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General Information
- Evidence
- Gene
- mRNA
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- Protein
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- Enzyme
- PPi
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- Structural
- Domain
- Ontology
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- Drug
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22363757 | 2012 | Cell line : - Source : - Sample Type : Plasma samples No. of Sample : 10 CRC patients group and 10 healthy control group , 419 subjects for ELISA, 41 sequential CRC patients Stage : - | MALDI-TOF/TOF and microQ-TOF, ELISA, Western blotting | Up-regulation | - | Alteration in expression of ORM2 suggests that ORM2 could be used as a potential biomarker in the diagnosis of CRC. The ORM2 level in plasma was confirmed to be significantly elevated in patients suffering from CRC compared with the controls. ORM2 expression in CRC tissues was significantly increased compared with that in corresponding adjacent normal mucous tissues (P<0.001). |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Lipocalins |
| Description | This gene encodes a key acute phase plasma protein. Because of its increase due to acute inflammation, this protein is classified as an acute-phase reactant. The specific function of this protein has not yet been determined; however, it may be involved in aspects of immunosuppression. | Chromosome | 9 |
| Location | 9q32 |
| Start | 114329789 |
| End | 114333256 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 3468 |
| OMIM ID | 138610 |
| HGNC ID | HGNC:8499 |
| Unigene ID | Hs.719954 |
| Ensembl ID | ENSG00000228278 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_000608.2 |
|---|---|
| Exon | join(1..230,646..788,1004..1074,1779..1886,2038..2141, 3281..3468) | mRNA Sequence | Download Select all |
| Length | 844 |
CDS Information
| Location | join(117..230,646..788,1004..1074,1779..1886,2038..2141, 3281..3346) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS6804.1 |
Protein Information
| Protein ID | NP_000599.1 |
|---|---|
| Protein Name | orosomucoid 2 |
| Molecular Wt. (Da) | 21651 |
| Protein Sequence | Download Select all |
| Length | 201 |
| Uniprot ID | P41235 |
| Ensembl Protein ID | ENSP00000312987 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| N | Glycosylation | 103 |
| C | Disulfide Bridge | 23;165 |
| N | Glycosylation | 33 |
| N | Glycosylation | 56 |
| N | Glycosylation | 72 |
| C | Disulfide Bridge | 90;183 |
| N | Glycosylation | 93 |
| N | Glycosylation | 98 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
| PDB ID | 3APU |
|---|---|
| Resolution | 2.1 |
| Method | X-RAY DIFFRACTION |
| Chains | A, B |
| Molecule | Alpha-1-acid glycoprotein 2 |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam00061 | 40-180 | Lipocalin |
| cl21528 | 40-180 | Lipocalin superfamily |
Ontology Information
| HPRD ID | 840 |
|---|---|
| Molecular Class | Secreted polypeptide |
| Molecular Function | Transcription regulator activity (GO:0030528) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P19652 | DB00477 | Chlorpromazine | SmallMoleculeDrug |
| P19652 | DB00497 | Oxycodone | SmallMoleculeDrug |
| P19652 | DB01041 | Thalidomide | SmallMoleculeDrug |