGAGGCGG AGGTTGCAGTGAGCCGAGATTGTGCCGTTACACTCCAGCCTGGGCAACAAGAGAGAAACTCCATCTGCAA AAAAAAGAAGTTCCTTTAGAAGATTTTCATCCAAGTTGTACAAAATGTTTTGGAAAATTATTATCTTTAT TTTAGTACCACTCCAGTTGCGGAGAGATTTTTCACCAGTTCCACCTCTCTGACTCTAAAGCATGCTGCAT GGTATCCAAGTGAAATCCTGGATCCCCACGTAGTGCTGTTAACATCAGACAACGTAATCAGGTAAATTTT ATTTCTCTCTCTTGAAGCCTTGCGAGTGGGAAAGCTCTGTTTCTGTTTGCCAATTAACAGCTCAACATAG AACGAAGTGAGTCATTGAATGAGTCAGTGCTTTTATTGGATGGCTGTTGTAACCCATTCTCAATCATAAG AATTGCCTAACTGCTCTAACTTACCACTATTCCTTCTCAACTAGTCTTCCTGCCTCCAGGTATCTCCTCT CCTAATCTGACACCTTAGAATAATCTTTCCAAAACTCTTTCATCATTGTCACCCTTTTGGTAATAATGTA GCATAAAGGAAAGAGAATGTAAGTGTAAATTTAGAGATTTGAATTATTGTCCCACCTCCTTTTCTGTTAT CTTTGAGATCTTGAGCTTTTTAGGGGTTGGGGGGCTCAGTTTCCAATCTTTTAAATTGAGCAGGTTTGAT TCAATAGTTTCTAACGCCCCTTCCAAGCTTTGCACTCTATGATTAAATGCCCTAATGCTACGTAGATTTC TACTCTATTATCAGCTAACTTTCTGGATCGGCCTTATGTAAAAAGTTATTGGGGGGACTCAGCAGAGGTA CAGATACCTTCAGTTTTATTTTTCGTAATCACTGCTTTTAACTGTGCTCTACTAAATCTTCCTTCACTGC TGAATGACTCACCCCTTAATGATGTCTTATACAGATCCCCATAGCTTTCTCGTTACTTCTAGTTATGAAA ACAGTGTGTCCAGTTTAAAACTCATCTTGGCTGGTTGCAGTGGCTCACACCTGTAATCCCAGCACTTTGG GAGGCCGAGGTGGGAGGATCATTTGAGCCCCTGAGTTCGAGACCAATGTGGGCAATACAGTGAGATCCTG TCTCTGCAAAAAAAATTAGCTGGGCATAATGGCATGTGCCGGTAGTCCCAGCTACTCAGGAGACTGAGGT AGGAAGATTGCAGCCTGGGTGACAGAGTAAAACCCTGTCTAAAGAAAATAAGAATGTCGAAAGCTATTTG ATCTCAAATCTTTCACAACTATGTCCTGGCCCTTTTGTAGGTCAGACCTGTGTTTTGTGGGATCAGAAGT GATTGGAGAGTGTGCGGTCTGCTCTTTCACTCTTCCTGTTATCCCAGCACTTTGGAACATAGGGTGAAGT GTAAGGAATGGGCTGCCCCCTCCTTCCTCCAAATCTAACTCCTTCAGTGTGGGGTAGGGGAGTGGGACAG GTGAGGTAGAGATCTTACCGAACTGGTAGCCTGTGAGTGATGGGGAAGTATGCCTGATCTTGTTTGAATC TCGTTCCATCTGTCACTAGTGAACTCTGTTGATGTGGTAGTCTCTGCATAGATGGTGTGTTTGTGTGTGT GTATGTGGGGGGGTGGGGTGGTGTTGGAGGGCAGTGTTGAACTTCCAGCTCCCCCCATCACTGAGGAGCT CTGGCTCCCATTGGCTCCTGTCAGTTCTCTATGCCCTGAATCTTCTCTCAAGATGGGGTACAGTATACTT TATCTGCAGGGTGTGTGTTCCAAGACCCCCCAGTGAATGCCTGAAACTGTAGATAGTACTGAACGTGATA CGTGTGTATTGCTATGTTTTTTCGATCTTATAACTGAGACAGCTACTAAGTGACTAAGGGGCATTCAGCT AGGAAATGCACCAGTCTCCCTTATTACAGGTACCTCCACATCTGGCTGTTTCCTAGAGCCTTCCCTGCCC ACCCATTTGGCTTTAGAGTTCAGGGCAGAGAAAGAGGAGAGGGAAAATCTTCCCATTACAAACATTATAC TGTACTCCTAAGGAATCTTTGACATCCTCTCTTCTTAGTCTTCCTTTTATATGCTATGATGGAAAAGGAG ATGGTGGGAAGATAGCATAGGTACAGTTCTTAAGCCCCAAAGGAAGTATCTGGCCCCAAATATTGAAGGT TCTTTTTTAAAATATGTGGTATTTAACACTTCTGTTTTCCTAAGCTTTGGAGATTTTGGGCAGTTTCAGA GCAAAAGGAAATTTTCACCGAATGCCCTGTTGCACCTTCTTTTTCTTTCACTGTTCCCCAGTACAACATT ATTGCCTAGTATTTATGTGTATTTTGAAGTTAGTAACGCTTGTAGGAACCTAGGAAGACTGTAATAAATG TGTATTCAAATGGATCAAGTTATCATTAAAAATTTATTAAATACTTAATGTGGCATTTTATTGATATTGG AAGAAACCAAGTTAAAAAATTCTTAGTGGCGTCAGACAAAATAAGTGATTATAAGGGACACTGGATTTCT AAAATGACATTACTGGCCTTTTGAAAATTCCCTTTTTCACAATAGCCTTATATGCTGTGAAATGTAGGTT ACTTTAAATTAAAATAATTTTGGTTAAAAAAATTCAGTATTATACTTTCCCTTGAAAATAGAGATGATAC GATACTGGGTTTGTTTGTTTGGTTTTTTTTTTTTTTTTTGAAATGGAGTCTCGCTCTGTCGCCCAGGCTG GAGTGCAGTGGCGTGATCTTGGCTCACTCCAGCCTCCAGCTCACCGCAACCTCCACCTCCCAGGTTCAAG TGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGTGTGTGCCACCACACCCAAATAATTTTT GTATTTTTAGTAGAGACGGGGTTTCATCATGTTGGCCAGGCTGGTCACGAACTCCTGACCTCAAGTGATC TGCTCACCTCGGCCTCCCAAAGTGCTAGGATTACAGGTGTGAGCCACCGTGCTTGGCCAATATTGGGTTT TTATATAACAAACACATAAGTAGATTTGCAGGCTAAATATCACTCACTCTGTCAGCCAGTTGGCATATAA AGAATAAGATACAGTTCTTTCTCTGGTGGGATTTGGTGTCCAATAGGCAGAGATAGATGTGTGTAGTTGA AGGAAAACTGGCAAGCTTAGGGGCAATAGTGAGATGACTGGACAAGGCGAGTATAGCTAAGGGCTCAGGA CGGAAGTGACAGAGGTGCGATGTTATGGAATAGGCTGTTAAAGGGTATTGGTAAGGATAGAGAACATTTC TTCAGGCCCCAATGAAACTCCCTTATGTAGTTAAAGAATAAATGAACTAGACTACTTTGCAACAGCAAGA TTTTTGCAAAGAAATAGTTGTGATAAGTGTTAGAAAATTCTCAAGAACTGACTAGATGGAGAGGAAAGTG CAGTTTTGGGAAATGAAAACAGAATTTTAAGTGCTGGTTTTCTTCTCTTTTGGTTGCTAGAATTTACTCA CTACGTGAGCCGCAGACACCCACTAACGTGATAATACTTTCAGAAGCCGAAGAGGAAAGTCTAGTACTCA ATAAAGGGTAAGTTTTTATTTGAGTCTTGAAATGGTTTTTTAATTAGCTTATTGGGATTATAAATGCAAT TTTAACAGGTTGCAAGGTTTTTCAGAGGTGACTAGCATGCTTTTGGTAATGTGAGAAGTAAGTGTATTTT TAGTAGAACAGGGATTCGTCGTGTTGGCCAGGCTGGTCTGGAACTCCTAGGCTCAAGTGATCCTGCTCGT CTCAGCCTCCCCAAAGTGCTGGAATTACAGGCCTGAGCCACCATTCATTTCTTTATCACCTTTCTATGTG ATAAAGAAACTAAGATAATATCTTGCATTGATGTTTGCTCTCTCAACTATATGAAATTGTGATTTCATTT TAACCATATTTGTTAACTTTGTATTGAACTAGAATCTTCCTGAATAACTACAGTAAATTTTAAATATAAA AACAGCATGGTTTTATGATTTGCCTTCTTGATATACATGTAATGTATATTTGCTGTAGAAAATTGAGAAA AATAGATCAAAGTATTAGGAAGAAAATGAAAATCTTTGTAATCTCCTATAGCTATAGCCTGTTTCAATAC AGCACCCAAAGTTTAATCACATCATTCTACTTTAATCTAAGTTTAATCAGATCAGTTTAATCAGATCATT CTACTTCCCTGCTCTCCATACCCCATTGATTTCCCAGAGTCTTTACCTATAAAGGGTCCACAGGTATGCC ACCTGATTGCCTTTCCAGCTTCATTCCTCCCTCTGTGCCCTGGCTCTCTGGGCTCCAGGCACCTTGGCCT CCTTGCCATTCCACAGACATTAAGCACTTCTACCTTAGAGCATTTGCTCTCCACCTCAACTGCTCCTTCC CTAGTTAACCACAGACTTGCTCTCTTACTTCCTTCAGATCTTTGCTCAAATATCTTATCAGAGTCTTTCC TATACCAAGTAGTCTAAAGTAGCACCTCCATCAATACCCTCTTACCCTACTTTATTTTTCATGATATTTT CTGAGTTTATGTTCCATCTTTATTTCTTCTCTTTTTGTGGTATTTCTCTCTCTAGAGGGCAGGACATTTG TTTAATTCACTGACATATTCCCAGACCCTAGAAAAGTACCTGGCACAGAGTAGGTGCTTTGCGAGTATTT GTAGAACTTACGGATCCTGCTGCTCAGAGACAACTGTTGATGTTTTCATGTGTTTTCCTGTTTCCTTTTT GCATTTATGTGTGTGTATATAATAAATTTTTGCTATTTGTATATCTGTGTATTTAAACTATTTAAGATGA GAGTAGAACCAAATAATTTTATGGCCAGCTTTTTTCACTTAATTTCATGAGAATTTTTTTTTTTTTTTTT TTTTTGAGACGGAGTTTCGCTCTTGTCGCCCAGGCTGGAGTGCAATGGCACAATCTCGGCTCACTGCAAC CTCCGCCTCCCAGGTTCAAGCAATTCTCCTGCCTTAGCCTCCCAAGTAGCTGGGACTACAGGCACCTGCC ACCACGCCCAACTAATTTTTGTATTTTTAGTAGAAACGGGGTTTCACCATGTTGGCCAGGCTGGTCTCGA ACTCCTGACCTCAGGTGATCCACCCACCTCGGCCTCCCAAATTGCTGGGATTACAGGCATGAGCCACTGC ACCCAGCTGAGAATTTTTAAATGTTAACATTCTTCATAATCATTTTTTGTCTTTTCAGTCCATTGCCTAC AAATTCCATACATACCCACCTCCTGTTATTAGACATTTTGTGTTTTTGTTTTGTTTTGTTTTTCTTTTTA CTTTTTGTTGTTTTTGTTTTTAACAAGTTGGTTTTTACATCTCTTTCCAGAAGGGCGTATACCGCATCTC TAGGAGAGACAGCAGTTGCATTTGACTTTGGGCCATTGGCAGCAGTCCCAAAGACTCTATTTGGACAAAA CGGCAAAGATGAAGTAGTGGCATACCCACTGTACATCTTATATGAAAATGGAGAGACTTTCCTGACATAC ATCAGTCTGTTACACAGGTAAGTTGAGGTGGTCACCCACCTGAAATGAAAACTCAGTTTGGGCTCCAGTA GATATCATTGAGGCTGGACTTGGGAGCCATGTTTTTGAGTCTGTGGAAATGTTGCAGCCTTCACATGCTT GGCTTGCATATTTTTGAGAAAGAGTTAGTACAGGTCATTTGGCCTTTCATTTCTTCATATTATTTGGGTA AGTTCTATAGAATTCTTGGATAATCACTTATGATAGGCCTGGATTTGTGTTCACAAATTCTAGTTATCCG AACAAGTGCTTATTGTTTATCTTATATGAACAAGACACCACGTAGGCGTGGTAATCTGGTATCTTATGTC CCAGTTGTGGGGAGAAAGATACATACACATGAAAAAATACTATCCATACCACAGTATTGGTACACAGACA GTAAGAACCCCGAGGAAGGAGAGATCATTCTGACTGGGAGGTTAAGGAAATTTTCGTAGAGAAGGAGTGG TGTCATGTGTGACTTAAAGGTCTCATTCAGGATTAAATGAAGTATCAAGGAAGAGTGAGACCATTTCTGT CAAGGGCAGCATAAAGTAGCGTCTGAAAATAAGCAAGTGCAAGTGTCATTCAAGCTTAATTTATTAGACA TTCTGGGCTAGAGCTGAGGATTCATGTAGGGAGCATTAAGTGATAAAGCTGGAGTATCTGTCCCGAGAAA ATTTGCTGGAATTAAAAATACCTCGTTAAAAGAGTGAGTGTGGGTTTTTTTTCTGTAGGAATAGGGTAGT AGGAAGCCAGTGATGGTTTCTGAACAGAAGGACAAAACAATTGGTTAGGGAGGGGACTGGGACAGAGACT TTTAAAGAAGCTTTTGCAAAATTGAGCTTGTCATTTATGAGAGTTTGAACTTGGGTGGTAATAGAACAGA GGGAAAAATGAAACACAGTAGATAACAACAAAGGAAGGATAAATAAGACTTAGTTACTGTTTGGATAAGG GAGTATGCCATGAACAGAAACAGGTCAGTAAAGGCTGCTAATTGGGGGAGAAGATTTATTTCTAAGTAAA TCAGTGTAAGATAGTATTGGACCAATAAAATGGAAATATTCCATGGACAGTTGGAAATACAGGATGATGA CAGACAAGAAGAATTAAAATAGAGGTATGAGAATCATCTTTCATGGTGAGAGAGTCTATACAGGATAAGA ATTTGAGGGAAAACTGCAGAGGCATAAGGCTAAGGGCTGAGCATTAGAGTTTATTCGCTTGTAAATCGAC TTAACAGATACTTATTCAGGACCCACTCTGGCAGAAGATGGAAATACAAGATTGAAGGCAAGGTTCCTGC CATGTGGTTCCTTAACTACCAGAAGGGCATACAACTAAACCAGTAACTATAGTACAGTGTCATGTGCTCA GGGCATCACCGGGTTCTTCAGGAGTGTGATGGAGTAAATGAGTAGGCCTGCTCATCTTGGAAGACTTTAA GGAAATGCTATTACAAAAGCTTGAACTTGAAGGATTCACTAGACAGAATCAGAAGTGGGTACAGGAGAGA GAAGAGAGTACGCAAAACCATAAAGATTAGAAAGATGAAAGAGCTCGGTAGGTTACAGAATGGTGAGGAT TCACTGTTGAGTGCATTCTCCTTGGCAGAAATGTTCTCTGCCTTTCACACATGATCTCAGGAGGATTTTG TGGTAACTTTAGTACCTTCCCTTACCCTTTCTCCTCTTGCTGCTGAGCCCTCATTTGTCCAAACCATGAT CTGCCTAGTAACGTTAGCCCAAAACCCAAAAGTTTTCTTCATCCTTACATTTCATCAGTCCCAAATTTCT ATTGATTTTGTGATTTAAATTTTTCGAAAGTATACACCAAGCTTGTCCAACCCACGGGCTGCGCGCAGCC CAGGACAGCCTTGAATGCAGCCCAACGCAAATTTGTAAACTTTCTTAGAACATTATGATATTTGTTTGCG ATTTTCTTTTCTTTTCTTTTTTTTTTAAAGCTCATCACGTATTGTTAGTGTATTTTCTGTGTGGCCCAAA ACAATTGTTCCAGTGTGGCCCAGGGAAGCCAAAAGATTGGACACCCCTGATTATACACCCTTCTCTGCAT TCCTCTGTCCCTGCTTCAGAACTGCATCATCTGCCTACTTCACCATCTGCCTGGCTTATTTTCTTAAATA GTTTCCCCAAATCCCATTTTGGACCCTTCCATGTCTTCCTCCCTAATACCAGACTGATTTGTAAAGTGAG GCTCCATCGCTTGATTTAAACCTCTAGTGATATACTGTTACCCGGCAGATAGATTTCAAATAGTTTAACA TAGCACACAAGACTGTGTACTTCATAAGCCAGTCCTGGATGTCTGTCTAGCTATTTTGCCGTTGCCTTCC ACCTTGTACTTTGCCTCCCATCATACTAAATAAGTTTTCTTGTTCTTAGTTCTTTGTCTTTCATGTTTCC AGGACTTTGCATAAACTGATCTCTAGCTTGGAATGCTCAACAATCCCCTTCCCAGAAATCATTCTTTCTC ATTTTTCTCATTTATTTTTTATAGCTTTCTTCATTATCTTTGTATCTTTTTGTCATTCCTTTGTACACCA TAAATCCTTCTGTTGTTGCACTTATCACATGGTATAGTAATTCTGGTTAAATGTCTGCCTCATCAACTAA ACCATCATTCACTGGGAGTATCATCTAGCACTCAATAATAAGTATTTGTCAAATCAAATTTAATATGGGG ATCCAAAGCCTTGAAGAGAAGCTACATTTTAGAAGAAAGGATTTGGTAGTCTTTGAATATAGATGGTAGT TAAAACGAGGCATAGTTTAACAGGCTCTCATTTAAGTGTGTATTTTGAAAAAAGTCAAAGCATACAACAG AATCCTGGAGAACACCAATATTTAAGAGACAGAAATTAGAAAAGGACGTTAGAAAATTGTGTTTAAAGAG GTAGGAAGAGAGAACTACAAGAAAGAATTGTTACAGCTGTTGAGTAGCAGTAGTCGTTAACCAGTGATAA ATGCAGCAGAAGGTTAAGTGCATTTTGGATTTAGCAAATCTCACAGGTGACCTTTGCCACAGTAGCTTCA GTGGAGTGGTGAAAGCATAAACCATAGTAAATTTAGGGCAAGGGTTTTCAACCTTTGTACTATTGACATT TTGGTCTGAATTATTGTTTGTTTTAGAGGTGCTGTGCTGTGCGGGAATGTTTAGCGGCTTCTGTCTAGCC TCTAACCACTAGATGCTAATACCTCCCCCCACATTGTGACAACCAGTTGTGACAAGCCAAAATGTCTTCA GACATTGCCACTGTCCGCTAGGGCAAAATTATCTCTGGTTGAGAAACACAGAGTGGTGGGATCTGAGTGG GAAAGCGAGAAGATGGAGTATTGGGAATACACTACATTTATAATGAAGGTATGATAGCTGGAGGAAAACA AAGTCAAAGAATGGTTTTATGGGATGAGCATGCATACTGTCAACATTTCCCAAATATGTTTTTACTCCTT CTTTAGCCCTGGAAATATTGGAAAGCTGTTGGGTCCATTGCCCATGCATCCTGCGGCTGAAGATAACTAT GGTTATGATGCGTGTGCTGTACTCTGCTTACCCTGTGTCCCCAATATCTTAGTGATCGCTACTGAATCAG GAATGCTGTATCACTGTGTCGTGCTAGAAGGGGAAGAAGAAGATGACCACACGGTAAGTGCAGGCTGCTG TGGTTGTTTGTATCTTCAACACCTGGCATAGTTCCTGACCCAATATGAATGCTTAATATATGAGAAGGAA TTTTAACTTACTTATGGAACTTCTGATATTTTGGAAATTAAACAGTTAAAAAAGTAGCTGAAGCACACTT AGCAGTCTAAGTGGAAAGAAGTTAGAAGGTTGCCCAACTTACTTGGTCCACCAGTCTGCATGTTACTTTC TGGTCTCTATATTGCAATCTTCAGGGACAGATACAAAGAGCCTTGGAATCACTGAATTGGCTTTTTTCAC AAACATCTTCCTAAAGGAAGAGAGACGTTTTGTCTTCAGAATAACAGTGCACTGTTAGGATAGAGGTGGA ATTAAGAATTTGAAAGTACTGTTTGACCCAGCTTTTTTTTCAATTTTTTTATTTATTTTTTATTATTATT TTTTGGAGACAGAGTTTCGCTCTTGGTGCCCAGGCTGGAGTGCAATGGTGTGATCTCGGCTCACTGCAAC CTCTGCCTCCTGAGTTCAAGCGATTCTCTTGCGTCAGCCTCCCCAGTAGCTGGGATTACAGGCACCCACC ACCACGCCCGGCTGATTTCTTGTACTTTTAGTAGAGACAGGGTTTCAGTATGTTGGCCAGGCTGGTCTCG AACTCCTGACCTCAGATGATCCACCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCAAGAACAGCCG CACCCGGCCCTGACCCAGCTTTTTGCCTGTTTTTAATTGTGTACATTTTCAAATTAACATGCAAGATCAA AATTACAACACTTTTTTTTACAGTCAGAAAAGTCCTGGGATTCCAGGATTGACCTCATTCCTTCTCTGTA TGTGTTTGAATGTGTTGAGTTGGAGCTTGCTTTGAAACTGGCATCTGGAGAGGATGACCCTTTTGATTCT GACTTTTCTTGTCCAGTCAAACTTCATAGAGGTAAGCTCTTCAATAAATGTAGTGCTTTTTTCCCATGAT TTTTATACTAAGACTATCATAGACTGTTCCTATGTAATGTATTTGTTCTGTGGTTCCAGCCTTTAAAAAG TTGACTGGGTTTTTTTTAGCTTTTTAGTCACTATAGTACACTTTTTGTCTAAGGCAGACTGAGCAAATTT CCCAAGTTTTAAAATAGTGGTCTTTGGTCCAGATCACCAGATTCCTAATAGTGAATTTTTCCTGGTCCTT TCAAAAGTAGAACTACCATGTTATTCAGTAGTTCCACTACTGGGTATGTCAAAAGGAAAGGAAATAATAG GTTGAAGGGATACCTACACTCCCATGCCCATTGCAGTGTTATTCACAACAGCTAAGATGCTGAATCAACC TGTGTCCATCGACAGACCAAATGGATTTTGTTGTTGTTGTTGTTGTTGTTGAGATGGTGTCTGGCTCTGT CACCCAGGCTGGAGTCTAATGGCGCAATCTCGACTCACTGCAACCTCCATCTCCCAGGTTCAAGCGATTA TTTTGCCTCAGCCTCCCAAGTAGCTGGATTGCAGGTACCCACCACCATGCCTGGCTAATTTTTATATTTT TATTTCATTTATTCATTTATTTTGAGATGGAGTCTCGCTCTGTTGCCCAGGCTGAAGTGCAGTGGCACCA TCTCAGCTCACTGCAACCTCCGCCTCCTGGGTTCAAGCAATTCTTCTGCCTCAGCCTCCCTAGTAGCTGG GACTACAGGCATGTGCCACCACGCCCTGCTAATTTTTGTATTTTTAGTAGAGACGGGGGTCTCACCATAT TGGCCAGGCTGGTATCGAACTCCTGACCTTGTGATCCGCCCACCTCGACCTCACAAAGTGCTGGGATTCC AGGCGTGAGCCACTACGCCTGGCAATTTTTGTATTTTTAGTAGAGGTGGGATTTCACCATGTTGGCCAGG CTGGTCTCAAACTCCTGGCCTCAAGCAGTCCACCTGCCTCGGCCTTCCAGAAGTACTGGGATAACAGATG TGAGCCACCGCGCACCTGGCCCCAAATGGATTTTTAAAATGTGGCATTGTATACACAGTGGAATACCATT TGGCTTTTGTGTGTGTGTGTGTGATATGATCTCACTGTGTCATCTAGGCTGGAGTACAGTGGCGTGATCT TGGCTCACTGCTTTGCCTCCCAGGCTCAAGCAATCCTCTCACCTCAGCCTCTGGAGTAGCTGGGACTACA GGTGTGCACCACCACGCCTAATTTTTGTATTTTTGGTAGATACGGGATTTTGCCATGTCGTCCAAGCTGA AAGTCCTGAGCTCCAGTGATCCTTCTGCCTCAGCCTCTCAAAGTGCTGGTCCACAGGTGTGAACCACCAT GCCCAGCCCTATTTGGCTTTAAAAAAGAATGAAATCGTGTCATTCACTGCAACATAGGAGGATTTCAATC TTGTAGCAGTTTGACCTACTCTCCTTACAGTTCTTGTTAGCCAGTTTGCCTAGTTCTGGTAATAACGGCC TCAACTCTGTACTAAAGTATAGGCAAAACATTTAAGGGGGCAGAATTCCTTACATAACAAACCAGCAAAG AGTGTACATTGGGTTTGTCTAATTAAGGTATTTTGAGATTTATATTGTCTAAGAATTTTATAGATGAGGA AACAGACCAAATGAAGTAAAGTGACATAAACTAATTGGTTTCCTCATATAGATACGTATATCTTTGGGAA ATCTTAAGTGTAGACGTGGACGTTTTGTTCTTGGGTTTTGTTTTTTGTATTTTGTTTTTTGTTTTTTTTT TTGAGATGGAGTTTTGCTCCTGTTGCCCAAGCTGGAGTGCAATGGCACGATCTTGGCTCACTTCAACCTC CGCCCCCTGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCAAATAGCTGGGATTATAGTCATGCGCCACC AGGCCTGGCTAATTTTTGTATTTTTAGTACAGATGGGGTTTCACCATGTTGGTCAGGCTGGTCTCGAACT CCTTATCTGTCCACCTTGGCCTCCCACAGTGCTGGGATTTTAGGCATAAACCACCATGCCCAGCCTTTTC TTGGTTCTTCTAATGAGAGTAACATTTTCATATGTGAAACTAAGAAATTTTTGACTTGTTCCTAATTGTG CTGAACAAGGCATATTATAATCACTGAGGCACACCAGATTTCTTAGTGACAAAGTGAAATGGCTACAGTA TAGCATAGGGTGGTATCTAACAAATTTCCTGTTAAGTAAATGTTGGCTCTTTTTAGTAATCAATTTGTTT TACACCCCAGTGTTAAGACTTTTCTGTTGATGTTAGCACTACAGGTTTTGAAAAGCCATTTTAACAATGT TAGATTTAATGAGATGATTTGAGCCTTAAGTCTTAAAACATACGCAAATGAAAAGAAAATTTTCAATATT TTAATTATGCAAACAGATGATTCCCATAGATGAGGGTTTTTTAAACTTTTTATAGCAGAATGCTGTTTTC TAAGATGTTTTATGGAACCTCAATATATAAGACAGAAAAATAATATATCAGCTTTAGAATATTAATTTAT GATAAAGTCACTAACCACAAAGTGAGACTGTTAGATTAAAGGAAAATTTAATTTAGGGGTTTTATGGGTT ATTGTTGCCATTTTATCAGCTTTAATATATACCTTATCTCTGTATTTTGTTTTAGTTTAATAACATTATT ATTTTGTGTTTTTTTTTGAGACGGAGTTTCGCTCTTGTTGCCCAGGCTGGAGTGCAGTGGTACAACTCGG CTCACCGCAACCTCCACCTCCCAGGTTCGAGCGATTCTTCTGCCTCAGCCTCCCGAGTAGCTGGGATTGC AGGCATGTGCCGCCACGCCTGGCTAATTTTGTATTTTTAGTAGAGACGGGGTTTCTCCATGTTGGTCAGG TTGGTCTTGAACTCCTGGCCTGAGGTGATCCGCCCACCTTGGCCTCCCAAAGGGCTGGGATTACAGGCGT GAGCCACCACACCCGGCCAATAAGATTATTATTAATATTAATAATAAAAATATTGAGTTACAGAGATAAA TATTTATACATAATAATAGGTATTCAGTAGTTTATCTTTTAGTCTCAGGATTGTCTTACTGATACTGGGG CTCAAAGGAGGTACAGAAATTTTTGTTTCAAAATCAGTTAATTAAAATTGTATAACAACTACTCATACTT CTTAGTTATAAATGATTGTCAAACAAAAAGAGCATCCAAAACTGAAAATAACCTTTGAAACTATCTGTAA GTCAACATTATGAAGACATACGAAACTTCACTTCTCATTTCACACCTTACTACACTGATAGAACTGTTCC CTGAGCCGTTGTGTTAAAGTCTTTTGTGATAACTATGCTGTAGAAGTGCATTTGCTTCAACAATTTTATT TAAGTCGATGTATGCAAGCATAAGCATAGGTTTTCTACAGAGCTGCTATTTTAACCACCATTTTCTTTTG AAGAACTAAATAAATGCACAGAGAAAAGCATAAATGAGTTACTTGCCAGCAAGTATTTATGTTTTGGTGA ACCTCATTGTGTTCATATTTAGAAAATAACATTTGGATTGAGTTTTTTTTTTTTTTTTTTTTTTTTGAGA CGGAGTTTCACTCTCGCCCACGCTGGATTGCAGTGGCGCAATCTCGGCTCACTGCAACCTCCACCTCCCG GGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATCACAGGTGCATGCCACCACGGCCAGC TAATTTTTGTATTTTAGTAGAGACGGGTTTTCACCATGTTGATCAGGCTGGTCTCGAACTCCTGACCTTG TGATCCTCCCACCTCGGCCTCCCAAAGTGCTGGGATTACAGACGTGAGCCACCACACCCAGCCATTTTTT ATACTTTTTAAAACATAGGCATACCTCCTCATTTTATTGTGGTTCACAGTGCTTTTTTTTTTTTTTTTTA ACAAATGAAAGATGTGGCAACCCTGCATCAAGCAAGTCTATCGGCACCATTTTTCAAACAGCACGTGCTG TCTCTGTGTCAGCATTTTTTAGCAATAAAAAATGGTTAAGGTATGTACATATTTTTTGACGTAACACTAT TGCGTACCTACTAGTATAAACATAACTTTCTGCATAGTGTAAACATAACGTTCTTATGTACTGGGAGACC AAAAGATTTGTGTGACTCACTTTATTTCTGTATTCGCTTTATTGCAATGGTCTGGAACCAAACCCACAGT ATCTCTGAGGTATATCTGTACTTAAAATATATTTGAAATTTGAATTCAAATTTTAAAATTTCAAAACCCC TAACAATATGAAAGTCTTTTATAAAACCTTCCATCAACAAATGCGTTTGTAGGCTAATGTGGAGTAGCCA ACAAATTTGAGGTAAATTTTTTTAGTTATCCACTGGCTACCTTTGTATCATTAATCATTCCATTTGCAGA TCCCAAGTGTCCTTCAAGATATCACTGTACTCATGAAGCTGGTGTACATAGTGTTGGGCTAACTTGGATT CATAAACTTCACAAATTTCTTGGATCAGGTGAGTTTACTAACTCTCTGCACTTTTAATAGATTTCAGAGG AAAAATAGATTTAATAGATTTCAGAAAAGTAGTTTGGAATAGAAAAATGATAGAGAAAATCAGTGAAACC GAAAGGTTCTTTGAAAAGATCAACCACATTTCACAAGCCTTTAGCTAGACTAACTATAATCAAGAATAAA AGCAGGGATATTACTATTGACCTTACAGAAATAAAAGATTATAAAGGAATATTATGAACAAATGTATGCC ATTTACATAATCTAGATGGAATGGACAAATTCCAAGAAAAAAAAAAACTACCAAAACTGACTCAATCAGG GTCTGGGATAATTTGCTTTAAAAAAAAAAAAAAAAAAAAGGCCGGGTGCGGTGGCTCACGCCTGTAGTCG CAGCACTTTGGGAGGCCGAGGTGGGTGGATCACAAAATCAGGAGATTGAGACCATCCTGGCTAACATGGT GAAACCCCATCTCTACTAAAAATACAAAAATAAATTCTCCGGGCGTGGTGGCGGGCGCCTGTAGTCCCAG CTACTCGGGAGACTGAGGCAGGAGAATGGTGTGAACCTGGGAGGCGGAGCTTGCAGTGAGCCAAGATCAC GCCACTGCACTCCAGCCTGGGCAACAGAGCGAGACTCCGTCTCAAAAAAAAAAAAAAAAGGCTGGGTGCA GTGGCTCATGCCTTTAATCCCAGCACTTTGGGAGGCCAAGGCGGGCGGATCATGAGGTCAAGAGATTGAG ACCATCCTGGCCAACCAACATGGTGAAACCCTGTCTCTACTTAAAATACAAAAATTAGCTGGGTGTGGTG GCACACACCTGTAGTCCCAGCTACTCGGAAGGCTGAGGTAGGAGAGTCGCTTGAACCAGGGATGGAGGTT GCAGTGAGCCGAGGTCATGCCACTGCACTCCAGCCCAGGCGACAGAGCGAGACTCTGTCTCAAAAAAAAA AAAAAGTTAGGCCAGGCACAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCTTGTGGAT CACCCGAGGTCAGGGGAGTTTGCGAACAGTCTAGTCAACATGGCGAAACCCCGTCTCTACTAAAAATACA AAAATTAGCCAGGCATGGTGGTGTGCGCCTATAATCCCTGCTACTCTGGAGGCTGAGGCAGGAGAATCGC TTGAACCCAGGAGGCGGAGTTGCAGTGAGCCGATATCGTGCCACAGCACTCCAGCCTGGGTGACAGAGCA AGACTCCGTCTCAAAACAAACAAACAAAAACTGACACAAAGAGATTGATTAGTAATCAAAACTATCCAAA AAGAAAAGCTGAGGACCACATGGATTCACATTTAAAGAATTAATACCGGTCAGGTGCAGTGGCCTACGCC TATAATCCCAGCACTTTGGAGGCCGAGGCACTTGAGGTTAGGACTTCAAGACCAACCTGGTCAAAATGGT GAAACCCTGTCTCTACTAAAAAAAAAAATACAAAAATTAGCCAGGCATAGTGGCGGATGCCTGTAATCCC AGCTACTCGGGAGGCTGAGACAGGAGAATCGCTTGAACCTGGGAGGTAGAGACTGCTGTATTCGAGTCGA GATCACACCACTGCACTCCAGCCTGGGTGACAGAGCAAGACTCCATCTCAAAAATGAAAATAAAAAATAA ATTAAAAAAAAGAATTAATACCAATTATTCACAGAGTGAGAGCAGTTAAAAAAAATCTAGCAGCCTTTCA TGTTAAAAATACTCAACAAACTTAATAGAAAGGAACTTCCTCAAACTAGTGAGGAAACTTTTCATCTACA AAAAACTTGGAACCAACACAATGCTTAATGGTAAAAAGACTGAATCCGTTATTGGCTTTCTACTGCTACT GTTGTAAATCATCACAGACTTAGTGGCTTAAAACATGACAAATTTGTTATCTTATAGTTTTGTAGGTTAG AAGTCCTGCATGGTTCTCACTGGGCTTAAGTTGGCACAGCAGTTTTCCTTTCTGAAAGCTCTAGGGTAGA ATGCATTTCCTACCCTTTTTCAGCTCCTGCCACATTCCTTGGCTTGTAGTCTCTTCCTCTATCTTCAAAG GCAGCCAGCAACAGTGGGCTGGGTTGAGTCCTCATGTTGTATCACTCTGTTTCACTTTTAAAGAAACTTG TGGTAACATTAAGTCTGCCCGGATAATCCAAGGTAATGTCCCTATTTAAAAAAAAAAAATTCTTTTAAGA GACAGAGGGTCTCACTCTGTTGTCTGGGTGGGAGTGCAGTGGTGCAGTCATTGGTTGCTGCAGTCTCGAA CTCCTGGGCTCAAGCAGTGCTCCTGCCTCAGCCCCCAAAGTATCTGGGACTACAGGAGTGAGCCACCATG CCCAGCTAATTTTTGTGTTTTTTGTAGAGATGGGGTTTTACCGTGTTGCCCAGGCTGGTCTCAAACTCGT GGGCTCAAATGATCCACCCACCTCAGCCTCCCAAAGTGCTAGGATTACAGGTGTGATCCACCGCACCTGG CCATCAAAATTTAAATCTTTTTTCTTCAAGAATACTATTACAAAAGGGAAAACAGCCCACAAAATGAGAG AAAATATTTGTGTGATAATGGACTCGTATGGAGAACAATATAAAGAACCCTTAGCATTTGATACAGTTGG GCAAATAGCATATATATAAAAAGATGTACAACATTATTAGTCATTATGGAAATAAGATACCACAAAACCA CAATGAGGTATCACGTCATATCCACTAGTATAGCTAAAATGAAAAAGATGGACATTAACAAGTGTTGAGG ATGTGGGAAAAAATGGGGACTTTTATACAGTGCTTATAGAAATGTAAAATGGTACAGTCTTTGGAAAACA ATCTGGCAGTTCCTCAAATGATTATTCATAGAGTTACCATGTACCTGATAGTCCAGTCCTGAGTATATTT CCAAGAGAAATGAAGACCTGTATCCACACAAATACTGGTACATGAGTGTTCACAGCAGCATTATTCATCA TAGCCCAGAAGCCACATACCCAAGTGTCCATAAGCTGATGAATGGATAGATAAAATGTGGTGTGTCTATA CAACAGAGTATTATTCAACAATGAAAAGGAATGAAGTACTGATACATGCTCCAATATGGATGAACTGTGA ACAGATGCTAAGTGAAAGAAGCCAGTTACAAACAACTGTATGGCTGTTTATATGAGATGTCCAGAATAGA CAAATGTACAGAGACAGAAAGTAGATTAGTTGCCTAGGTCTGGGAAGTTTGGTAGAAACTGAGGAGTGAT TGCTAATGGTTATGTGGGTTTCTTTTGGGGAAATGAAAATATTCCAAATTGTTAATGATAGGTATACAAT TTTTTTTTTAGACGGAGTTTCACTCTTGTTGCCCAGGCTGGGGTGCAATGGCATGATCTTGGCTCACCAC AACCTCCACCTCCTGGGTTCAAGCGATTCACCTGCCTCAGCCTCTCGAGTAGCTGGGATTACAGGTGCCC ACCACCACGTCCAGCTAATTTTTGTGTTTTTAGTAGAGACGGCGTCTCGCTATGTTGGCCAGGCTGGTCT TGAACTCCTGACCTCGGGTGATCCACCCACCTTGGCCTCCGAAAGTGCTGGGAATTACAGGCATGAGCCA CCGCACCCTGCCAGGTATACAATTCTTACACTAAAAACTTACTGAATTGTATACTTTAATGGGTATACTT TAAATGGATGACTTGTATGGTACTGTGAATTACGTTTCAAAAAGCTGTTACAGGCCAGGCGTGGTGGTTC ACACCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGTAGATCACCTGAGTTCAGGAGTTCGAGACCAG TCTGGCCAATACCGTGAAACCCTGTCTACTACTAAAACCTGGGCGTGGTGGCGTCCACCTGTAGTCCCAG CTACTCAGGAGGCTGACGCAGGAGAATCACTTAAACCCAGAAGCCGGAGGTTGCATTGAGCAGAGATTGG GCCACTGCGCTCCAGCCTGGGCAACAGAGGGAGACTCCATCCAAAAAAAAATAAAGCTGTTATAAATTGA GTATCCCTACTCTGAAAAATTTGAAATCCAAAACTTTTCTTTTTTCCATCCTTGAACCTGAGTGAGCTAC AAAAGTTTTTGAGTGCTGTCATGACAACAGAAATGCTCATTGGAGCATTTAGGATTTTAGATTTTCAGAT AAGAGATGTTCAACTACTAAGTATAATGCACATATTCCAAAATCCAAAAAAAAAATGTGAAATCCAAAAC ACTTCTGATCCCAAGCATTTTGGATAAAGGATACTCAACCTTTATGAAAATAAAATCAGTGTGGGTAAGC AGCACCCTAGAAGAGAATGATTTCACTGTTCTTAGTGAAACATTTTTGCATTCAGAGACATTACGAAGGA AAATCCTACTTCTTGGGGCGGAAATCTAGACCCCCTGGGAAAGCGTATGCCTATGTCAGAAAAGCATAGT ACTTGAGAAGCAATGTTTTCAGACAAGAACCTCACTGCATTTAACCCAATATCATTAGCATTTTAATTTG GAGACTTGTCTAAGCATCATTTCATTTATGTAATGTCTTCCATGGTAGATGAAGAAGATAAGGATAGTTT ACAGGAACTCTCTACAGAACAGAAATGCTTTGTTGAACACATCCTTTGTACGAAGCCATTGCCCTGCAGG TAAGGACTCTCCCTCCCTTGTATATCAGAAAACAATTGTTCATTTCAGCAGTTCAGATACGTTTGTATCC GTTACACTCACATCCACAGTATTCACTGCTGAGTCATTTGAAAGTTGCAGACGTGATACTTCTCCCCTAA GAGTGTCCTGCTCATCAGAAGCTTTCTCCTCTCCAGGGCCACTCGACATACTGTTTCCTGACTGGAAGGT CCTTCCCCAGCCCCAGCCCCAGCCCCAGCTTGCTGTCTTCTCTTGGCTAACTCCTACCCTTCTTTCTGAT CTTAATGTCACTTCTTCACAGAGAACACCCTTGACTCCCCAGTCTAACTTGGGGCTCTCCTATTCTCTTA TCCATTGTAGCACATATTACACTATTTATATTTGCATTTTTTTAATGTCTGTCGCCACTACCGGAATGTA TATGTTTCATGAGAGCAGAGACTGTGTCTGCCCTTCACTGCATTGCTGTGTTTATTTGATGTGGTTGCCC ATGTCTCCTCTTTGAAACACATTCTCCTTGGCATCCTTGACGTCTGTCCCTCCAGGTTCTCCTTCAGTCC CGCCAGCAGCCCTTTTCTCAAGTTTCCTTCTTGGGCGGGTTCCTCTGCCTCTACTCACTGCTTATAAGTA ATGCTCACAACTCTTTCCTTGGGTCTTCTCTATTCTTTCTAGGTCCTTTCCTGAGTAACTTCTGCCGTAA TCATGGCTTCAGTGCTGACAGTTCCCGCATCCATATCGCCCTAGCCCAGACCACTCTGAACTCCAGATTC ACATACCCAGCTGCCTACTGGGCTCCTCCACTTGGATATCCTATAGGAACATAAAACTCCAGATGTCCCC TTAACTCATCTTCTGTCTTTCCAAATCTGCTCTCTCTCCTGTGTCCCATTTTTCTGAAGGGTGCCATATC ACCCCAGTTATCCCCAGTAGAAACCTGGAAGGTATTCTAGATACCTCCCTTTATTCTGTTCATCAATTAC TAGATATCTCATAAGCACTCTGTTAGACATGGAGTATACACAGACATGAGACAAATAGCATACACTAAGA AATAGACATAATCTAGGTTTGGCAATACAGAGGACCACAGGGAAAACGCTTGGTGGGGAATGAGAAGGAT AGCAAACTGTACCAGCTTGAAAAGTGAACAGTGAAACCAGGCACTGTGGCTTACGCCTATAATCCCAGCA TTTTGGGAGATCGAGGTGGGTGGATCACACGGTCAGGAGTGCAAGACCAGCCTGGCCAAGATGGTGAAAC CCCATCTCTGCTAAAAACTACAAAAATTAGCCAGGCATGGTGGCAGACACCTGCAATCCCAGCTACTCGG GAGGCTGAGGCAGGAGAATTGCTTGAACCCGGGCAGCACAGGTTGCAGTGAGCTGAGATCATGCCACTGC ACTCCAGTCTGGGTGACAGAGTGAGACTCCATCTCAAAAAAAAAAAAAAAAAAAGAAAAGTGAACAAGGA AAATACATAATAAAATCCCATGTAGGCTGGGCATGGTGGCTTACACCTATAATCCCAGCACTTTGTCAGG TGAGGCAGGAGGATCACTTGAGGCCAGGAGTTTGAGACCAGCCTGGGCAACATAGTGAGACCCTTTACAA AAAAATTTAAAAATTAGCTAGGTGAGGCCAGGCGTGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAG GCTGAGGCAGGCGAATTACTAGGTCAGGAGTTCGAGACCAGCCTGGCCAACGTGGTGAAACCCCGTCTCT ACTAAAATACAAAAAAAAAATTAGCTGGGTGTAGTGGCGGGCACCTGTAATCCCAGCTACTCAGGAGGCT GAGGCAGGAGAATCGTATGACCCTGGGAGGTGGAGGCTGCAGTGAGCCAAGATCATGTCACTGCACTCCA GCCTGGGCAACAGAGTGAGACTCCGTCTCAAACAAAAAAAAAAATTAGCCACTGTGGTAGCATGTACCTG TGGTCCCAGCTACTCAGGAGGCTGAGAAGGAAGGATTGTTTGAGCCCACGAGGTCAAGGCTGCAGTGAGT CGTGATCGCACTATTGCACTCCAGCCTCGGCAACAGAGTGAGACCCTATCTCAAAAAAACCCCAAAATCC CATTTATATCAATTTCAGAAACAGGTAAAATTAAACAGTCTTGCCTAGGAGTGAATACATAGATAGGAAA ACTATAAAGCAAAGCAAAGACATGATATTATGAATGTCAGAGTAGCGGCTACTTCTCTGGGGAGTGAAAG GCTATGACCAGGGAAGGTCGCATGGGAACCCTGAGGCCCCCTGCAGTGTCCTGATTCTTGACCTGGATAC TGGTTACATAGTGTATAGCCCAGTAGTGTGTAGATTTCACACTGATAATAAAAAGTTAAAGTTTACAACC TTCCAGATATCGTCTCCATGTCTTGTCCAAAAAGGTAAATGGGAGCTATGGAAGGGGAACTAGTGTTTTC AACTGCTGTTTAAAGACTGCTGGTTCTAAAGGGATGGCGAGAAAGAATAGGTTAAGGGGAACTGGACATT ATATTGAAATGAGAGTATTTTAAATGGAAGAGACATGAGTTTGCAAGCTGAGGGGAAGTAGATAATAGGG AGATTTTGAAACGACACAGTTGATGGTACAATTTTCAGAAGGTGTGAGAGGAGGCGGCATCCACATTCGG GGGCAGATGTGTGTTGTAGGCATGCAGGTGGGATGGGCATGGGAGCCGCTAGGAGAGCATGTTGGCAGAA TGACAGTTCCCATCTGAGGTCTCAGTTTCCAGTGTCTTCACTGAAGTGGGAAGGAAGACTGAGAGAGATA CACGCTGTGCGTGCCAAGTGATTTCCTGTGACATTGACATTGGGCCTCATTGAGAGAGACTCGGTAGTTC TGTTCATTCAACAGTTTCTAAGCACTTAATTTGTTAGCACTGGGCTAGGCAAACAAAGATAGCTGGGGCT TATGTGCAAGTTGGAGAGATCTTCAGTGTAACGTGTAACTTTTGAGATTACAGTCAGCAGCACGCTACAG TTAGGGATTCCTGAGTGACTTAGTCACATGGGCTCTAGACTTTAGTGTGGAGCTGCATTAAAGGTTTCCA AGCCACCACTTTTGAGGTTATGGTACTGATAGGATGTCCCAAGCAACTTCAGCCCAGGCCTGAGAAGGCC GCGGACCTGTCATGTCTTTGCTCTTGGTTCCATTGCATTTGCTGCTTTGTAATTTAACTATGACTGTGTT TTTCCAGGCAGCCAGCTCCAATTCGAGGATTTTGGATTGTACCTGACATTCTGGGACCCACGATGATCTG CATCACCAGTACCTATGAATGCCTCATATGGCCGTTATTGTACGTCCCATTTTATATTCTCCACACAGCT CTTGTTAATTCTGCAATATCTAAGTTGGGAAAATGCACTCAGTAACCAACTTGAAGCTATACATGTGTGG TTTATACTTTGGCTTCTGACTTGAGGGTTGGAAGGATGGATATTTCTGTTCCTGCCATCATCTCTATAAG GTTTCATTGTAGGTATAGTTTCTGGCATCCCCTGCACCTAGCTGAGAGTCAGGAGCTTTTCTTCAGAGTG TGGAGAAAAAATACTAAAATTGAATACCAAATTCCATTATCGATATGAGTAATAATTATCAAGCTGTGAC CATACGCCAAGCTCAGAAGTAAGCCACGTACCCGCACTGCCTCCTGGAATCATCAGGGCAGCCCTGTAAG GAAGGCACTGTCATTTCCATTTTATAAAAGTGGAAACGGGGATCGAGAGGTTAGTAAATGCTGAAGTCAC AGGTAACAAATAGAGCTGGGATACAGATGCAGGTCTCATTGACTCAGAAGTCCATACTCATACTCTTTAA TTTCTCCATCTCTGCCAGCCTGAGGGACACTGTAGACTATGTAAACTGGAATAAAGCTGAACTCAGGCTG GGTGCAGTGGTGGTTCATGCCTGTAATCCCAATGCTTTGGGAGGCCCAGAGTTCGAGATCAGCCTGGGCA AAACAGTGAGACCCCCATCTCTACAAAAAACAAAAAAATTAGCCAGGCATGGTGGTACACATCTGTAGTC CTAGCTGCTCAGGTGAGAGGATTGCTTAAGCCCAGGAGTTTTAGGCTGCAGTGAACCATGATCATGCCAC TGCACTACAGCCTGGGTAACAGAGCAAGACCCTGTGTCTTTTAAAAAAAAAAACAAAAAAGCTGAACTCT TAGTCTTTGCTCCTTTAAGGAACTCAGATAATTAAGCTGTAATCACTATGTTCCTTTTCCAACAGCCCTG GAAGATCATTCTGAGTTACATAAATGTAGGAATATGAGTACCAAAAACAAAAGTCACTGGAGCTTCAAAC ACTAGACAACACCCCCACCCCTTGTCCGTTCAAAGCTTGCACCTCTGGATGCTGACATAAATTCCTAATA CTGGCAGTAGTTTACTGTCCTTAGAGGATCTTCCATAGTCTTTGAAGCTTGATTAAGTTGTACTATCTGG ATGTAAAAATAAATATAAATTTTGTGTTATTTACACTGAAGGCACTAAAAGCTAGCAAGACCAAACAAAA ATAATAAAATCACTGGAGAAAAAATTACCTGTAAGTTACCTCAGCATACTTTTTAAACACCCACAGTACA TTTAGTAAAATAAAACCTAGTCACACTAGCTTACTTCAGAATAAATATGAATCCCAAAGGGGAAAAATAA ACATTAATTGTCTGGATATTTTTTTTTTTTTTTTTTGAGACGGAGTTTGCTGTGTTGCCCAAGCTGGAGG GCAGTGGCACGATCTCAGCTCACTGCAACCTCTGCCTCCCGGGTTCAAGTGATTCTCCTGCCTCAGCCTC CCTAGTAGCTGGGATTACAGGCGCACACCACATGCCCAGCTAATTTTTATATTTTTAGTAGAGATGAGGT TTTGCCATGTTGGCCAGGCTGGTCCTGAACTCCTGACCTCAGGTGATCCACCCACCTCGGCCTCCCAAAG TGCTGGGATTACAGGCATGAGCCACCGTGCCAGGCCAATTATCTGGATACTTTCAGATCATATTTCTGCC AACTCCCTGAAATACAAGTTGTCTATAAAGTTATGCTATTTCATGAACTTTCACTTTTTTTTTTTTTTTT TTTTGAGACAGAGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGTGTGATCTCAGCTCACTGCAACCT CCGCCTCCTGGGTTCAGGCGATTCTCATGCCTCAGCCACCCAAGTAGCTGGGATTACAGATGTGTGCCAC CACACCCAGCTGATTTTTATATTTTTAGTAGAGACAGTTTTACCACGTTGGCCAGGCTTGTCTTGAACGC CTGACCTCAAGTGATCCACCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCACGCCC AACCAAACATTCACGTTAGAATTGTTGCCTTCAGAGTAAGTCACTTGCCATGCTGCCGAAGTCTGTGAGA TCTTTTAAGCTCTTTTTGAAGTTTGAGTATTTGCACTTGACTGAATAGTTTTTAGAAATGAAATTATATA GAACCAATATGGTATATACAGCAGTTTCTTGGCTTAATATTGGTTTTGATCAACTCTAAACCTAACAAAT AAGTAATTTATGTTTGTGGCTCCGGCTTATAAACTGGCTTTCAAGTCCTTTGCCAAGAATCCATGCTAGG TGTTTGTGCTGCCTTGATCTTTTAGAAAAGAACTGGAAATGGCAGTCAGAAATGCTTTCACAAATCAGGG GCATTGGAATAATAAGGGTGTAGCTTCCCAAAGTGACCTTTTCAAGGTGGAAAACATGCATTCTTGCACT TTTACAAAAGTTACACTTTATTTTATATTCTGAAAGTTCTGGATTAATGTGGTTTCTGCTTTCCTGTAAT ACAGTAAATCACTCCATGGTAGAATTCAATTTACTTACTTATTTTGCAGAAGTACAGTCCATCCAGCGTC TCCTCCCCTGCTTTGTACTCGAGAAGATGTTGAAGTGGCAGAGTCTCCCCTCCGTGTTCTGGCTGAAACC CCAGATTCCTTTGAAAAGCATATTAGAAGCATTTTGCAACGTAGTGTTGCCAATCCAGCATTTTTGAAGT ATGCAACCTTGGGCATAGCGGTTTTATGAATGGGTTCTCTTCTGTCTTCAGAATTACTGTGCATCCTTTC TGTCCTCATCTGTTTCATATACTTTTTACTGTGATAAATTTGGAAGAAACTGGATATATTTGATCAGCTA GTGAATGGGGAGCAGGAGGGAAGTGGCACCTGAGAATGATAAACAGGAAGTGTTTAAAAAGAAGTTAGGC TAGGCCGGGCGTGGTGGCTCACACCTGTAATCTCAGCACTTTGGGAGACCAAGACGGGTGAATCGCGAGG TCAGGAGATCGAGACCATCCTGGCTAACACAGCAAAACCCCATCTCTACTAAAAATACAAAAAAAAATTA GCTGGGTGTGGTGGCAGATGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAACCGCTTGAACC TGGGAGGCAGAGGTTGCAGTGAGCTGAGATCCCACCACTGCACTCCAGCCTGGGCGACAGTGAGACTCGT CTCAAGTTAGGCTGGGCACGGTGGCTTACAGCTGTAATCCCAGCACTTTGGGAGGCCCAGGCAGGCGGAT CACCTAAGGTCAGGAGTTCAAAACCAGCCCGGCCAACATGGTGAAACCCTGTCTCTACTAAAAATGCAAT AATTAGCCAGGCGTGGTGGTGGGCACCTGTAATCCCAGCTACTCGAGAGGCTGAGGCAGAAGAATTGCTC GAACCTGGGAGGTGGAGGTTGCAGTGAGCCGAGATAGCACCAATGCACTCCAGCCTGGGTGACAGAGCGA GACTGCATCTCAAATAAATAAATTAAAAATATAAAAAGTTTAAAAAGCACCTGTGACTTGAGTCTATTTA TTTTCAGTTGTTTTACTCAGCTAAGGAAAATAAAGGTAGAAACTTTGTTTTTAAGAGCTTCTGAAAAGGA CATAGCCCCTCCTCCTGAAGAATGCCTTCAGCTCCTCAGCAGAGCCACCCAGGTGTTCAGAGAGCAGTAC ATTCTCAAACAGGACTTGGCAAAGGAGGAGATTCAGCGGAGGTATGATGTCCTGTGTTCACAAACCATCG ATCCCTGGCTGGTAGCTGATGCTGTATGGTAGCCTAGACCTGGCTTCTGAATAAACTCTATTTCTTTTTG TTTTTAAAGGGTCAAATTATTATGTGACCAAAAAAAGAAACAACTAGAAGATCTCAGTTATTGTCGAGAA GAGAGGTAAGTGTCAAAAATAAGAAGAATACAATAGGTCAGTAAGACTGGAACCATATTCTCACCCTAAG ATGCTGAGCCACATTAGGTGGTTTCAGCATCAAGGGGTGGACCTCAAGAGTCTCTTGTGTCTTACATCAT TAGGAAAAGTCTGCGGGAAATGGCTGAGCGTTTAGCTGACAAATATGAGGAAGCTAAAGAAAAACAAGAG GATATCATGAACAGGTCAGTGGGCTGTATAACATTTAGTTACCTAGTCAGGTACTAACAACGATATTTAA GAAAATGGGCATTGGCAGGTGCTTACATACCTACGGAACTGAACTGATCCCCCTGCCTCTCCTCTGAAGT ATATGTTGGGGAAAACATGAGGCTCTCCCCTAACCCTTCCTATGGGGCCTACTTCAGAAACACCAGATTC ATGAATTATGAGCTTGTGATTATGTTTCTCCTAATTAGTAGAGACCTTAAATTGAGATGTTTGCTTGCCT TTTCTAAAGGATGAAAAAACTACTTCACAGTTTTCACTCTGAGCTCCCAGTTCTCTCTGATAGTGAGCGA GACATGAAGAAAGAATTACAGCTGATACCTGATCAACTTCGACATTTGGGCAATGCCATCAAACAGGTAG GAATAGATCCAAACTAGCTAAATTTGGTAATTTTTCTTAAAGCACTTATTCTACAGAAAATTTTACAAAA ATGTAAAAAGAACAGATTCAAATAGATACTGTGAAAATGTGTGGCAAACCACTGCCAAAATATCTATTAT TTTAATACTTAAGGTTACTATGAAAAAGGATTATCAACAGCAAAAGATGGAGAAGGTGTTGAGTCTTCCA AAACCCACCATTATTCTCAGTGCCTACCAGCGAAAGTGCATTCAGTCCATCCTGAAAGAGGAGTAAGTAA ATACTTCCAATCAGCTATTATCGTGAGATAGTTTTTCCTTTACAGTATGCCAGAATCAACCTGTCTTAAT AGAAACCTGAATCTTGGTATTTGCATGTCAAGTAATTACTGGGATGAGAGCCACATGATACATAGGGACT TAAGAAATGACTATGGTGGGAGGATTGAAAGGGATGACCTTCTAGTAACATGATTTTGTTGTGTGGCCAA AGGTATTTTACAGTAATTATGTTCAAAAATATTTCCAGTACTTGCACCGTTTGCCACCTTAAATGAATAG TGAACACTATTGCTATCCACCTGAAACCTTCAGCTGTTAATTTTAGCAAAGCAGTTCTTAGATGTTTCAA CATTACCAGTTTAAATTCTTAAGAATCCATATAAATGGTTTATTATAATTCCAAAAGTGAGTGACTTTAC AATTTTACAGGGGTGAACATATAAGGGAAATGGTGAAGCAAATCAATGATATCCGCAATCATGTAAACTT CTGACACCACCAGGAGCTGACTCACACCTGAACTGAACACCATTGAAGGCTTAAACCCATATTGTAAAAC AGGTAGAATTATCTAATTTATAAAAAGGTGTTTTGATGACCTTTGGTGTGGTTCATCTTTTTAAATATGT TGTTTTATAATAATTGAGTAAATGCTTTTATTTAAAATTTGGAA Download Select all
Length	33714
OMIM ID	602552
HGNC ID	HGNC:8067
Unigene ID	Hs.584784
Ensembl ID	ENSG00000108559
PharmGKB ID	-

mRNA Information

mRNA ID	NM_004703.5
Exon	complement(<33400..>33714)
mRNA Sequence	>4927 ATTGGCCGAAACAGTGAGTGGACGGCCGCGGATTGGCTGTGCTCAGCGGCGGGCTGAGCAACTG GAGTGAGGGGAGCAGTTGGGCCAAGATGGCGGCCGCCGAGGGACCGGTGGGCGACGGCGAGCTG TGGCAGACCTGGCTTCCTAACCACGTCGTGTTCTTGCGGCTCCGGGAGGGACTGAAAAACCAGA GTCCAACCGAAGCTGAGAAACCAGCTTCTTCGTCGTTGCCTTCGTCGCCGCCGCCGCAGTTGCT GACGAGAAACGTGGTCTTTGGCCTCGGCGGAGAGCTTTTCCTGTGGGACGGAGAAGACAGCTCC TTCTTAGTCGTTCGCCTTCGGGGCCCCAGCGGCGGCGGCGAAGAGCCCGCCCTGTCCCAGTACC AGAGATTGCTTTGCATAAATCCACCCCTGTTTGAAATCTATCAAGTCTTGTTAAGCCCAACACA ACATCATGTAGCACTTATAGGAATAAAAGGACTTATGGTATTAGAATTACCTAAAAGATGGGGG AAGAATTCTGAATTTGAAGGTGGAAAATCAACAGTGAATTGTAGTACCACTCCAGTTGCGGAGA GATTTTTCACCAGTTCCACCTCTCTGACTCTAAAGCATGCTGCATGGTATCCAAGTGAAATCCT GGATCCCCACGTAGTGCTGTTAACATCAGACAACGTAATCAGAATTTACTCACTACGTGAGCCG CAGACACCCACTAACGTGATAATACTTTCAGAAGCCGAAGAGGAAAGTCTAGTACTCAATAAAG GAAGGGCGTATACCGCATCTCTAGGAGAGACAGCAGTTGCATTTGACTTTGGGCCATTGGCAGC AGTCCCAAAGACTCTATTTGGACAAAACGGCAAAGATGAAGTAGTGGCATACCCACTGTACATC TTATATGAAAATGGAGAGACTTTCCTGACATACATCAGTCTGTTACACAGCCCTGGAAATATTG GAAAGCTGTTGGGTCCATTGCCCATGCATCCTGCGGCTGAAGATAACTATGGTTATGATGCGTG TGCTGTACTCTGCTTACCCTGTGTCCCCAATATCTTAGTGATCGCTACTGAATCAGGAATGCTG TATCACTGTGTCGTGCTAGAAGGGGAAGAAGAAGATGACCACACGTCAGAAAAGTCCTGGGATT CCAGGATTGACCTCATTCCTTCTCTGTATGTGTTTGAATGTGTTGAGTTGGAGCTTGCTTTGAA ACTGGCATCTGGAGAGGATGACCCTTTTGATTCTGACTTTTCTTGTCCAGTCAAACTTCATAGA GATCCCAAGTGTCCTTCAAGATATCACTGTACTCATGAAGCTGGTGTACATAGTGTTGGGCTAA CTTGGATTCATAAACTTCACAAATTTCTTGGATCAGATGAAGAAGATAAGGATAGTTTACAGGA ACTCTCTACAGAACAGAAATGCTTTGTTGAACACATCCTTTGTACGAAGCCATTGCCCTGCAGG CAGCCAGCTCCAATTCGAGGATTTTGGATTGTACCTGACATTCTGGGACCCACGATGATCTGCA TCACCAGTACCTATGAATGCCTCATATGGCCGTTATTAAGTACAGTCCATCCAGCGTCTCCTCC CCTGCTTTGTACTCGAGAAGATGTTGAAGTGGCAGAGTCTCCCCTCCGTGTTCTGGCTGAAACC CCAGATTCCTTTGAAAAGCATATTAGAAGCATTTTGCAACGTAGTGTTGCCAATCCAGCATTTT TGAAAGCTTCTGAAAAGGACATAGCCCCTCCTCCTGAAGAATGCCTTCAGCTCCTCAGCAGAGC CACCCAGGTGTTCAGAGAGCAGTACATTCTCAAACAGGACTTGGCAAAGGAGGAGATTCAGCGG AGGGTCAAATTATTATGTGACCAAAAAAAGAAACAACTAGAAGATCTCAGTTATTGTCGAGAAG AGAGGAAAAGTCTGCGGGAAATGGCTGAGCGTTTAGCTGACAAATATGAGGAAGCTAAAGAAAA ACAAGAGGATATCATGAACAGGATGAAAAAACTACTTCACAGTTTTCACTCTGAGCTCCCAGTT CTCTCTGATAGTGAGCGAGACATGAAGAAAGAATTACAGCTGATACCTGATCAACTTCGACATT TGGGCAATGCCATCAAACAGGTTACTATGAAAAAGGATTATCAACAGCAAAAGATGGAGAAGGT GTTGAGTCTTCCAAAACCCACCATTATTCTCAGTGCCTACCAGCGAAAGTGCATTCAGTCCATC CTGAAAGAGGAGGGTGAACATATAAGGGAAATGGTGAAGCAAATCAATGATATCCGCAATCATG TAAACTTCTGACACCACCAGGAGCTGACTCACACCTGAACTGAACACCATTGAAGGCTTAAACC CATATTGTAAAACAGGTAGAATTATCTAATTTATAAAAAGGTGTTTTGATGACCTTTGGTGTGG TTCATCTTTTTAAATATGTTGTTTTATAATAATTGAGTAAATGCTTTTATTTAAAATTTGGAAA AAAAAAAAAAAAAAAAAAAAAA Download Select all
Length	2518

CDS Information

Location	join(90..386,3058..3227,5606..5731,8951..9037, 10831..11007,14497..14683,15494..15641,20090..20188, 24759..24849,28078..28179,30780..30938,31836..31961, 32070..32135,32274..32354,32630..32756,32914..33032, 33471..33534)
CDS Sequence	>gi\|317108147:90-2315 Homo sapiens nucleoporin 88kDa (NUP88), mRNA ATGGCGGCCGCCGAGGGACCGGTGGGCGACGGCGAGCTGTGGCAGACCTGGCTTCCTAACCACGTCGTGT TCTTGCGGCTCCGGGAGGGACTGAAAAACCAGAGTCCAACCGAAGCTGAGAAACCAGCTTCTTCGTCGTT GCCTTCGTCGCCGCCGCCGCAGTTGCTGACGAGAAACGTGGTCTTTGGCCTCGGCGGAGAGCTTTTCCTG TGGGACGGAGAAGACAGCTCCTTCTTAGTCGTTCGCCTTCGGGGCCCCAGCGGCGGCGGCGAAGAGCCCG CCCTGTCCCAGTACCAGAGATTGCTTTGCATAAATCCACCCCTGTTTGAAATCTATCAAGTCTTGTTAAG CCCAACACAACATCATGTAGCACTTATAGGAATAAAAGGACTTATGGTATTAGAATTACCTAAAAGATGG GGGAAGAATTCTGAATTTGAAGGTGGAAAATCAACAGTGAATTGTAGTACCACTCCAGTTGCGGAGAGAT TTTTCACCAGTTCCACCTCTCTGACTCTAAAGCATGCTGCATGGTATCCAAGTGAAATCCTGGATCCCCA CGTAGTGCTGTTAACATCAGACAACGTAATCAGAATTTACTCACTACGTGAGCCGCAGACACCCACTAAC GTGATAATACTTTCAGAAGCCGAAGAGGAAAGTCTAGTACTCAATAAAGGAAGGGCGTATACCGCATCTC TAGGAGAGACAGCAGTTGCATTTGACTTTGGGCCATTGGCAGCAGTCCCAAAGACTCTATTTGGACAAAA CGGCAAAGATGAAGTAGTGGCATACCCACTGTACATCTTATATGAAAATGGAGAGACTTTCCTGACATAC ATCAGTCTGTTACACAGCCCTGGAAATATTGGAAAGCTGTTGGGTCCATTGCCCATGCATCCTGCGGCTG AAGATAACTATGGTTATGATGCGTGTGCTGTACTCTGCTTACCCTGTGTCCCCAATATCTTAGTGATCGC TACTGAATCAGGAATGCTGTATCACTGTGTCGTGCTAGAAGGGGAAGAAGAAGATGACCACACGTCAGAA AAGTCCTGGGATTCCAGGATTGACCTCATTCCTTCTCTGTATGTGTTTGAATGTGTTGAGTTGGAGCTTG CTTTGAAACTGGCATCTGGAGAGGATGACCCTTTTGATTCTGACTTTTCTTGTCCAGTCAAACTTCATAG AGATCCCAAGTGTCCTTCAAGATATCACTGTACTCATGAAGCTGGTGTACATAGTGTTGGGCTAACTTGG ATTCATAAACTTCACAAATTTCTTGGATCAGATGAAGAAGATAAGGATAGTTTACAGGAACTCTCTACAG AACAGAAATGCTTTGTTGAACACATCCTTTGTACGAAGCCATTGCCCTGCAGGCAGCCAGCTCCAATTCG AGGATTTTGGATTGTACCTGACATTCTGGGACCCACGATGATCTGCATCACCAGTACCTATGAATGCCTC ATATGGCCGTTATTAAGTACAGTCCATCCAGCGTCTCCTCCCCTGCTTTGTACTCGAGAAGATGTTGAAG TGGCAGAGTCTCCCCTCCGTGTTCTGGCTGAAACCCCAGATTCCTTTGAAAAGCATATTAGAAGCATTTT GCAACGTAGTGTTGCCAATCCAGCATTTTTGAAAGCTTCTGAAAAGGACATAGCCCCTCCTCCTGAAGAA TGCCTTCAGCTCCTCAGCAGAGCCACCCAGGTGTTCAGAGAGCAGTACATTCTCAAACAGGACTTGGCAA AGGAGGAGATTCAGCGGAGGGTCAAATTATTATGTGACCAAAAAAAGAAACAACTAGAAGATCTCAGTTA TTGTCGAGAAGAGAGGAAAAGTCTGCGGGAAATGGCTGAGCGTTTAGCTGACAAATATGAGGAAGCTAAA GAAAAACAAGAGGATATCATGAACAGGATGAAAAAACTACTTCACAGTTTTCACTCTGAGCTCCCAGTTC TCTCTGATAGTGAGCGAGACATGAAGAAAGAATTACAGCTGATACCTGATCAACTTCGACATTTGGGCAA TGCCATCAAACAGGTTACTATGAAAAAGGATTATCAACAGCAAAAGATGGAGAAGGTGTTGAGTCTTCCA AAACCCACCATTATTCTCAGTGCCTACCAGCGAAAGTGCATTCAGTCCATCCTGAAAGAGGAGGGTGAAC ATATAAGGGAAATGGTGAAGCAAATCAATGATATCCGCAATCATGTAAACTTCTGA Download Select all
CCDS ID	CCDS11070.1

Protein Information

Protein ID	NP_002523.2
Protein Name	Nucleoporin 88kDa
Molecular Wt. (Da)	83411
Protein Sequence	>4927 MAAAEGPVGDGELWQTWLPNHVVFLRLREGLKNQSPTEAEKPASSSLPSSPPPQLLTRNVVFGL GGELFLWDGEDSSFLVVRLRGPSGGGEEPALSQYQRLLCINPPLFEIYQVLLSPTQHHVALIGI KGLMVLELPKRWGKNSEFEGGKSTVNCSTTPVAERFFTSSTSLTLKHAAWYPSEILDPHVVLLT SDNVIRIYSLREPQTPTNVIILSEAEEESLVLNKGRAYTASLGETAVAFDFGPLAAVPKTLFGQ NGKDEVVAYPLYILYENGETFLTYISLLHSPGNIGKLLGPLPMHPAAEDNYGYDACAVLCLPCV PNILVIATESGMLYHCVVLEGEEEDDHTSEKSWDSRIDLIPSLYVFECVELELALKLASGEDDP FDSDFSCPVKLHRDPKCPSRYHCTHEAGVHSVGLTWIHKLHKFLGSDEEDKDSLQELSTEQKCF VEHILCTKPLPCRQPAPIRGFWIVPDILGPTMICITSTYECLIWPLLSTVHPASPPLLCTREDV EVAESPLRVLAETPDSFEKHIRSILQRSVANPAFLKASEKDIAPPPEECLQLLSRATQVFREQY ILKQDLAKEEIQRRVKLLCDQKKKQLEDLSYCREERKSLREMAERLADKYEEAKEKQEDIMNRM KKLLHSFHSELPVLSDSERDMKKELQLIPDQLRHLGNAIKQVTMKKDYQQQKMEKVLSLPKPTI ILSAYQRKCIQSILKEEGEHIREMVKQINDIRNHVNF Download Select all
Length	741
Uniprot ID	P51679
Ensembl Protein ID	ENSP00000332659

Post-translational Modification Information (Source : HPRD)

Residue	Type	site
S	Phosphorylation	517;-
S	Phosphorylation	96;-
S	Phosphorylation	35
S	Phosphorylation	45
S	Phosphorylation	50
S	Phosphorylation	46
S	Phosphorylation	49
T	Phosphorylation	57
S	Phosphorylation	168
S	Phosphorylation	170
T	Phosphorylation	525
S	Phosphorylation	540
S	Phosphorylation	442
S	Phosphorylation	646
S	Phosphorylation	167
T	Phosphorylation	37
T	Phosphorylation	169
T	Phosphorylation	166

Enzyme Information

No matching records could be found.

PPi Information

(Click to view network : Source STRING) View

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
4928	NUP98	3012	NP_057404.2	in vitro;in vivo	12589057
8021	NUP214	258	NP_005076.3	in vitro	9488438

Pathway Information

Pathway Name	Pathway ID
RNA transport	hsa03013

Structure Information

No matching records could be found.

Domain Information

ID	Location	Description
cd07596	583-682	BAR_SNX
cl12013	583-682	BAR superfamily
pfam10168	11-741	Nup88
TIGR02169	559-740	SMC_prok_A
COG4913	510-741	COG4913
pfam05483	546-731	SCP-1
COG1196	559-740	Smc
TIGR02169	573-666	SMC_prok_A
pfam09789	573-692	DUF2353
COG1196	570-727	Smc
COG0711	573-724	AtpF
pfam07767	550-675	Nop53
TIGR02168	562-695	SMC_prok_B
TIGR03319	571-737	RNase_Y
TIGR02168	562-687	SMC_prok_B
PRK12704	583-732	PRK12704
TIGR02169	613-736	SMC_prok_A
COG1196	574-741	Smc
COG0419	559-740	SbcC
TIGR02168	509-681	SMC_prok_B

Ontology Information

HPRD ID	3065
Molecular Class	Transport/cargo protein
Molecular Function	Transporter activity (GO:0005215)
Biological Process	Transport (GO:0006810)

SNP Information

View SNP Geneview Report

Drug Information

No matching records could be found.

External Links

ArrayExpress GO
ICGC GO
Cancer3D GO
COSMIC GO
NCG GO
TSGene GO
Tumor Gene Family of Databases GO
CCDB GO
G2SBC GO
Osteosarcoma Database GO
RCDB GO

ArrayExpress	GO
ICGC	GO
Cancer3D	GO
COSMIC	GO
NCG	GO
TSGene	GO
Tumor Gene Family of Databases	GO
CCDB	GO
G2SBC	GO
Osteosarcoma Database	GO
RCDB	GO