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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| OIP5 | 11339 | Opa interacting protein 5 | 15 | MIS18B, hMIS18beta, CT86 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20510019 | 2010 | Cell line : LoVo, HCT15, DLD1, HT29, HCT116, Colo205, SW480, SW620, SNUC1, SNUC2A, KM12C
KM12SM, SNU1, SNU16, SNU216, SNU601, SNU620, SNU638, AGS Source : Samsung Medical Center (Seoul, Korea). Sample Type : CRC tumor and normal tissue No. of Sample : 66 Stage : TNM stages II, III | - | Up-regulation | 3.7-fold | OIP5 might be a potential cancer therapeutic target, although the mechanisms of OIP5-induced carcinogenesis should be elucidated. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The protein encoded by this gene localizes to centromeres, where it is essential for recruitment of CENP-A through the mediator Holliday junction recognition protein. Expression of this gene is upregulated in several cancers, making it a putative therapeutic target. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015] | Chromosome | 15 |
| Location | 15q14 |
| Start | 41601466 |
| End | 41624819 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 23354 |
| OMIM ID | 606020 |
| HGNC ID | HGNC:20300 |
| Unigene ID | Hs.661645 |
| Ensembl ID | ENSG00000104147 |
| PharmGKB ID | PA134887641 |
Protein Information
| Protein ID | NP_009211.1 |
|---|---|
| Protein Name | Opa interacting protein 5 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 229 |
| Uniprot ID | Q9ULH1 |
| Ensembl Protein ID | ENSP00000429900 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 47 |
| S | Phosphorylation | 48 |
| T | Phosphorylation | 221 |
| S | Phosphorylation | 225 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 673 | BRAF | 1264 | NP_004324.2 | yeast 2-hybrid | 12620389 |
| 5894 | RAF1 | 1265 | NP_002871.1 | yeast 2-hybrid | 12620389 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam03226 | 76-173 | Yippee-Mis18 |
| cl03943 | 76-173 | Yippee-Mis18 superfamily |
Ontology Information
| HPRD ID | 2253 |
|---|---|
| Molecular Class | Unclassified |
| Molecular Function | Transcription factor activity (GO:0003700) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.