Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| PADI4 | 23569 | peptidyl arginine deiminase, type IV | 1 | PAD, PDI5, PDI4 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 19183436 | 2009 | Cell line : A549, SKOV3, U937 Source : Several hospitals in the Shandong region of China. Sample Type : CRC tumor and normal tissue No. of Sample : 1673 Stage : - | Immunohistochemistry, real-time PCR, western blotting, ELISA | Up-regulation | - | PADI4 expression is increased in the blood and tissues of many malignant tumors. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Peptidyl arginine deiminases |
| Description | This gene is a member of a gene family which encodes enzymes responsible for the conversion of arginine residues to citrulline residues. This gene may play a role in granulocyte and macrophage development leading to inflammation and immune response. [provided by RefSeq, Jul 2008] | Chromosome | 1 |
| Location | 1p36.13 |
| Start | 17634690 |
| End | 17690495 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 55806 |
| OMIM ID | 605347 |
| HGNC ID | HGNC:18368 |
| Unigene ID | Hs.522969 |
| Ensembl ID | ENSG00000159339 |
| PharmGKB ID | PA32903 |
Protein Information
| Protein ID | NP_036519.2 |
|---|---|
| Protein Name | peptidyl arginine deiminase, type IV |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 663 |
| Uniprot ID | Q9BY64 |
| Ensembl Protein ID | ENSP00000334276 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd04214 | 7-112 | PAD_N |
| cl19115 | 7-112 | Cupredoxin superfamily |
| pfam03068 | 278-663 | PAD |
| cl09549 | 278-663 | PAD superfamily |
| pfam08527 | 113-273 | PAD_M |
| cl07230 | 113-273 | PAD_M superfamily |
| pfam08526 | 1-111 | PAD_N |
Ontology Information
| HPRD ID | 5540 |
|---|---|
| Molecular Class | Enzyme: Hydrolase |
| Molecular Function | Receptor binding (GO:0005102) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| Q9UM07 | DB00155 | L-Citrulline | SmallMoleculeDrug |
| Q9UM07 | DB00207 | Azithromycin | SmallMoleculeDrug |
| Q9UM07 | DB00254 | Doxycycline | SmallMoleculeDrug |
| Q9UM07 | DB00759 | Tetracycline | SmallMoleculeDrug |
| Q9UM07 | DB01082 | Streptomycin | SmallMoleculeDrug |