CoReCG

Search results:

General Information

Gene_Symbol	Gene_ID	Gene_Name	Chromosome	Alias
PAK4	10298	p21 protein (Cdc42/Rac)-activated kinase 4	19	-

Evidence
Gene
mRNA
CDS
Protein
PTM
Enzyme
PPi
Pathway
Structural
Domain
Ontology
SNP
Drug
External Links

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
23233484	2013	Cell line : HCT116 Source : ATCC Sample Type : - No. of Sample : - Stage : -	Immunoblotting,RNAi and transfection,Cell proliferation and survival assays,Spheroid growth assays,Immunofluorescence microscopy,Flow cytometry	Up-regulation	-	PAKs in the proliferation of mutant KRAS-driven colorectal carcinoma cells via pathways not involving RAF/MEK/ERK and PI3K/AKT signaling.
25791829	2015	Cell line : - Source : - Sample Type : - No. of Sample : - Stage : -	TaqMan real-time polymerase chain reaction and immunohistochemistry and clinical analysis.	Up-regulation	-	PAK1 and PAK4 expression were associated with colorectal cancer metastasis and infiltration, PAK1 high expression may indicate poor prognosis of colorectal cancer.

Gene Details

NC_000019.9 (39616417..39670046)
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Gene Type	protein coding
Gene Family	-
Description	PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	19
Location	19q13.2
Start	39616417
End	39670046
Strand	+
Gene Sequence	>gi\|568815579:39125780-39179406 Homo sapiens chromosome 19, GRCh38.p2 Primary Assembly AGCCCCGGATGTTCGTTGGGGATTCAACATGGCGGCGGGAGTGTCCGCGGTGGTGGCGGTGCAAGAGAGC TGAGGGAGGCGCGAGGGCGCGGAGTTCCAGGTCGAGCAGTTAGGCCGCGAGCGACTGCGGCGCCGAGCCG GTAGGATAAGGGGTCCGGCCAGGGGCTTGCGGTGGGCCGGGCGCTGGCGGCGGGACGGCGTTTCCGCGAG GAGGGGGGCGGGGCCGCCGGGGTCAAAGGTCACTGGTGGAGGGAAGGGTCGCGTCCGAGGGGTCGGGGGT TAACGCAGACTGGAGGGAGTTGTAGTGGAGGTCGGAGATCAAACCAGCGAAGGGGGCGTGGCGAAGGGGA GTGCAAAGTTTGAAATTCGAAGTGGGGGCGCGTTCGAGGGGTTCTGGGCGAGTCTCAAAAAAGGCAGGGT CAAAGTTAATAATTTGAGGGAAGGCTGCCCCCACGAGGGTCAGAGGTCACAGCCCCAGGGGCGCCAGGTT GGAGGTTTAAAGCTGCCCCTAGCGGAGCAGATGAATGAGTTTTAGGTTCGGGGGCGTCTTTTAGGGGTTC AAAGCTGGGGCGTGCCTAGAAGGTACAAAGGTGAGAATCTGACAGCGGGGCAGCTGTTTCCCAGAGTCAA AAATTAAAACCCAAGGAGGGCGTATTGCGGGGGACGGGGGGGGGGGGGGGGGCCGGGTCAGAGATGCTTC CTGGTGACAGGAGAAGGGGGAACCCTCCCACAAATAATAATGGCAAACACTCATGAAACACTATGGGCTA GACCCTCTTTTTAACGCTTTACTTGTATGAGCTTATTCAGTCCTCACTATAGTCTTAGGGGGTCTTAACC TGGTATTAAGAGGTTAAGTGATTTGCACAAGGTCACCCGATGCATAAGTTGTGCGCTGGGATTCTAACTC CGGAGTTCTGGCCCAGAGCCCTGCTCTGGCCGACCGCCTCTCAAATCATCATAATGTCGGTTAATGTTTA ATGAGGGCTCACACTGTGCTCCACGCCCTGTGTGCCCGGTCGTATTTCACTCCTGCTGCAATCTTGTGAA GTGAGTGCTCAAGATGAACCTACTTTACAGACGGGAAAAATGAGGCTCAGAAGCTTCTGCTGAAGGCAGA GTTAGAATCGAAGCTGGGCCTGGGTGATTCCAGGGCTCCTGCCCCTGGTCGCCACATTGTCCGCTGCCAG CCATTAGGTCTCTCCTGGAAGCAGGGGGCTGGGCAGGGCTGGGCCACTCCCTGGGCGGATCGGATTGTCT GCTTGGTTTCCTTGGAAGGGTGTGATCTGGCAGGGAAGATTCCTGTGAGCCTATGGGAGTAGGGTGTTTG TAGGTGGTCTGGAGTCCGAGCAAGGGAGTCCGACGGGCTTCTGACTGGGGAGAGTGTCCCTGGGTGGTAC CCTGGGCAGAGCGGGGTGTTCACTGTTCTTAAAACCCTAAGCTCTCACTGTGGTCCTTAGTCACTCCCAC CTCACTTCTTATGGCTCTGCCCATTTCTCCCCAGCCCCTTTACTGTTCTCCAACTCCAGGCCCATGCCTC CCGCCCGGTCTTTGACCTTCCTGTTCCTTCTGCTGGGAATCCTTTCCCCACCCTGCCCTCTCTCACTGAC GGGTCGCTCACTCTCAGCTGGCCCGGGACCACCCTGGCTCGCCTTGCTGCAGGCTCTTTTTCTCTCATCT GACCAGCCCTTACCTCCCTCCTTACCTTAATTATTAGGGTGCATGGTGGAATTGCTCTGTGGGGTTCCTT GCCTCGGTCCCCACTGAAGCCCTGCCTGGCCTGCAGAGGATGTGACATTGCTGGGGGTTGACTGTTGGGC ACTGTGCCGGGTGCTGGGAGTGTGGCAGGGGACGAGATCCACAGAGCCCCTAGCCTCAGAGGGCACTCAG TTCCCTGGTGGGAGCAGAGTGGAACCAGCCCCCAAGCCAGTGACACAAGACTGCGTCTCTGCAAACGGTG ATGTGGCTTGCGAGGGCATCTTCAGAGAGCCGGGAGAGTGCCCCTACCCTGGGCTGAAGCCTGAGTCCCT TTCCCCTGGGAAGGCTCTGAAGGATGGGGAGGAGGGCTGGGAATGGGCTTACCAGGCAGGAGGAGCAGTG TGTGCAGAGGCCCTGGCATGACTGGAGGTCAGGACTCGGGTGCACAGTTGGGGATCTGGGCAACACGTAG CCTGTGCAGGTTCAGGGCAAGACGCTGAGGGGACTCAGCTTTGGAGGGACGGTGGGAGCAGGGGAGGGCT GAGGAGTACCTGTATGTGTGGAGCTGCCTGAGGCCTTGATGGAGCGTGATTCAGAAAGCAGTGCTGGGCC AGAGATGCCTGGTACACACCCCTCTCCATCACTCACAGAGCATGTGAGGACCTCCGTTTCCACTTCTGCA AGATGGGCATAGTGTTAGCGCTGCCTCATAGAATTGCTGTGAGGATGCAGGCTAGAGAGCCTTGGCCCAA GGCCTGGCATACAGTAGTTGCTGTGTAAGCATTAGTCTTGCTGCTGCTGCTGCTGCCACCCCACCACTGC CTGGGGAGGGCCTCAGAGACAGTGGAGGCCCTCGCTCCACCTGCCTCCTGGCTTTCTCTGGCAGCCACCC CATCCCTACCTGGCTCTGGCAGGGTCAGGGAGCCGGCACACTGCCAGGCAGCCCTCTGAGGCTGGCCCAG CCTCCCAGCCTTGCAGTGCCAGCTCACTCAGCATCTCAGGGTTTGGCACAGATAAAGAAGGATAGGGTTT GGGCATTGGAGACCCATATTCAGGTCCCTCCCTTGTCACTTACCAGCCATGGGACAAATGATTTATTTGC CACTTTTATTCCTTCAACACGTTTGGCTAGGGGAAAAAGGGCTTTCAGTATAATGAAACACTCATGCATC CGGCCATCGTCTGGCCTGGGACAGAACACACCGTGATACAGTTAGAGGCCAAGGGTCTCCTCCTCACCCC CCCTCCTCCCTCCCTTCCAGGGGCAGCCTCTGTCCTGGGTGTGGCAGTCACCATTCCTCTGCAGCCTTTC ATACTTTGACTGCCCTTGAATGTATTCACCAACAGTAGAGCAACAGCTCTTGCCCCTGGCTGCACATTGC AACTCCCTGGAGAGCTTTGAAAAGATGCCTTGGCCCAGGCCCGCCATGGAAATTCTGCTTCCAACTTACT TGGTCTGGGCTGGGGCTGGCCTCAGGCTTTTGGAAGCTCCCTGGGCAGTTCTTATGGCCAGCAGGGGCTG ACGACTGTTGTTTCACAGTTCAGATAAATGGTGTCACCATAAACATGCCTTTCTGCAAGTTGCTGTTTTT GTTCAACATTATAGGTATATTTGAGATGGGATCTTGCTATGTTGCCTAGACTGGACTCTTAACTCCTGGG CTCAAGCTATCCTCCCACCTCAGCCTCTGGAGTAGCTGGGATTACAGGCGCGCACACCTGCTCCCCGCTT TGAGCTGAGCATTGGAGTCTGGATGTCTCTTGGTGGGGATGTGTGTAGGCCTGGGACAGGCCATTTGTTT TTCCTGATGGTGTTTCTTTTTGTGATCGTGTCACACAGGAGTTGCCTGTTCACCTGTTGATGGCCACTGA GGTGGTCCGTTGGAGCTATAACCGTGCAGCAGTGGGCCTTCTGGAACGCGTGTTCCTGTAGACCATGGCC AGAGTCTCTCTGGCATATGCCTAGTAGTGGAAAAGCCGGAGCTCCCCGCTTTCCTAGCGGTTGCCAAGTC ATGCCCCCAGTGGCTGGACCACTGTGCTCCCCAGCAGGCTCCGGGGCTCCCTTTATTTCAAGTCCTGCTT TGGGCAGCTTTGTGGCCCTCACTGAAACGATTTCCTCGGCCGTGACATGGGAGGTTTATGGGCCCACCCA CCCACCCACCAGGCTGTTTGGAAACAGATGGGGAGATGGTTCACACAACTGGCTTAGCTGGGACCTCGTC CCCACTGACTCCCTACAACCACAGGAGAAGAAAGGATGGAAGGGCTTTCACCTTTACCCCCTTGGGCATC CAGGACGGTGACTGCAGCTTTGCCCCAACTGCCCTTGGGGGCAGGTGCCAGGGGTGACAGCTGGGAAAGA GAACTATACTGATTCGAACCTCTCAGGAGGGAGGCAGGGAGGACGGAGGTGAAAGTTGGAGGATGGGTGA GGCCTTGTAACATTCTTTCTGTGTATCTGACTGTTGGTCCCAGTGGTAACCAACACAGCCCAGCTCTACC CTTGTAGATTATAGTACAGTGAAGGAGACAGACCTGCTGTCCCCAGACGGTGACAGCCCAGAGAGGCCAG GGCTGTGAAGGAGAGGCCTAGGCGAGGGTCAGGGCGGGATGTGGGGGGGACCCAGGCAGAAGGGTCAGGG CGGGATGTGGGGGGGACCCAGGCAGAGGGGTCAGGGTGGGGTGGTGGGACCCAGGCAGATGGGTCATGGC GGGATGGGAGCGGGGACCCAGGCAGAGGGATCAGGGTGGGACTGGGGGGGACCCAGGCAGAGTGGTCAGA GAAGGATGGGGAAACCCAGGCAGAGGGGTCAGGGCGGGATGGGGAAACCCAGGCAGAGGGGTTGGGGCTG GATGGTGGGGAGGGGCACAGAGAGGGATTGGGACTGGGATGGAGGCGCAGGGACCGTAGGAAGCCCGAGG AGGCATGTGGCCCAGCGTGGGGAGTTGAGGAGGGCTTTCTGGATAAGATGACATCTGACTGATGAGAACA TATGAGCGAGGCTGGAAGGAGGTGGAAAGAATGTAACAGGTCATGGGTACGGAAGTGCCAAGGCCCTGAG GGTCGGAATGACCTCGGAATGGTCGAGGATCATCAGATAGGCCGGTGTAGGCTATGCTGTGCACCCTGAC TGTGTGGTAGCCTTGCTCTGCAAAGAGCAGTTAAAGAAATACATAAAATATAAAATAAATAAATAAATAA AAAAGCAAAAAAAAGAAGCCAGTGTGGCTGAGCAGGGGGTGGGGTCAGAGGCTTGGAGGCGGTGTTGGAT ACAGCAGGGCCTAGCAGAGCCAGGTGGGGTGTGTGGATTCCATTCTGTGCATAATGGGAAGTCATCAGAG GCTTTAGTGACATCTGGTTTTCCCCTTATAAAGATTGCTCAGGCTGCTGTGTGGGGGACGGATCGCGGGG GGTGGCGACAGGGAGGCTGTGGGGAGGCTGCTGTGACAGTCCAAGCAGAAGAGGGTGGAGAAGACGAGGG GACAGTGATGGAGGAGCGTCCTCGTGCCAGCTGAGGTCATCAGCGCTTTACCCCTGTTACCTCACTTCAT CTTCACAGCAACCTGTGAAGTAGGTGCTAGTATCATCCTCACTCTAGAGATGAGAAAGGAGGCCCAGAGA GGTACGGGACTTGCTTAAGGTCACACAGCAGGCAGTGGCAGAGGTAGGATTGAACCCCAGGCCTTGGGGC TTCAGTGTCACTGATTACTGGGGCTGCCCTCCCGTGGTTTGGAACTGGCTCGGACAAGACAGGCCTGATT CCTGTTCAGCTGGTTCTTACCCAGGCTCCTTTGTTGACAGAAGTTCCGTGGAGACCTGTTCCCCCTGGGT AGTTTCTGGGCGCTGGGTCCCTACCTCCCTCAGGGCCTCCCTTTCCTTTCTCATCTACTCCTCGTCCCAC TGGCTCGTGGTGAGCCAGACTTCCTGGCCAGACACCGGTCAGGGGTGTCCCCAGCAGCTGTTTCTCCCAT CACCGAGCCCAGCCCCGCACATGCTGCCAGCAGGAAGCAACCTCCTTCCAAGTCATGGCCAGGGAAGTGG GACCCTTCCCGCCTAGTCACCCATCCGGGGCCAAGGCTTCTTGTCTGCCAGACGCCTTGGCCCACAGGAA GGTTGGAGGGGCCGAGGAGGGTGAGAAGGGGAACACTCTCCCATCCCAGGGGAGCCAGCGCTGGCGGATG CGACAGAAGCCACCGCTCACTGAAGCCTCTCTCCTGGGACCCTCCGGTCCTGCCCCGACCCTTCCCAGGC TGGGAGGCCATCTGCTGCCTTCCCGAGGGGCAGTGGAACTTCCCTGCCAGGGCTGCTCAGTCCACACACA TCCCTTAGCCTTTTTCACTAGCTGGGAGCCCCTGGGGAAGAGACAAAGAACTTCCCTGGGCCTCTGATTC CTCACCTGTTACAGGGAGTATTGGTGGCCACCTCTCAGGGCTGTGGGAGGGCGGAAGATCATGTGTGTGC GTCGTGCTTAGCCCGATGCTCAGCACTCAGTAAGTGCTTGGTAAATGTTGAACTTGGTGCGTTCGATGGT TTCCGTCCCTTGCACCCTGTCCCCCTCTGGGTTCTCATCCCGTAGTGAGCTGTAATAACCCCAGCCCCCC GCCCGGGGTCCCAGCTCCACGTGCCAGGCACGCGTGTGCTGTGAGTCTATGAGCATGGTCATGTGGCTGT ACCCAGAGACCCTGAGGAGGAGGTGTTTTTAACCTCGTTTCTCTTTTCCCGTGTTTCAATTTTCAGAAAG CACGTTTTTCCTCCATGTGCATGCATTACCTATTCCCCTAAATAATCACTGAAAAACTGCACACAGCACA AAAGGATGTACAGGGACGAGCAAATCTCTTTCCCACCCGCCTGCCAGGCCCTTCCCAGAGATAGCATCAT CACCCCCGGTTTCTTTTCTTTCTTTCTTGAAATATTTGTTCCCCCAAGTGCCCGCCCCTCCCTTTTGTTT TTACTCAAATGGAGCGGACTTCCCATGTTTATATTCTGTCCTGTGCTTTGCGTTTCCCACTCCGAAGCTC GCTGTCAGGACACAGAGTGCCGCCTCGTGTCCCACGCACACGCGTGCCCCCACGGACAGCACAGCCATTC TGTGCTGATGGCCATCAGGCCATTCCCATCTTTCCGTGCTGTGAACAGGGCTGCGCCCGCCTGAGTGTGG CTGTGCATATGTCTCTAGGTGTGAGTCTGAGCTTGTGGCCTCGTGGTCTGAGACAGGTGCCCCGTTAACT TTGCCGGTAGTGTTAGTGTTTCACCCTGCTGGGGAGGTTGTCTGGCTCACACTCCCACCCCCCAGTGTCT GATGACACCGGGGTTTCCTCACTCCCTTGCTGGAATAGACGGGTGTCACCTGACATTCTCACCTTTGCCA GTCAGATAGGTGACAAACAGTCTCATCATGGTTCTGATTTTAATCAGAGCAAAGTGGGACAGCTTTGTGT TGTTGAAAGCCATCTTGAGCTTCCTTTTCTTGGAGCTGTCTATTCCTGATAATTTTACTTTCTCTGAGAA GGGGAAACTGAGGCACAGGCCAGCAGTCCCACAGCAAATACGTGGCAGATGTGGCACTCAAACCTTGGCT CCGTTCTGGAGCTCCTAACCCATCTGACACAGAAGAGGTCAAGGGCTTGGCCTCCGGAGCCAGCTTTGTC TCTTACTAGCAGTGTGACCCCAGACAAGTCACATCACCTCTCTGTGCCCGGGTGTCCTCATCTGTAAAAT GAGGGTGCTAATGATATCTACTCTTAGAGTTGTTTTGAGGATCTAAATGTATATTCGGCAGGCAAAATGT ATAGTAAGTGCTCAAAGACTGTTAGCTGCGTTACTAATAGCCGTATTATTAATATTATAGCTATGTCACC AATAGCCATGTTATTAATATGAGCAGGCACTGTTTGAGTGCTTTCTGTGAACTAACCTACTGGACCCTCC CATCAACTCCAAGACACACGTGTTCTTAGGATCTCCCTTTTCTAGGGAGGAGACTGAGAGCCTGGGGGAC CTGGCCCCGTCACAGAGCAAGAGGAACTGGGATTTGGATGCTGGAGGCCTGGCTGGTAATCGCTGTGGCC GCTTCCCCTGCTACCCGGGGCTAAGCCTGAGGGTTACAAAGCTCTCCCTCCTGCTTCCCCCACCCACCTT CTGCTGTCTGCATTCCAGGCAGGCTGCCCAGGAGCTTTCGAGCAGACACCTTGAGGGTTGGGAGCACCGG GTGGGCAGGGTCCTCACCTAGAGAGCTCCCCGTCCCAGACCCTCCCTGCTCCTGCCACCTGTCCTGGGAA CTCCTGATAAAGCAGCATTGTGCAGCGGTTTTGAGTTCACTTCCCAGCCCGGTTTTGCCACTCCCACACT TCACTCCCAGAGGCGGAAGGCGGCCGGTCTTCCTGGGCTGCGTGGGGTGCCAGCCCCCCTCCCCTTCCCT TCCCTCCCTCACTGCGCCCACAGTCACCGGTCAGCACTGGCCATGGGGAGAAAGTAGGACCCTGCGGGCC ACTGGCCCCTCCACAGACCCGTCCCCAGGTGAAGACCCCTCCCTGCCCTCCCCACAGGAGGCCCCTGTCC TTCTCTCCCGAGGAACCCTCCTTCCCTGCCGCCCACAGGGGCCTCCATAGTTCTGTCGTCCCTTCCCCGC AAATCTTCCACTGCAGCCTGGGCCCACGTTATTTGACTCTCAAATGCTATATATATACACAGCGCTTCTA ACTCCACTGCTTTTAAAAAACCTTTAATAATTGTCAATTATAATATGCCCATAGAAAAGTGCATAAAATG CACAGGTAAGTTTAGCAAAGAATTACAAAGTGAACAACGCTTCCCCACCACCTCGGTAAAGACAGAACAC AACCTCCCAAAAGCCGCCTGCCCATAACCCCTGTCCATCACGACCACAGTCGTGAGTGCTCTCCTGACCT TGGTGGTCACTGTGTCCTTGCTTTTCCTGATAGTTTTTACCATGAGGTATGCATCCTTGAATTACAGAAT GTCATCTTGCCTGCTTTTGAACTTGACATAAATGGAATCTTCCAGTATGTCCTTGTCTGTGCTTTCTTTC GCCCTTAGGCCTGTGAGATCCATCTGTGTGCTGAGTGTATCTGTAGTCATTCATCTTTGTTGCTGTATAA TATTCTTTTTTTTTCTTTGACACAGAGTCTCGCTCTGTCACCCAGGCTGGAGTGCAGTGGTGCAATCTTG GCTCACTGCAGCCTCTGCCTCCTGGGTTCAAGCGATTCACCTGCCTCAGCCTCCCGAGTAACTGGGATTA CAGGCATACACCGCTATGCCTGGCTAATTTTTTTTTTTAATTTTTAGTAGAGAGGGGGTTTCACCACGTT GGCCAGGCGAGTCTTGAACTCTTGACCTCAGGTGATCCACCCACCTCAGCTTCCCAAAGTGCCGGCATTA CAGGCGTGAGCCACTGTGCCCAGCCCCATATAATATTCTGTTCCTCCATCTCCTGCTGCGCTGATGCGAG CCATCTCTTTGTAGCATCTCCTGGGGTGCCGGTGCCTGCGTTTCTTCAGGGAATATACCCAGGAGTGCGT AGCCCAGGGCAGAGGGTGGGGTAGCTTCAGATTTAGTGGGCGCTGCCACACAGCCTCCCAAGGTGGTCAA ATCTGTGTATCCTCCTAGCGGTGGTGACTGAGGATCTTAGTTGCTCCACCTCCTCACCAACATTTGGTAC CGTCAGACTTTTTGGTTGACCTTGGAACATTTTTATTCTTTTTTCCTGCAAAAGTAACACCACTGGTTAT CATCGGGCTGAGCCCCTCATGTTATTTTGTCCTCCCCTTGCTCCTGTCCATTCCGACTCTCACCCATTCT GTGGACAGGAGTCAAGTGCTTATTCTTTTTTTTTTTTTTTTTTTTTTTTTTTTTGAGATGGAGCCTTGCT CTGTCACCAGGGCTGGAGTGCAGCAGCGCGATCTCAGCTCACTGCAACCTCCGCTTCCCAGATCCAAGCC ATTCTCCTCCCTCACCCCCTCAAGTAGCTGGGATTACAGGCATGTGCCACCACGCACGGCTAATTTTGTA TTTTTAGTAGAGACAGGGTTTTACCATGTTGGCCAGGCAGGTCTCAAACTCCTGACTTCAAGGGATCCAC CTGCCTCAGCCTCCCAAGGTGCTGGGATTACAGACGTGAGCCACTGCGCCCTGCCCAAGCGTGTATTCTT TGACCAGCTTTGCGCTGGGGCCCAGCGACTGAAGGGTGAACCCAAACAACAGGCAGCCCTCCCCGAGCTC AGTCCAGTGGGAACACAGACCTCGACTGCAGAGCAACAGAAAGATAAGCCGGGCTGGAGGCTCCCGGCCC CCATCTTCCCACAGTGACCCCATTTTGGGAACAGGAACCCCCATCCCTCGTCTTGTTTCGGGATTAGGCT TCTCCAAATCTGGCACCCTATCACCTTGACTCCTCTCTTGCCCCCCCGCCACATCCAAAGTGTCTGGAAA GCCTGTCACTCTACATGACAATGTAACCTGGTGCTGCGGGCTCCTCTTCCTTGTCACTCCCCTTCCTCGT CATCCCCCTTCTTCGTCACCCCCCTTCCTCGCCACCCCCTTCCTGGTCACACCTCTTCCTCGTCACCCTT CTTCCTTGTCACCCCTCTTCCTCGTCACCCCCCTTCCTCATCATCCCCCTTCCTCGTTACCCCCCTTCCT TGTTACCCTTCTTCCTCGTGGCCCCCTAGTTCAAGCCACCCTCATCTCCCTCCTGGACCATTGAGGCGTG CTCCCTGCTCCCTTCTCCCCCACTGTCCCCACAGTTGTCCGCACACAGCCAGAGGTAGCCGTGCACACCT GGTCAGGGCAGGAACCCTCCCCTGGCTCCACCTCTCCCAGCAGAGAAGCTTGCAAGGTCCCAGGCAACCT GGCCACTTTCCTGCCTGCCCTGCTTCCCTCTTCTCCTGCCACCATTCCTGGAACATTCCAGGCAGGTCCT ACCCCGGGGCCTTTGTTCTTGCTGCCCCCTGGGCAGGCAGCACCCTCCTTCCTTCTGTTCAGTCAGCCTC TGCTGACAGTGGCCCCCTTGGGGAGATGTTTCTTCCCGACCATGGGTCCCCAGGAGCAGCCCCTGTCACC CTCCCTCTAGCACCTTCCCCCGGTAACCCTCATGATGGTTACTTCCATTATGACATGTGGGTCTGTTGGT TTATTTTGTCTCCCGGCATAACGTAGCCTCAGGGCATGGGGGTAGGGGTAGAACCACAGGGCCTTGCCCT GCCCCTTGCTATGTTCTCAGGGATTGGAGTGTGGTAGTCTCTCAGTAAATGCTGGTTGACTGACTGACTG ACTGACTGACTGAACTGTAGTAAGCTGGGCTGCCAGAGCGTCTAATGGGGACCCGCCCTGGGTGGGGCAC ACCGGGAAGGTTTTCCTGAGGAGGAAATGCCACTTGAAGGATGAACTTGGCCTCGACTAAGGGAGGAGGC TGAGGCAGCTGCCATTGCAGAGGTCTCCCGGCGGGGGAGTGCAGGGGGCCTTTGAGGAATTGAAGGAAGA CAGGTAGGTCGGTTCTTGGGTTGGTCTGGATTCCAGTCTTGACAGCTGCTTGGGCCTCTCTCTGCCTCAG TGTCTTCCTCTCTAGAAGGTGGCTGCTTCAGGTGTTCCTGGACATTCCTGAAGTTCTGCTCCTAACACAC TTATCCTGGTGCCTGATACATAAATATAAATGTGATTGTTTATTTTTTTCCAACAAATTTGGTGGAGTGC TGACCCGTGTGGCCTCCAGGGATGCGGTGGTGGATAAACAGACCCGGTTGCCGCCCATTTGGAGCCTGGC CTCTGGAGCCATCTGGGGCACCCCTGCTTGGAGGCAGGAGAAGGCCTGGTGTGACCTTGGGCCCGGGGAG TCCTTATTCTAGATCCGGGAAGCTCTTCAGGGTGATGAATAGGAAAGACGAATGGAGGGTTTGTGCGTGC CGGCCCTGTGTCCCGGCCAGTGCTCCCAAGCTGCTGCCTGGGCCTCCCTGAAATCCCAGGAGGTAGCTGC ACCCGTGTGACCCATTTCACAGATTGGGAGGTGAGGGGGGCACCAATGCTAAGTCCTTCGCCCATTTTGC AAACTAGAGTAGATCTGGTGGTGTTTCCTCTGTGGTCTGATGTGTTTTTCTGGTAGCCAGTCAGGTGGGG CAGCTTTCAATTTGTTCTTCCAGACTCCTGTGAAGGAAGGGCCAGTTCAGGTCACTTTCCTTTTTTTTTT TTTTTGAGACAGAGTCTCACTCTGTCACCCAGGCTGGAGTGCAGTGGCACGATCTTGGCTCACTACAACC TCCGCCTGCCGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCGGAGTAGCTGGGACTACAGTCGTGCGCCA CCATGCCTGGCTAATTTTTTGTGTTTTTAATAGAGATGAGGCTTTGCCGTGTTAGCCAGGATGGTCTCGA TCTCCTGACCTTGTGATCCGCCCACCTTGGCCTCCCAAAGTGCTGGGATTACAGGCGGGAGCCACTGTGC CTAGTGTCTTAGCCATTCCTGAGGTTTTTTTTTTTTTTTTGAGACAGGGTCTTGCTCTGTCACCCAAGCT GGAGTGCAGTGGTTCAAGATTGGCTCACTGCAGCCTCCACCTCCTGGGTTCAAGCAATTCTCTTTCCTCA GCCTCAGTAGCTGGGACTGCAGGTACACGCCACCACCCTGGGCTAATGGGCTAATTTTTTTTATTTTTAG TAGAGGTGGGGTTTCACTATGTTGGCCATCCTGTTCTCAAACTTTTTTTTGTTGTTGTATTTTTATAGAG ATGGGATTTCACCATGTTGCCCAGGCTAGTCTCAAACTCCTGAGCTCAAGCCAGCTGCCCGCCTCAGCCT TCCAAAGTGCTGGGATTACAGGCATGAGCCACTGTAATGGGCATCCAGCCCATTCTTGACTTTTTGTAAT TCCCTTTAAATATTAGACAAGCATGTTGTCAGTGTATGTACGTGTGCTCGTGCGCACACACCTGACACTG AGTCTCCCAATCCATGAACGTGGTATGTCTCTCCATTTGTTTATGTCTTCTCGTTCATACTTTTCCAGCC GACGCCTTGCCCACCTCTTGTGGGGTTTTTCCCAGGGTAGTTCATGATGTGGCAGGGAGTCTGTGCCCTC CACTCCCACAAGATGCCGTGCACCCTGGGTTTAGCCTTGCTGGCTGAGGACCTCATGGCGGTGGCAGGAG GCCACTTCTCCCATTCTCTGCTTCTTCCCTGGTACCGCCCCTGGACCCTGGCGGAGGGCGGGCAGGGTGC CCAGAAAGGAGGCTGTAATTTTCCTGAATGATTTCAAGGGCTAATTAAAGGTTTGCCTTGACTAATCAGC TTACGGTTTAATTATTAGGGAACAGGCTCTGGGATGCGGGAAGCAGCTCAGCTGGGGTCTCCCCACAGCG TGGCAGGAAGGAGCCAGGACCCAGCCCTACTCTGGGGGGCTGGCAGGATATGGGGATACCCCAGCACCCT CCAGTGGGTCAGTGGGGGGTTCTCCATCCCCCACTGAGCTGTGACAGGTGGAGGGCAGCAGGTGTGATGG AGATTACAGCCGATTCCTCCCCTGATTCACATCATCCCCCACAGCCCATGGCTGGCTGGGGAGGGGCTGG CCCTGTCCCTCCAGCAGCTTTGGCAGGGCCCGTCCCTCCCCACTTTCCTGCAGCACCCCAGCCTCGCTGG CCTTTGTGGAGTGCTCGGACTTCATTTATTCTGTGGGTCTTGGCTTAAAGGTCAGCACCTCTGGGAAGCC TCCTCGGGCCTCCCTCCTGTCAGAGCTGGTGATCAGCCGCACGGCCCCTTGCCAGTTCTTGGGATCATGG TTGTTCATCTGCTGCAACTCCTGCAGACACTGAGAAGTACACTGAGGGGGATGCCTGAGCTGGGCCAGTG TCGGGGTACCCAGCGGGATAAAGGGTTCGGGACCTGGGCTCCAAGGAGGGGGCTGGGAAGGGGTGTTCAG GGAGGACTGAGTGATGGCTTGGAGGCGGCTGGACCAGGAACACCTCATGGGAGTTTGCGAATGGGGAGGG GACTCTGGAGATGGCTGTGCCAGGCCTGACTTCATTCCTTGCATTCCTCAGCAGGCCCCAGACTCCTGAT GGTCCTAAGTGGGGGAAGGTGAGCCAGAGAGGGCCTTCTGGGTACTGCCCTCCCCCCACTCCATCAGTCT GTCTCAGTCTCTCTTTACACCCTCCCCCATCCAGGTCTCAGGGCTGGATCCATCCTCCTGCCCACTCCCC AATCTCCTTATCCTTTGGCTGCGCCTTAGGGTCACCCGGGGTGGGAGGCACTGCAGGGGCCCAAGCTGGA CCATTTGAAGCTGACTGTACAGCTGTGGGGTCTGGGCCTTGGGGTTTTTTAATGCTCCCCTGGCGACTCT GACATGCTTCTGAGCTGGAGTGAGGGCTGCTGGCCTGCAGGAATGGCAACAAATGTGTTTTAGCTTTTGG CATGTTCTGGGTGCTTTTCTAGGCTTCTGACATGGAGGGGTTAAGTCACGGCACGCTACGGGGACATGTG ACTGTGATTCCTGTGTTCCAGATAAGGCAACTGAGGCCCAGAGAAGGCCTCGAGCTTGGCGATGGCAGTC TCTGTCACTGTCTTATCTTCCCATTTCTGGTCTGTCCAGATGTCTGTCTGGGCCTTCTCTGTTTCACCTC TGTCTCTCTCCCTGTTTTTCTGCCTCTTATCTCCCTTCCCCACCCCACCCTCCTGCATTTCAGCTTCCCT CCTCCCCTGGCAGAAACTTCCCAGATTTCTGTGTTTTGAGGCAGGATCTGGCTGAAGCCACAGAGGGGAG ATGGGTTCTGCAGGCCCAGGACATCCTTCTGAGGGGAAGGATGCTGATGTCACCACGCTGGCCTCCCTAA CAGCTCCTGACACGTGGAGTCTGGGGCTGGGGGCAACACACCATCTGACTGACAGTCCAAGGGTGGCTAG GGCTGGCTCTGCAAGTTTGCAGGGAGGACTGTCCCCACGGGTTGACTCTGACATGCCCTGTGACACCAGC CACCTCTACGGTCCCGGGAGTCCTCTACTGCCAGTTAATGTTTCAGCTTTTGTGGGTAGGACTGCCTGTC GGTCAGTAGTTTAATTGCAACAAAGGTTTGTGCTAGAAAGGCGAATATTACATTGCAAGAGCCTTTATTA TTTGATGGGACTAGGGGGGACTGATAGCTGATGGTCCCGTATGTCCCCACTCACTGAGGGATGAGGGCTC CCCTTGCCTCCTCTCCCCCTACCCCTCTCCAGCGAAGGGCTCAGGAGTCCAGCTCCACCTGCAGCCTCTC CCTGCTCCGGCACAGCATCCTCTGACCTTGGGCGAGGCCCTGAGCCTCAGATGTTTTTGAGTTCCCACAT CTGGAGCAGGAGGATAATGATTCCTGCTGCCTCCCAGGGTTGCTGGGAGGATGAAGTGAGTCTGCTGTGT GATGCTCAGAACAGGGCCACTGTCATTATGCCATTCTGGTTACTAGTACTCTTATTACCATTACACTTAT TAGAGAGGCAGGATCCGTGCTTGGATTTAGTAGTTAGGATTCACAGGGTGAGTGATCCATAATTCTTTGC CATTACGATGAGGTCACATTTCCTTTGGTAAAATGTTGAACACCTTTGTATTATGGAAATGTTCACACAT ACCCAGAAGAATAGTCTCGCGCCCTCCTGGGGTCCCTGTCAGCAGCTCAGCAGGTAGCAGCTGTGGCCAG GCCTTGTCGCCTGTGCCTGCTCCTCACCTCCCTGCTTATTTCAGAGCAAATCCCAAACGTCGTACAGCCA GAAATATTCCACACTTTTCCAGAACAAGCCTGCCTCAGTCTCCTCATGCTTCCCCAGTTGTCTTATAATC CTTTTTTTTTTTTTGAGACAGAGTCTCACTCTGTCACCCAGGCTGGAGTGCAGTGGTGCGATCTTGGCTC ACTGCAACCTCCGCCTCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGG CGTGTGCCATGATGCCCGGCTAATTTTTGTATTTTTAGTAGAGATGGAGTCTCACCATATTGATCAGGCT GGTCTTGAAGTCCTGACCTCAAGTGATATAACCATCTCAGCCTCCCAAAGTGCTGGAATTATAGGCGTGA GCCACCGTACCCTGCCATAATCCTTTTTCATTTGTTTTTTGTTGTTGTTGTTTGAGACAGAGTCTCACTC TGTCTCCCAGGCTGGAGTGCGGTGGCACGATCTCGGCTCACTGCAACCTCCGCCTCCCAGGTTCAAGCAC TTCTCCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCGCCCGCCACCACGCCTGGCTAAGTTTTGT ATTTTTTAGTAGAGACAGAGTTTCCTAGGCTGGTCTCGAACTCCTGACCTCAAGTGATCCACCCGCCTCG GCCTCCCAAAATGTTGGGATTATAGGCGTGAGCCACGGCGCCCGGCCCATTTGTTTGATTTGGGTCTGGA CAAGGTCTACACTTTGCATCCGGTTGATAGGCCTCTTTTTTTTGTTTTGTTTTGTTCCCTTTGTTACCCA GGCTGAAGTGCAGTGGAGCGATCAGAGCTCACGTGCAGCCTTGACCTCCCCTGCTCAAGCAATCCTCCCG CCTCAGTCTCCTGAATAGCTGGGACCACAGGTGTGCGCCGTCATGCTCAGATACTGGCATCAGCTCTTTG GCGTGCATGTTGTCGTAGTTTTTCTACAGGCGACCTAGGCCATTTGTCCTGGAGTTTTGCAGTCTGGGGC CAGCTGATACATCCTTGTGGTGTCATTGCACGTGTTCTCTGTCTCTGTGCTTCCTGTAAGTTAGGACTTA GGTCTAGAAGCTCGATCTGATGCAGGTTCAGTTTCTTCTGGCAAGCACGCTTTCTTAGGTGGTTGCTTGG ATGAGCATCAGAATTACTTACATGTCTGTATGACTGTCAAGTTCAGTTTTCAAGTAAAAATTAAGTTTTT TTTAAAAAAGCGAGTGGGTTGAGAAGAACACTCTGAAGTCACTCCTAGTAAGGCTGGTACCCAGATCCAG CAGAAGTAGGGTGGGAGGGACCAAAGGACTGAGGCTCGGGTCCCCCCTTCCCCACCCCCCGGGGCCTGGG AGCAATAGGCTGGGTGCCCCGGCTTCAAGTAAACCAGTGGCATTAACATGTGGGCCTCTGGTTCCTGCTT TGCTAGGGCCACAGGCTTCCAGCTGAGAGCTGCTGCCACCCACCCTGGCAACCCCTTCCGCATCGCGTGG TGGTGACACCTTCAGAACAGAGTGGTCTCCCACCCCAGCTCTACCCTTGGCTGCCTGTGTCACCCTGGGT GGCTTTCCCAGCCTCTCTACCTGCTTCCTTCTTGACAGCCTGATGGTGGCCATACGTCCCTTGGGCTGTG GTGACTGGGCCTCTGGGAGCTGCCCTTCCACTTCTGCATTTTAACATAAACCTCCTTGACCTCAGCTGCT CCATTCTCTGCTCCCTTCCAGCCACTCGGATTCCAGTCCTGGGGGCCTCCTCACTGACCATGCCCTCCAC CCTCAGTGCTGTTCCCTGGTACTCTGCATGGCTTCCTCACCTGTATCCCGTCTTTGCTCAGACGCCACCC CTTTAGAGACCTCCCTGACTGTGCCCTCTGAAAGAGCACCTTGTCACTCTCTGTCCCTTCTCCCACTTGT TTACTTGTATATTGTGTTCCCACTAGAATGTCAACTCCAGGAGAGCAGAGACTCTTGTCTTATTCACTGC TGTGTCCCTGGTGCCTAGAACAGTGCCTGGCACCTGCTAAGTGCATATTAAGGAGTCGTTGCTCACTGGG TAGAAGCATTAAAAAAAAAAAAAAAAAAAGGCTGGGTGTGGTGGCTCACGCCTGTAATCCCAGCACTTTG GGAGGCAAAGGTGGGTGGATCACCTGAGGTCAGGAGTTCGAGACGAGCCTGGCCAACACAGTGAAACCCC GTCTCTACTAAAAATACAAAAAAATTAGCTTGGCGAGGTGGCAGGTGCCTGTAATCCCAGCTACTTGGGA GGCTGAGGCAGGAGAATCGCTGGAACCCAGGAGGCGGAGGTTGCAGTGAGCCAAGATCACACCAATGCAC TCCAGCCTGGGTGACAGAGCAAGACTCTGTCTCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAGAATTG TTGAGTGCATGAATGAATAAAAGAAAGAAAATGACTGGGCACAGTGGCTCACATCCCAGCACTCTGGGAG GCTGAGGTGGGCAGATCACTTGAGCCCAGGAGTTTGAGACCAGCCTGGGCTATAGTGAGACCTCTGCTCT ACAAAACATTTTTAAAATTATTGTTTTAAAATAATTTAAAAATTATTTAAAATGTAAAAGGGCGTGGTGG CATGTGCCTGTGGTCCTAGCTACTCAGGAGGCTGAGGTGGGAGGATTGCTTGAGCCCAGGAGTTGGAGGC TGCAGTGAGCTATGATGGGGTCCTAGCTACTCAGGAGGCTGAGGTGGGAGGATTGCTTGAGCCCAGGAGT TGGAGGCTGCAGTGAGCTCTGATTGCACCACTACACTCCAGCCTGGGTGACAGAGCAAAACCTATGATGA TAGATAGATAGATAGATAAGATAGAGCGAGCAAGACCCTATCTCAGGTAGATAGATAGATAGATAGATAG ACAGACAGACAGACAGACAGACAGATAGATAGATAGATAGATTAGATTAGATAGATAGATAGATAGATAG ATAGATATGGTTAAGTGAGTGGACTTTGGTCCTGGTCAGACTTGCCACGGAATCCCAGTTCTGATACACT CGCCGTGTGACTGAGGGCTGACATGTCTTCTCTCTGAGCTTCACTCTCCTGCTTCACACACCGTGTGAAC GGCACCCTCCTCGCTGCCTTCTTTTGCACCAGGATGGAGCCTGCACGTAACACTTTGTAGTGGTCTCACT GCTGTCCTGTCTCCAGCACGGGGCACCGATGAGCCAGCCAGAAGCCGTCCCTGCCGGGGGGATGCTTGAC CCAAATCTTCAGTAATAACTCCTTCCACTCTGGGTGACCAGCTGTGGTGCCCCAGGGCAGGGACTTGTTG ATCTGGGTTTGTTCTGGAGGCCAGAAGGGTTTCCTGGGGACTGGGATTGGAGCAGGATTGAGAGTGCCTG GTATGTGGAGAGACCTGGCTGTTGTGGCATGAGTCCGAGGGCTCAGGGGCCGGCTGCTTCCCGGCCTTTG TCTTCCTTGCAGGAAACAGGCCAGGAGTTACAAGGGGCCAGAGGATGCTGCTGTGGTTATGGTGGAAGTT AACAGCTTTGGGAAGTGTGCATGTGTGTGAGTGTGTGTGTGTGTGCACTTGTGCTCATTGTAAAGAGAGA CGGTAAAGAAATGAGGAGAGACTGCAGGCACATGCAAATACAGAGAAAGCTTTCAGTTGTCAGGATCGCT CTCCCGGTTTTTCCTGCATGGTGGTGTAAAATCTGACATGTGTACAGAAAAGTGTGTAAAACCTCCATGT TCAGTTTAATGAATAATTATAAAGCAAACAGCCATGAAACTACCACCCAGATCAAGAAGACAGGCATCAC CAGCTCCCTGAAAGCCCTCTCCTTCACCTGCCCTTCCCAGTGCTAACAAAAACATTCTCCTCCCTTTCTT TTCATTGTTCCTCTTTTTTGGTGAATTGTGAAAGATTTCAGACACCCCCAAGAGAAGAGAGAATCACCTG CTGACCACCCTCAGGCCCGCTGCCCAGCTAAAAGACGAAATGCTTGCTGTGGGTGCAGCCCCCAGGTGCC TCCCCCAGGGCCCCAGGCGTCGCTGGCCCTGCGTCTGCTTCCCTAAACAGTGTCCCGCATTGTTCTGCAG GATTTTAAACTGCGTGTAAATGGTACGAGGCCAGCGGCACTTGGCTGCAACTCTCTCAATATTTTGTTCT TGAGATTTCTCTGGGTGGAGTAATGAAGCTCTGTGCCAGAAGGAATGGTTCCCAGCGGGGGTCAGGGCAC CCCTACCCCTGGCCAGAGGAAAGCAGCTCTGTCCTGGGGGGGCCCCAGGAGGACGCTCTGGGCTCCTCTC ACCCAGGCCCGCAGCCCCCTGCTCCACGTGGGTTTGAGGCGGCCACCTCCAGTGGAAGTGGTAGAGCGCC GTTGGCTTCCTAGGGCACCACATAGGACCCAGTTACAGCCGTGATGTGAAGGGGCCCTCCCTGAGCTTAT GTAAGGTGTAATGGGGCGCTGGTGCCGCCTGGGGCCTGTGTGCACCACGGAGGGGCCTTCTCTGGAGGAG GGCATAGATCAGCAGCTGGGGCAGGAGGGCCTCTTCTCTTCCCATACTGCCCTCCCCCTGCGCCCGCCCA CTGCCCACCCTCACCCGCCCTGTTTGCCAGGCTCACACAGCCTTTCTTGGAGAGGCCCTCTGGCGGGGAG TTTACTCTCAAAGGCTCTATATCTAGCTGACCTGGGATTGCCACCCAGCTCCGCCACCTTCTAGCTGGAC GGCCCTGGGCATGTGTTGACCCCTGCCCCACCTCTGTTGGCCTCAGTTTCCCCATTTGTAAAATGGAATT GTGTGAGGGTTATTTCATCCATGCAAAGCCTTCGTAGAAGCTAGTGTGTGGAAGCCTCTTAATGAGCCTT AGCTGTTAGTATCTTTGTCATGCTTGCCATTCATTCACTCATTTTTGTTGATAGTAACTTTTTGCCTCCT CTGAGTCCAGCCCTGTCAGGCTGAGGTCCTGCCTTCATGGAGCTTATAATACAGTGAGGGAGACAGACAT GGTACTAGGCAGTGACAAACCAGAGTGACCTTGGAAAGCACAGGCCAGAGTGTGACAGCTGTGATGGGAG AAGACCCAGAGGACTGTGGGAGGCCCTGGCTCCAGCCTAGGAAATCAAGGAAGGCCTCCTGGAGGAGGAG ACTTCAGAGCTGAGGCCTGAAAGAGGAGCAGGGTTAGTTTGCGGAACATTGTCCCAAGGAGAGCAAATAG CATGTTCAAAGGCTAAAAGTTGGGAAAGGGTCTGGCATTTTAAATAAACCATTACTATTTTTAAGAAAAC TTTAAATTCTGAGATCATTGTAGATTCTCCTACAGTTGTAAGAAGTAACTCAGAATGGCCAGGCGCAGTG GCTCACGCCTGTAATTCCACCCCATTTGGGGAGGCCAAGGCAGGAGGATCGTTTGTGCCTAGGAGTTCGA GATCAGCCTGGGCAACCTGGGGAGACACCATCTCTTCACAAAATAGAAAAGCTTATCTGGCTGTGATGCT GTGCACCTGGAGTCCCAGCTACTTGGGAGGCCGAGGTGGATCACTTGAGCCTGGGAGGTTGAAGCTGCTG TGAGCTGTTAATGGCACCACTGCACTCCAGCCTGGGCAACAGAATTAAGGCTCTGTTGCAAAAGAAAGAG AGAAAGAGAGAGAGGGAGAAAGGGAGAGAGGGAGGGAGGGAGAGGGGGGAAGGAAGGAAGGAGAGAAGGA GAGAGGGAGAAAAGAAAAGAAAAGAAAGAAATAATACAGAGAGGAGGTCTGGCGCACCTTTACCCAGTTT TCCCCAATGGTAACACCTGCGAGACTGTAGTACCAGATACCAGAGTGTCAACTGACATTGACACTGTCAT TGTCAATTGACAATTGTCATTGTCAATTGTCAATGACAATGTCATTGACATTGACATTGTCAGTCACAAG GATCCCTCCTAATACCTTCTCATAGCTACACCCTTCCCCTGCCCATCCCTAACCTCTGGCAACCACTCAT CTGTCTATTCCCCCATTGTTAGGATTTTGTCAATTCAAGAATGTTATGTAAATGGAGCCACCCAGTATGC ACCCTTTTTGCATTGACTTTATCCCCTCAGCATGATTCTCTGGAGGTGCATCCGCATTGTGGTGCTGATA GTGACTACTGAGTAGTATTCCGTGGTCTGGATGCCCCACCGTTTGTTTAACCATTTCCCGTTGGAGGACA TCTGGGTTTTTCTAATTTTTTGGCTATTACAGACAAAGCCACTATAAACCTCGACAAAGAGGGTTTCGTG TGAATGTCAGTTTTTGTTTCTCTGGGGCCAATACCCAGAGGTACAATTGCTGGGCAGCGTGCTGGTTGCA TGTTTTAAGAAAACCATCAAAACCATTTTCTAGAGTGGCTGTACCATGTTATATTATCACCAGCAGCAGG TTCCCCACATCCTCACCAGCATTTGGTGTTGTCACTATTTTTTATTTTAGCTCTTCTAATAAGTGTGCAG TGATAACTCATTGTGGCTTTAATTTGCATTTCTCTAATGGTAATGATGTTGATTAGCTTTTCACGTGCTT ATCTGCCATCTGTGTATCCTCTTCAGTCAAAGGTCTCTTCATGTCTTCTGCTCATTTTCTTATTGGATTG TTTGTTTTCGGGTTTTTTTTTTTTTTTTTTTTTTTTGCTGTTGAGTTTTGAGTTTTCACTGTTGTTCTTT TTTTTTTTCTTAGCCCCACCAGGTTCTCATATGAGATCTTTATCTATTCTCTCTCTTTTTTTTTTTTTTT TAGATGGAGTCTCACTCTGTCGCCCAGGCTGGAGTACAGTGGTGTGATCTCGGTTCACTGTGGCCTCCGC CTCCCGGGTTCGAGCGATTTTTCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCATGTGCCACCACG TCCAGCTAATTTTTGTATGTTTAGTAGAGACGGGGTTTCACCATGTTGGCCAGGCTGGTCTCGAACTCCT GACCTCAGGTGATCCGCCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGTGCCTGG CGAGATCTTTATTCTACATACTAGTCTTTTGTCAGATACGTGGTTTGCAAATATTCTCTCCCAGTTTGTA GCATGTCTTTTAATACTTTTCATACGGACTTTTGCAGAGCAAAAGTTTTTAATTTTGTATTAATTTTTTT CTTTTATGGATTGTGCATTTGCTGTCAAGTCTCAGAACCCTGTGCCCTGTCTTAGGTACCAAATAAGTTT CTTCTGCTTTTTTTTTTTTTTTTTTTTTGAGAGAGAGTCTCGCTCTGTTGCCCAGGCTGGAGTGGGCTCA CTGCAGCCTCTGCCTCCTGGGTTCAAGTGATGCTTCTGCTTCAGCCTCCCAAGTAGCTGGGACTAGGGAG GCGCCCACCACCATGCCTGGCTAATTTTTGTGTTTTTAGTAGGCACAGGATTTCACCATATTGGCCAAGC TGGTCTTGAACTCCTGACCTCGTGATCCGCCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCGTGAG CCACCACACCCTGCCTGCTTTTTTTTTTTCCATAAAAGTTTGATAGTTTTACATTTAAGTCTGTGATCCA TTATGAGTTAATTTTTGTACAAAGTATAAGTTTTGGATTAAACTTCTTTTTTTCCCCCGTTTGGCATGTG GATGTCCAGTTGTTCCAGCCAGCATTTGTTGAAAATGCTGTCTTTCCTCTGTTGAATTGCTTAGGCTTCT TTCACAAGAATCAGTTACCACGATGAGATACTACATCACACCTACTAGGATGGCTGCTGTCAAAAAAACA AAAATAACAAGTGTTGGGAGGATGTGGGGAAATTGGAGCCCCGTGCATTGCTTGTGAGAATGTAAAATGG TGCTGTCGCTGTTCGGCATAGAATTACCTTGTGACCCAGCAATTCCGCTCCCAACTGTTCGTCCAAAAGA ATTGAAAGCAGGGACTCGAACAGATATTTGTACACCCAGGCTCATCACAGCATTATTCACAAGAGCTAAA AGGTGGAAACAGCTCCGTGTCCATCAGTGGATGAATGGAGGAACAAAAGATGGTATACATGATGGAATAT TATTCAGCCATAAAAAGGAATGGAATTTTGGGTAGAAAGCTATCATGTGGATGGTCTTGAAAACATTATG CTTAGTGAAATCAGCCAGACACAGAAGGAGAAATCCTCTATGATTCCACTTGTACGAAGGACCTAGAGTA GGCAAATACAAAGAGACAGAAAGCATGCATGGAGTCCCAGCTATTCGGGGGCAGGAGGATCACCTGAGCC TAAGAGGTTGAGTTCAGCCTGGACAACATAGTGAGACCCGGTCTCTTTTAAAATATATGTATATAGGCCA GGCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCTGGCAGATCAAGAGGTCAGGAG ATCGAGACCATCCTGGCTAACACGATGAAACCCTGTCTCTACTAAAAATATAAAAAATTAGCTGGGCGTG GTGGTGGGCGCCTGTAGTCCCAGCTACATGGAAGGCTGAGGCATGAGAATGGCTAGAACCCGGGAGGCGG AGGTTGCAGTGAGCTGAGATTGCACCATTGCACTCCAGCCCAGGCAACAGAGAGAGACTCTGTCTCTAAA TAAATAAATAATAAAATATATGTTTATGTATATATAGAGAGAAAGAAAGTAGAACAGAGGTTATCAGGGT TTGAGGGGAACAAGGAGCTGTTGTTTATTGGGTACATAGTTTTTGTTGGAATGATAAACATGTTTGAATA TAGATGGTGGTGATGGTTATACAACATTGTGGATATATTTAATGCCACTGAATTGTATACTTACAGATGG TTAACAATGATAAATATGCTGTATATTTTACCATAATAAAAATAAATTTTTGAAACCAGCTAGGTATGTT GGTGTAGATCTGTTTCTGAGTTCTCTGTCCTGTTCCGCTGCTCTGTTGCTGTGACTGTCCCACCCCATCT GGGTTACTTGCTGCAGCGCTGGGAGAGGGATTCCTCTGGCTTCCTCTCTCTTTTCTCTTTTTCAAGATTG AGCTCTTGAAAAAAGAGCTCTGGGAGCTGGCATTTTGGAGCTCCTCTAGGGTTCCGCGTGTAGAAGATGG CACTGTGTTGGGCCTAGGTTCAGAGTCGTCCTTGACACCACCTCATCCTCAGCCCGTGTCTGACTCATCA GCGAGCATTGCCTTTTCTTGGTAGACATAGCCCAGGTCTGTCCCCCTCTCTCCACTGCCACTGTCCTGGC TGCCTCACAGTTGCCCAAACAGCGCTGCCTCCTTGTCACTCATCCTCACGCCCACTCAGGCCCCTTGATT CCGTCCTTCACAGGGCAACCAAAGTTACATCTGTAAAACCCAGGCCTGGACCAGGTGGAGTGGCTCCCAC CTGTAATCCCAGCACTTGGGGAGGCCGAGGTGGGCAGATGGCTTGAGCTCAGGAGTTCAAGACCAGCCTG GACAACGTAGTGAGACCTTGTCTCTAAAAAAAATAAATTAATAAAAATTAAAAAAATGTAAAAACCCAGG CCTGTCCTTGGCACCCACGTTGTCTCCCCTTGCTCTCTCATGATCTGCCTCCACCACACCGTCCCCGTTC AGGCCTGCTGCCCACCCATCCCTCCAGCCAGTGTGTGTCCGCTGGACTTTCACATTTTTTGCGTGTGGTG CTTGACTATAAGCCTGATGGGGTAGGGCCCACACTGCACTTCTGCCCCCGCACAGGCGGCACGTGACAGA CGTGCATTAGATTTCTGTCGGTGGACGCCATGAACGTGGGAAGGAGGCTGCCTGTGGCCGGAGCAGGTGG TTGGGGGCGGAGAGTGTGCAAAAATGAGGACAGAGAGGTGGGCGCGACCTCGGTGAGGAGACGGCTTTAG CTCTGTGGGCCTGAGTAGGTTTTTAGCAGGAGAGGATACAATCAGATTAGATTTACAAAGGTCTCCCTGA CCTAGCAGAAAAAGGCAAAGGCTTTGAATAGACACTTAGCGGAAGAGGACATTCTGATGGCTTTTATAAA TATGAAAAATGCTCAACCCTACTAAATAGAAAAATACAAATGAAAACTAGGCTGAGGGGGGCCACACCTC ACATATCAGCAGAGATCAGAGAGACTGGCCACGCCCCGTGCTGCAAGGCCGAGGGGAGATAGGCCCTGGC ACCGCCGAGGGGCTGTGAGTGGGGACAGGCCTCACGCAGGGCCACTTGGCAGTGGTGAACTTCACTGGAC ATTTACCCACAGACAAACTTGCACACCTGTGAAATGACAGCTGCACACAGTGAGTGTTGCCGCACCATTT ATAAGAGCAAAAGACAGGAAACCACCACTCTGGCCCGATGGGGACTGGCTCCAGACATCACGGTCCTTCC ACACAGCTGCCAAAGCAGCAAGGCAGTGCTCTGCCAAGATCAAGGCAGGGAAAGATCACCAAGACCCACA TATATATGCAGCATGTCTGTGGTTTCAGTTACCTGTGACCAACCATGGCCCAAAAGTACATGGAAAATTC CAGAAATAACCAATTCATATGTTTTATTTATTTATTTTTTTGAGATGGACTCTCTGTCACCCAGGCTGGA GTGCAGTGGCACCATCTCAGTTCACTGCAACCTCCGCTTCCTGGTTTCAAGCGATTCTCCCACCTCAGCC TCCCAAGTAGCTGGGATTACAGGCATGCGCCACCACGCGCAGCTAATTTTTGTATTTTTAGTAGAGACAA GGTTTCACCATGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAAGGAATCCACCCAAAGTGCTGGGATT ACAGGCATGAGCCACTGCGCCGGCCCAACAGCTCATACATTTTAAATTGTGCACCATTCTGAGTTATCGT GATTTTTTTTTTTTTTGTAGAGACGAGGTCTCCCTATATTGCTCAGCTGGTCTCGAACTCCTGGGCTCAA ATGATCCTCCTGCTTCAGCCTCCCAAAGTGCTGAGATTACAGGCAGGAGCCACTGCACAGCCTCGTGATG AAATCTTGAGCCATCCCACTCTGTCCCGCCCGGGACGTGAATCACCTTTCTTACCCCACATATCCATGGT GTATGTGCTACCCATCTGTGGCTACTCAGTAGCTTTCTCGGTTCTCACATCCACTGTTGCCGTATCACAG TGCTTATGTTCAGGTAGCCTTTATTTCACTTAACATTGTCCCCAAAGTGCAAGAGTAGCGATGCTGGCAA TTTGGATATGCCAAAGAGAAGCTGTAAAGTGCTTCCTTTAAGTGAAAAAGGGGAAAGTATTGAACCTAAT AAGGAAAAGAAAAAAAATTGTATGCTAAGGTTACTAAGCTTTACAGTAAGAACGAACCTTCTATCCATGA AATTGCGAAGAAGGGAAAGAATTTGTGCTGGGTTTACTGTCACACCTCAAACTGCGAAAGTCAACAGCCA CAGGGCATAAGGGCTTGGTTAAGATGAAAAAGGCATTACGTTTGGGGGGGTGGAAGACAGGAACAGAAAC GTGTTCCAACTGATGGCAATCGGGTTCAATGTTATCCACAGTTTCAGGCATCCCATTGGGGGTCTTGGAA CATACGCCTTGCAGATAAGGGGAACTGCTGTATATATAGTTGGCCCTGGGTATCATGGGCCCTCAGGATC ACGGGTTCTGCACCCACCCATTCAACCAACGAAGGACTGAAAATTTACTATGGAGGGCCAGCTTTTCCAT CCGCGGTTATGGAGGGCTGACTGAGGGACGTGAGCATCCCTGGATGTGGTACCTCCTGCGGGGGTTCTGG AGCCAATCTCCCTCAGCTACCGAGGGAGAATTGTATAGATATATCAATTTTTTTCTTTCAAATCATAATT ATAAATTGTTAGGATACACAGTGAAAATTGCATAAAACATAAATGTATAGCAAAACCAATTACTATAAAG GGAAAAATCTATGTAGCCACCCCTCCAGGTGAAGAAACAGATGGTGCCAGCCTCCCCCAACCCCCAAAAG CTCCCAGTCCCTCCCTTCCCCCAGAAGCATCCACTCTTTTTAATTTTAATTTTTTTTGAGACAGAGTCCC ACTCCATCACCCAGGCTGAAGTGCAGTGGCACAATCTCAGCTTACTGCAACCTCCACCTTCTGGGTTCAA GCAATTCTCGTACCTCAGCCTCCCGAGTAGCTGGAATTACAGGCATGTGCCACCACACCCGGCTAATTTT TGTGTTTTGTTGTTGTTGTTTTATTTTTTTGAAACAGAGTCTCACTCTGTCACCCAGGCTGGAGTGCAGC GGCACCATCTCGGCTCACTGCAACCTTCGCCTCCCAGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGAG TAGCTGGGATTACAGGCGCCTACCGCCACGCCACGCCAATTTTTATATTTTTAGTAGAGACGGAGCTTCA CCATGTTGGTCAGGCTGGTCTTGATCTCCTGACCTCAGGCGATCCACTCGCCTTGGCCTCTCAAAGTGCA GGGATTACAGGTGTGAACCACCCCACCTGGCCTTAATTTTAATTCTCTAAAAATGTAGAGATGGGGTTTC ACAATGTTGGCCAGGCTGGTCTCGAACTCCTGGCCTCAAGTAATCCTCCCGCCTCGGCATCCCAAAGTGC TGGGATTACAGGCATGAGCCACCGTGCCCAGTCCAACTCTCCTGACTTTTGAGGCCATCATATGCTTGCT TTTCTCTCTGTTTGCCACCTCTGTATGCAGCCTGAAGCAGTTTCCTTTTGCCTGGCTTTGAACCTTAAAG TCCGAGGATGGAGTATTGTTCGATGTTTTTGCCTCTTCTGTGTGGCGTCTTCTTTGATGCTCATCCACAT GTAGCTGTAGTCATTCATTCATTCATTCTCCCTATCATGTGCGGTGCCATGGAGCCTTCATTCACCACCT CCTGGGGACGAGCATTTGTCTTGTTTCTAGTCTCTTCTCGCGTGTGCTCCCTGCCCCATGGGCCTGCGTT ATGCTGGAGTGTGTACCCAGGAGAGCTCTTGCTAGGTCAAGCGTGTGTCCCCACTTCCACTCGATGCTGC TAAGCTCCTGCCAAATGCCAGCAGCGTGGGAGAGCCACGGAATGTTTTCGAGAAGAGCAAAGTACAGAAT ATTGTGTGTCATGTGGCTGCCATTTCTCTTGTTTTTTTAAAAAGCAGGTAATCATGTGTGTACCCATACA CACACGTAGGATCTCTCAGAAAGGAAAAGAAAAAACCTGAAAGTCTAGTAGCGGTTGCCTCCAGGGCTGA GCTGGGCCAGGGTGGAAGGAGGACATCCTGTCACAGTTTACCCTTTGGTGCCTTTTGTCTTTTGAACCGT GTGCCTGTATTACAAAGACAGAGAGAAGGAAAAGAAGGAAAAGGGGTAGATGAGTGTAAATGTGGTAAAG TGAGAATCACTGAGAATCGCCCAGTGCAGCTCCCTCTCCGTCCATTGGGGACCTCGTTTCCTGTGGCTGT CCAGAGCTGTCCAATCCCCATCCACTCCCCGCCAGAGCCCAAACCTGCCCGTCTGGTTTGCAGAGCTGCC CCACGTGGCTCCTCTGCGGGTGGTTACTCGACAAATGCCCCACCCCCCACCCCATGGGGAGGCAGTGGCC TGAGATCTGGGACTTCTGGATCTAGGCCCCTAGACCTGCCCTGCTGTGGTCCAGAGCCTGGCCCAGCCCC TCCTTGGACTTCCTCCTCACTGTGACAGGGGGTGGACAGAGGTGGGGATGGGAGTTCCAGGCCCTGAGAG CAAGCGCTGGCCTCCCAGCCCACGTTCTGTGTGTGGAGATAACATCTGCCCTTGAGGAGTTGGCTGCAGG GGCAGGGGTGTGCCAGAGCAGGGTAGTGGGAAGGACCCAGGTGCGTCTGTCTGCTGTGTGCCGGGGCGCT TGCTCACTGTTGTCCCTGGATTCACCATGGCCTGGGTGCCCATCCTGGGTCCGGGCACCCAGCAGCCTTG GTCCCTACCGCCTACCAGACTGGAGTCCCTGGTAGAGCCCCTCTAGGGTGTCAACTCCCGTGGGCAGGAA GTTTTGTGGAGTTTGTTCAGTGCTGAACTATCAGGGCCTCCCACAGGTGTGCCTGGTATGTGCCTGGAGC TCAGTGAATGAATGAGAGGCGGGCAAGCTGCAGACAGTGACAGCCTGGGTGCTCAGGGCTGGCATGGGGA GGTGCAGGGTGGAGTGCACAGGGCTGGAGCCCAGAGGATACCTGACCCAGCCTGGGGTGGCAGGGAGGGC TTCGTGGAGGAGCAGGTGCCTCAAGTGGGGCCGGAGGGTGAGAAGGGATGAACCAAGCAGCCCTCCGGAG GCCTCGAGGGGAACAGACAGTGTTCACAGGAGAAACAGTTACACCTGCGAGCTCTGCCTCGGGCCAGCCT TTGCACTGGAGGTGGGATTTGAAGGGGAGGGAGGGGTGCTGTGGAGCATCTTTTTCTTCTGTTCCTGAAC GGGGGTTCTGATCACATCAGCCTCATGCTTGGAGCAGCTGGTTAAGGGCACAGACACCGGGACAGACATC CAGCCTGGGAGTCCCAGCGCCTGACCTCCCCTCGGGCATCAAGTCACTCCGCCTCTCCGCGCCTCAGTTT CCTCCATGATGAAAGGGGCCTGCTGAAGGACCTGTCTCATTTAGGGCAGCAGTGAGGCAAAGCCCCGGAG CCCATGCCTGTGCCAAGAGCAGGGCCTGGCCCAGAATATGGCCTTGTCACGTTGAGCTGCCTTTTTTCAG CAGGGTTAGTTTCATCCTGGTGAGGCGGCGCCAGCATGGCGTTCCACCTTCTTGGCCTCCTCTCCCTCCT CCCTTTCCTGCCATCCACACCTCCCGGCCCTATTCTCACACCTCAGGATGGCGATATGGGGGCTTCACCG TGGTCTCCCCTGACCTCGCCCCTCCCCCGGTCAGGCTAAGTCTCAGATTCCTCCTCATGGGTGAGGGGGG CAGAGTGGCCCCTTTCCTCCAGCCCATGCTGGGCACTTGCTAGAATCCCAGCCTTGGTCGGGGTGGAGGA GAAGCAAGTTCCAGCTCTCCAGTTCTGCCTCCATATCAGAGAGCCCACCCACCCCTCTCCCCAGGGCTCT ATCCTGCACCTAGTGGCCCCTGTCACTCCCCAGCCACCCCCACGTACATACCCTGGTCCCTTGTTTCAAA CCTGGCTGCCCCTTAGCCGCCTGGCCAGCCGCTTGCAGGTACTCAGCCTTGCTGTGTAGTCACCCCCTCC AGCCCCTGGCACCTAGCCTGGCATAGGGGGGTGAGGCGGGGTGTGCCTGTTGGTGGGAGGCTGACCCTGC TGAAGCAAAGGCTGTGGTTGGGGTCCCCGCCCAGCCCTGCCCTCTGTCCAGGCAGCTATGAGCCACGTGG CCCAGGCCCACCCACCCCAGCTCCAGGCCCAGCCCCGCCTCCCTCCCGCCCTCCGTGGGTGGAAACCACA GCCGAGGCTCAACTCCTGGCCGCGTCACCACCGCTGCCCTGCAGGCTGGAGCATAGAGCCCAGGCAGCCC TCCTCGGTGGGTGCCCATGTTGAGGGCCTGGGGAGCCCTGGATCTACTCTGCTTTCCCAGCTGGAAGCCT GTCTGTCCACAGGCCCGCCCCATTGAGGGTGGCCCAGGAAGTGGGAAAGAGCGTGGTGGAGGTGAGCTGG CCAGGCCTCGGGAGGGGAGGGGGAGGGCTAGACTGGCTGCCAGGGAAGGAGGGTCTGCCCCTGGCCACTG GAGCCAGTGTGAGCATGTGCGAAGGCCACACCTTTCTTGGGGTTGGAGCGGGGTCACTGTGTTTCCATGT GTGCGAGATGGCAGGTGCCTGTCTGCTGGGGACTTGCAGGCATCTGAGCATAGGTCCCTGAGCCTCTCTG TGGGAGCACGCTCCTGGGGTCTGGCTTGCACGAGGGCAGAAGTTTCCGTGAGACTGTGCCTCACTCAGTC ACTCTGGGTGACCCTGGAGTTGACTGGGTGTGCCTAGGTCCATGGAGGTCTCCTTGCCTACTGTGTGTGG TTTTGGGGTCGGGGGGGTGCCTCCTAGTGTAGCTTTGTATCTTGGGGGTTATTCCTAGGTGCGTGTGTGT CCTGGGGTGCAGTGCGGCTTTCCCTCGAAGTCATGGAGTGTCTGCGGCATTGTGTGTATACACACGTGTC CCTGTGTATCTATGTGTGGATCTCTTTGGGAGTCTCTGCATCTCTGGGTGCACGAGTCTTTGCAGTGTGT ATGAAAGGGTCGCAGTCCACGGTCCATCCATGGCTCTTCTGGGGCCCATGTGCAGGCTGGCTGAGCCGCG GCCTTCCCATTTGCTGCGCATGTACTCTGAGCCAGGCTGGCTTTAAGAGCCGCTCCCCCACCTTCTCCCA CTGAAGTCTCAGAAGCTCCCTCTGGGGCACGCTCTGCTGGTGCCCCATATTCTAGAGACATGAACGGAGG CTCTTGGTAAATGTCCTTTTCCCCTGCCCCACGGCAAGCAAGGCACTGACCCCTGGCCACCAGCCTCCTG AGCCCATGGTCCTGTACGGGCCGCCGCGAGGTGCTCAGGATGTTGTAGGGTTGAGGGTGGATTGCTGCTG TTGCCGGCTAGCCGGGAAGTTTTCTTTTTTTGGCCTAAGATAAATATTGGAGAAGAATGGCCCGGGAGCT TTCCATGTGACCAGTTCATGTGCCTGGAGGCCTGTGGTTTGTGTGGCTGGGTATGTATCTGCATGTCTGT GTGATGGTCTTAGGACTCGGCTCTATGTGGTGTCAGCTGCGGACATCTTGCATGCTCTGGCATGTCCTCA CATGCATCTGTGTCTAGGGATCATGCATGTGTGTATGCATGTGTGTGAGTGTGCATGTATGTGAGCATGT ATTTGTGAGCGTGTGTGTGAGCATGCATGTGTGTGTGTGCATGTGTGTGCATGCATGTGAGCATTGTGTG AGTGCGTGCGTGCATGTGTGAGCGTGCGTGTGTGCACATGTGTGCATGTTTGTGAGTGTGCATGTGTGTG AGCGTGCATGTATGTGCATGTGTGGGTGTGCGTGTGTGTGCATGTGTGTGCGCGCATGTGTGAGCATGCA TGTGTTGCGGGATGGCTTCGCTCGCTGCTGTGTGTTGGGTCTGTGAGGAGAGGCCGTGGTTGCTGCCTGG TGTATGTCCTGGCGTCTGTGCACGGCCTTGTGTGTTGCATGGCAGGGGAGGTAGACAGTGAGAGGGCTTG GGTGCTGGAGCCTGAGAGGGGCAGGGCCTCTTTCCTGCCACATCACCCCCTTCCCCCTGCCCAGCCTCAG GCGAGGAATAAATGACGTCTGCTCTGATTTCCCAGGCCGTATGGGCTCCCACACACTCTCTGTTGTGGTG TCCATCCCCACCCTGAGTACCTCTGGGGGGTGAAGGGCACCAGCAGTGCCCTTTGTGTCTGTGCCCTTTT GTGCTGGGCCAGATTCGGGGCAGGAGGGCTTGGCCCTGGCATCACTGGGGGCTCTGAGCGCCAGCCTGGG CCTAGCTGGGTAAAGGAAGCATCATCTCTTCGTTGAGCCACACTCTCTGCGCTGGGCAAGCCTGGGGACA CAGAGATGGCCCCAGGCCCTGCCCTCCTGGGTCTCCCAGTCCAGTGGGAGAGGCAGACCTGTTATCAGAC AATAACAGCCCATCAGGCTCCTCCCTCCCAACCCTGGAGAAGGTAAGACTAGCATATTTGCTCGGCAGAA GGGACCATGCCCGGCATCCTCTGTAGTGTGTTTGTTCATTCATTCATTCATCATTCAGCAGCAAGAATGG CAGTAATGATAACAGCAGCGAGCCTGCAGTGAGGCCCCACTCGGCACCAGTCACTGTTGTAAATGTTTTA CATGTGTCGTCTTATTCGCTCGTCCAACATGCTCAGGAGGTAGGGACTATCACTACCCCCAGTTTGCAGA TGAGGACACTGAGGCCCAGAGAGGTTGAGTCACTTGTCCAGGGGCACACAGCTTGGAGTAGTAGAGCCAG TACCTGGGACTGGGCAGTCGGCTCTTAACCACCAGTACAGGCCTGCTGAGCCCCTGTACTGCGCCAGGCC TCTGCTGAGGACAAAGCAGTGGCTAGGAGAGACAGGCCCTGTCCTCGTGGGGCTGCCCGTTCATTGCAGG AGACATACTAATTAAGGACTATAAGGACAAAGGTAAAATTACAGCTGTGACAGATGCTGTCAAGGGGAAG GCACGGGACATGCAGGGTTTTTTTCAGACAGAGTCTCACTCTGTCGCCCAGGCTGGAGTGCAGTGGCGTG ATCTTGACTCACTGCAACCTCCGCCCCCTGGGTTCAAGTGATTCTCGTGCCTCAGCCTCCCAAGTAGCTG GGACTAGAGGCACATGCCACCACGCCCAGCTAATTTTTGTATTTTTTTAGTAGGGATGGGGTTTTGCCAT GTTGGCCAGGCTGGTCTCGAACTCCTGACATCAGGTGATCCACCTGCCTCGGCCTCCCAAAGTGCTGGGA TTACAGGCATGAGCCACTGTGCCCGGCCATGGACCTGCAGTTTGAAGGAAGAGGAAGGGATAACAAGGTG AAGGTTGAGGGGGCAGGGGGCTCTTCAGGACCCAGGCTAAGGGCACAGTCCATGCAGAGGCCTGGTGGCG GGGACGGCGCTATACCTGGAGGAACGAAGGAGAGCAGGGCTGCCCCCTCCACCCTCCACAGACGCTGCTG AATCCAGGCCCCACTTCCAAAGGCGTCCCCCCCACTGGATCTGTGTCTTTATGGGCTTTTACCCATTGTG GGGGCTCATGGATTTCCAGAGGCACCCCCCATGTGATTTGGCTTTTGCCAGGATACGCTGCCACTTCCTG AGATTCCCAGCGTAGGCCATGTGGCTGGGTGGGCCCCCCTGCAGTGGGGAGGGCCTGGGCGTTCACAGTG GGGGTACCTTTTGTGGTGCTGGGACACACACCAGCTTACTTGCTGAACAGCCAGATTCAGTCTCTGAAGA CCCATTTTCTCCCCAGGCGTCAAGGTCAGACTTCCAGGGAGTGAGTGTACGAGGCCCAGGGACTTGTGTC TGTCTCGGCCCCATCCCCGTGCCCTGCGCCTCCTCAGGGACCAGGCTCATTACTTTGGTAATGGCATCAC CCATTTGTTCCACAGATATGTCTCGAGCACCTACTGTGTTCCAGCCACTGCTCTAGATGCCGGCAAGAAC CAGACAGACAGACAGGTCCCTGCCCTCAGGGCACTGACATTCTGCTGGGGGCACTGCCAGTCAGTAGGTG TAGGATGCCAGGGGGTGGTAAGTGCCACAGAGACATAAAAAGCGAGGTGCACATTTTGTTCAGGGGTCAG GCAGCCTCTCGGAGGAGGTTTTATTTGCACTAAGACCTGAATATCAAGAAAGGCTGAGCAGTGCAGTTCT GGCTGAGGGAAGATAGGTGCAGAGGCCCGGAGGCTGGAACAGCTGTGATGAGTCCAAGACATACACGGAG GCAGCCAGCGCGGCTGGAGAGAAGCGAGGGGAGGAGATGAGGTTTGCGAGGTTGGCAGGGCCCTCCCAGT CAGGGCCGTGTTGAATCAGTGTTTGAGCCAAAGTGGGAAGCCCTGTAGAACTGTGTGTGTACATTTGTGT AATGTCTTCAGATTCCCTTCTAACCACGGTGGCTTTTCTGGTCTTGGTCTGGTCATTGTCAGGGACATTG TCCCTTCCTGTTTTTGTCCCATAAACCTCCAAGGTCCTTTCTTTAGAGTGGAGGCCTTGGCTGGAGCCGG GACCACTGGGGAACAGGAGGCTGGGGGATGTTGACTTGCCTTCTCTGTGGGACAGAGTGGCTGCTTTTGT GACCTGGCACTGGATAGCCCTGGGCAGTGAGTTCCCCTCTCGGCCTCAGTTTCCTGGTTTGGGGAACAGG AAGGAAGAGGACTCCCCACCCAGCACCCAGCACTGTTTAGAGGGCTCCGCGTGGCCTGGTCTGTGTGCCT GGCACAGCCTGGGCAAGTCCACAGCCACGAAGGGGAGCCCTTGTGAGTCCACGCCCTGCTGTAGGCACTG AAATGCAGCCATCATGAACCAAAACGCGGTCCCTGTCCATATGAGTCACTGACTTAGCGAGGAAGATGGC CACAGACAGGCAAACAACTGTAATGTGTGAGGCAACGCTGAGGGCCCTGGAGGGAACGGACCTAGGCTGA CTGCGCCAGGCTCCGCGCCAGGTGCTGGGGGTGCCACATGGAGCAAGACCAGGCCAAGCCCCTGCCTATG AGCTCACGCTGCAGCCCTCGGCCAGTCCTGCCACCTCCACCTTTACAGTGTGCCCAGAACCTGCTCATGC CGCCCCCTCTGCAGCCCCCACAAGGTCCTGCCCCCTTGATTTCCACTGGGCCATCACAGCCTCCTCCTCC CTGGTCCCCCTTTCCGTTCTGCCCCCACAGACTGTTCCCAGCCAGTGGGAGCCTGTGAACTCCTGAGTCA GGCGGTGGCCCTCCTGGGCTCAGAGACCCCTGCAACTCCGTCTCACTCGGGAAAGGACCAGGCCCTCCCG GTGGCCCCCAAAGCCCCACACGATCTGCCCCATTACCTCCTTGGCCTGTCCTTCCACTTGCCCCCTCGCC CACCCTGCTCCAGCCACGTGGCCTCCTCGCTGTCCCTTGACCATATCAAGCAAATTCCTACCGCCCTGGC TGTTCCTTCCTCCTGGGCTGCCCTTCCTCCAGAGCCCTACATGGCTCCCTCTCCCCTCCTCACGCAGGTC CCTGCTCACGTGTCCCCTTCTCAGCAAGGCCTGCCTGACCACTTTATTTTATAATAATAGTTATTATTAT TATTTTGAGATGGAGTCTCACACTCTGTCGCCCAGGCTGGAGTGCAATGGTGCGATCTTGGCTCGCTGCA ACTTCCACCTCCCAGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGACTACAGGCGCCTG CCACCACGCCAGGCTAATTTTTTGTATTTTTAGTGGAGATGGGATTTCACCATGTTGGCCAGGCTGGTCT CCAACTTCTGACCTCAAGTGATCTGCCTGCCTTGGCCTCCAAAAGTTCTGGGATTACAGGCATAAGCCAC TGCACCCAGCCTGTTATTCTTATTTTTGAGACAAGGTCTCACCCTGTCACCTAGGCTGGAGTGCAGTGGC ACGATCACTCACTGCAGCCTCGACCTCCCAGGCTCGGGTGATTCTCCCGCCTCAGCCTCCTCAGTAGCTG GGACCACAGGCGCACACCACCACACCTGGCTAAATTTTTATTTATTTTTTATTTTTGGGGTAGAGACAGG GTCTCACTAGGTTGCCCAAGCTGATCTTGAACTCCTGGGCTCAAGCGATCCTCCCTCCTTGGCCTCCCAA AGTGCTGGGATTACAGGCGTGAACCACCGTGCCCGGCCTTGACCACTTTATTGAGAATTCCAGCCTCCCC TCCCCTCAGCTCCTTTCTGATTGCTGCGTTATTTTCTATGTCAGCATTTCTCACCCGACTTAGTAGATGT TTTTCTGATTTATCTCATACATTGACTGCCTCCTTCCTTCTAGAATGTGAGTGCTGCGAGGACAGGGATG TTTCTGACTGTTGGGTGCACTGCTATGGGCCCCAGGCCCAGCAGAGTCAGCCCTTGGTAGACATGGACGG GTGCGTGGGTCGATGCGTGGGTGGGTGTGATCGGGTCACTTGTGGGTGGAGTAGGTGTTTGCTAAGGCAG ACTCTGGGGATGTGTCGGTCCCAAACCTGAGGACTCCTTGGAGGAACGAGGCTCAGTGTGGGAGGCCTGA AGAGAGATGTGGTTAGAGGAGGGTTGGGGGCCGTGCAGGATGGGGGCAAGAGCTAAGCCAAGGTTTGGAG GCAGGAATGGCTTGGGGGACTCAGGACAGCGAGGAGCCTGCTGTGCCGGGACGGGAAGCCAAACTCCCAG CGCCTCCACCATCAAAGCACATGCCAGAAGGTAGGAGGTAAACTGAGGCAGGGAGGGGCCCTCCCAGAGC TGGTAGGTGAAGATTGTGGCAGGGTGGTGAGTGGGACCCAATGGTGGAAGGCTGAGTGCAGGCTGGAGGC AGTGAGCGGTCTGGGTCCCCTTCCTGATTCGAGTTTCATTTTGGTAACGATGAAAGGATGCCTGTGGTCC TGGCCACCTCCCCTGCTCTGCCCCTGGGCCCCTGTGTTCTGGGTGGGCCAGCCCCCTCCCTTCCAGGGGC AGCAGCTTTGATCAGAGCCTGGAGGGGGCGGGGCAGGAGGTAAGGGTTTTTGCACGCTCACGTCTGCTGA CACTGACAGCTTTGTCGCACGGTGGATCTTGCTTTTCCATTTGGGCCAGTTAACCTTGTGGGGGAGAATG GGGGTGGTGGGACCCTTTTCCTCCCAGAAAAGGTCAGAGGATGCAGGGGGTGACTGGAAAATCTGAAGTG TCTGCTAGGCCAGGTCAACGCTGCCTGTCCCGCATGTTAAAGAATTCAAAAGATTTTTTAAAATTTGAAA TAAACATTTTAGAGTAGGATACAAAATGCGCTTGCATTTCTGGGATCAAATACTGGACTTCAGAGGCATC TGTGCCCCGGCTGGGGCAGAAGGCTGCACCTTCCTGCTGCTCTGGGACTACTGCCCCCAGGTCCCAGCTG CTTATCTGAAAGATTTCCCGGGTGCTGCTGGGCCTTGTCCAAGGCCTCTGAGCAGGGGAATAATGCAGCG GACAGGGACGATCATTCCACGGAGTCCCTACTGTGTGCTGCCCTGGGCTACGAGGGGGTAAGACAGAGGA CAGTCCCTGCCCTGTGAAGCTGACACATTCTAAGGGAGAGGCAGATGCTAAAGAATTACACATATGGCTG GGCCCGGTGGCTCACGCCTGTAATCCCAACACTTTGGGAGGCTGAGGCAGGTGGATCACCTGAGGTGAGG AGTTCAAGACCAGCCTGGCCAACATGGTAAAACCCCATCTCTACTAAGAATACATAAATTAGCCGGGTAT GGTGGCGGACGCCTGTAATCCCAGCTTCTTGGGAGGCTGAGGCAGGAGAAGCACATGAACCCACTAGGCG GAGGTTGCAGTGAGCCAAGATCATGCCATTGCACTCCAGCCTGGGCAACAAGAGTGAAACTCTGTCTCAA AAAAAAAAAAAAAAAAAAAGAATTATACACACACACACAAGCACGCCATATATGTGGTAAGAGCCCTGAG GAAAGATAAAGCAGAGACAGGTGTAGAGGGCGACAGGACAGGAGCAGGGCTTGTGAGCACAGGCGGGCCT GGGAAGTCAGGGAAGGTGGGAGATCAGTGAGAGGAGAGTTCCAGGTGGGGCACTCGCCCATGCAAAGGCC CTGAGGTGGAACCATGTCTAGGATTTGAGGAACAGCAGGGGGACCTGTGTGGCCAGGGCACAGTGAGTAC AGGGGTGCTTGGGAGAAGAGGAGGGCAGCATGGTGATGGGCGCATCCTGTGGGGACTCTCAGGCCACGAG GAGGCATTTTGGGGGCCAGCAAAGGGTTTAAGGCTGTGAACTCTGGAGTGGGCAGGACTCTGGAATGGGC AGGACTCTGGCTTCCAGGCCCAGCTCTGCTCGGTGAGCTTAGTGAGAGATTTTACCTTTGTGAGTCTCTG TTTCCACAGCTGCAAAATGGGGCTCAGAATGGCCACTCCACCGTGGTTGAGGGCGCCTGCGAGCTCAGCG TCAGCGTCTGCTCTGGGCCATGGGTCCCTTGTGGTGGTGGCGATGGTGGTGGGAGTACCGAGCTGAGCCT CAGGCCACATTTGGTGGGAGGGGTTGGTTTTAAGCATCTTTCCTGCTGCACAGGCCCATGGGAAAGGCTG GTGTACAGCCATTGGGGAGGTGGGGGCCCCGGGGCCCACTTTGTGCTTCCTCCCACTACCCGTGGGGTCC AGGACAGGTCACACAGGAGGGAGGGACCCTCACTCAGCAGAGACTAGGCAGGAGAGGAAAGGCAAGGTCT GGGTGTAGACAGAAAGAATGGGAACGGAGGGAGAGGGGAGGCCAGGACCAGCCTTGAGAGGATGATGATG ATGATGATAATAATAATAATAATAATAATAAGGCCGGGCGCGGTGGCTCACGCCTGTAATCCCAGCATTT TGGAAGGCCGAGGCAGGTGGATCATGAGGTCAGGAGATCGAGACCATCCTGCCTAACACAGTGAAACCCC ATCTCTACTAAAAATACAAAAAAAAAAAAAAAAAAATTAGCCGGGCATGGTGGTGGGCACCTATAGTCCC AGCTACTGGGGAGGCTGAGGCAGGAGAATGGCGCAAACCCGGGAGGCGGAGGTTGCAGTGAGCTGAGATT GCACCACTGCACTCCAGCCTGGGCGACAGAGCAAGACTCCCTCTCAAAATAAATAAATAAATAAATAAAT AAATAAATAAATAAAATAATAATAGACAAAACCAACAGTGTCACCTCAGCCCTCCAGGGCAGCAGGACAG GCAGGTAAGAGCCCAGCCTTCAGTGCCTTCCATACACAACCGCCCAGGTTCAAATCCTGGCTGCTTCTCA TGTCTGCCTCTCACTGGCTGCTTCTCCTGTCCATGCCCTGGACAAGGGCCTTCCCTTCTCTGGGCCTCAG TTTTCCCATTCATGAATTGGGATGAGGATGCTTGTGAGGATGGAACGGGATTAGACGCACAGCAGGGCCG GAACCCGCGAATCTCTGCAGACAGGCCTGGAGTCTGGTGTCCACTCTGCCACCCTAGCTGGGCCACCTGG GTTAATGAGGTCCCCCTCTGTGCCTTGTTTTCCCTGTCTGTAATCCGGGGCTTATTAATGGCCCCTCCCT CCAGGATCATATGTGGGACTCCGGGTAAAGTGCCTGGAAGAGGGCTGGTATACAGTAGGTACTCAGTAAG TGCTGGCTGCTATTGGAATGGTGACCGGCACTTACTGAGCACTTACTGTGTGTGTGATTTGCCTTGGTTC TGATCCCAACCACTGTCTCTGGGCCAGGCCCTCCGTGCCCTCTGTTCTGCGTAATTCCTTATAAAAACTC CAGGAAGGCCAGGCGCAGGGCTCACGCCTGTAATCCTAACACTTTGGGAAGCCAAGGCAGATCACTAGAG GTCAGACCAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCTGGGCGTGGT GGCAGGCGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATTGCTTGAAGCCGGGAGGCGGAG GTTGCAGTGAGCCAAGATCGCACCACTGCACTCCAGCCTGGGCGACAGAGCAAGACTCCGTTTAAAATAA ATAAATAAATACTCCACGAAGCAGCTACTATTATCGCCGTCTTTGAACAGAGGAGGAAACTGAGGCACAG CGTGGCTGAGTTGCTCACCCAGGGCCACATATTGAGGTCCCCAGGTTGGGTTAGAGCTCCAGTTCACAGA CACAGAAAGTGAGGTCATATAGGGCCAGTCGTGGCAGCCCTGCTGGGGTTTGGAGCCCTAGGCAGCCTGA CTGCCAAGCTTGGAGCTGGCCTGGGAGCCCAGCCCCCACCCTTCCCTCCCTGCACCTGGGCAAGCCCAGC CTTTCTGCCTAGCTCTTCTCCCTCTTCCCAGGCCTGGCACGGCCTCTGTGGCCCCCATGAGGTCAGGAGC ATCTGTTGGGAAGGGAGCGCCTGCTGGGGAAGCCGGCAGGGCTTGGAGCTGCACAGGACGGCCCAGGGTG GGGTCCCTGCCTGGTCATTATAAACATGTTCAGTTCCTCTGTTTGTCCTGCCCTCTGTGCAGTGCCCAGA GGGAAGGGGTGGCCCCAGGCAAATATCCGGAGGCGTGCCCCTTGCCCCCTTCCCTTGGGGGTTTATGGGT GGGAGGGCAGGAGGCCAGGCGTCGGAGGACATCCCCCAGACCCCATGCTGCCAGCTGGGCCAGCCGCCCG CCCTCCAGGCTGCTCTTGCCCCGTCCCCAGGTGTCCCCCACCTCAGGGTCTGCCCCGCTGTCCGCCCTCC GGGCTTAGTGAGGGGTCACATGGCTGATCCTCTTCCCGTGGCTCTGGGAACTGCCTAGTGCCCCGCAGTG GGGAGGGAGCGGGATGGGGCGGGGCGACAGGTTCACGATGAAGAGGCCTGGGCTGGGCATGGGGCCAAAG GGGGTGGAGGGACATCTGGGAGGACGGAGAGGCCGGAGGACATGGGACGCAGATCTGGAATGACAGCAGG CAGAGTGGGCAAATGGGGACTGTTGGGGTATGTGGATGACCCTGGGAGCTGGGCCTAGAAAGCCATGAGA GAGTAGGTCAGGGCCACCAGGGGTGGGCTGGGCTGGAAGGCCACGAGGGAGGGGTGGGCAGCACTCAGGG CGCCAGCATTGGGCTCAGAGAAGGGGCTGGGCAGAGACAAAGGAGGCCCCCCGTCCGCCCTCCATCCTGG GCCCCAGGGCAAGCAGGGAAACTGGGCCAACCCTGGGAGCCTTGGCCAGGCCCGGCTCTGACCACCCGCT GGCCTCTTGGGACCAGCTGAGACAGGTTGGCTGCCGGGCCCCCACCCCCCTCCCACGGGGCTCCCGCTGC CAAACCGGTTCCCCTGGCTGGCTCCCATGGATGGTCCTAGCTCTGGGCAGGGCCTCACCTTTCCCAGCTG CTCCCAGGAAGGCAGCCTGAGCCGGGAGGAGAAGTAGGTGTGGAGGGGCTACGTGCATCTGCGCGTCCTC TGTCCTCTCACTAGGGCTACAGGACTTGCTGTGCCACGCGCTGTGCCAGGCGCGGGGGAGCCAGCTGGGA CAAGACAGAACAGAAACTCCACCTGCATGTCCCCTCGTCCCCTGGTCTCAACTCTTCCCCTCTTCCTGGA AGCCTTCCTGCTGCCCACCCCGCGTCCCTCCAGACTGGGTCCCGTGCTCCCGTCCCCCAGCCCTGACCAC CCTGGGCAGCTGCTGCATGGGGACAGGTCTGTCTGCCCCACACGAATTTCCCATGAGGTCAAAGGCTGTC TGGGTCACTGCAGTGGCCACAGAGGAGGCCCATTGCTGAGTTATTCCCAAATGAATGAATGAATGAGTGA GTGAATGGATGCATTCCTCTCATTTTACAGATGAGTAACCCGAAGCCCCTAGAGGAGTGGTCACCTGCCT GAGGGCACTTCTGTCCCACCAGCATCAGACCAGGTGTGTGCAGGTGTGTGCGACTCCAGGGCCCAGGCCC GGGGCAGCTGGGGTGGGGCCTTAGGGGGGAGCAGGACCTGGGCCCCTCCTCCCACAGGCACTGTGGGAGC CGCCCCAGCCATCACAGTGGTCCCCACCGATAGGCCCCCCATATTTGCCCAGCCCTGCACCAAGCTCTTT GCTCCCAGTCACCCATTACCCCTCGCAGCAGCCCTGTGGGGGTTCATCCACAGCACAGAGAGGTTGTCAC CTGCCCAAGGTCACGGCAGCATGTGATGGAGAGTCGAACTCTGGCCTCTTGGCTCCCCCTCCCATCTTTC TCCAGGCTCTCTATGGGATGCCGCCATCAGAATGTCTCTTCCTCAGCCCCTTTGTTTTTTAAAGTGGCTT TGGTCGACCATTTGCTCTGTGCTTGGTACTGTGTCAAGGGCCCGATTGAAGACCACAGATCCTAAAGATA GGGGAGTGTCGCGACAAGGCTGCCTGGGGTGCCCTCTTAACCCAGGGGATCAGTAACCCTGTGCTGAGTC AATATCCAAAGGTGTGGGCGTCCCCAGCCCAGACTCATGGCTGGACCAGTGGCAGTGGCCAGGCCATCAG TGACCGTCCATCCAGTACACACCATGTACCAGGCATAGCAGGGGATGTGGGGAAGCGGGGCAGACGAGAC CCAGCCAGAATGTGGCACTGACACTCTAGCGGTGCGGTGTGGATGCTGCACTCATGAACCTAAGAAGGAA CAACAAACAGGATTTCCATGAGTTCCGGGCTGTGACTGTGATGTAGAGCGGGGGGACGGCGGGACACGGG GCTCTTTGCCTTGGGGTGGTCAGGAAAGGAGTCACTGCTGCTCTGAGAACTGAAGGAGGGGACGGGGAGC CCTGTGCAGACACTGGGAAGTGAGCTCCTGGCAGAGGGGCCAGCCCGTGCAAAGGCTCTGAGGTCTCCAG GGGGGGTGAGAACAGAGAGGTGATGGGGCCTTGTGGGCCCGCAGGAGACAGAGCGGCAGGAAAGTTCTGA GCAGAGGGACGTGACCGCTCGGGTGCTCACGGGTACCCTCTGGCTGTGTGTGCCACACAGATGGGCGCAG GGGGTGGGCAGGGAGACCCAGAAGGAGGCTACTGCCTCCTGTTGGTCCCGGTGTAAGATGAGGATGGGAG GGACAGAGCAGGGGCAGAGGAGGAAGAGACATGGGCAGGCTCTCACTCACCCACCGTGATTCCCTCCCGC AGGCCGCACCGAGTCCCCGGCACCATGTTTGGGAAGAGGAAGAAGCGGGTGGAGATCTCCGCGCCGTCCA ACTTCGAGCACCGCGTGCACACGGGCTTCGACCAGCACGAGCAGAAGTTCACGGGGCTGCCCCGCCAGTG GCAGAGCCTGATCGAGGAGTCGGCTCGCCGGCCCAAGCCCCTCGTCGACCCCGCCTGCATCACCTCCATC CAGCCCGGGGCCCCCAAGGTATGTGGCACCCACCACCACCTCCCCCAGCCCACCCCAACCCCCGAGTGGC CCTGGCCCTCAACCCCACACTCGACCCTGTGACCGACACCTCCTCACTGACATGGAAATGGAGACAAACC CCAGCCTTCCACCCCTATCCTGGGTCCAGTGCTGGCCTTTCACCCTCCACCCACTGGCTCCAAGTCCTAA GAACCCATGCCACCCCAACCTGAGCCTCCCCCACGGCCCATCTGACAGCCCCCACACCAGCCTCCAAGCT CTGCTGTCTCCCGCAGACTCATGTCCCGGGGGCCATGCTGCTGTACCCCGGACCACACTCCTGTCTCACC CAACCTTGAGCCTTTCCAGAGCTCCTGGCAGTGGAAGACAGACCCATTCCCAGAGGGTGACAGCCCCAAG TGGTCAGGGCTTGGGTGGGGGAGCCCGGAGGAGGCACCTGACACAGACCAGGGGTCCAGGCAAGCTTCTG GGAGGAGGGGACACCGAGGCAGAGCCCAGGGCTGAGGAGGAGGAGGAGAAATTCCAGCAGATGCTGGGGA AGCCGGGCTTTAGTGGAGAAAATCACTCCTGTGAAACGCTGGGGGCTTTTTGGTTTTGGGTTTTTTTTTT TCTTCCTGCCATCTAGAGCAAAATGGCAAGGTTGGGATTTGAACCAATGTCTGTTTCCAAGGCCCGTGCT CTTAACCCCTCTGCTGCCTCCATGTGAAATCATAAGAGTTGTGGAGCCGGTGTCTGGGTGTGGCCTGGCA TGAGGCTGGCCTGGCCTGAGCCCGTGCTGGGCCTCTGAAGCCAGCCTTGGAGCCTGGACTCTCTCCCATG GTCAGTGGGGACCAGGAGGGGCCGCAGGCCAAGGGGAACTCGGCCAGGTTTGCATCCAGCGGGTGGAGAT GGGTGTGCCTGGGGACTCACCCTCCCGGTGCCCAGCCCAGCCTGGCGGGGAGAAGCCCCAAGGCCCACAA GTTGGCCATAGACACAAGTGCAGCCTCAATGTGGTAGCCCACTGAGGGGTCCGTGTGGTCCTTGCAGGGT GCTTTTGAATGCTTTGACTTCTTTGCCTCCACTGAGAAAGTGACAGACTTCACTTCCAAAGCCGTTTCTG GCATCTGGTGACAGACCAGCTGGAGGCGAGTGGCAGCTGCCTCCACGGGCAGGGCACTGGCTCTTCTGGG CCACAGGCCGCACCCGACCCACCTCAGCTCCACGCCCTGCCTGGCTCTGTGGCCACTTGCATGTAGGCTT TGCCCCCACCAAGGTGTCTCCAAAAACCCAGCCCCTGCCTGGCTTGCCAGATGTGAGGCCTGCCTGTGAC TGTCCCAGCAGGAGGCAGGGCACTTGAATTCACACATGGGGCCTTGTGGCCAGCACTGTCCTGGGGCCCC ATAGGCACTTGTGTTTGCTGCCCTTGACCGGGCCTCAGGCCTCCCAGGACCTTCTCGACTCCCTGTTGGT TTTTTTTTTTTTTTTTTTGAGAGACATTCCTGCTCTGTCTCCCTGGCTGGAGTGCAGTGGCGCCACCTCG GCTCATGCAACCTTCGCCTCCTGGGTTCAAGCGATTTTCCTGCCTCAGCCTCCCGCGTAGCTGGGATTAC AGGCGCCCACCACTATGCCCATCTAATTTTTGTATTTTTAGTAGAGACGGGTTTTCGCCATTTTGGCCAG GCTGGTCTCAAACTCCTGACCTCAGGTGATCCTCAGCCTCCCGAGGTGCTGGGATTATAGGCGTGAGCCA CTGCTTCTTGCCTCAACGCCCTGTTCTAACAGCAAAGTCTGGCCTTGTGTCCACCTTGACTTCCTGGGGC CCCTGGGCAAGGCCCGGCTTCAGGCAGACAGCCACGGCCAGGAGAGACAGGGCAGCGGCAGACCACGGAT TTTGTGGGATCAGTGTTTTCTACACGTTACAGGCAGGCCTCTGGCTGGAGGATGCCTGGCAGCCCCAGGC AGGGTCCGGGTTTCGTGGGATCAGTGTTTTCCACACATTAGAGGCAGGCCTCCGGCTGGAGGACATCTGG CAGCCCCGGGCAGGGTCCTTGTCAGCAGGGCCCACGTTCTCAGCTCACTGTGGCCTTTGCACAGACACCT CACTCACTACGTGGTTTAGCAAAAGTTCACTGAGCCCCTGCTGTGCGCCAGATGCTGGTCTAGGTGCTGA GATGGAGCAGGACCCGAAGCAGACAGGAAAAAACAATCCCTGCCCAGAGCATGCACTAGGCAGAGCCGGG AGCAGACAGATGCCTGTGTGCTCTGTATCAGCTGCTGTTAGGTGCTCTAGGTAGAATGCAGGCAGGGCAG GGGCCGGGGAGGGCAGGGGCTGGCATTTTAGATGATGGGAGGCCAGCAGAAGCCTCACTGAGAAGCTGAG TTTTGAGCAAAGACCTGAAGGAGTGGAGGGAGGGAGCCACAGGGACCCTGAGAGCTGATGTTCCAGGCAG AGGGAGCCGCCAGCGGAGAGGCCCTGGGCGCAGGGGGGCGGGGGTGGGGGAGACACCCGTGTGTCTGGAA ATGGAACGGGGGCAGAGGGGGCCTGCAGGACACGACTCAGACCACAGAGGGTGGGGACCGGGTGACTCGG GATGCACTGGATGCTCTGCCTGGTCCCCATCTGCATTTGCATTTGCCACCCGGCTCCTGGGACCCCCTTG CCCTCTACTTTGGGACCAGGCCTTTCTGACTCTCCCTGTCCCCCACTCCTTGTTGTTCATGGGAGCAGAG AGTGTGGTTTTGGGGCTAAGGAACACTGGCGCCCACATGGGAGGAAGTGCCAGGCCAGGCCCTGGCCCCA GCGCCCTGTCATTTGCAGCCCTCGGGGCTGATTATGGGGTGGGTCAATTTCTGCCCTTCCTCCCCCAAAC CCCTCAGGGCAGGACTATTCCACCAGTGTGAGGAACAGGAGAAAAACAAGGGGGGCCTCTCCAGGGTCCC ACCGAGCCCAGGGGGCAGCAGCCTGGCCATGGCGATCACTCCTCTGGCCCCTGCAGCTGTGTCCCCAGGG AGGGGAGGGGCTGCACTGCCCATGCCATTGTCACTCCATGGCATCTCTTCATTGCGTCTCTGTCTTGTCT CTGTGTGTGTCGTGCTGTCCTGTCCCTGCGTGTCGGATGCACGTCCTGTGTGCCCCACTCCTTGCTGGGC CCCCACCCACCATTGCCTGGGACCCCAGACCATCGTGCGGGGCAGCAAAGGTGCCAAAGATGGGGCCCTC ACGCTGCTGCTGGACGAGTTTGAGAACATGTCGGTGACACGCTCCAACTCCCTGCGGAGAGACAGCCCGC CGCCGCCCGCCCGTGCCCGCCAGGAAAATGGGATGCCAGAGGAGCCGGCCACCACGGCCAGAGGGGGCCC AGGGAAGGCAGGCAGCCGAGGCCGGTTCGCCGGTCACAGCGAGGCGGGTGGCGGCAGTGGTGACAGGCGA CGGGCGGGGCCAGAGAAGAGGCCCAAGTCTTCCAGGGAGGGCTCAGGGGGTCCCCAGGAGTCCTCCCGGG ACAAACGCCCCCTCTCCGGGCCTGATGTCGGCACCCCCCAGCCTGCTGGTCTGGCCAGTGGGGCGAAACT GGCAGCTGGCCGGCCCTTTAACACCTACCCGAGGGCTGACACGGACCACCCATCCCGGGGTGCCCAGGTA ACCCATCCCCCGCCCCAGGGCCCCCACTGTCCCCTGCCCGTTGCTCCTCTGTCCCCACCTTCCAGCCCCG CCCCACCACCGTGCATCTCATCCTGACCACCCATGTGTCTGTCCCATCGCTGGGTCTCTCTCCTGCTTAG GGAGCAGAGCTGCTCCCTGGCACCCATCACTGACAGCTACCTCTCTTCTGTTTCAGGGGGAGCCTCATGA CGTGGCCCCTAACGGGCCATCAGCGGGGGGCCTGGCCATCCCCCAGTCCTCCTCCTCCTCCTCCCGGCCT CCCACCCGAGCCCGAGGTGCCCCCAGCCCTGGAGTGCTGGGACCCCACGCCTCAGAGCCCCAGCTGGCCC CTCCAGCCTGCACCCCCGCCGCCCCTGCTGTTCCTGGGCCCCCTGGCCCCCGCTCACCACAGCGGGAGCC ACAGCGAGTATCCCATGAGCAGTTCCGGGCTGCCCTGCAGCTGGTGGTGGACCCAGGCGACCCCCGCTCC TACCTGGACAACTTCATCAAGATTGGCGAGGGCTCCACGGGCATCGTGTGCATCGCCACCGTGCGCAGCT CGGGCAAGCTGGTGGCCGTCAAGAAGATGGACCTGCGCAAGCAGCAGAGGCGCGAGCTGCTCTTCAACGA GGTGCGGGCGCTGCTGCCCTGCCGCCCTGCTGGTCCTCCCACCCCTCCCTCCCACCCTCCCTCCCCTCCT CCCTCCTCTCCCTGCACTCCTCCGTGCTGGGCCAGGCTCCCCTCCTCCCCTCACTCTTCTCCCTCCCCAG GCCGTCTCGTCCGCCCCAGCTGGGTCCCTGCCTCTGTCCTCACAGCACCCTCACCCACATCTCTGTCCCT GAGCCCCAGACCCAGGGTTCCTCGGGCCACTGACCCCCGACCCAGTGTCTTCCAGGCCCCTCGCACCCAC TGAGGCCCGCCTGGGCTCCAGGGTACAGTGTCCTCCAGACCTGCCCCTCCTGGGTTCCCTGTGCCCCGCC CTGGCCTCCACTCCTGGGTGTCCCTCGGCACAGCCCACACAACCACCAAGAGTATGTTTCTGACGTTCAG GCCCACCCCCTCCCCGTCCCTCCTTAGAGACCCTGGCAGTGCCCCGTAGCACCCTGACGATAGGAAGCCC AGGTCCCTTTGCCGGGTGTGTGAGGCCCCTCTCGACCCCGTTGCCCATCACAGTGCCGGGCTGCACCATG GAGCTCCTCGCCTGGGTTCCTCATCCTCCCGCCGACACACGCCTCTTCTCTCATCCTTGCCCTTGTCCGG GTCTCAGCCCTGTGATTGAACGCTCTCTTCCCACCTGCCCCCCAGCACTAGCCCAGGACTGACCTGAGAT GGGCGTGTGCCCAGGGGGGCGCGCCCCCAGAAGGGAGGCGTGGGCTTCAAGCTGGCTCTGAGGCCCACGT GGCTGTGGCAGTAGGGGAGGGCAGTCCAGGTGGCCCCAGTGAGCACAAGCTTAATGTGGAACTGCAGGGG GAGCCAGGGGGGTGGCGGTGGCTGGGTCTGGCACTGGCAGCCCTCCCGCCTCCCTCCACCACTGACCCAG CCCCTGCACAGGTGGTAATCATGAGGGACTACCAGCACGAGAATGTGGTGGAGATGTACAACAGCTACCT GGTGGGGGACGAGCTCTGGGTGGTCATGGAGTTCCTGGAAGGAGGCGCCCTCACCGACATCGTCACCCAC ACCAGGTATTTCTGGGGCCTCAGACCCCTCCTGTGACACGACCAAGTCCCCTCCAGACCACTAGGGGTGG GGCCACATCTCCAAACCAGCTGTGCTCCGGGCCCCTGGGATGGGGTCGTGTCTTCCATTCCTCCCACTCC AGAGTGGGGTCGAGTGGTCTCAGATTCCTCCCACTGCAAGGCAGGGCTGCGTCCCCCTCGGCACCCCGGG GTGCTGTCCAGCTGGCTGCTCACCCCCCACCCCACCCCGCAGGATGAACGAGGAGCAGATCGCGGCCGTG TGCCTTGCAGTGCTGCAGGCCCTGTCGGTGCTCCACGCCCAGGGCGTCATCCACCGGGACATCAAGAGCG ACTCGATCCTGCTGACCCATGATGGCAGGGTGAGGGGACGGGCGGCGGGGTACGGGGGCGGCAGGTTTCC GGCTGCGGGGCTTCCCTGCCTCTTCCCATCCCCTGTGAGGGTAGGTGAGCTCTGACCCCCAGGTCTGTGT CTTGAGGAGCTGGGAACTTCGTCCCTCCCTGGTGGAGCAGCCCAGAGTCAGGTTCCAGCTCAGTGGGGAC TCTGTGCAGTGGGAGGGCACAGGCTGGCGGGGGCTCTGCCATCAGCACAGGACACTGGGCCCAGGGGCAG GGATCTGGGCAGACAGCGCAGCCCCCGCCACAGGCTTCTTCCTCCACTGAAAAGCTGCTCCCTGCCCAGC ACCCAGGGCGGTCCATGGACCCCAGTCCTGTCTTCCATGCTTTGGACTGAGGTTCCAAATCTGAGGCTGT GACAATTATAACGTCGGGTGGACATGATTTTCTGTGAGAGAGGGCCCTTGACTTGAATGAAATGCTTGCA GAAGTGGATGACTCCATCCCCTCCCCCAAGGAAGATTAAGCCACACCATTAGTCCAGGCAGAGGCAGAGA GAGCTCTGTGTCACTGACAGTCTGAAAATCTCCAGATGTCTATAGATGTGTTTTGGGGGCGATGTCTATG GGCCACCTGAGATTGTCCACACACGGTTGTGGGGATGTTTGCTGGAGGCAGGAAGACCCATAGAAATCCT CAAAAATCGGAAAGGGACCCACAGTTCCTAAGAAGGTGTGAGAGGCCTGGTTGTCGCAAAGGCAGGCTGT GTCCCCTCACGGCCCTAGTGCAGGGCTACTTTCTGCTCCAACCGAACTAAAGACTTGTTCCAGGGCAGCA GGGCCCCAGGGCACAGGCTTTTGGGGCCACCCCTGTTCCCAGCTCCGGCCCTGCCTTTGCTATCTGCAGT ACTCAGGCCAGTGTCCCCAAAAGCCCCAGAGGCTGTCAGGGAGGGAAATGGGGGGATCGTGGGGGAGGTG ACTTGCCCGAGGGCCCCCACCAGGAGGTGGTGGAGCTCCCCATTGGTCTGGCTCTAGACCCCAGCTCTGA CCCTAGACCCCAGCTCTGACCTCTGGGCCGCACATTGTGTCTGAAGCCAAGGAATGACGCAGGCAGACGC CCCTGCTCGCCCTCCTGCTGTGCCAGCTCCTCTGACCCCACTGCCTCTGCCCTGTCCCAGGTGAAGCTGT CAGACTTTGGGTTCTGCGCCCAGGTGAGCAAGGAAGTGCCCCGAAGGAAGTCGCTGGTCGGCACGCCCTA CTGGATGGCCCCAGAGCTCATCTCCCGCCTTCCCTACGGGCCAGAGGTGAGCCCCGGGGTGGCTTGGTTG TCCCGCCGTGGACAGCGTACGCTGCCATTTTCCAGCTGCAGCGCTGGCGGGAGATGGGGCCCAGTCTGGG GAGTCATTGCCAGGAATGGTGCTCTGGACAAGGAGGTACTGCAGGCATGCATGTATTCATTCTTCTTTTT TTTTTTTGAGATGGAGTCTCGCTCTGTTGCCCAGGCTGGAGTGCAGTGGTGCAATCTCAGCTCACTGCAA CCTCCACCTCCCGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCGAGAAGCTGGTTTTACAGGCACCCGC CACCATGCCTGGCTAATTTTTGTATTAGTAGAGATGGGGGTTTCACCATGTTGGCCAGGTTGGTCTTGAA CTCCTGACCTCAGGTGATCTATCCGCCTTGGCCTCCTAAAGTGCTGGGATTACAGATGTGAGCCACCGCG CCCAGCCTTGGCTCTGCCTTCTGAGCATTGTTTTCACAGGCCGGCTTTCCCCTTGTGGGAGCAGAGCTGG TCCCGGCAGCTCTGGGAAGTGTCTCCCACCTATGGGCTCCTCTTTTTCCCTGGGTGTTTTGGGTAAAGTC CCCAGGTTGGCTCTGATTGGCTCAGCCTGGGTCCTGTGCCTGTTTCTGAACCAATCACTGTGTCTCCACT GTGGTGATGAGGCCGCATGGGTCCTGAACCCACCAGTGGATGCTACCTGGGCTGAGGGAGGGAGGACACC TGGGGGCAGTTGACAGAAAGAAGAGGGGTGGGTGCTGGGGGGGCAGCTCTCTTGAGGGGCTCCCTGGAGG ACTAGTGCTCTGTGGACTGCTGGCTGGGTGCCCAAGAGGGAGTTCTGGGCCAAGGACTCCAGGAGCCAGA GGCAGAGACAGCGCTGGAGCGGTCCCTGCCTGAGGCCTCCCCAGGACCCACCATCCCCCAACAGCTCAGC CCTGCTGTCCCTTCTCCCGCCCCAGGTAGACATCTGGTCGCTGGGGATAATGGTGATTGAGATGGTGGAC GGAGAGCCCCCCTACTTCAACGAGCCACCCCTCAAAGCCATGAAGATGATTCGGGACAACCTGCCACCCC GACTGAAGAACCTGCACAAGGTAGGCCCCTCCCTGGCTGGGAAACTGTGCGCCAGCTGGCGGGTGGCAGG GCTCCAGGTGGAGCATGGGGTGTGGATGGGATGGGGACAATGATGGCGCCTGGGATGGCGCTTACTGTGT GCTGGGCCCCCCACCCCCGGGCCTCATGTGTCTGTGCAGACCCCCTCTGTGGGGCCTGGGCGACAGAGGC AGCAGAGCCACAGGCCCTCTGCACCCTCACCATTGCCCTGGGCCCCACCCAGCCCTAGAGAGATTTGCAC GTTTAGAAGTGGAGGACAGGGCCGGGACCTTCCTAGTGGAGGACTTGCCAGGAGGGAAAGGGGCACCTCT GGGCCCCAGTTGCTTTCAGCTTCTTGCTAAACCATGGAAATAGGGAGTACATGAGCCCCCAGGGTTTGTC ACTTCCTCTGGGGCCACATAGTAAGCGCCATCACAGGTGCCATCACTGTCCCTGTCCCGTCTACACCCCA AGATCTAGACACCCATGACCTCCGCCCCCTGCCCTCCTGCACAGTACATGCCGCCAGCCGACTTGGCAGA GGCGGACACTGCAGCCCTACAGCAAATGAACAGTGGGGAGCCTCGCCCCCTGACCCTCCCCTCCTTCTCG ACAGGTGTCGCCATCCCTGAAGGGCTTCCTGGACCGCCTGCTGGTGCGAGACCCTGCCCAGCGGGCCACG GCAGCCGAGCTGCTGAAGCACCCATTCCTGGCCAAGGCAGGGCCGCCTGCCAGCATCGTGCCCCTCATGC GCCAGAACCGCACCAGATGAGGCCCAGCGCCCTTCCCCTCAACCAAAGAGCCCCCCGGGTCACCCCCGCC CCACTGAGGCCAGTAGGGGGCCAGGCCTCCCACTCCTCCCAGCCCGGGAGATGCTCCGCGTGGCACCACC CTCCTTGCTGGGGGTAGATGAGACCCTACTACTGAACTCCAGTTTTGATCTCGTGACTTTTAGAAAAACA CAGGGACTCGTGGGAGCAAGCGAGGCTCCCAGGACCCCCACCCTCTGGGACAGGCCCTCCCCCATGTTCT TCTGTCTCCAGGAAGGGCAGCGGCCCTCCCATCACTGGAAGTCTGCAGTGGGGGTCGCTGGGGGTGGAGA GAACACTAAGAGGTGAACATGTATGAGTGTGTGCACGCGTGTGAGTGTGCATGTGTGTGTGTGCAAAGGT CCAGCCACCCCGTCCTCCAGCCTGCAAGGGGTGTCTGGCGCCTTGCCTGACACCCAGCCCCCTCTCCCCC TGAGCCATTGTGGGGGTCGATCATGAATGTCCGAAGAGTGGCCTTTTCCCGTAGCCCTGCGCCCCCTTTC TGTGGCTGGATGGGGAGACAGGTCAGGGCCCCCCACCCTCTCCAGCCCCTGCAGCAAATGACTACTGCAC CTGGACAGCCTCCTCTTTTCTAGAAGTCTATTTATATTGTCATTTTATAACACTCTAGCCCCTGCCCTTA TTGGGGGACAGATGGTCCCTGTCCTGCGGGGTGGCCCTGGCAGAACCACTGCCTGAAGAACCAGGTTCCT GCCCGGTCAGCGCAGCCCCAGCCCGCCCACCCCTGCCTCGAGTTAGTTTTACAATTAAAACATTGTCTTG TTTTGTG Download Select all
Length	53630
OMIM ID	605451
HGNC ID	HGNC:16059
Unigene ID	Hs.20447
Ensembl ID	ENSG00000130669
PharmGKB ID	PA32920

mRNA Information

mRNA ID	?NM_001014831.2
Exon
mRNA Sequence	>gi\|126273531\|ref\|NM_001014831.2\| Homo sapiens p21 protein (Cdc42/Rac)-activated kinase 4 (PAK4), transcript variant 2, mRNA AGCCCCGGATGTTCGTTGGGGATTCAACATGGCGGCGGGAGTGTCCGCGGTGGTGGCGGTGCAAGAGAGC TGAGGGAGGCGCGAGGGCGCGGAGTTCCAGGTCGAGCAGTTAGGCCGCGAGCGACTGCGGCGCCGAGCCG ATGAGTAACCCGAAGCCCCTAGAGGAGTGGTCACCTGCCTGAGGGCACTTCTGTCCCACCAGCATCAGAC CAGGTGTGTGCAGGCTCTCTATGGGATGCCGCCATCAGAATGTCTCTTCCTCAGCCCCTTTGTTTTTTAA AGTGGCTTTGGTCGACCATTTGCTCTGTGCTTGGTACTGTGTCAAGGGCCCGATTGAAGACCACAGATCC TAAAGATAGGGGAGTGTCGCGACAAGGCTGCCTGGGGTGCCCTCTTAACCCAGGGGATCAGTAACCCTGT GCTGAGTCAATATCCAAAGGCCGCACCGAGTCCCCGGCACCATGTTTGGGAAGAGGAAGAAGCGGGTGGA GATCTCCGCGCCGTCCAACTTCGAGCACCGCGTGCACACGGGCTTCGACCAGCACGAGCAGAAGTTCACG GGGCTGCCCCGCCAGTGGCAGAGCCTGATCGAGGAGTCGGCTCGCCGGCCCAAGCCCCTCGTCGACCCCG CCTGCATCACCTCCATCCAGCCCGGGGCCCCCAAGACCATCGTGCGGGGCAGCAAAGGTGCCAAAGATGG GGCCCTCACGCTGCTGCTGGACGAGTTTGAGAACATGTCGGTGACACGCTCCAACTCCCTGCGGAGAGAC AGCCCGCCGCCGCCCGCCCGTGCCCGCCAGGAAAATGGGATGCCAGAGGAGCCGGCCACCACGGCCAGAG GGGGCCCAGGGAAGGCAGGCAGCCGAGGCCGGTTCGCCGGTCACAGCGAGGCGGGTGGCGGCAGTGGTGA CAGGCGACGGGCGGGGCCAGAGAAGAGGCCCAAGTCTTCCAGGGAGGGCTCAGGGGGTCCCCAGGAGTCC TCCCGGGACAAACGCCCCCTCTCCGGGCCTGATGTCGGCACCCCCCAGCCTGCTGGTCTGGCCAGTGGGG CGAAACTGGCAGCTGGCCGGCCCTTTAACACCTACCCGAGGGCTGACACGGACCACCCATCCCGGGGTGC CCAGGGGGAGCCTCATGACGTGGCCCCTAACGGGCCATCAGCGGGGGGCCTGGCCATCCCCCAGTCCTCC TCCTCCTCCTCCCGGCCTCCCACCCGAGCCCGAGGTGCCCCCAGCCCTGGAGTGCTGGGACCCCACGCCT CAGAGCCCCAGCTGGCCCCTCCAGCCTGCACCCCCGCCGCCCCTGCTGTTCCTGGGCCCCCTGGCCCCCG CTCACCACAGCGGGAGCCACAGCGAGTATCCCATGAGCAGTTCCGGGCTGCCCTGCAGCTGGTGGTGGAC CCAGGCGACCCCCGCTCCTACCTGGACAACTTCATCAAGATTGGCGAGGGCTCCACGGGCATCGTGTGCA TCGCCACCGTGCGCAGCTCGGGCAAGCTGGTGGCCGTCAAGAAGATGGACCTGCGCAAGCAGCAGAGGCG CGAGCTGCTCTTCAACGAGGTGGTAATCATGAGGGACTACCAGCACGAGAATGTGGTGGAGATGTACAAC AGCTACCTGGTGGGGGACGAGCTCTGGGTGGTCATGGAGTTCCTGGAAGGAGGCGCCCTCACCGACATCG TCACCCACACCAGGATGAACGAGGAGCAGATCGCGGCCGTGTGCCTTGCAGTGCTGCAGGCCCTGTCGGT GCTCCACGCCCAGGGCGTCATCCACCGGGACATCAAGAGCGACTCGATCCTGCTGACCCATGATGGCAGG GTGAAGCTGTCAGACTTTGGGTTCTGCGCCCAGGTGAGCAAGGAAGTGCCCCGAAGGAAGTCGCTGGTCG GCACGCCCTACTGGATGGCCCCAGAGCTCATCTCCCGCCTTCCCTACGGGCCAGAGGTAGACATCTGGTC GCTGGGGATAATGGTGATTGAGATGGTGGACGGAGAGCCCCCCTACTTCAACGAGCCACCCCTCAAAGCC ATGAAGATGATTCGGGACAACCTGCCACCCCGACTGAAGAACCTGCACAAGGTGTCGCCATCCCTGAAGG GCTTCCTGGACCGCCTGCTGGTGCGAGACCCTGCCCAGCGGGCCACGGCAGCCGAGCTGCTGAAGCACCC ATTCCTGGCCAAGGCAGGGCCGCCTGCCAGCATCGTGCCCCTCATGCGCCAGAACCGCACCAGATGAGGC CCAGCGCCCTTCCCCTCAACCAAAGAGCCCCCCGGGTCACCCCCGCCCCACTGAGGCCAGTAGGGGGCCA GGCCTCCCACTCCTCCCAGCCCGGGAGATGCTCCGCGTGGCACCACCCTCCTTGCTGGGGGTAGATGAGA CCCTACTACTGAACTCCAGTTTTGATCTCGTGACTTTTAGAAAAACACAGGGACTCGTGGGAGCAAGCGA GGCTCCCAGGACCCCCACCCTCTGGGACAGGCCCTCCCCCATGTTCTTCTGTCTCCAGGAAGGGCAGCGG CCCTCCCATCACTGGAAGTCTGCAGTGGGGGTCGCTGGGGGTGGAGAGAACACTAAGAGGTGAACATGTA TGAGTGTGTGCACGCGTGTGAGTGTGCATGTGTGTGTGTGCAAAGGTCCAGCCACCCCGTCCTCCAGCCT GCAAGGGGTGTCTGGCGCCTTGCCTGACACCCAGCCCCCTCTCCCCCTGAGCCATTGTGGGGGTCGATCA TGAATGTCCGAAGAGTGGCCTTTTCCCGTAGCCCTGCGCCCCCTTTCTGTGGCTGGATGGGGAGACAGGT CAGGGCCCCCCACCCTCTCCAGCCCCTGCAGCAAATGACTACTGCACCTGGACAGCCTCCTCTTTTCTAG AAGTCTATTTATATTGTCATTTTATAACACTCTAGCCCCTGCCCTTATTGGGGGACAGATGGTCCCTGTC CTGCGGGGTGGCCCTGGCAGAACCACTGCCTGAAGAACCAGGTTCCTGCCCGGTCAGCGCAGCCCCAGCC CGCCCACCCCTGCCTCGAGTTAGTTTTACAATTAAAACATTGTCTTGTTTTGTG Download Select all
Length

CDS Information

Location
CDS Sequence	>lcl\|NM_001014831.2_cds_NP_001014831.1_1 [gene=PAK4] [protein=serine/threonine-protein kinase PAK 4 isoform 1] [protein_id=NP_001014831.1] [location=462..2237] ATGTTTGGGAAGAGGAAGAAGCGGGTGGAGATCTCCGCGCCGTCCAACTTCGAGCACCGCGTGCACACGG GCTTCGACCAGCACGAGCAGAAGTTCACGGGGCTGCCCCGCCAGTGGCAGAGCCTGATCGAGGAGTCGGC TCGCCGGCCCAAGCCCCTCGTCGACCCCGCCTGCATCACCTCCATCCAGCCCGGGGCCCCCAAGACCATC GTGCGGGGCAGCAAAGGTGCCAAAGATGGGGCCCTCACGCTGCTGCTGGACGAGTTTGAGAACATGTCGG TGACACGCTCCAACTCCCTGCGGAGAGACAGCCCGCCGCCGCCCGCCCGTGCCCGCCAGGAAAATGGGAT GCCAGAGGAGCCGGCCACCACGGCCAGAGGGGGCCCAGGGAAGGCAGGCAGCCGAGGCCGGTTCGCCGGT CACAGCGAGGCGGGTGGCGGCAGTGGTGACAGGCGACGGGCGGGGCCAGAGAAGAGGCCCAAGTCTTCCA GGGAGGGCTCAGGGGGTCCCCAGGAGTCCTCCCGGGACAAACGCCCCCTCTCCGGGCCTGATGTCGGCAC CCCCCAGCCTGCTGGTCTGGCCAGTGGGGCGAAACTGGCAGCTGGCCGGCCCTTTAACACCTACCCGAGG GCTGACACGGACCACCCATCCCGGGGTGCCCAGGGGGAGCCTCATGACGTGGCCCCTAACGGGCCATCAG CGGGGGGCCTGGCCATCCCCCAGTCCTCCTCCTCCTCCTCCCGGCCTCCCACCCGAGCCCGAGGTGCCCC CAGCCCTGGAGTGCTGGGACCCCACGCCTCAGAGCCCCAGCTGGCCCCTCCAGCCTGCACCCCCGCCGCC CCTGCTGTTCCTGGGCCCCCTGGCCCCCGCTCACCACAGCGGGAGCCACAGCGAGTATCCCATGAGCAGT TCCGGGCTGCCCTGCAGCTGGTGGTGGACCCAGGCGACCCCCGCTCCTACCTGGACAACTTCATCAAGAT TGGCGAGGGCTCCACGGGCATCGTGTGCATCGCCACCGTGCGCAGCTCGGGCAAGCTGGTGGCCGTCAAG AAGATGGACCTGCGCAAGCAGCAGAGGCGCGAGCTGCTCTTCAACGAGGTGGTAATCATGAGGGACTACC AGCACGAGAATGTGGTGGAGATGTACAACAGCTACCTGGTGGGGGACGAGCTCTGGGTGGTCATGGAGTT CCTGGAAGGAGGCGCCCTCACCGACATCGTCACCCACACCAGGATGAACGAGGAGCAGATCGCGGCCGTG TGCCTTGCAGTGCTGCAGGCCCTGTCGGTGCTCCACGCCCAGGGCGTCATCCACCGGGACATCAAGAGCG ACTCGATCCTGCTGACCCATGATGGCAGGGTGAAGCTGTCAGACTTTGGGTTCTGCGCCCAGGTGAGCAA GGAAGTGCCCCGAAGGAAGTCGCTGGTCGGCACGCCCTACTGGATGGCCCCAGAGCTCATCTCCCGCCTT CCCTACGGGCCAGAGGTAGACATCTGGTCGCTGGGGATAATGGTGATTGAGATGGTGGACGGAGAGCCCC CCTACTTCAACGAGCCACCCCTCAAAGCCATGAAGATGATTCGGGACAACCTGCCACCCCGACTGAAGAA CCTGCACAAGGTGTCGCCATCCCTGAAGGGCTTCCTGGACCGCCTGCTGGTGCGAGACCCTGCCCAGCGG GCCACGGCAGCCGAGCTGCTGAAGCACCCATTCCTGGCCAAGGCAGGGCCGCCTGCCAGCATCGTGCCCC TCATGCGCCAGAACCGCACCAGATGA Download Select all
CCDS ID	CCDS12528.1

Protein Information

Protein ID	NP_001014831.1
Protein Name	p21 protein (Cdc42/Rac)-activated kinase 4
Molecular Wt. (Da)	0
Protein Sequence	>lcl\|NM_001014831.2_prot_NP_001014831.1_1 [gene=PAK4] [protein=serine/threonine-protein kinase PAK 4 isoform 1] [protein_id=NP_001014831.1] [location=462..2237] MFGKRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACITSIQPGAPKTI VRGSKGAKDGALTLLLDEFENMSVTRSNSLRRDSPPPPARARQENGMPEEPATTARGGPGKAGSRGRFAG HSEAGGGSGDRRRAGPEKRPKSSREGSGGPQESSRDKRPLSGPDVGTPQPAGLASGAKLAAGRPFNTYPR ADTDHPSRGAQGEPHDVAPNGPSAGGLAIPQSSSSSSRPPTRARGAPSPGVLGPHASEPQLAPPACTPAA PAVPGPPGPRSPQREPQRVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVK KMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAV CLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRL PYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQR ATAAELLKHPFLAKAGPPASIVPLMRQNRTR Download Select all
Length	591
Uniprot ID	Q9GZV5
Ensembl Protein ID	ENSP00000353847

Post-translational Modification Information (Source : HPRD)

Residue	Type	site
S	Phosphorylation	474
S	Phosphorylation	474
S	Phosphorylation	474
S	Phosphorylation	321
S	Phosphorylation	321
S	Phosphorylation	181;-
S	Phosphorylation	181;-
S	Phosphorylation	181;-
S	Phosphorylation	291;-
S	Phosphorylation	291;-
S	Phosphorylation	291;-
S	Phosphorylation	138;-
S	Phosphorylation	138;-
S	Phosphorylation	126;-
T	Phosphorylation	207;-
T	Phosphorylation	207;-
T	Phosphorylation	207;-
S	Phosphorylation	104;-
S	Phosphorylation	104;-
S	Phosphorylation	104;-
S	Phosphorylation	104;-
S	Phosphorylation	258;-
S	Phosphorylation	258;-
S	Phosphorylation	258;-
S	Phosphorylation	105;-
S	Phosphorylation	105;-
S	Phosphorylation	167;-
S	Phosphorylation	167;-
S	Phosphorylation	167;-
S	Phosphorylation	309;-
S	Phosphorylation	181;-
S	Phosphorylation	181;-
S	Phosphorylation	181;-
S	Phosphorylation	148;-
S	Phosphorylation	148;-
S	Phosphorylation	148;-
T	Phosphorylation	478;-
T	Phosphorylation	478;-
T	Phosphorylation	478;-
T	Phosphorylation	325;-
T	Phosphorylation	325;-
T	Phosphorylation	313;-
S	Phosphorylation	99;-
S	Phosphorylation	99;-
S	Phosphorylation	99;-
S	Phosphorylation	99;-
Y	Phosphorylation	208
Y	Phosphorylation	208
Y	Phosphorylation	208
Y	Phosphorylation	480
Y	Phosphorylation	480
Y	Phosphorylation	480
Y	Phosphorylation	315
Y	Phosphorylation	327
Y	Phosphorylation	327
S	Phosphorylation	142
S	Phosphorylation	142
S	Phosphorylation	142
S	Phosphorylation	267
S	Phosphorylation	267
S	Phosphorylation	267
S	Phosphorylation	114
S	Phosphorylation	114
T	Phosphorylation	277
T	Phosphorylation	277
T	Phosphorylation	277
T	Phosphorylation	124
T	Phosphorylation	124
S	Phosphorylation	242
S	Phosphorylation	242
S	Phosphorylation	242
S	Phosphorylation	41
S	Phosphorylation	41
S	Phosphorylation	41
S	Phosphorylation	41
S	Phosphorylation	41
S	Phosphorylation	41
T	Phosphorylation	187
T	Phosphorylation	187
T	Phosphorylation	187
S	Phosphorylation	342
S	Phosphorylation	342
S	Phosphorylation	342
S	Phosphorylation	177
S	Phosphorylation	189
S	Phosphorylation	189

Enzyme Information

No matching records could be found.

PPi Information

(Click to view network : Source STRING) View

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
998	CDC42	309	NP_001782.1	in vitro;in vivo	9822598
3685	ITGAV	1903	NP_002201.1	in vitro;yeast 2-hybrid	12356872
3693	ITGB5	949	NP_002204.2	in vivo;yeast 2-hybrid	12356872
3984	LIMK1	3210	NP_002305.1	in vitro	11413130
7532	YWHAG	5639	NP_036611.2	in vivo	15324660
54815	GATAD2A	11741	AAO31797.1	yeast 2-hybrid	16169070

Pathway Information

Pathway Name	Pathway ID
Axon guidance	hsa04360
ErbB signaling pathway	hsa04012
Focal adhesion	hsa04510
MicroRNAs in cancer	hsa05206
Ras signaling pathway	hsa04014
Regulation of actin cytoskeleton	hsa04810
Renal cell carcinoma	hsa05211
T cell receptor signaling pathway	hsa04660

Structure Information

No matching records could be found.

Domain Information

ID	Location	Description
cd06657	300-591	STKc_PAK4
cl21453	300-591	PKc_like superfamily
cd01093	Oct-55	CRIB_PAK_like
cl00113	Oct-55	CRIB superfamily
cd06648	313-573	STKc_PAK_II
cd06659	299-591	STKc_PAK6
cd06658	298-589	STKc_PAK5
cd06614	320-573	STKc_PAK
cd05122	320-572	PKc_STE
cd06647	315-572	STKc_PAK_I
cd06654	300-585	STKc_PAK1
cd06656	302-585	STKc_PAK3
cd06655	302-589	STKc_PAK2
cd06612	326-572	STKc_MST1_2
cd06613	326-571	STKc_MAP4K3_like
cd06609	326-587	STKc_MST3_like
cd06606	327-572	STKc_MAPKKK
cd06608	327-572	STKc_myosinIII_N_like
cd06610	326-571	STKc_OSR1_SPAK
cd06627	326-572	STKc_Cdc7_like
cd06611	316-576	STKc_SLK_like
cd05117	326-571	STKc_CAMK
cd06917	327-582	STKc_NAK1_like
cd06607	327-572	STKc_TAO
cd14014	326-567	STKc_PknB_like
cd08215	326-572	STKc_Nek
cd06644	316-574	STKc_STK10
cd06645	316-574	STKc_MAP4K3
cd14003	326-571	STKc_AMPK-like
cd00180	327-570	PKc
cd06643	316-573	STKc_SLK
cd05123	327-571	STKc_AGC
cd06633	316-589	STKc_TAO3
cd06636	316-572	STKc_MAP4K4_6_N
cd14007	326-572	STKc_Aurora
cd06646	326-572	STKc_MAP4K5
cd06623	319-575	PKc_MAPKK_plant_like
cd06632	327-572	STKc_MEKK1_plant
cd06640	316-574	STKc_MST4
cd06641	316-580	STKc_MST3
cd06637	316-572	STKc_TNIK
cd14002	327-572	STKc_STK36
cd06642	316-589	STKc_STK25
cd06639	315-572	STKc_myosinIIIB_N
cd13999	327-568	STKc_MAP3K-like
cd06626	326-572	STKc_MEKK4
cd08217	326-572	STKc_Nek2
cd14008	327-572	STKc_LKB1_CaMKK
cd06638	313-572	STKc_myosinIIIA_N
cd05579	327-573	STKc_MAST_like
cd06635	316-589	STKc_TAO1
cd06605	321-575	PKc_MAPKK
cd06634	316-589	STKc_TAO2
cd06631	327-572	STKc_YSK4
cd06628	327-572	STKc_Byr2_like
cd14010	323-571	STKc_ULK4
cd14099	327-572	STKc_PLK
cd14009	327-571	STKc_ATG1_ULK_like
smart00750	401-580	KIND
cd06625	327-571	STKc_MEKK3_like
cd05580	323-573	STKc_PKA_like
cd06624	325-572	STKc_ASK
cd05581	324-571	STKc_PDK1
cd06621	326-572	PKc_Pek1_like
cd08216	326-586	PK_STRAD
cd07833	326-572	STKc_CDKL
cd08529	322-572	STKc_FA2-like
cd08530	326-570	STKc_CNK2-like
cd07829	326-572	STKc_CDK_like
cd14006	327-570	STKc_MLCK-like
cd14086	326-582	STKc_CaMKII
cd14095	326-570	STKc_DCKL
cd06629	327-572	STKc_Bck1_like
cd05118	326-572	STKc_CMGC
cd14098	327-571	STKc_Rad53_Cds1
cd14080	325-572	STKc_TSSK-like
cd14091	326-573	STKc_RSK_C
cd14084	326-572	STKc_Chk2
cd14069	327-572	STKc_Chk1
cd05573	323-571	STKc_ROCK_NDR_like
cd13983	325-572	STKc_WNK
cd05570	327-571	STKc_PKC
cd14078	327-572	STKc_MELK
cd14081	326-572	STKc_BRSK1_2
cd06620	326-575	PKc_Byr1_like
cd14120	327-571	STKc_ULK1_2-like
cd14121	326-571	STKc_ULK3
cd14083	327-570	STKc_CaMKI
cd05578	327-572	STKc_Yank1
cd14093	327-572	STKc_PhKG
cd07830	326-572	STKc_MAK_like
cd07847	326-571	STKc_CDKL1_4
cd13994	327-572	STKc_HAL4_like
cd14169	326-573	STKc_CaMKI_beta
cd08221	346-572	STKc_Nek9
cd05611	327-573	STKc_Rim15_like
cd07840	326-571	STKc_CDK9_like
cd14077	324-572	STKc_Kin1_2
cd05599	327-573	STKc_NDR_like
cd14087	327-572	STKc_PSKH1
cd06616	327-571	PKc_MKK4
cd00192	326-569	PTKc
cd08218	326-572	STKc_Nek1
cd14118	327-570	STKc_CAMKK
cd14167	327-573	STKc_CaMKI_alpha
cd08225	326-572	STKc_Nek5
cd08224	326-568	STKc_Nek6_7
cd05572	327-571	STKc_cGK
cd14185	327-571	STKc_DCKL3
cd13985	327-567	STKc_GAK_like
cd13997	326-570	PKc_Wee1_like
cd14166	327-573	STKc_CaMKI_gamma
cd07834	327-574	STKc_MAPK
cd14072	327-568	STKc_MARK
cd14079	327-572	STKc_AMPK_alpha
cd08528	327-560	STKc_Nek10
cd07832	326-572	STKc_CCRK
cd14181	327-572	STKc_PhKG2
cd06617	322-575	PKc_MKK3_6
cd14137	327-571	STKc_GSK3
cd14165	318-572	STKc_TSSK1_2-like
cd07846	322-571	STKc_CDKL2_3
cd14073	326-572	STKc_NUAK
cd06618	321-572	PKc_MKK7
cd14182	327-572	STKc_PhKG1
cd05590	327-572	STKc_nPKC_eta
cd14202	327-572	STKc_ULK1
cd14168	327-573	STKc_CaMKI_delta
cd05612	321-560	STKc_PRKX_like
cd07841	326-578	STKc_CDK7
cd08220	327-572	STKc_Nek8
cd14106	327-572	STKc_DRAK
cd14209	322-560	STKc_PKA
cd05584	369-578	STKc_p70S6K
cd05575	327-571	STKc_SGK
cd14184	327-571	STKc_DCKL2
cd14066	327-565	STKc_IRAK
cd06622	326-578	PKc_PBS2_like
cd14103	327-572	STKc_MLCK
cd14097	326-572	STKc_STK33
cd14074	327-572	STKc_SNRK
cd08223	323-572	STKc_Nek4
cd14085	326-572	STKc_CaMKIV
cd14201	347-572	STKc_ULK2
cd13995	327-572	STKc_MAP3K8
cd06619	327-572	PKc_MKK5
cd05598	325-573	STKc_LATS
cd05604	327-573	STKc_SGK3
cd14175	327-574	STKc_RSK1_C
cd14189	318-572	STKc_PLK3
cd05591	327-574	STKc_nPKC_epsilon
cd14663	327-571	STKc_SnRK3
cd06653	327-571	STKc_MEKK3_like_u1
cd07880	317-574	STKc_p38gamma
cd05595	327-572	STKc_PKB_beta
cd14114	320-572	STKc_Twitchin_like
cd13996	320-567	STKc_EIF2AK
cd05574	325-574	STKc_phototropin_like
cd14071	327-572	STKc_SIK
cd14075	347-572	STKc_NIM1
cd14004	326-572	STKc_PASK
cd14012	353-571	PK_eIF2AK_GCN2_rpt1
cd14082	327-518	STKc_PKD
cd07851	327-574	STKc_p38
cd14178	327-572	STKc_RSK3_C
cd05593	327-573	STKc_PKB_gamma
cd06652	327-571	STKc_MEKK2
cd06615	322-575	PKc_MEK
cd14131	326-572	PKc_Mps1
cd14050	326-570	PKc_Myt1
cd14047	318-569	STKc_EIF2AK2_PKR
cd14162	327-572	STKc_TSSK4-like
cd05620	327-572	STKc_nPKC_delta
cd06630	327-570	STKc_MEKK1
cd14116	321-572	STKc_Aurora-A
cd05603	327-573	STKc_SGK2
cd07845	326-578	STKc_CDK10
cd05619	321-572	STKc_nPKC_theta
cd05587	327-571	STKc_cPKC
cd07852	326-574	STKc_MAPK15-like
cd14186	327-572	STKc_PLK4
cd05582	327-573	STKc_RSK_N
cd05630	327-574	STKc_GRK6
cd14176	327-572	STKc_RSK2_C
cd14195	326-572	STKc_DAPK3
cd05571	327-573	STKc_PKB
cd14105	326-572	STKc_DAPK
cd07856	327-573	STKc_Sty1_Hog1
cd14177	327-573	STKc_RSK4_C
cd07843	326-571	STKc_CDC2L1
cd14092	327-585	STKc_MSK_C
cd14119	327-570	STKc_LKB1
cd14183	327-572	STKc_DCKL1
cd07855	326-574	STKc_ERK5
cd14194	321-572	STKc_DAPK1
cd05602	323-573	STKc_SGK1
cd05577	327-574	STKc_GRK
cd05592	327-571	STKc_nPKC_theta_like
cd05632	327-572	STKc_GRK5
cd14005	326-570	STKc_PIM
cd05601	327-574	STKc_CRIK
cd14115	327-571	STKc_Kalirin_C
cd14173	327-572	STKc_Mnk2
cd05609	327-571	STKc_MAST
cd14046	320-569	STKc_EIF2AK4_GCN2_rpt2
cd08219	327-567	STKc_Nek3
cd05594	327-573	STKc_PKB_alpha
cd14197	326-572	STKc_DRAK1
cd14058	327-568	STKc_TAK1
cd08222	326-572	STKc_Nek11
cd14192	327-572	STKc_MLCK3
cd14187	312-572	STKc_PLK1
cd14196	326-572	STKc_DAPK2
cd14665	323-571	STKc_SnRK2-3
cd05585	327-574	STKc_YPK1_like
cd14161	327-569	STKc_NUAK2
cd14070	326-572	STKc_HUNK
cd05616	323-560	STKc_cPKC_beta
cd14133	327-572	PKc_DYRK_like
cd14662	327-571	STKc_SnRK2
cd05631	327-570	STKc_GRK4
cd14199	326-572	STKc_CaMKK2
cd06651	327-571	STKc_MEKK3
cd13979	327-568	STKc_Mos
cd05596	323-518	STKc_ROCK
cd08228	321-560	STKc_Nek6
cd07848	327-570	STKc_CDKL5
cd14090	327-571	STKc_Mnk
cd13989	327-562	STKc_IKK
cd05626	324-573	STKc_LATS2
cd05615	323-560	STKc_cPKC_alpha
cd14111	314-572	STKc_SPEG_rpt2
cd07838	327-572	STKc_CDK4_6_like
cd14059	327-515	STKc_MAP3K12_13
cd14094	327-572	STKc_CASK
cd14200	326-572	STKc_CaMKK1
cd14096	326-572	STKc_RCK1-like
cd05625	324-572	STKc_LATS1
cd14088	338-572	STKc_CaMK_like
cd14164	327-572	STKc_TSSK6-like
cd07860	326-571	STKc_CDK2_3
cd14089	326-570	STKc_MAPKAPK
cd07854	327-573	STKc_MAPK4_6
cd05605	327-571	STKc_GRK4_like
cd14171	326-572	STKc_MAPKAPK5
cd14117	327-572	STKc_Aurora-B_like
cd05622	327-516	STKc_ROCK1
cd05621	327-572	STKc_ROCK2
cd14210	326-572	PKc_DYRK
cd07835	326-572	STKc_CDK1_CdkB_like
cd14190	327-572	STKc_MLCK2
cd05613	327-574	STKc_MSK1_N
cd08229	326-560	STKc_Nek7
cd07865	326-571	STKc_CDK9
cd14019	326-572	STKc_Cdc7
cd05610	327-573	STKc_MASTL
cd14188	342-572	STKc_PLK2
cd13993	326-568	STKc_Pat1_like
cd07849	326-573	STKc_ERK1_2_like
cd05583	327-571	STKc_MSK_N
cd07878	317-578	STKc_p38beta
cd05608	323-583	STKc_GRK1
cd07853	327-572	STKc_NLK
cd14193	327-572	STKc_MLCK4
cd05624	290-572	STKc_MRCK_beta
cd14198	321-572	STKc_DRAK2
cd14107	319-572	STKc_obscurin_rpt1
cd14174	327-572	STKc_Mnk1
cd07831	326-571	STKc_MOK
cd06650	322-575	PKc_MEK1
cd07879	317-572	STKc_p38delta
cd07877	317-578	STKc_p38alpha
cd07836	326-571	STKc_Pho85
cd14158	326-521	STKc_IRAK4
cd07864	327-572	STKc_CDK12
cd07858	325-574	STKc_TEY_MAPK
cd13986	326-569	STKc_16
cd14113	322-572	STKc_Trio_C
cd05597	327-571	STKc_DMPK_like
cd07850	327-572	STKc_JNK
cd05627	321-572	STKc_NDR2
cd07876	327-578	STKc_JNK2
cd14104	326-572	STKc_Titin
cd14191	326-572	STKc_MLCK1
cd05589	327-586	STKc_PKN
cd05629	327-573	STKc_NDR_like_fungal
cd05623	327-573	STKc_MRCK_alpha
cd14076	327-572	STKc_Kin4
cd07874	323-581	STKc_JNK3
cd05614	327-586	STKc_MSK2_N
cd13987	327-569	STKc_SBK1
cd07859	327-573	STKc_TDY_MAPK
cd14109	327-572	PK_Unc-89_rpt1
cd14154	327-515	STKc_LIMK
cd14060	328-515	STKc_MLTK
cd14222	327-509	STKc_LIMK2
cd05628	327-527	STKc_NDR1
cd14062	327-515	STKc_Raf
cd07866	319-571	STKc_BUR1
cd05600	325-515	STKc_Sid2p_like
cd14163	327-572	STKc_TSSK3-like
cd08226	343-571	PK_STRAD_beta
cd05617	327-560	STKc_aPKC_zeta
cd05038	320-545	PTKc_Jak_rpt2
cd07861	326-572	STKc_CDK1_euk
cd07839	322-571	STKc_CDK5
cd13991	326-566	STKc_NIK
cd14221	327-516	STKc_LIMK1
cd14170	327-575	STKc_MAPKAPK2
cd05607	320-560	STKc_GRK7
cd14110	326-572	STKc_obscurin_rpt2
cd07857	326-573	STKc_MPK1
cd13968	327-460	PKc_like
cd14052	327-570	PTKc_Wee1_fungi
cd08227	334-572	PK_STRAD_alpha
cd07870	319-572	STKc_PFTAIRE2
cd13990	350-571	STKc_TLK
cd14037	327-571	STKc_NAK_like
cd06649	326-575	PKc_MEK2
cd05588	327-571	STKc_aPKC
cd14033	320-572	STKc_WNK4
cd07875	323-578	STKc_JNK1
cd14180	327-585	STKc_MSK2_C
cd05606	327-571	STKc_beta_ARK
cd14039	327-570	STKc_IKK_alpha
cd05586	327-573	STKc_Sck1_like
cd14108	320-572	STKc_SPEG_rpt1
cd05618	327-515	STKc_aPKC_iota
cd14172	391-572	STKc_MAPKAPK3
cd05041	326-515	PTKc_Fes_like
cd14179	327-585	STKc_MSK1_C
cd05033	327-533	PTKc_EphR
cd13998	327-563	STKc_TGFbR-like
cd14151	326-538	STKc_B-Raf
cd14061	327-515	STKc_MLK
cd07842	326-571	STKc_CDK8_like
cd05059	324-568	PTKc_Tec_like
cd14149	326-543	STKc_C-Raf
cd14031	350-574	STKc_WNK3
cd14065	327-569	PKc_LIMK_like
cd14036	327-502	STKc_GAK
cd07863	326-572	STKc_CDK4
cd14112	328-572	STKc_Unc-89_rpt2
cd14048	327-569	STKc_EIF2AK3_PERK
cd05633	327-572	STKc_GRK3
cd14156	327-509	PKc_LIMK_like_unk
cd05112	325-517	PTKc_Itk
cd05039	327-519	PTKc_Csk_like
cd14132	326-571	STKc_CK2_alpha
cd05080	318-527	PTKc_Tyk2_rpt2
cd07862	326-513	STKc_CDK6
cd07837	326-571	STKc_CdkB_plant
cd07873	326-576	STKc_PCTAIRE1
cd14225	327-572	PKc_DYRK4
cd14147	327-515	STKc_MLK3
cd14223	327-572	STKc_GRK2
cd14148	327-515	STKc_MLK2
cd14150	326-517	STKc_A-Raf
cd05082	327-566	PTKc_Csk
cd13977	326-510	STKc_PDIK1L
cd14146	327-515	STKc_MLK4
cd14205	342-527	PTKc_Jak2_rpt2
cd05073	317-528	PTKc_Hck
cd14032	325-574	STKc_WNK2_like
cd07871	326-572	STKc_PCTAIRE3
cd05065	327-533	PTKc_EphR_B
cd05114	324-568	PTKc_Tec_Rlk
cd05056	326-566	PTKc_FAK
cd05049	327-516	PTKc_Trk
cd14063	321-538	PK_KSR
cd07844	326-572	STKc_PCTAIRE_like
cd14038	326-562	STKc_IKK_beta
cd05085	327-515	PTKc_Fer
cd14155	327-515	PKc_TESK
cd14030	325-572	STKc_WNK1
cd14145	344-515	STKc_MLK1
cd13978	327-524	STKc_RIP
cd13975	374-504	PKc_Dusty
cd14142	344-537	STKc_ACVR1_ALK1
cd14011	422-572	PK_SCY1_like
cd14049	320-567	STKc_EIF2AK1_HRI
cd14136	326-572	STKc_SRPK
cd14056	327-541	STKc_TGFbR_I
cd07872	326-583	STKc_PCTAIRE2
cd05032	327-515	PTKc_InsR_like
cd07869	315-531	STKc_PFTAIRE1
cd05064	327-574	PTKc_EphR_A10
cd14051	326-570	PTKc_Wee1
cd14134	310-572	PKc_CLK
cd05053	317-568	PTKc_FGFR
cd05046	317-568	PTK_CCK4
cd14064	327-523	PKc_TNNI3K
cd05113	316-515	PTKc_Btk_Bmx
cd05060	325-566	PTKc_Syk_like
cd05083	326-515	PTKc_Chk
cd05066	327-533	PTKc_EphR_A
cd14101	327-572	STKc_PIM2
cd14027	358-517	STKc_RIP1
cd13974	411-569	STKc_SHIK
cd13982	326-571	STKc_IRE1
cd13992	344-563	PK_GC
cd14211	327-515	STKc_HIPK
cd14053	345-519	STKc_ACVR2
cd05061	317-538	PTKc_InsR
cd14226	327-575	PKc_DYRK1
cd05079	318-509	PTKc_Jak1_rpt2
cd14229	327-515	STKc_HIPK3
cd05063	327-529	PTKc_EphR_A2
cd13984	350-572	PK_NRBP1_like
cd13988	327-515	STKc_TBK1
cd05084	326-517	PTKc_Fes
cd14152	327-519	STKc_KSR1
cd14100	327-572	STKc_PIM1
cd14664	327-568	STK_BAK1_like
cd05148	326-515	PTKc_Srm_Brk
cd14102	327-572	STKc_PIM3
cd05072	317-515	PTKc_Lyn
cd05067	317-538	PTKc_Lck_Blk
cd14054	327-563	STKc_BMPR2_AMHR2
cd05040	326-515	PTKc_Ack_like
cd14228	327-515	STKc_HIPK1
cd05081	342-508	PTKc_Jak3_rpt2
cd14227	327-515	STKc_HIPK2
cd14022	374-572	PK_TRB2
cd05044	347-515	PTKc_c-ros
cd14212	326-572	PKc_YAK1
cd14144	326-534	STKc_BMPR1
cd14024	375-572	PK_TRB3
cd05055	317-515	PTKc_PDGFR
cd14135	427-572	STKc_PRP4
cd14000	327-570	STKc_LRRK
cd05093	326-516	PTKc_TrkB
cd05068	317-562	PTKc_Frk_like
cd14001	348-567	PKc_TOPK
cd14143	327-534	STKc_TGFbR1_ACVR1b_ACVR1c
cd14034	350-572	PK_NRBP1
cd14153	347-538	PK_KSR2
cd05050	317-566	PTKc_Musk
cd14041	327-572	STKc_TLK2
cd05092	326-566	PTKc_TrkA
cd14159	327-514	STKc_IRAK1
cd05069	317-515	PTKc_Yes
cd05094	326-577	PTKc_TrkC
cd05045	327-568	PTKc_RET
cd14067	327-541	STKc_LRRK1
cd07868	366-572	STKc_CDK8
cd05071	317-515	PTKc_Src
cd14017	326-551	STKc_TTBK
pfam00786	Oct-64	PBD
cd14138	326-570	PTKc_Wee1a
cd07867	366-572	STKc_CDC2L6
cd14139	326-570	PTKc_Wee1b
cd05098	314-568	PTKc_FGFR1
cd05101	317-529	PTKc_FGFR2
cd05052	326-515	PTKc_Abl
cd14016	326-479	STKc_CK1
cd05090	344-538	PTKc_Ror1
cd14203	326-515	PTKc_Src_Fyn_like
cd05035	327-515	PTKc_TAM
cd05100	314-529	PTKc_FGFR3
cd14055	375-564	STKc_TGFbR2_like
cd05075	327-515	PTKc_Axl
cd05034	326-515	PTKc_Src_like
cd14220	326-568	STKc_BMPR1a
cd05103	415-569	PTKc_VEGFR2
cd13976	374-572	PK_TRB
cd05047	327-515	PTKc_Tie
cd05057	347-519	PTKc_EGFR_like
cd05099	363-568	PTKc_FGFR4
cd14140	336-509	STKc_ACVR2b
cd14023	375-572	PK_TRB1
smart00285	Nov-43	PBD
cd05058	327-515	PTKc_Met_Ron
cd05088	327-515	PTKc_Tie2
cd05070	317-515	PTKc_Fyn
cd05116	326-515	PTKc_Syk
cd14207	415-568	PTKc_VEGFR1
cd14040	345-590	STKc_TLK1
cd05074	327-515	PTKc_Tyro3
TIGR03724	394-489	arch_bud32
COG3642	389-469	Bud32
smart00220	326-572	S_TKc
pfam00069	326-572	Pkinase
COG0515	326-573	SPS1
smart00219	326-568	TyrKc
pfam07714	326-569	Pkinase_Tyr
smart00221	326-568	STYKc
PTZ00263	327-575	PTZ00263
PLN00034	317-579	PLN00034
PTZ00267	311-572	PTZ00267
PTZ00283	316-570	PTZ00283
PTZ00426	323-573	PTZ00426
PTZ00024	321-569	PTZ00024
PHA03390	351-572	pk1
PHA03212	356-569	PHA03212
PRK13184	326-568	pknD
PTZ00266	326-578	PTZ00266
PLN00009	326-576	PLN00009
PTZ00036	318-583	PTZ00036
PHA03209	330-520	PHA03209
PHA03207	330-516	PHA03207
PHA03210	363-573	PHA03210
TIGR03903	348-573	TOMM_kin_cyc
PHA03211	416-507	PHA03211
COG0478	393-468	RIO2

Ontology Information

HPRD ID	10057
Molecular Class	Not Available
Molecular Function	Receptor activity (GO:0004872)
Biological Process	Cell communication (GO:0007154); Signal transduction (GO:0007165)

SNP Information

View SNP Geneview Report

Drug Information

No matching records could be found.

External Links

ArrayExpress GO
ICGC GO
Cancer3D GO
COSMIC GO
NCG GO
TSGene GO
Tumor Gene Family of Databases GO
CCDB GO
G2SBC GO
Osteosarcoma Database GO
RCDB GO

ArrayExpress	GO
ICGC	GO
Cancer3D	GO
COSMIC	GO
NCG	GO
TSGene	GO
Tumor Gene Family of Databases	GO
CCDB	GO
G2SBC	GO
Osteosarcoma Database	GO
RCDB	GO