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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| PA2G4 | 5036 | Proliferation-associated 2G4, 38kDa | 12 | EBP1; HG4-1; p38-2G4 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22997602 | 2012 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | - | Mutation | - | Mutation due to inactivation of DNA mismatch repair system results MSI. |
| 17641068 | 2007 | Cell line : - Source : ATCC Sample Type : Serum sample No. of Sample : 10 CRC patients, 10 nonimmunized CRC patients, and 10 healthy individuals Stage : - | Immunoscreening, Immunohistochemistry, Immunoblotting, flow cytometry | Up-regulation | - | Increase in Ebp1 expression in colorectal tumor fields compared with neighboring normal colon tissue, as observed by immunohistochemical analysis in all colorectal tumors tested, indicate that overexpression is the most likely mechanism of immunogenicity observed in CRC for the novel Ag Ebp1. By screening a cDNA expression library from a CRC cell line with patients sera, we were able to isolate and characterize Ebp1 as a novel immunogenic tumor Ag, capable of eliciting CD8 T cell-mediated responses both in vivo and in vitro, confirming its possible usefulness in anticancer immunotherapeutic therapies. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes an RNA-binding protein that is involved in growth regulation. This protein is present in pre-ribosomal ribonucleoprotein complexes and may be involved in ribosome assembly and the regulation of intermediate and late steps of rRNA processing. This protein can interact with the cytoplasmic domain of the ErbB3 receptor and may contribute to transducing growth regulatory signals. This protein is also a transcriptional co-repressor of androgen receptor-regulated genes and other cell cycle regulatory genes through its interactions with histone deacetylases. This protein has been implicated in growth inhibition and the induction of differentiation of human cancer cells. Six pseudogenes, located on chromosomes 3, 6, 9, 18, 20 and X, have been identified. [provided by RefSeq, Jul 2008] | Chromosome | 12 |
| Location | 12q13.2 |
| Start | 56104319 |
| End | 56113910 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 9592 |
| OMIM ID | 602145 |
| HGNC ID | HGNC:8550 |
| Unigene ID | Hs.524498 |
| Ensembl ID | ENSG00000170515 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_006191.2 |
|---|---|
| Exon | join(1..507,2270..2398,2672..2777,2869..2938,3203..3295, 4912..4975,5539..5617,6081..6159,6241..6374,6646..6740, 6864..6991,7158..7211,8505..9592) | mRNA Sequence | Download Select all |
| Length | 2643 |
CDS Information
| Location | join(420..507,2270..2398,2672..2777,2869..2938,3203..3295, 4912..4975,5539..5617,6081..6159,6241..6374,6646..6740, 6864..6991,7158..7211,8505..8570) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS8902.1 |
Protein Information
| Protein ID | NP_006182.2 |
|---|---|
| Protein Name | Proliferation-associated 2G4, 38kDa |
| Molecular Wt. (Da) | 43656 |
| Protein Sequence | Download Select all |
| Length | 394 |
| Uniprot ID | P32248 |
| Ensembl Protein ID | ENSP00000246657 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 363 |
| T | Phosphorylation | 366 |
| S | Phosphorylation | 363 |
| T | Phosphorylation | 366 |
| S | Phosphorylation | 363 |
| T | Phosphorylation | 366 |
| T | Phosphorylation | 386;- |
| S | Phosphorylation | 2;- |
| T | Phosphorylation | 19;- |
| S | Phosphorylation | 361 |
| S | Phosphorylation | 383 |
| T | Phosphorylation | 11 |
| S | Phosphorylation | 360 |
| S | Phosphorylation | 335 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 367 | AR | 2437 | NP_000035.2 | in vitro;in vivo | 956 558 615 583 694 |
| 2065 | ERBB3 | 1820 | NP_001973.2 | in vitro;in vivo;yeast 2-hybrid | 106 826 831 132 552 000 000 000 |
| 5925 | RB1 | 1574 | NP_000312.2 | in vitro;in vivo | 11268000 |
| 25942 | SIN3A | 9690 | NP_056292.1 | in vitro;in vivo | 16254079 |
Pathway Information
No matching records could be found.
Structure Information
| PDB ID | 1HD0 |
|---|---|
| Resolution | - |
| Method | SOLUTION NMR |
| Chains | A |
| Molecule | PROTEIN (HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN D0) |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| cd01089 | 18-334 | PA2G4-like |
| cl00279 | 18-334 | APP_MetAP superfamily |
| TIGR00495 | 1-388 | crvDNA_42K |
| cd01088 | 20-329 | MetAP2 |
| PRK08671 | 20-334 | PRK08671 |
| COG0024 | 20-255 | Map |
| TIGR00501 | 75-334 | met_pdase_II |
| pfam00557 | 20-174 | Peptidase_M24 |
| cd01086 | 76-188 | MetAP1 |
| PRK05716 | 76-188 | PRK05716 |
| cd01066 | 18-181 | APP_MetAP |
| TIGR00500 | 76-188 | met_pdase_I |
| PRK12896 | 6-188 | PRK12896 |
| cd01087 | 77-190 | Prolidase |
| cd01092 | 67-160 | APP-like |
| PRK12897 | 55-154 | PRK12897 |
| PTZ00053 | 62-329 | PTZ00053 |
| PRK12318 | 76-188 | PRK12318 |
| COG0006 | 67-173 | PepP |
| PLN03158 | 76-174 | PLN03158 |
| PRK15173 | 89-160 | PRK15173 |
| PRK14575 | 89-160 | PRK14575 |
| PRK14576 | 88-160 | PRK14576 |
| PRK10879 | 83-169 | PRK10879 |
Ontology Information
| HPRD ID | 3848 |
|---|---|
| Molecular Class | Transcription regulatory protein |
| Molecular Function | Cytoskeletal protein binding (GO:0008092) |
| Biological Process | Cell growth and/or maintenance (GO:0008151) |
Drug Information
No matching records could be found.