Search results:
General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21986994 | 2011 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 28 colorectal frozen tissue samples, 126 paraffin-embedded tissues. Stage : - | MALDI-MS/MS, Western blot, Immunohistochemistry, Chromatin Immunoprecipitation Assays | Up-regulation | - | OLFM4 is regulated by the Ras-NF-kappa B2 pathway, one of the main oncogenic pathways deregulated in colorectal tumors. Identified olfactomedin-4, which was overexpressed in adenomas and in early stages of colorectal tumors. This early stage overexpression was confirmed by immunohistochemistry in 126 paraffin-embedded tissues. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | |
| Description | This gene was originally cloned from human myeloblasts and found to be selectively expressed in inflammed colonic epithelium. This gene encodes a member of the olfactomedin family. The encoded protein is an antiapoptotic factor that promotes tumor growth and is an extracellular matrix glycoprotein that facilitates cell adhesion. | Chromosome | 13 |
| Location | 13q14 |
| Start | 53028741 |
| End | 53052061 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 23321 |
| OMIM ID | 614061 |
| HGNC ID | HGNC:17190 |
| Unigene ID | Hs.508113 |
| Ensembl ID | ENSG00000102837 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_006418.4 |
|---|---|
| Exon | join(1..300,5608..5760,13170..13382,14365..14524, 21229..23321) | mRNA Sequence | Download Select all |
| Length | 2935 |
CDS Information
| Location | join(97..300,5608..5760,13170..13382,14365..14524, 21229..22031) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS9440.1 |
Protein Information
| Protein ID | NP_006409.3 |
|---|---|
| Protein Name | olfactomedin 4 |
| Molecular Wt. (Da) | 55175 |
| Protein Sequence | Download Select all |
| Length | 510 |
| Uniprot ID | P06756 |
| Ensembl Protein ID | ENSP00000261023 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 718 | C3 | 400 | NP_000055.2 | in vitro | 2824652 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam02191 | 250-503 | OLF |
| cl02549 | 250-503 | OLF superfamily |
| smart00284 | 249-503 | OLF |
| COG0419 | 98-233 | SbcC |
| PRK03918 | 112-225 | PRK03918 |
| PRK03918 | 112-227 | PRK03918 |
| PRK03918 | 109-225 | PRK03918 |
| TIGR02169 | 114-232 | SMC_prok_A |
Ontology Information
| HPRD ID | 2506 |
|---|---|
| Molecular Class | Unclassified |
| Molecular Function | Cell adhesion molecule activity (GO:0005194) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.