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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
PACSIN3 29763 Protein kinase C and casein kinase substrate in neurons 3  11SDPIII 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
22968445   2012Cell line : -

Source : Department of Pathology of Wrocaw Medical University.

Sample Type : CRC tumor and normal tissue

No. of Sample : 8

Stage : -

Laser capture microdissection,FFPE-FASP,SAX fractionation,LC-MSMS,Label-free quantitation.Up-regulation3.2-


Gene Details



Chromosome: 11; NC_000011.9 (47199073..47208010, complement)

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Gene Type protein coding
Gene Family -
Description This gene is a member of the protein kinase C and casein kinase substrate in neurons family. The encoded protein is involved in linking the actin cytoskeleton with vesicle formation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]  
Chromosome 11
Location 11p12-p11.
Start 47177522  
End 47186459  
Strand -  
Gene Sequence

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Length 8938  
OMIM ID 606513   
HGNC ID HGNC:8572   
Unigene ID Hs.334639    
Ensembl ID ENSG00000165912   
PharmGKB ID -   

mRNA Information


mRNA ID NM_001184974.1
Exon join(1..111,3395..3456,3696..3786,3901..4057,5770..6005, 6119..6274,6874..7049,7181..7301,7430..7566,7973..8094, 8414..8938)  
mRNA Sequence

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Length 1913  



CDS Information


   
Locationjoin(3733..3786,3901..4057,5770..6005,6119..6274, 6874..7049,7181..7301,7430..7566,7973..8094,8414..8529)
CDS Sequence

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CCDS ID CCDS31481.1



Protein Information


      
Protein IDNP_001171903.1
Protein NameProtein kinase C and casein kinase substrate in neurons 3
Molecular Wt. (Da)48356
Protein Sequence

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Length 424  
Uniprot IDQ14517
Ensembl Protein ID ENSP00000406229  



Post-translational Modification Information (Source : HPRD)


Residue Type site
TPhosphorylation335;-
SPhosphorylation341;-
SPhosphorylation344;-
TPhosphorylation347;-
SPhosphorylation276;-
TPhosphorylation326;-
SPhosphorylation319;-
TPhosphorylation324
SPhosphorylation327
SPhosphorylation354
SPhosphorylation383
TPhosphorylation331
SPhosphorylation358

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                         
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
1759DNM13851NP_004399.2in vitro;yeast 2-hybrid11082044   
6654SOS11681NP_005624.2in vitro;in vivo14679214   
6655SOS23149NP_008870.2in vitro;in vivo14679214   
8751ADAM155674NP_997080.1in vitro1   053   137   916   374   500   
8976WASL5448NP_003932.3in vitro11082044   
11252PACSIN25390NP_009160.2in vitro;yeast 2-hybrid11082044   
29993PACSIN15936NP_065855.1in vitro;yeast 2-hybrid11082044   


Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd0768116-273  F-BAR_PACSIN3
cl1201316-273  BAR superfamily
cd0765516-273  F-BAR_PACSIN
cd0767916-273  F-BAR_PACSIN2
cd0768016-272  F-BAR_PACSIN1
cd11997365-420  SH3_PACSIN3
cl17036365-420  SH3 superfamily
cd11843367-420  SH3_PACSIN
cd11998366-420  SH3_PACSIN1-2
cd11999365-420  SH3_PACSIN_like
pfam0061115-102  FCH
smart00326365-420  SH3
cd00174367-418  SH3
smart0005515-98  FCH
pfam14604370-420  SH3_9
cd11763367-420  SH3_SNX9_like
cd11827367-420  SH3_MyoIe_If_like
cd11772368-420  SH3_OSTF1
cd11826367-420  SH3_Abi
cd11819367-420  SH3_Cortactin_like
cd11933365-422  SH3_Nebulin_C
cd0764722-246  F-BAR_PSTPIP
cd11935369-422  SH3_Nebulette_C
cd11960367-420  SH3_Abp1_eu
cd0767122-255  F-BAR_PSTPIP1
cd11882367-420  SH3_GRAF-like
cd11823367-420  SH3_Nostrin
cd11840367-420  SH3_Intersectin_5
cd11789367-420  SH3_Nebulin_family_C
cd11934364-422  SH3_Lasp1_C
cd11786369-421  SH3_SH3RF_1
pfam00018369-416  SH3_1
cd0765127-244  F-BAR_PombeCdc15_like
cd11758367-420  SH3_CRK_N
cd11761370-420  SH3_FCHSD_1
cd11805367-420  SH3_GRB2_like_C
cd11896367-420  SH3_SNX33
cd0761025-253  FCH_F-BAR
cd11790367-420  SH3_Amphiphysin
cd11873368-420  SH3_CD2AP-like_1
cd11841368-419  SH3_SH3YL1_like
cd11820367-419  SH3_STAM
cd11950368-420  SH3_GRAP2_C
cd11804369-419  SH3_GRB2_like_N
cd11897367-420  SH3_SNX18
cd11778368-418  SH3_Bzz1_2
cd12073370-420  SH3_HS1
cd11963367-419  SH3_STAM2
cd11849368-420  SH3_SPIN90
cd11875367-420  SH3_CD2AP-like_3
cd11877368-420  SH3_PIX
cd11767367-420  SH3_Nck_3
cd11894368-420  SH3_FCHSD2_2
cd11874367-420  SH3_CD2AP-like_2
cd11864369-420  SH3_PEX13_eumet
cd11851367-420  SH3_RIM-BP
cd11964367-419  SH3_STAM1
cd11762368-420  SH3_FCHSD_2
cd11912367-420  SH3_Bzz1_1
cd11959370-420  SH3_Cortactin
cd12054369-420  SH3_CD2AP_2
cd11995367-420  SH3_Intersectin1_5
cd12142369-420  SH3_D21-like
cd11996367-420  SH3_Intersectin2_5
cd11855367-420  SH3_Sho1p
cd11821367-418  SH3_ASAP
cd11961368-420  SH3_Abp1_fungi_C2
cd11766367-420  SH3_Nck_2
cd11972367-422  SH3_Abi2
cd11783367-419  SH3_SH3RF_3
cd11771368-420  SH3_Pex13p_fungal
cd11948370-420  SH3_GRAP_N
cd11911367-421  SH3_CIP4-like
cd12013367-420  SH3_RIM-BP_3
cd11976369-420  SH3_VAV1_2
cd11818367-418  SH3_Eve1_5
cd11836367-420  SH3_Intersectin_1
cd11812367-419  SH3_AHI-1
cd11876370-419  SH3_MLK
cd11971367-422  SH3_Abi1
cd12058370-419  SH3_MLK4
cd11825368-420  SH3_PLCgamma
cd11781369-420  SH3_Sorbs_1
cd11824369-420  SH3_PSTPIP1
cd11803369-422  SH3_Endophilin_A
cd11886368-418  SH3_BOI
cd11842367-420  SH3_Ysc84p_like
cd11951368-419  SH3_GRAP_C
cd11920369-420  SH3_Sorbs2_1
cd11833370-419  SH3_Stac_1
cd11887367-420  SH3_Bbc1
cd0767220-248  F-BAR_PSTPIP2
cd11925370-422  SH3_SH3RF3_3
cd11845368-418  SH3_Src_like
cd12052372-419  SH3_CIN85_1
cd11885367-419  SH3_SH3TC
cd11768368-420  SH3_Tec_like
cd11780367-420  SH3_Sorbs_3
cd11839369-420  SH3_Intersectin_4
cd11946370-420  SH3_GRB2_N
cd11895368-420  SH3_FCHSD1_2
cd11837367-419  SH3_Intersectin_2
cd11838370-419  SH3_Intersectin_3
cd11830370-420  SH3_VAV_2
cd11774368-419  SH3_Sla1p_2
cd11949368-420  SH3_GRB2_C
cd12009368-419  SH3_Blk
cd11769365-420  SH3_CSK
cd0767338-227  F-BAR_FCHO2
cd12014381-420  SH3_RIM-BP_1
cd11816367-419  SH3_Eve1_3
cd11926370-419  SH3_SH3RF1_3
cd12004368-419  SH3_Lyn
cd11928369-421  SH3_SH3RF3_1
cd11992370-419  SH3_Intersectin2_3
cd11817370-418  SH3_Eve1_4
pfam07653367-420  SH3_2
cd11775367-420  SH3_Sla1p_3
cd11870367-420  SH3_p67phox-like_C
cd11858369-420  SH3_Myosin-I_fungi
cd12007370-419  SH3_Yes
cd11796367-419  SH3_DNMBP_N3
cd11878368-418  SH3_Bem1p_1
cd12003369-420  SH3_EFS
cd11969368-420  SH3_PLCgamma2
cd12006370-419  SH3_Fyn_Yrk
cd12061368-422  SH3_betaPIX
cd12064367-420  SH3_GRAF
cd12059370-419  SH3_MLK1-3
cd11903368-419  SH3_Nck2_3
cd11866369-419  SH3_SKAP1-like
cd11765368-419  SH3_Nck_1
cd11987369-420  SH3_Intersectin1_1
cd12045369-419  SH3_SKAP2
cd12053372-420  SH3_CD2AP_1
cd11988366-420  SH3_Intersectin2_1
cd11782367-420  SH3_Sorbs_2
cd12046368-420  SH3_p67phox_C
cd12008370-419  SH3_Src
cd11970368-420  SH3_PLCgamma1
cd12055367-420  SH3_CIN85_2
cd12065367-420  SH3_GRAF2
cd12056369-419  SH3_CD2AP_3
cd11916369-422  SH3_Sorbs1_3
cd11929367-420  SH3_SH3RF2_1
cd11844369-420  SH3_CAS
cd11787369-418  SH3_SH3RF_2
cd11883368-418  SH3_Sdc25
cd11904368-419  SH3_Nck1_3
cd11966367-419  SH3_ASAP2
cd11807366-418  SH3_ASPP
cd11906367-419  SH3_BTK
cd11813367-420  SH3_SGSM3
cd12060368-420  SH3_alphaPIX
cd11884368-420  SH3_MYO15
cd11846367-419  SH3_Srms
cd12066369-420  SH3_GRAF3
cd11784370-419  SH3_SH3RF2_3
cd12047367-419  SH3_Noxa1_C
cd11947369-420  SH3_GRAP2_N
cd11779367-420  SH3_Irsp53_BAIAP2L
cd11958368-418  SH3_RUSC1
cd11770367-420  SH3_Nephrocystin
cd11962367-420  SH3_Abp1_fungi_C1
cd11773368-418  SH3_Sla1p_1
cd11924370-420  SH3_Vinexin_2
cd12005368-419  SH3_Lck
cd0765816-266  F-BAR_NOSTRIN
cd11791368-420  SH3_UBASH3
cd11898367-422  SH3_SNX9
cd0767644-239  F-BAR_FBP17
cd11856369-420  SH3_p47phox_like
cd11985370-420  SH3_Stac2_C
cd11907366-419  SH3_TXK
cd12072369-420  SH3_FNBP1L
cd0764838-301  F-BAR_FCHO
cd11956370-419  SH3_srGAP4
cd0765343-249  F-BAR_CIP4-like
cd11815371-420  SH3_Eve1_2
cd11919369-422  SH3_Sorbs1_1
cd11952368-418  SH3_iASPP
cd11927369-420  SH3_SH3RF1_1
cd0767438-291  F-BAR_FCHO1
cd12012370-420  SH3_RIM-BP_2
cd11965367-419  SH3_ASAP1
cd11922370-422  SH3_Sorbs1_2
cd11937368-420  SH3_UBASH3A
cd11785367-420  SH3_SH3RF_C
cd11918369-422  SH3_Vinexin_3
cd12001366-417  SH3_BCAR1
cd11901372-419  SH3_Nck1_2
cd11793368-420  SH3_ephexin1_like
cd11954368-417  SH3_ASPP1
cd11921369-420  SH3_Vinexin_1
cd11978370-420  SH3_VAV3_2
cd11809370-419  SH3_srGAP
cd11777369-419  SH3_CIP4_Bzz1_like
cd12139367-420  SH3_Bin1
cd12002369-420  SH3_NEDD9
cd0765438-222  F-BAR_FCHSD
cd0767744-222  F-BAR_FCHSD2
cd11908368-419  SH3_ITK
cd11991370-419  SH3_Intersectin1_3
cd11923370-422  SH3_Sorbs2_2
cd11848370-419  SH3_SLAP-like
pfam01025175-246  GrpE
cl03075175-246  GrpE superfamily
cd12000369-417  SH3_CASS4
cd11986370-419  SH3_Stac3_1
cd11828370-419  SH3_ARHGEF9_like
cd11764368-420  SH3_Eps8
cd11869367-422  SH3_p40phox
cd11905368-419  SH3_Tec
cd11977370-420  SH3_VAV2_2
cd11835374-422  SH3_ARHGAP32_33
cd07307145-251  BAR
cd11889367-419  SH3_Cyk3p-like
pfam1351483-237  AAA_27
PTZ00121128-229  PTZ00121
PTZ00121128-238  PTZ00121


Ontology Information


   
HPRD ID2670
Molecular ClassAdapter molecule
Molecular FunctionDeoxyribonuclease activity (GO:0004536)
Biological ProcessRegulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO